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Volumn 12, Issue 5, 2010, Pages

Silencing of the IKKε gene by siRNA inhibits invasiveness and growth of breast cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYCLIN D1; DOXORUBICIN; I KAPPA B KINASE EPSILON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEIN BCL 2; SMALL INTERFERING RNA; I KAPPA B KINASE;

EID: 78650866392     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2644     Document Type: Article
Times cited : (61)

References (41)
  • 3
    • 37549004392 scopus 로고    scopus 로고
    • Nuclear factor-κB activation: from bench to bedside
    • 10.3181/0707-MR-196, 18156302
    • Sethi G, Sung B, Aggarwal BB. Nuclear factor-κB activation: from bench to bedside. Exp Biol Med (Maywood) 2008, 233:21-31. 10.3181/0707-MR-196, 18156302.
    • (2008) Exp Biol Med (Maywood) , vol.233 , pp. 21-31
    • Sethi, G.1    Sung, B.2    Aggarwal, B.B.3
  • 4
    • 33748756170 scopus 로고    scopus 로고
    • IKK-i/IKKε controls constitutive, cancer cell-associated NF-κB activity via regulation of Ser-536 p65/RelA phosphorylation
    • 10.1074/jbc.M603133200, 16840782
    • Adli M, Baldwin AS. IKK-i/IKKε controls constitutive, cancer cell-associated NF-κB activity via regulation of Ser-536 p65/RelA phosphorylation. J Biol Chem 2006, 281:26976-26984. 10.1074/jbc.M603133200, 16840782.
    • (2006) J Biol Chem , vol.281 , pp. 26976-26984
    • Adli, M.1    Baldwin, A.S.2
  • 5
    • 0033623848 scopus 로고    scopus 로고
    • IKKε is part of a novel PMA-inducible IκB kinase complex
    • 10.1016/S1097-2765(00)80445-1, 10882136
    • Peters RT, Liao SM, Maniatis T. IKKε is part of a novel PMA-inducible IκB kinase complex. Mol Cell 2000, 5:513-522. 10.1016/S1097-2765(00)80445-1, 10882136.
    • (2000) Mol Cell , vol.5 , pp. 513-522
    • Peters, R.T.1    Liao, S.M.2    Maniatis, T.3
  • 7
    • 65649114699 scopus 로고    scopus 로고
    • Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKε promotes cell transformation
    • 10.1016/j.molcel.2009.04.031, 2746958, 19481526
    • Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC, Cantley LC. Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKε promotes cell transformation. Mol Cell 2009, 34:461-472. 10.1016/j.molcel.2009.04.031, 2746958, 19481526.
    • (2009) Mol Cell , vol.34 , pp. 461-472
    • Hutti, J.E.1    Shen, R.R.2    Abbott, D.W.3    Zhou, A.Y.4    Sprott, K.M.5    Asara, J.M.6    Hahn, W.C.7    Cantley, L.C.8
  • 8
    • 0038374178 scopus 로고    scopus 로고
    • IKKi/IKKε plays a key role in integrating signals induced by pro-inflammatory stimuli
    • 10.1074/jbc.M303001200, 12736252
    • Kravchenko VV, Mathison JC, Schwamborn K, Mercurio F, Ulevitch RJ. IKKi/IKKε plays a key role in integrating signals induced by pro-inflammatory stimuli. J Biol Chem 2003, 278:26612-26619. 10.1074/jbc.M303001200, 12736252.
    • (2003) J Biol Chem , vol.278 , pp. 26612-26619
    • Kravchenko, V.V.1    Mathison, J.C.2    Schwamborn, K.3    Mercurio, F.4    Ulevitch, R.J.5
  • 9
    • 33847687659 scopus 로고    scopus 로고
    • Multiple functions of the IKK-related kinase IKKε in interferon-mediated antiviral immunity
    • 10.1126/science.1136567, 17332413
    • Tenoever BR, Ng SL, Chua MA, McWhirter SM, Garcia-Sastre A, Maniatis T. Multiple functions of the IKK-related kinase IKKε in interferon-mediated antiviral immunity. Science 2007, 315:1274-1278. 10.1126/science.1136567, 17332413.
    • (2007) Science , vol.315 , pp. 1274-1278
    • Tenoever, B.R.1    Ng, S.L.2    Chua, M.A.3    McWhirter, S.M.4    Garcia-Sastre, A.5    Maniatis, T.6
  • 10
    • 65449163494 scopus 로고    scopus 로고
    • Over-expression of IκB-kinase-epsilon (IKKε/IKKi) induces secretion of inflammatory cytokines in prostate cancer cell lines
    • 10.1002/pros.20912, 19170126
    • Peant B, Diallo JS, Dufour F, Le Page C, Delvoye N, Saad F, Mes-Masson AM. Over-expression of IκB-kinase-epsilon (IKKε/IKKi) induces secretion of inflammatory cytokines in prostate cancer cell lines. Prostate 2009, 69:706-718. 10.1002/pros.20912, 19170126.
    • (2009) Prostate , vol.69 , pp. 706-718
    • Peant, B.1    Diallo, J.S.2    Dufour, F.3    Le Page, C.4    Delvoye, N.5    Saad, F.6    Mes-Masson, A.M.7
  • 11
    • 29244439558 scopus 로고    scopus 로고
    • Inducible IκB kinase/IκB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-κB activation in breast cancer cells
    • 10.1158/0008-5472.CAN-05-1602, 16357145
    • Eddy SF, Guo S, Demicco EG, Romieu-Mourez R, Landesman-Bollag E, Seldin DC, Sonenshein GE. Inducible IκB kinase/IκB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-κB activation in breast cancer cells. Cancer Res 2005, 65:11375-11383. 10.1158/0008-5472.CAN-05-1602, 16357145.
    • (2005) Cancer Res , vol.65 , pp. 11375-11383
    • Eddy, S.F.1    Guo, S.2    Demicco, E.G.3    Romieu-Mourez, R.4    Landesman-Bollag, E.5    Seldin, D.C.6    Sonenshein, G.E.7
  • 12
    • 16244409820 scopus 로고    scopus 로고
    • Inactivation of ErbB3 by siRNA promotes apoptosis and attenuates growth and invasiveness of human lung adenocarcinoma cell line A549
    • 10.1038/sj.onc.1208381, 15688028
    • Sithanandam G, Fornwald LW, Fields J, Anderson LM. Inactivation of ErbB3 by siRNA promotes apoptosis and attenuates growth and invasiveness of human lung adenocarcinoma cell line A549. Oncogene 2005, 24:1847-1859. 10.1038/sj.onc.1208381, 15688028.
    • (2005) Oncogene , vol.24 , pp. 1847-1859
    • Sithanandam, G.1    Fornwald, L.W.2    Fields, J.3    Anderson, L.M.4
  • 14
    • 67249090051 scopus 로고    scopus 로고
    • TGF-beta1 gene silencing for treating liver fibrosis
    • 10.1021/mp9000469, 2743970, 19388665
    • Cheng K, Yang N, Mahato RI. TGF-beta1 gene silencing for treating liver fibrosis. Mol Pharm 2009, 6:772-779. 10.1021/mp9000469, 2743970, 19388665.
    • (2009) Mol Pharm , vol.6 , pp. 772-779
    • Cheng, K.1    Yang, N.2    Mahato, R.I.3
  • 15
    • 4243066440 scopus 로고    scopus 로고
    • Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets
    • 10.1038/sj.gt.3302267, 15238996
    • Cheng K, Fraga D, Zhang C, Kotb M, Gaber AO, Guntaka RV, Mahato RI. Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets. Gene Ther 2004, 11:1105-1116. 10.1038/sj.gt.3302267, 15238996.
    • (2004) Gene Ther , vol.11 , pp. 1105-1116
    • Cheng, K.1    Fraga, D.2    Zhang, C.3    Kotb, M.4    Gaber, A.O.5    Guntaka, R.V.6    Mahato, R.I.7
  • 16
    • 78650858508 scopus 로고    scopus 로고
    • TScratch
    • TScratch. , http://www.cse-lab.ethz.ch/index.php?&option=com_content&view=article&id=363
  • 17
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • 10.1038/nature06174, 17898713
    • Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007, 449:682-688. 10.1038/nature06174, 17898713.
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 18
    • 77249105346 scopus 로고    scopus 로고
    • Small molecule inhibition of arylamine N-acetyltransferase type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells
    • 10.1016/j.bbrc.2010.01.087, 20100460
    • Tiang JM, Butcher NJ, Minchin RF. Small molecule inhibition of arylamine N-acetyltransferase type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells. Biochem Biophys Res Commun 2010, 393:95-100. 10.1016/j.bbrc.2010.01.087, 20100460.
    • (2010) Biochem Biophys Res Commun , vol.393 , pp. 95-100
    • Tiang, J.M.1    Butcher, N.J.2    Minchin, R.F.3
  • 19
    • 0035896513 scopus 로고    scopus 로고
    • ERK5 and ERK2 cooperate to regulate NF-κB and cell transformation
    • 10.1074/jbc.M009764200, 11118448
    • Pearson G, English JM, White MA, Cobb MH. ERK5 and ERK2 cooperate to regulate NF-κB and cell transformation. J Biol Chem 2001, 276:7927-7931. 10.1074/jbc.M009764200, 11118448.
    • (2001) J Biol Chem , vol.276 , pp. 7927-7931
    • Pearson, G.1    English, J.M.2    White, M.A.3    Cobb, M.H.4
  • 20
    • 0031563790 scopus 로고    scopus 로고
    • Effects of cyclin D1 overexpression on G1 progression-related events
    • 10.1006/excr.1997.3713, 9344597
    • Imoto M, Doki Y, Jiang W, Han EK, Weinstein IB. Effects of cyclin D1 overexpression on G1 progression-related events. Exp Cell Res 1997, 236:173-180. 10.1006/excr.1997.3713, 9344597.
    • (1997) Exp Cell Res , vol.236 , pp. 173-180
    • Imoto, M.1    Doki, Y.2    Jiang, W.3    Han, E.K.4    Weinstein, I.B.5
  • 21
    • 0028108451 scopus 로고
    • Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle
    • 10.1073/pnas.91.17.8022, 44537, 8058751
    • Musgrove EA, Lee CS, Buckley MF, Sutherland RL. Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle. Proc Natl Acad Sci USA 1994, 91:8022-8026. 10.1073/pnas.91.17.8022, 44537, 8058751.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8022-8026
    • Musgrove, E.A.1    Lee, C.S.2    Buckley, M.F.3    Sutherland, R.L.4
  • 23
    • 67649969188 scopus 로고    scopus 로고
    • Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer
    • 10.2353/ajpath.2009.080767, 2708818, 19497997
    • Guo JP, Shu SK, He L, Lee YC, Kruk PA, Grenman S, Nicosia SV, Mor G, Schell MJ, Coppola D, Cheng JQ. Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer. Am J Pathol 2009, 175:324-333. 10.2353/ajpath.2009.080767, 2708818, 19497997.
    • (2009) Am J Pathol , vol.175 , pp. 324-333
    • Guo, J.P.1    Shu, S.K.2    He, L.3    Lee, Y.C.4    Kruk, P.A.5    Grenman, S.6    Nicosia, S.V.7    Mor, G.8    Schell, M.J.9    Coppola, D.10    Cheng, J.Q.11
  • 24
    • 76849100745 scopus 로고    scopus 로고
    • SUMOylation-dependent localization of IKKε in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death
    • 10.1016/j.molcel.2010.01.018, 20188669
    • Renner F, Moreno R, Schmitz ML. SUMOylation-dependent localization of IKKε in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. Mol Cell 2010, 37:503-515. 10.1016/j.molcel.2010.01.018, 20188669.
    • (2010) Mol Cell , vol.37 , pp. 503-515
    • Renner, F.1    Moreno, R.2    Schmitz, M.L.3
  • 25
    • 33750432183 scopus 로고    scopus 로고
    • Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression
    • 10.1038/sj.onc.1209942, 17072330
    • Basseres DS, Baldwin AS. Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression. Oncogene 2006, 25:6817-6830. 10.1038/sj.onc.1209942, 17072330.
    • (2006) Oncogene , vol.25 , pp. 6817-6830
    • Basseres, D.S.1    Baldwin, A.S.2
  • 26
    • 38349124180 scopus 로고    scopus 로고
    • Identification of a novel blocker of IκBα kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-κB
    • 10.1158/1535-7163.MCT-07-0406, 18202022
    • Sung B, Pandey MK, Nakajima Y, Nishida H, Konishi T, Chaturvedi MM, Aggarwal BB. Identification of a novel blocker of IκBα kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-κB. Mol Cancer Ther 2008, 7:191-201. 10.1158/1535-7163.MCT-07-0406, 18202022.
    • (2008) Mol Cancer Ther , vol.7 , pp. 191-201
    • Sung, B.1    Pandey, M.K.2    Nakajima, Y.3    Nishida, H.4    Konishi, T.5    Chaturvedi, M.M.6    Aggarwal, B.B.7
  • 27
    • 34548763142 scopus 로고    scopus 로고
    • Lupeol suppresses cisplatin-induced nuclear factor-κB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model
    • 10.1158/0008-5472.CAN-07-0801, 17875721
    • Lee TK, Poon RT, Wo JY, Ma S, Guan XY, Myers JN, Altevogt P, Yuen AP. Lupeol suppresses cisplatin-induced nuclear factor-κB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model. Cancer Res 2007, 67:8800-8809. 10.1158/0008-5472.CAN-07-0801, 17875721.
    • (2007) Cancer Res , vol.67 , pp. 8800-8809
    • Lee, T.K.1    Poon, R.T.2    Wo, J.Y.3    Ma, S.4    Guan, X.Y.5    Myers, J.N.6    Altevogt, P.7    Yuen, A.P.8
  • 28
    • 34247274248 scopus 로고    scopus 로고
    • Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin
    • 10.1038/nature05656, 17377533
    • Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M. Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin. Nature 2007, 446:690-694. 10.1038/nature05656, 17377533.
    • (2007) Nature , vol.446 , pp. 690-694
    • Luo, J.L.1    Tan, W.2    Ricono, J.M.3    Korchynskyi, O.4    Zhang, M.5    Gonias, S.L.6    Cheresh, D.A.7    Karin, M.8
  • 29
    • 20444419344 scopus 로고    scopus 로고
    • Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance
    • 10.1038/ncb1258, 15864305
    • MacKeigan JP, Murphy LO, Blenis J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol 2005, 7:591-600. 10.1038/ncb1258, 15864305.
    • (2005) Nat Cell Biol , vol.7 , pp. 591-600
    • MacKeigan, J.P.1    Murphy, L.O.2    Blenis, J.3
  • 30
    • 0034284637 scopus 로고    scopus 로고
    • Mitochondria as the central control point of apoptosis
    • 10.1016/S0962-8924(00)01803-1, 10932094
    • Desagher S, Martinou JC. Mitochondria as the central control point of apoptosis. Trends Cell Biol 2000, 10:369-377. 10.1016/S0962-8924(00)01803-1, 10932094.
    • (2000) Trends Cell Biol , vol.10 , pp. 369-377
    • Desagher, S.1    Martinou, J.C.2
  • 34
    • 34447630051 scopus 로고    scopus 로고
    • Targeted therapy against Bcl-2-related proteins in breast cancer cells
    • 10.1186/bcr1323, 1410745, 16280040
    • Emi M, Kim R, Tanabe K, Uchida Y, Toge T. Targeted therapy against Bcl-2-related proteins in breast cancer cells. Breast Cancer Res 2005, 7:R940-R952. 10.1186/bcr1323, 1410745, 16280040.
    • (2005) Breast Cancer Res , vol.7
    • Emi, M.1    Kim, R.2    Tanabe, K.3    Uchida, Y.4    Toge, T.5
  • 35
    • 0034068054 scopus 로고    scopus 로고
    • Antisense-mediated inhibition of the bcl-2 gene induces apoptosis in human malignant glioma
    • discussion 368-369, 10.1016/S0090-3019(00)00178-6, 10825522
    • Julien T, Frankel B, Longo S, Kyle M, Gibson S, Shillitoe E, Ryken T. Antisense-mediated inhibition of the bcl-2 gene induces apoptosis in human malignant glioma. Surg Neurol 2000, 53:360-368. discussion 368-369, 10.1016/S0090-3019(00)00178-6, 10825522.
    • (2000) Surg Neurol , vol.53 , pp. 360-368
    • Julien, T.1    Frankel, B.2    Longo, S.3    Kyle, M.4    Gibson, S.5    Shillitoe, E.6    Ryken, T.7
  • 36
    • 2342538514 scopus 로고    scopus 로고
    • Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells
    • 10.1038/sj.cgt.7700706, 15031723
    • Lima RT, Martins LM, Guimaraes JE, Sambade C, Vasconcelos MH. Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells. Cancer Gene Ther 2004, 11:309-316. 10.1038/sj.cgt.7700706, 15031723.
    • (2004) Cancer Gene Ther , vol.11 , pp. 309-316
    • Lima, R.T.1    Martins, L.M.2    Guimaraes, J.E.3    Sambade, C.4    Vasconcelos, M.H.5
  • 38
    • 0001003612 scopus 로고    scopus 로고
    • Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members
    • 10.1073/pnas.94.23.12401, 24966, 9356461
    • Hsu SY, Kaipia A, McGee E, Lomeli M, Hsueh AJ. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc Natl Acad Sci USA 1997, 94:12401-12406. 10.1073/pnas.94.23.12401, 24966, 9356461.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12401-12406
    • Hsu, S.Y.1    Kaipia, A.2    McGee, E.3    Lomeli, M.4    Hsueh, A.J.5
  • 39
    • 0028331092 scopus 로고
    • Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining
    • Gillett C, Fantl V, Smith R, Fisher C, Bartek J, Dickson C, Barnes D, Peters G. Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res 1994, 54:1812-1817.
    • (1994) Cancer Res , vol.54 , pp. 1812-1817
    • Gillett, C.1    Fantl, V.2    Smith, R.3    Fisher, C.4    Bartek, J.5    Dickson, C.6    Barnes, D.7    Peters, G.8
  • 40
    • 33751182887 scopus 로고    scopus 로고
    • Cyclin D1 and breast cancer
    • 10.1016/j.breast.2006.02.005, 16675218
    • Roy PG, Thompson AM. Cyclin D1 and breast cancer. Breast 2006, 15:718-727. 10.1016/j.breast.2006.02.005, 16675218.
    • (2006) Breast , vol.15 , pp. 718-727
    • Roy, P.G.1    Thompson, A.M.2
  • 41
    • 77950470765 scopus 로고    scopus 로고
    • IKKε phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer
    • 10.1074/jbc.M109.078212, 19940156
    • Guo JP, Shu SK, Esposito NN, Coppola D, Koomen JM, Cheng JQ. IKKε phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer. J Biol Chem 2010, 285:3676-3684. 10.1074/jbc.M109.078212, 19940156.
    • (2010) J Biol Chem , vol.285 , pp. 3676-3684
    • Guo, J.P.1    Shu, S.K.2    Esposito, N.N.3    Coppola, D.4    Koomen, J.M.5    Cheng, J.Q.6


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