-
1
-
-
0026725757
-
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-defi cient mice created by homologous recombination in ES cells
-
Plump , A. S. , J. D. Smith , T. Hayek , K. Aalto-Setala , A. Walsh , J. G. Verstuyft , E. M. Rubin, and J. L. Breslow. 1992 . Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-defi cient mice created by homologous recombination in ES cells. Cell . 71 : 343-353.
-
(1992)
Cell
, vol.71
, pp. 343-353
-
-
Plump, A.S.1
Smith, J.D.2
Hayek, T.3
Aalto-Setala, K.4
Walsh, A.5
Verstuyft, J.G.6
Rubin, E.M.7
Breslow, J.L.8
-
2
-
-
0023037569
-
Familial apolipoprotein E deficiency
-
Schaefer , E. J. , R. E. Gregg , G. Ghiselli , T. M. Forte , J. M. Ordovas , L. A. Zech , and H. B. Brewer, Jr. 1986 . Familial apolipoprotein E deficiency. J. Clin. Invest. 78 : 1206-1219.
-
(1986)
J. Clin. Invest
, vol.78
, pp. 1206-1219
-
-
Schaefer, E.J.1
Gregg, R.E.2
Ghiselli, G.3
Forte, T.M.4
Ordovas, J.M.5
Zech, L.A.6
Brewer Jr., H.B.7
-
3
-
-
0027976942
-
Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression
-
Reddick , R. L. , S. H. Zhang , and N. Maeda . 1994 . Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression. Arterioscler. Thromb. 14 : 141-147.
-
(1994)
Arterioscler. Thromb
, vol.14
, pp. 141-147
-
-
Reddick, R.L.1
Zhang, S.H.2
Maeda, N.3
-
4
-
-
0028917252
-
Lipoprotein and receptor interactions in vivo
-
Herz , J. , and T. E. Willnow . 1995 . Lipoprotein and receptor interactions in vivo. Curr. Opin. Lipidol. 6 : 97-103.
-
(1995)
Curr. Opin. Lipidol
, vol.6
, pp. 97-103
-
-
Herz, J.1
Willnow, T.E.2
-
5
-
-
0029922119
-
Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain
-
Kim , D. H. , H. Iijima , K. Goto , J. Sakai , H. Ishii , H. J. Kim , H. Suzuki, H. Kondo, S. Saeki, and T. Yamamoto. 1996 . Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. J. Biol. Chem. 271 : 8373-8380.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 8373-8380
-
-
Kim, D.H.1
Iijima, H.2
Goto, K.3
Sakai, J.4
Ishii, H.5
Kim, H.J.6
Suzuki, H.7
Kondo, H.8
Saeki, S.9
Yamamoto, T.10
-
6
-
-
0026778830
-
Rabbit very low density lipoprotein receptor: A low density lipoprotein receptor-like protein with distinct ligand specifi city
-
Takahashi , S. , Y. Kawarabayasi , T. Nakai , J. Sakai , and T. Yamamoto . 1992 . Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specifi city. Proc. Natl. Acad. Sci. USA . 89 : 9252-9256.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 9252-9256
-
-
Takahashi, S.1
Kawarabayasi, Y.2
Nakai, T.3
Sakai, J.4
Yamamoto, T.5
-
7
-
-
0001575898
-
Type III hyperlipoproteinemia (dysbetalipoproteinemia): The role of apolipoprotein E in normal and abnormal lipoprotein metabolism
-
C. R. Scriver, A L. Beaudet, D. Valle, et al., editors, McGraw-Hill, NY
-
Mahley , R. W. , and S. C. Rall , Jr . 2001 . Type III hyperlipoproteinemia (dysbetalipoproteinemia): the role of apolipoprotein E in normal and abnormal lipoprotein metabolism. In C. R. Scriver, A. L. Beaudet, D. Valle, et al., editors. The Metabolic and Molecular Bases of Inherited Disease. McGraw-Hill, NY. 2835-2862.
-
(2001)
The Metabolic and Molecular Bases of Inherited Disease
, pp. 2835-2862
-
-
Mahley, R.W.1
Rall Jr., S.C.2
-
8
-
-
0026718601
-
The role of apolipoprotein E genetic variants in lipoprotein disorders
-
Rall , S. C. , Jr ., and R. W. Mahley . 1992 . The role of apolipoprotein E genetic variants in lipoprotein disorders. J. Intern. Med. 231 : 653-659.
-
(1992)
J. Intern. Med
, vol.231
, pp. 653-659
-
-
Rall Jr., S.C.1
Mahley, R.W.2
-
9
-
-
34247170098
-
Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT
-
Kypreos , K. E. , and V. I. Zannis . 2007 . Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT. Biochem. J. 403 : 359-367.
-
(2007)
Biochem. J.
, vol.403
, pp. 359-367
-
-
Kypreos, K.E.1
Zannis, V.I.2
-
10
-
-
0020355825
-
Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2
-
Breslow , J. L. , V. I. Zannis , T. R. SanGiacomo , J. L. Third , T. Tracy , and C. J. Glueck . 1982 . Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2. J. Lipid Res. 23 : 1224-1235.
-
(1982)
J. Lipid Res
, vol.23
, pp. 1224-1235
-
-
Breslow, J.L.1
Zannis, V.I.2
SanGiacomo, T.R.3
Third, J.L.4
Tracy, T.5
Glueck, C.J.6
-
11
-
-
0015641365
-
Primary dysbetalipoproteinemia: Predominance of a specifi c apoprotein species in triglyceride-rich lipoproteins
-
Havel , R. J. , and J. P. Kane . 1973 . Primary dysbetalipoproteinemia: predominance of a specifi c apoprotein species in triglyceride-rich lipoproteins. Proc. Natl. Acad. Sci. USA . 70 : 2015-2019.
-
(1973)
Proc. Natl. Acad. Sci. USA
, vol.70
, pp. 2015-2019
-
-
Havel, R.J.1
Kane, J.P.2
-
12
-
-
0027193817
-
Genetic mutations affecting human lipoproteins, their receptors, and their enzymes
-
Zannis , V. I. , D. Kardassis , and E. E. Zanni . 1993 . Genetic mutations affecting human lipoproteins, their receptors, and their enzymes. Adv. Hum. Genet. 21 : 145-319.
-
(1993)
Adv. Hum. Genet
, vol.21
, pp. 145-319
-
-
Zannis, V.I.1
Kardassis, D.2
Zanni, E.E.3
-
13
-
-
0026584011
-
The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia
-
Horie , Y. , S. Fazio , J. R. Westerlund , K. H. Weisgraber , and S. C. Rall , Jr . 1992 . The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia. J. Biol. Chem. 267 : 1962-1968.
-
(1992)
J. Biol. Chem
, vol.267
, pp. 1962-1968
-
-
Horie, Y.1
Fazio, S.2
Westerlund, J.R.3
Weisgraber, K.H.4
Rall Jr., S.C.5
-
14
-
-
0037470173
-
The central helices of apoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid effl ux. Amino acid residues 220-231 of the wild-type apoA-I are required for lipid effl ux in vitro and high density lipoprotein formation in vivo
-
Chroni , A. , T. Liu , I. Gorshkova , H. Y. Kan , Y. Uehara , A. Von Eckardstein , and V. I. Zannis. 2003 . The central helices of apoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid effl ux. Amino acid residues 220-231 of the wild-type apoA-I are required for lipid effl ux in vitro and high density lipoprotein formation in vivo. J. Biol. Chem. 278 : 6719-6730.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 6719-6730
-
-
Chroni, A.1
Liu, T.2
Gorshkova, I.3
Kan, H.Y.4
Uehara, Y.5
Von Eckardstein, A.6
Zannis, V.I.7
-
15
-
-
0037077197
-
The effects of mutations in helices 4 and 6 of apoA-I on scavenger receptor class B type I (SR-BI)-mediated cholesterol effl ux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for effi cient lipid transport
-
Liu , T. , M. Krieger , H. Y. Kan , and V. I. Zannis . 2002 . The effects of mutations in helices 4 and 6 of apoA-I on scavenger receptor class B type I (SR-BI)-mediated cholesterol effl ux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for effi cient lipid transport. J. Biol. Chem. 277 : 21576-21584.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 21576-21584
-
-
Liu, T.1
Krieger, M.2
Kan, H.Y.3
Zannis, V.I.4
-
16
-
-
0035827693
-
Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoproteintriglyceride secretion
-
Kypreos , K. E. , K. W. Van Dijk , Z. A. van Der , L. M. Havekes , and V. I. Zannis . 2001 . Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoproteintriglyceride secretion. J. Biol. Chem. 276 : 19778-19786.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 19778-19786
-
-
Kypreos, K.E.1
Van Dijk, K.W.2
Van Der, Z.A.3
Havekes, L.M.4
Zannis, V.I.5
-
17
-
-
0032478271
-
A simplifi ed system for generating recombinant adenoviruses
-
He , T. C. , S. Zhou , L. T. da Costa , J. Yu , K. W. Kinzler , and B. Vogelstein . 1998 . A simplifi ed system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA . 95 : 2509-2514.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 2509-2514
-
-
He, T.C.1
Zhou, S.2
Da Costa, L.T.3
Yu, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
18
-
-
14844357362
-
Deletions of helices 2 and 3 of human apoA-I are associated with severe dyslipidemia following adenovirus-mediated gene transfer in apoA-I-defi cient mice
-
Chroni , A. , H. Y. Kan , A. Shkodrani , T. Liu , and V. I. Zannis . 2005 . Deletions of helices 2 and 3 of human apoA-I are associated with severe dyslipidemia following adenovirus-mediated gene transfer in apoA-I-defi cient mice. Biochemistry . 44 : 4108-4117.
-
(2005)
Biochemistry
, vol.44
, pp. 4108-4117
-
-
Chroni, A.1
Kan, H.Y.2
Shkodrani, A.3
Liu, T.4
Zannis, V.I.5
-
19
-
-
27544444653
-
Point mutations in apolipoprotein a-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase defi - Ciency
-
Chroni , A. , A. Duka , H. Y. Kan , T. Liu , and V. I. Zannis . 2005 . Point mutations in apolipoprotein a-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase defi - ciency. Biochemistry . 44 : 14353-14366.
-
(2005)
Biochemistry
, vol.44
, pp. 14353-14366
-
-
Chroni, A.1
Duka, A.2
Kan, H.Y.3
Liu, T.4
Zannis, V.I.5
-
20
-
-
0041817571
-
Domains of apoE required for binding to apoE receptor 2 and to phospholipids: Implications for the functions of apoE in the brain
-
Li , X. , K. Kypreos , E. E. Zanni , and V. Zannis . 2003 . Domains of apoE required for binding to apoE receptor 2 and to phospholipids: Implications for the functions of apoE in the brain. Biochemistry . 42 : 10406-10417.
-
(2003)
Biochemistry
, vol.42
, pp. 10406-10417
-
-
Li, X.1
Kypreos, K.2
Zanni, E.E.3
Zannis, V.4
-
21
-
-
0029619230
-
Two-dimensional nondenaturing electrophoresis of lipoproteins: Applications to high-density lipoprotein speciation
-
Fielding , C. J. , and P. E. Fielding . 1996 . Two-dimensional nondenaturing electrophoresis of lipoproteins: applications to high-density lipoprotein speciation. Methods Enzymol. 263 : 251-259.
-
(1996)
Methods Enzymol
, vol.263
, pp. 251-259
-
-
Fielding, C.J.1
Fielding, P.E.2
-
22
-
-
0023835033
-
Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions
-
Lalazar , A. , K. H. Weisgraber , S. C. Rall , Jr ., H. Giladi , T. L. Innerarity , A. Z. Levanon , J. K. Boyles, B. Amit, M. Gorecki, R. W. Mahley, et al . 1988 . Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions. J. Biol. Chem. 263 : 3542-3545.
-
(1988)
J. Biol. Chem
, vol.263
, pp. 3542-3545
-
-
Lalazar, A.1
Weisgraber, K.H.2
Rall Jr., S.C.3
Giladi, H.4
Innerarity, T.L.5
Levanon, A.Z.6
Boyles, J.K.7
Amit, B.8
Gorecki, M.9
Mahley, R.W.10
-
23
-
-
0024826082
-
High receptor binding affi nity of lipoproteins in atypical dysbetalipoproteinemia (type III hyperlipoproteinemia)
-
Chappell , D. A. 1989 . High receptor binding affi nity of lipoproteins in atypical dysbetalipoproteinemia (type III hyperlipoproteinemia). J. Clin. Invest. 84 : 1906-1915.
-
(1989)
J. Clin. Invest
, vol.84
, pp. 1906-1915
-
-
Chappell, D.A.1
-
24
-
-
0021367509
-
Defective hepatic lipoprotein receptor binding of beta-very low density lipoproteins from type III hyperlipoproteinemic patients. Importance of apolipoprotein E
-
Hui , D. Y. , T. L. Innerarity , and R. W. Mahley . 1984 . Defective hepatic lipoprotein receptor binding of beta-very low density lipoproteins from type III hyperlipoproteinemic patients. Importance of apolipoprotein E. J. Biol. Chem. 259 : 860-869.
-
(1984)
J. Biol. Chem
, vol.259
, pp. 860-869
-
-
Hui, D.Y.1
Innerarity, T.L.2
Mahley, R.W.3
-
25
-
-
0025171570
-
Apolipoprotein E distribution among human plasma lipoproteins: Role of the cysteine-arginine interchange at residue 112
-
Weisgraber , K. H. 1990 . Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112. J. Lipid Res. 31 : 1503-1511.
-
(1990)
J. Lipid Res
, vol.31
, pp. 1503-1511
-
-
Weisgraber, K.H.1
-
26
-
-
0024395117
-
Differential distribution of apolipoprotein E isoforms in human plasma lipoproteins
-
Steinmetz , A. , C. Jakobs , S. Motzny , and H. Kaffarnik . 1989 . Differential distribution of apolipoprotein E isoforms in human plasma lipoproteins. Arteriosclerosis . 9 : 405-411.
-
(1989)
Arteriosclerosis
, vol.9
, pp. 405-411
-
-
Steinmetz, A.1
Jakobs, C.2
Motzny, S.3
Kaffarnik, H.4
-
27
-
-
0028339789
-
Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia
-
Ji , Z. S. , S. Fazio , and R. W. Mahley . 1994 . Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia. J. Biol. Chem. 269 : 13421-13428.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 13421-13428
-
-
Ji, Z.S.1
Fazio, S.2
Mahley, R.W.3
-
28
-
-
0020606476
-
Atypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3
-
Havel , R. J. , L. Kotite , J. P. Kane , P. Tun , and T. Bersot . 1983 . Atypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3. J. Clin. Invest. 72 : 379-387.
-
(1983)
J. Clin. Invest
, vol.72
, pp. 379-387
-
-
Havel, R.J.1
Kotite, L.2
Kane, J.P.3
Tun, P.4
Bersot, T.5
-
29
-
-
0024559621
-
Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant
-
Rall , S. C. , Jr ., Y. M. Newhouse , H. R. Clarke , K. H. Weisgraber , B. J. McCarthy , R. W. Mahley , and T. P. Bersot. 1989 . Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant. J. Clin. Invest. 83 : 1095-1101.
-
(1989)
J. Clin. Invest
, vol.83
, pp. 1095-1101
-
-
Rall Jr., S.C.1
Newhouse, Y.M.2
Clarke, H.R.3
Weisgraber, K.H.4
McCarthy, B.J.5
Mahley, R.W.6
Bersot, T.P.7
-
30
-
-
0027216450
-
Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E
-
Fazio , S. , Y. L. Lee , Z. S. Ji , and S. C. Rall , Jr . 1993 . Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E. J. Clin. Invest. 92 : 1497-1503.
-
(1993)
J. Clin. Invest
, vol.92
, pp. 1497-1503
-
-
Fazio, S.1
Lee, Y.L.2
Ji, Z.S.3
Rall Jr., S.C.4
-
31
-
-
0028314348
-
Altered lipoprotein metabolism in transgenic mice expressing low levels of a human receptor-bindingdefective apolipoprotein E variant
-
Fazio , S. , Y. Horie , W. S. Simonet , K. H. Weisgraber , J. M. Taylor , and S. C. Rall , Jr . 1994 . Altered lipoprotein metabolism in transgenic mice expressing low levels of a human receptor-bindingdefective apolipoprotein E variant. J. Lipid Res. 35 : 408-416.
-
(1994)
J. Lipid Res
, vol.35
, pp. 408-416
-
-
Fazio, S.1
Horie, Y.2
Simonet, W.S.3
Weisgraber, K.H.4
Taylor, J.M.5
Rall Jr., S.C.6
-
32
-
-
0028605302
-
Co-expression of cholesteryl ester transfer protein and defective apolipoprotein E in transgenic mice alters plasma cholesterol distribution. Implications for the pathogenesis of type III hyperlipoproteinemia
-
Fazio , S. , K. R. Marotti , Y. L. Lee , C. K. Castle , G. W. Melchior , and S. C. Rall , Jr . 1994 . Co-expression of cholesteryl ester transfer protein and defective apolipoprotein E in transgenic mice alters plasma cholesterol distribution. Implications for the pathogenesis of type III hyperlipoproteinemia. J. Biol. Chem. 269 : 32368-32372.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 32368-32372
-
-
Fazio, S.1
Marotti, K.R.2
Lee, Y.L.3
Castle, C.K.4
Melchior, G.W.5
Rall Jr., S.C.6
-
33
-
-
34547111320
-
A dominant negative form of the transcription factor c-Jun affects genes that have opposing effects on lipid homeostasis in mice
-
Drosatos , K. , D. Sanoudou , K. E. Kypreos , D. Kardassis , and V. I. Zannis . 2007 . A dominant negative form of the transcription factor c-Jun affects genes that have opposing effects on lipid homeostasis in mice. J. Biol. Chem. 282 : 19556-19564.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 19556-19564
-
-
Drosatos, K.1
Sanoudou, D.2
Kypreos, K.E.3
Kardassis, D.4
Zannis, V.I.5
-
34
-
-
34548689363
-
LCAT can rescue the abnormal phenotype produced by the downloaded from
-
ELSEVIER BV, on December 29, 2010 natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN
-
Koukos , G. , A. Chroni , A. Duka , D. Kardassis , and V. I. Zannis . 2007 . LCAT can rescue the abnormal phenotype produced by the Downloaded from www.jlr.org at ELSEVIER BV, on December 29, 2010 natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN. Biochemistry . 46 : 10713-10721.
-
(2007)
Biochemistry
, vol.46
, pp. 10713-10721
-
-
Koukos, G.1
Chroni, A.2
Duka, A.3
Kardassis, D.4
Zannis, V.I.5
-
35
-
-
0030614849
-
Apolipoprotein A-IFin. Dominantly inherited hypoalphalipoproteinemia due to a single base substitution in the apolipoprotein A-I gene
-
Miettinen , H. E. , H. Gylling , T. A. Miettinen , J. Viikari , L. Paulin , and K. Kontula . 1997 . Apolipoprotein A-IFin. Dominantly inherited hypoalphalipoproteinemia due to a single base substitution in the apolipoprotein A-I gene. Arterioscler. Thromb. Vasc. Biol. 17 : 83-90.
-
(1997)
Arterioscler. Thromb. Vasc. Biol
, vol.17
, pp. 83-90
-
-
Miettinen, H.E.1
Gylling, H.2
Miettinen, T.A.3
Viikari, J.4
Paulin, L.5
Kontula, K.6
-
36
-
-
0031468464
-
Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein lipase is inhibited by apolipoprotein E in a dosedependent manner
-
Jong , M. C. , V. E. Dahlmans , M. H. Hofker , and L. M. Havekes . 1997 . Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein lipase is inhibited by apolipoprotein E in a dosedependent manner. Biochem. J. 328 : 745-750.
-
(1997)
Biochem. J
, vol.328
, pp. 745-750
-
-
Jong, M.C.1
Dahlmans, V.E.2
Hofker, M.H.3
Havekes, L.M.4
-
37
-
-
15844414655
-
Apolipoprotein E effectively inhibits lipoprotein lipase-mediated lipolysis of chylomicronlike triglyceride-rich lipid emulsions in vitro and in vivo
-
Rensen , P. C. , and T. J. van Berkel . 1996 . Apolipoprotein E effectively inhibits lipoprotein lipase-mediated lipolysis of chylomicronlike triglyceride-rich lipid emulsions in vitro and in vivo. J. Biol. Chem. 271 : 14791-14799.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 14791-14799
-
-
Rensen, P.C.1
Van Berkel, T.J.2
-
38
-
-
0029833864
-
Structure-function relationship of lipoprotein lipasemediated enhancement of very low density lipoprotein binding and catabolism by the low density lipoprotein receptor. Functional importance of a properly folded surface loop covering the catalytic center
-
Salinelli , S. , J. Y. Lo , M. P. Mims , E. Zsigmond , L. C. Smith , and L. Chan . 1996 . Structure-function relationship of lipoprotein lipasemediated enhancement of very low density lipoprotein binding and catabolism by the low density lipoprotein receptor. Functional importance of a properly folded surface loop covering the catalytic center. J. Biol. Chem. 271 : 21906-21913.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 21906-21913
-
-
Salinelli, S.1
Lo, J.Y.2
Mims, M.P.3
Zsigmond, E.4
Smith, L.C.5
Chan, L.6
-
39
-
-
0030054720
-
Lipoprotein lipase binds to low density lipoprotein receptors and induces receptor-mediated catabolism of very low density lipoproteins in vitro
-
Medh , J. D. , S. L. Bowen , G. L. Fry , S. Ruben , M. Andracki , I. Inoue , et al . 1996 . Lipoprotein lipase binds to low density lipoprotein receptors and induces receptor-mediated catabolism of very low density lipoproteins in vitro. J. Biol. Chem. 271 : 17073-17080.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 17073-17080
-
-
Medh, J.D.1
Bowen, S.L.2
Fry, G.L.3
Ruben, S.4
Andracki, M.5
Inoue, I.6
-
40
-
-
0032504182
-
Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins
-
Huang , Y. , X. Q. Liu , S. C. Rall , Jr ., and R. W. Mahley . 1998 . Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins. J. Biol. Chem. 273 : 17483-17490.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 17483-17490
-
-
Huang, Y.1
Liu, X.Q.2
Rall Jr., S.C.3
Mahley, R.W.4
-
41
-
-
15644366977
-
Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia
-
Huang , Y. , X. Q. Liu , S. C. Rall , Jr ., J. M. Taylor , A. Von Eckardstein , G. Assmann , and R. W. Mahley. 1998 . Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J. Biol. Chem. 273 : 26388-26393.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 26388-26393
-
-
Huang, Y.1
Liu, Q.X.2
Rall Jr., S.C.3
Taylor, J.M.4
Von Eckardstein, A.5
Assmann, G.6
Mahley, R.W.7
-
42
-
-
0023900109
-
Human apolipoprotein E3 in aqueous solution I. Evidence for two structural domains
-
Wetterau , J. R. , L. P. Aggerbeck , S. C. Rall , Jr ., and K. H. Weisgraber . 1988 . Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains. J. Biol. Chem. 263 : 6240-6248.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 6240-6248
-
-
Wetterau, J.R.1
Aggerbeck, L.P.2
Rall Jr., S.C.3
Weisgraber, K.H.4
-
43
-
-
0023937366
-
Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains
-
Aggerbeck , L. P. , J. R. Wetterau , K. H. Weisgraber , C. S. Wu , and F. T. Lindgren . 1988 . Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains. J. Biol. Chem. 263 : 6249-6258.
-
(1988)
J. Biol. Chem
, vol.263
, pp. 6249-6258
-
-
Aggerbeck, L.P.1
Wetterau, J.R.2
Weisgraber, K.H.3
Wu, C.S.4
Lindgren, F.T.5
-
44
-
-
0025860481
-
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E
-
Wilson , C. , M. R. Wardell , K. H. Weisgraber , R. W. Mahley , and D. A. Agard . 1991 . Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science . 252 : 1817-1822.
-
(1991)
Science
, vol.252
, pp. 1817-1822
-
-
Wilson, C.1
Wardell, M.R.2
Weisgraber, K.H.3
Mahley, R.W.4
Agard, D.A.5
-
45
-
-
0028092997
-
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms
-
Dong , L. M. , C. Wilson , M. R. Wardell , T. Simmons , R. W. Mahley , K. H. Weisgraber , and D. A. Agard. 1994 . Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J. Biol. Chem. 269 : 22358-22365.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 22358-22365
-
-
Dong, L.M.1
Wilson, C.2
Wardell, M.R.3
Simmons, T.4
Mahley, R.W.5
Weisgraber, K.H.6
Agard, D.A.7
-
46
-
-
0029766916
-
Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins
-
Dong , L. M. , and K. H. Weisgraber . 1996 . Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. J. Biol. Chem. 271 : 19053-19057.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 19053-19057
-
-
Dong, L.M.1
Weisgraber, K.H.2
-
47
-
-
0028303072
-
Apolipoprotein E: Structure-function relationships
-
Weisgraber , K. H. 1994 . Apolipoprotein E: structure-function relationships. Adv. Protein Chem. 45 : 249-302.
-
(1994)
Adv. Protein Chem
, vol.45
, pp. 249-302
-
-
Weisgraber, K.H.1
-
48
-
-
33645808672
-
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease
-
Mahley , R. W. , K. H. Weisgraber , and Y. Huang . 2006 . Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc. Natl. Acad. Sci. USA . 103 : 5644-5651.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 5644-5651
-
-
Mahley, R.W.1
Weisgraber, K.H.2
Huang, Y.3
-
49
-
-
33644772107
-
LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice
-
Kypreos , K. E. , and V. I. Zannis . 2006 . LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice. J. Lipid Res. 47 : 521-529.
-
(2006)
J. Lipid Res.
, vol.47
, pp. 521-529
-
-
Kypreos, K.E.1
Zannis, V.I.2
-
50
-
-
1842577738
-
Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer
-
Zannis , V. I. , A. Chroni , K. E. Kypreos , H. Y. Kan , T. B. Cesar , E. E. Zanni , and D. Kardassis. 2004 . Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer. Curr. Opin. Lipidol. 15 : 151-166.
-
(2004)
Curr. Opin. Lipidol.
, vol.15
, pp. 151-166
-
-
Zannis, V.I.1
Chroni, A.2
Kypreos, K.E.3
Kan, H.Y.4
Cesar, T.B.5
Zanni, E.E.6
Kardassis, D.7
-
51
-
-
0024397001
-
Human apolipoprotein E. Receptor binding activity of truncated variants with carboxyl-terminal deletions
-
Lalazar , A. , and R. W. Mahley . 1989 . Human apolipoprotein E. Receptor binding activity of truncated variants with carboxyl-terminal deletions. J. Biol. Chem. 264 : 8447-8450.
-
(1989)
J. Biol. Chem
, vol.264
, pp. 8447-8450
-
-
Lalazar, A.1
Mahley, R.W.2
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