Molecular characterization of the AdeI mutant of Chinese hamster ovary cells: A cellular model of adenylosuccinate lyase deficiency

Molecular Genetics and Metabolism

Volumn 102, Issue 1, 2011, Pages 61-68

  Vliet, Lydia K ^a   Wilkinson, Terry G ^a   Duval, Nathan ^a   Vacano, Guido ^a   Graham, Christine ^a   Zikánová, Marie ^b,c   Skopova, Vaclava ^b,c   Baresova, Veronika ^b,c   Hnízda, Aleš ^c   Kmoch, Stanislav ^b,c   Patterson, David ^a  

^a UNIVERSITY OF DENVER   (United States)

^b CHARLES UNIVERSITY   (Czech Republic)

^c Charles University in Prague and General University Hospital in Prague   (Czech Republic)

Author keywords

Adenylosuccinate lyase deficiency; Cell culture models; Chinese hamster ovary cells; Inborn errors

Indexed keywords

ADENYLOSUCCINATE LYASE; ALANINE; COMPLEMENTARY DNA; VALINE;

ADEI GENE; ADENYLOSUCCINATE LYASE DEFICIENCY; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INACTIVATION; FEMALE; GENE; GENE DELETION; GENE MUTATION; GENETIC COMPLEMENTATION; GENETIC TRANSFECTION; GENOTYPE; HOMOZYGOSITY; NONHUMAN; NONSENSE MEDIATED MRNA DECAY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPLICING DEFECT; WILD TYPE;

ADENYLOSUCCINATE LYASE; AMINO ACID SUBSTITUTION; ANIMALS; CATALYTIC DOMAIN; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME ASSAYS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROTEIN STRUCTURE, QUATERNARY; PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

CRICETULUS GRISEUS;

EID: 78650861458     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2010.08.022     Document Type: Article

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