Genome analysis of treponema pallidum subsp. pallidum and subsp. pertenue strains: Most of the genetic differences are localized in six regions

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Mikalová, Lenka ^a   Strouhal, Michal ^a   čejková, Darina ^a   Zobaníková, Marie ^a   Pospíšilová, Petra ^a   Norris, Steven J ^b   Sodergren, Erica ^c   Weinstock, George M ^c   Šmajs, David ^a  

^a MASARYK UNIVERSITY   (Czech Republic)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; GENE AMPLIFICATION; GENE SEQUENCE; GENE STRUCTURE; GENETIC DIFFERENCE; GENOME ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; RESTRICTION MAPPING; SEQUENCE HOMOLOGY; STRAIN DIFFERENCE; STRUCTURAL HOMOLOGY; TREPONEMA; TREPONEMA PALLIDUM; TREPONEMA PERTENUE; BACTERIAL CHROMOSOME; BACTERIAL GENE; BINDING SITE; BIOLOGICAL MODEL; COMPUTER PROGRAM; DNA SEQUENCE; GENETICS; GENOME; HUMAN; MICROBIOLOGY; MOLECULAR GENETICS; PHYLOGENY; SYPHILIS; YAWS;

SIMIAE; TREPONEMA PALLIDUM SUBSP. PALLIDUM;

BINDING SITES; CHROMOSOMES, BACTERIAL; GENES, BACTERIAL; GENOME; GENOME, BACTERIAL; HUMANS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PHYLOGENY; SEQUENCE ANALYSIS, DNA; SOFTWARE; SYPHILIS; TREPONEMA PALLIDUM; YAWS;

EID: 78650817952     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015713     Document Type: Article

References (57)

1. Fribourg-Blanc A, Niel G, Mollaret HH (1963) Note of Some Imunological Aspects of the African Cynocephalus. 1. Antigenic Relationship of Its Gamma Globulin with Human Gamma Globulin. 2. Guinean Endemic Focus of Treponematosis. Bull Soc Pathol Exot Filiales 56: 474-485.
2. Fribourg-Blanc A, Mollaret HH, Niel G (1966) Confirmation serologique et microscopique de la treponemose du cynocephale de Guinee. Bull Soc Pathol Exot Filiales 59: 54-59.
3. Fribourg-Blanc A, Mollaret HH (1969) Natural treponematotis of the African primate. Primates Med 3: 113-121.
4. Medina R (1963) WHO Technical Report WHO/VDT/RES 63.64.
5. Smith JL (1971) Neuro-ophthalmological study of late yaws. I. An introduction to yaws. Brit J Vener Dis 47: 223-225.
6. Smith JL, David NJ, Indgin S, Israel CW, Levine BM, et al. (1971) Neuroophthalmological study of late yaws and pinta. II. The Caracas project. Br J Vener Dis 47: 226-251.
7. Levréro F, Gattis S, Gautier-Hion A, Ménard N (2007) Yaws disease in a wild gorilla population and its impact on the reproductive status of males. Am J Phys Anthropol 132: 568-575.
8. Norris SJ, Cox DL, Weinstock GM (2001) Biology of Treponema pallidum: correlation of functional activities with genome sequence data. J Mol Microbiol Biotechnol 3: 37-62.
9. Hollander DH (1981) Treponematosis from pinta to veneral syphilis revisited: hypothesis from temperature determination of disease patterns. Sex Trans Dis 8: 34-37.
10. Hollander DH, Turner TB (1954) The role of temperature in experimental treponemal infections. Am J Syph 38: 489.
11. Hudson EH (1965) Treponematosis in perspective. Bull World Health Org 2: 735-748.
12. Baker BJ, Armelagos GJ (1988) The origin and antiquity of syphilis. Curr Anthropol 29: 703-737.
13. Hackett C (1963) On the origin of the human treponematoses. Bull WHO 23: 7-41.
14. Antal GM, Lukehart SA, Meheus AZ (2002) The endemic treponematoses. Microbes Infect 4: 83-94.
15. Noordhoek GT, Wieles B, van der Sluis JJ, van Embden JD (1990) Polymerase chain reaction and synthetic DNA probes: a means of distinguishing the causative agents of syphilis and yaws? Infect Immun 58: 2011-2013.
16. Walker EM, Howell JK, You Y, Hoffmaster AR, Heath JD, et al. (1995) Physical map of the genome of Treponema pallidum subsp. pallidum (Nichols). J Bacteriol 177: 1797-1804.
17. Centurion-Lara A, Castro C, Castillo R, Shaffer JM, Van Voorhis WC, et al. (1998) The flanking region sequences of the 15-kDa lipoprotein gene differentiate pathogenic treponemes. J Infect Dis 177: 1036-1040.
18. Centurion-Lara A, Molini BJ, Godornes C, Sun E, Hevner K, et al. (2006) Molecular differentiation of Treponema pallidum subspecies. J Clin Microbiol 44(9): 3377-3380.
19. Gray RR, Mulligan CJ, Molini BJ, Sun ES, Giacani L, et al. (2006) Molecular evolution of the tprC, D, J, K, G and J genes in the pathogenic genus Treponema. Mol Biol Evol 23: 2220-2233.
20. Harper KN, Ocampo PS, Steiner BM, George RW, Silverman MS, et al. (2008) On the origin of the treponematoses: a phylogenetic approach. PLoS Negl Trop Dis 2: e148.
21. Strouhal M, Šmajs D, Matějková P, Sodergren E, Amin AG, et al. (2007) Genome differences between Treponema pallidum subsp. pallidum strain Nichols and T. paraluiscuniculi strain Cuniculi A. Infect Immun 75: 5859-5866.
22. Šmajs D, McKevitt M, Wang L, Howell JK, Norris SJ, et al. (2002) BAC library of T. pallidum DNA in E. coli. Genome Res 12: 515-522.
23. Centurion-Lara A, LaFond RE, Hevner K, Godornes C, Molini BJ, et al. (2004) Gene conversion: a mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection. Mol Microbiol 52(6): 1579-1596.
24. Pillay A, Liu H, Chen CY, Holloway B, Sturm AW, et al. (1998) Molecular subtyping of Treponema pallidum subspecies pallidum. Sex Transm Dis 25(8): 408-14.
25. Fraser CM, Norris SJ, Weinstock GM, White O, Sutton GG, et al. (1998) Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science 281: 375-388.
26. Harper KN, Liu H, Ocampo PS, Steiner BM, Martin A, et al. (2008) The sequence of the acidic repeat protein (arp) gene differenciates veneral from nonveneral Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis. FEMS Immunol Med Microbiol 53: 322-332.
27. Matějková P, Strouhal M, Šmajs D, Norris SJ, Palzkill T, et al. (2008) Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays. BMC Microbiol 8: 76.
28. Brinkman MB, McGill MA, Pettersson J, Rogers A, Matějková P, et al. (2008) A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. Infect Immun 76: 1848-1857.
29. Livingstone FB (1991) On the origin of syphilis: an alternative hypothesis. Curr Anthropol 32: 587-590.
30. Marra CM, Colina AP, Godornes C, Tantalo LC, Puray M, et al. (2006) Antibiotic selection may contribute to increases in macrolide-resistant Treponema pallidum. J Infect Dis 194: 1771-1773.
31. Citti C, Kim MF, Wise KS (1997) Elongated versions of Vlp surface lipoproteins protect Mycoplasma hyorhinis escape variants from growth-inhibiting host antibodies. Infect Immun 65(5): 1773-1785.
32. Coil DA, Vandersmissen L, Ginevra C, Jarraud S, Lammertyn E, et al. (2008) Intragenic tandem repeat variation between Legionella pneumophila strains. BMC Microbiol 8: 218.
33. Liu H, Rodes B, George R, Steiner B (2007) Molecular characterization and analysis of a gene encoding the acidic repeat protein (Arp) of Treponema pallidum. J Med Microbiol 56: 715-721.
34. Centurion-Lara A, Sun ES, Barrett L, Castro C, Lukehart SA, et al. (2000) Multiple alleles of Treponema pallidum repeat gene D in Treponema pallidum isolates. J Bacteriol 182: 2332-2335.
35. Fenno JC, Muller KH, McBride BC (1996) Sequence analysis, expression, and binding activity of recombinant major outer sheath protein (Msp) of Treponema denticola. J Bacteriol 178: 2489-2497.
36. Centurion-Lara A, Castro C, Barrett L, Cameron C, Mostowfi M, et al. (1999) Treponema pallidum major sheath protein homologue TprK is a target of opsonic antibody and the protective immune response. J Exp Med 189: 647-656.
37. Centurion-Lara A, Godornes C, Castro C, Van Voorhis WC, Lukehart SA (2000) The tprK gene is heterogeneous among Treponema pallidum strains and has multiple alleles. Infect Immun 68: 824-831.
38. Morgan CA, Lukehart SA, Van Voorhis WC (2002) Immunization with the Nterminal portion of Treponema pallidum repeat protein K attenuates syphilitic lesion development in the rabbit model. Infect Immun 70: 6811-6816.
39. Morgan CA, Molini BJ, Lukehart SA, Van Voorhis WC (2002) Segregation of B and T cell epitopes of Treponema pallidum repeat protein K to variable and conserved regions during experimental syphilis infection. J Immunol 169: 952-957.
40. Morgan CA, Lukehart SA, Van Voorhis WC (2003) Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein K. Infect Immun 71: 5605-5612.
41. Wendel GD, Jr., Sanchez PJ, Peters MT, Harstad TW, Potter LL, et al. (1991) Identification of Treponema pallidum in amniotic fluid and fetal blood from pregnancies complicated by congenital syphilis. Obstet Gynecol 78: 890-895.
42. Cox DL, Luthra A, Dunham-Ems S, Desrosiers DC, Salazar JC, et al. (2010) Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum. Infect Immun. In press. doi:10.1128/IAI.00834-10.
43. Julvez J, Michault A, Kerdelhue V (1998) Serologic studies of non-venereal treponematoses in infants in Niamey, Niger. Med Trop (Mars) 58: 38-40.
44. Wilson J, Mauger DG (1973) Syphilis in pregnancy supervening on yaws: case report. N Z Med J 77: 384-388.
45. Turner TB, Hollander DH (1957) Biology of the treponematoses. Geneva: World Health Organization.
46. Baseman JB, Nichols JC, Rumpp O, Hayes NS (1974) Purification of Treponema pallidum from infected rabbit tissue: resolution into two treponemal populations. Infect Immun 10: 1062-1067.
47. Weinstock GM, Norris SJ, Sodergren E, Šmajs D (2000) Identification of virulence genes in silico: infectious disease genomics. In: Brogden KA, Roth JA, Stanton TB, Bolin CA, Minion FC, Wannemuehler MJ, eds. Virulence mechanisms of bacterial pathogens. 3rd ed. Washington, DC: ASM Press. pp 251-261.
48. Rozen S, Skaletsky HJ (2000) Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S, eds. Bioinformatics Methods and Protocols: Methods in Molecular Biology. Totowa, NJ: Humana Press. pp 365-386.
49. Wilgenbusch JC, Swofford D (2003) Inferring evolutionary trees with PAUP*. Curr Protoc Bioinformatics Chapter 6: Unit 6.4.
50. Calendini F, Martin JF (2005) PaupUp v1.0.3.1 A free graphical frontend for Paup* Dos software.
51. Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, et al. (2007) Clustal W and Clustal X version 2.0. Bioinformatics 23: 2947-2948.
52. Posada D, Crandall KA (1998) MODELTEST: testing the model of DNA substitution. Bioinformatics 14: 817-818.
53. Page RD (1996) TreeView: an application to display phylogenetic trees on personal computers. Comput Appl Biosci 12: 357-358.
54. Nichols HJ, Hough WH (1913) Demonstration of Spirochaeta pallida in the cerebrospinal fluid. JAMA-J Am Med Assoc 60: 108-110.
55. Stamm LV, Kerner TC, Jr., Bankaitis VA, Bassford PJ, Jr. (1983) Identification and preliminary characterization of Treponema pallidum protein antigens expressed in Escherichia coli. Infect Immun 41: 709-721.
56. Liska SL, Perine PL, Hunter EF, Crawford JA, Feelez JC (1982) Isolation and transportation of Treponema pertenue in golden hamsters. Curr Microbiol 7: 41-43.
57. Gastinel P, Vaisman A, Hamelin A, Dunoyer F (1963) Study of a recently isolated strain of Treponema pertenue. Ann Dermatol Syphiligr Paris 90: 155-161.