Parametric imaging using subharmonic signals from ultrasound contrast agents in patients with breast lesions

Journal of Ultrasound in Medicine

Volumn 30, Issue 1, 2011, Pages 85-92

  Eisenbrey, John R ^a   Dave, Jaydev K ^a,b   Merton, Daniel A ^a   Palazzo, Juan P ^a   Hall, Anne L ^c   Forsberg, Flemming ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b DREXEL UNIVERSITY   (United States)

^c GE HEALTHCARE   (United States)

Author keywords

Breast cancer; Parametric imaging; Subharmonic imaging; Ultrasound contrast agent

Indexed keywords

CONTRAST MEDIA; TISSUE; ULTRASONICS;

BENIGN LESION; BREAST CANCER; BREAST LESION; BREAST TISSUES; FLOW PARAMETERS; GE HEALTHCARES; HIGH CONTRAST; MAXIMUM INTENSITIES; PARAMETRIC IMAGE; PARAMETRIC IMAGING; SAMPLE SIZES; SUBHARMONIC IMAGING; SUBHARMONIC SIGNALS; SUBHARMONICS; TIME TO PEAK; TIME-INTENSITY CURVES; TISSUE SIGNALS; ULTRASOUND CONTRAST AGENT; WAUKESHA;

PARAMETER ESTIMATION;

ALBUMINOID; CONTRAST MEDIUM; DIAGNOSTIC AGENT; FLUOROCARBON; PERFLUTREN;

ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ARTICLE; BREAST DISEASE; BREAST TUMOR; DIFFERENTIAL DIAGNOSIS; DOPPLER FLOWMETRY; ECHOGRAPHY; ECHOMAMMOGRAPHY; FEASIBILITY STUDY; FEMALE; HUMAN; IMAGE ENHANCEMENT; METHODOLOGY;

ALBUMINS; ANALYSIS OF VARIANCE; AREA UNDER CURVE; BREAST DISEASES; BREAST NEOPLASMS; CONTRAST MEDIA; DIAGNOSIS, DIFFERENTIAL; FEASIBILITY STUDIES; FEMALE; FLUOROCARBONS; HUMANS; IMAGE ENHANCEMENT; ULTRASONOGRAPHY, DOPPLER; ULTRASONOGRAPHY, MAMMARY;

EID: 78650882289     PISSN: 02784297     EISSN: None     Source Type: Journal    
DOI: 10.7863/jum.2011.30.1.85     Document Type: Article

References (23)

1. American Cancer Society. Breast Cancer Facts and Figures 2009-2010. Atlanta, GA: American Cancer Society; 2009.
2. Smith RA, Cokkinides V, Eyre HJ. American Cancer Society guidelines for the early detection of cancer, 2006. CA Cancer J Clin 2006; 56:11-25.
3. Kopans DB. Breast Imaging. 2nd ed Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
4. Zonderland HM, Coerkamp EG, Hermans J, van de Vijver MJ, van Voorthuisen AE. Diagnosis of breast cancer: contribution of US as an adjunct to mammography. Radiology 1999; 213:413-422.
5. Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst 1992; 84:1875-1887.
6. Gasparini G, Harris AL. Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. J Clin Oncol 1995; 13:765-782.
7. Goldberg BB, Raichlen JS, Forsberg F. Ultrasound Contrast Agents: Basic Principles and Clinical Applications. 2nd ed. London, England: Martin Dunitz Ltd; 2001.
8. Wiesmann M, Meyer K, Albers T, Seidel G. Parametric perfusion imaging with contrast-enhanced ultrasound in acute ischemic stroke. Stroke 2004; 35:508-513. (Pubitemid 38174439)
9. Siedel G, Cangür H, Meyer-Weithe K, et al. On the ability of ultrasound parametric perfusion imaging to predict the area of infarction in acute ischemic stroke. Ultraschall Med 2006; 27:543-548.
10. Harrer JU, Hornen S, Oertel MF, Stracke CP, Klötzsch C. Comparison of perfusion harmonic imaging and perfusion MR imaging for the assessment of microvascular characteristics in brain tumors. Ultraschall Med 2008; 29:45-52.
11. Pollard RE, Sadlowski AR, Bloch SH, et al. Contrast-assisted destruction-replenishment ultrasound lor the assessment of tumor microvasculature in a rat model. Technol Cancer Res Treat 2002; 1:459-470.
12. Correas J, Bridal L, Lesavre A, Mejean A, Claudon M, Helenon O. Ultrasound contrast agents: properties, principles of action, tolerance and artifacts. Eur Radiol 2001; 11:1316-1328.
13. Frinking PJ, Bouakaz A, Kirkhorn J, Cate FJ, de Jong N. Ultrasound contrast imaging: current and new potential methods. Ultrasound Med Biol 2000; 26:965-975.
14. Shi WT, Forsberg F, Hall AL, et al. Subharmonic imaging with microbubble contrast agents: initial results. Ultrason Imaging 1999; 21:79-94.
15. Forsberg F, Shi WT, Goldberg BB. Subharmonic imaging of contrast agents. Ultrasonics 2000; 38:93-98.
16. Forsberg F, Piccoli C, Merton D, Palazzo J, Hall A. Breast lesions: imaging with contrast-enhanced subharmonic US - initial experience. Radiology 2007;244:718-726.
17. Forsberg F, Liu JB, Shi WT, et al. In vivo perfusion estimation using sub-harmonic contrast microbubble signals. J Ultrasound Med 2006; 25:15-21.
18. Dave JK, Forsberg F. Novel automated motion compensation technique for producing cumulative maximum intensity subharmonic images. Ultrasound Med Biol 2009; 35:1555-1563.
19. Hudson JM, Karshafian R Burns PN. Quantification of flow using ultrasound and microbubbles: a disruption replenishment model based on physical principles. Ultrasound Med Biol 2009; 35:2007-2020.
20. Schwarz KQ, Chen X, Bezante GP, Phillips D, Schlief R. The Doppler kinetics of microbubble echo contrast. Ultrasound Med Biol 1996; 22:453-462.
21. Bland JM, Altman DG. Multiple significance tests: the Bonferroni method. BMJ 1995; 310:170.
22. Perneger TV. What's wrong with Bonferroni adjustments. BMJ 1998; 316:1236-1238.
23. Dave JK, Forsberg F, Fernandes S, et al. Static and dynamic cumulative maximum-intensity display mode for subharmonic imaging: a comparative study with mammography and conventional ultrasound techniques. J Ultrasound Med 2010; 29:1177-1185.