Molecular characterization and analysis of a gene encoding the acidic repeat protein (Arp) of Treponema pallidum

Journal of Medical Microbiology

Volumn 56, Issue 6, 2007, Pages 715-721

  Liu, Hsi ^a   Rodes, Berta ^a,b   George, Robert ^a   Steiner, Bret ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC REPEAT PROTEIN; ANTISERUM; BACTERIAL PROTEIN; GLUTAMIC ACID; PROTEIN ARP; SIGNAL PEPTIDASE I; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL INFECTION; BACTERIAL STRAIN; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; GENE ARP; HUMAN; IMMUNOGENICITY; MOLECULAR CLONING; MOLECULAR GENETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE; RABBIT; REAGIN TEST; SEQUENCE ANALYSIS; SEROLOGY; TREPONEMA PALLIDUM; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; BASE SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CLONING, MOLECULAR; CONSERVED SEQUENCE; DNA, BACTERIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, TERTIARY; RABBITS; REPETITIVE SEQUENCES, AMINO ACID; REPETITIVE SEQUENCES, NUCLEIC ACID; SEQUENCE ANALYSIS, DNA; SERUM; SYPHILIS SERODIAGNOSIS; TREPONEMA PALLIDUM;

EID: 34250371388     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.46943-0     Document Type: Article

References (38)

1. Anders, R. F., Coppel, R. L., Brown, G. V. & Kemp, D. J. (1988). Antigens with repeated sequences from the asexual blood stages of Plasmodium falciparum. Prog Allergy 41, 148-172.
2. Anderson, B. E., McDonald, G. A., Jones, D. C. & Regnery, R. L. (1990). A protective protein antigen of Rickettsia rickettsii has tandemly repeated, near-identical sequences. Infect Immun 58, 2760-2769.
3. Andrade, M. A., Perez-Iratxeta, C. & Ponting, C. P. (2001). Protein repeats: structures, functions, and evolution. J Struct Biol 134, 117-131.
4. Chamberlain, N. R., Brandt, M. E., Erwin, A. L., Radolf, J. D. & Norgard, M. V. (1989). Major integral membrane protein immunogens of Treponema pallidum are proteolipids. Infect Immun 57, 2872-2877.
5. Cox, D. L. (1994). Culture of Treponema pallidum. Methods Enzymol 236, 390-405.
6. Cox, D., Liu, H., Moreland, A. & Levine, W. (2003). Syphilis. In An Atlas of STD, pp. 23. Edited by S. A. Morse & R. Ballard. New York: Mosby Publisher.
7. Deitsch, K. W., Moxon, E. R. & Wellems, T. E. (1997). Shared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections. Microbiol Mol Biol Rev 61, 281-293.
8. Eisenberg, D., Bowie, J. U., Luthy, R. & Choe, S. (1992). Three-dimensional profiles for analysing protein sequence-structure relationships. Faraday Discuss 93, 25-34.
9. Felger, I., Marshall, V. M., Reeder, J. C., Hunt, J. A., Mgone, C. S. & Beck, H. P. (1997). Sequence diversity and molecular evolution of the merozoite surface antigen 2 of Plasmodium falciparum. J Mol Evol 45, 154-160.
10. Fraser, C. M., Norris, S. J., Weinstock, G. M., White, O., Sutton, G. G., Dodson, R., Gwinn, M., Hickey, E. K., Clayton, R. & other authors (1998). Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science 281, 375-388.
11. Garnier, J, Osguthorpe, D. J & Robson, B (1978). Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Mol Biol 25, 97-120.
12. Gravekamp, C., Horensky, D. S., Michel, J. L. & Madoff, L. C. (1996). Variation in repeat number within the alpha C protein of group B streptococci alters antigenicity and protective epitopes. Infect Immun 64, 3576-3583.
13. Harbaugh, M. P., Podbielski, A., Hugl, S. & Cleary, P. P. (1993). Nucleotide substitutions and small-scale insertions produce size and antigenic variation in group A streptococcal M1 protein. Mol Microbiol 8, 981-991.
14. Hollingshead, S. K., Fischetti, V. A. & Scott, J. R. (1987). Size variation in group A streptococcal M protein is generated by homologous recombination between intragenic repeats. Mol Gen Genet 207, 196-203.
15. Hood, D. W., Deadman, M. E., Allen, T., Masoud, H., Martin, A., Brisson, J. R., Fleischmann, R., Ventor, J. C., Richards, J. C. & Moxon, E. R. (1996). DNA repeats identify novel virulence genes in Haemophilus influenzae. Proc Natl Acad Sci U S A 93, 11121-11125.
16. Jameson, B. A. & Wolf, H. (1988). The antigenic index: a novel algorithm for predicting antigenic determinants. Bioinformatics 4, 181-186.
17. Joh, H. J., House-Pompeo, K., Patti, J. M., Gurusiddappa, S. & Magnus, H. (1994). Fibronectin receptors from Gram-positive bacteria: comparison of active sites. Biochemistry 33, 6086-6092.
18. Kajava, A. V. (2001). Review: proteins with repeated sequence - structural prediction and modeling. J Struct Biol 134, 132-144.
19. Kruglyak, S., Durrett, R. T., Schug, M. D. & Aquadro, C. F. (1998). Equilibrium distributions of microsatellite repeat length resulting from a balance between slippage events and point mutations. Proc Natl Acad Sci U S A 95, 10774-10778.
20. Liu, H. (2004). Treponema pallidum, Treponema pertenue, Treponema endemicum and Treponema carateum. In Encyclopedia of Diagnostic Genomics and Proteomics. Edited by J. Fuchs & M. Podda. New York: Marcel Dekker.
21. McGavin, M. J., Gurusiddappa, S., Lindgren, P.-E., Lindberg, M., Raucci, G. & Hook, M. (1993). Fibronectin receptors from Streptococcus dysgalactiae and Staphylococcus aureus: involvement of conserved residues in ligand binding. J Biol Chem 268, 23946-23953.
22. Moxon, E. R., Rainey, P. B., Nowak, M. A. & Lenski, R. E. (1994). Adaptive evolution of highly mutable loci in pathogenic bacteria. Curr Biol 4, 24-33.
23. Pillay, A., Liu, H., Chen, C. Y., Holloway, B., Sturm, A. W., Steiner, B. & Morse, S. A. (1998). Molecular subtyping of Treponema pallidum subspecies pallidum. Sex Transm Dis 25, 408-414.
24. Pillay, A., Liu, H., Ebrahim, S., Chen, C. Y., Lai, W., Fehler, G., Ballard, R. C., Steiner, B., Strum, A. W. & Morse, S. A. (2002). Molecular typing of Treponema pallidum in South Africa: cross-sectional studies. J Clin Microbiol 40, 256-258.
25. Pope, V., Fox, K., Liu, H., Marfin, A. A., Leone, P., Sena, A. C., Chapin, J., Fears, M. B. & Markowitz, L. (2005). Molecular subtyping of Treponema pallidum from North and South Carolina. J Clin Microbiol 43, 3743-3746.
26. Radolf, J. D. (1994). Role of outer membrane architecture in immune evasion by Treponema pallidum and Borrelia burgdoferi. Trends Microbiol 2, 307-311.
27. Radolf, J. D. (1995). Treponema pallidum and the quest for outer membrane proteins. Mol Microbiol 16, 1067-1073.
28. Rakonjac, J. V., Robbins, J. C. & Fischetti, V. A. (1995). DNA sequence of the serum opacity factor of group A streptococci: identification of a fibronectin-binding repeat domain. Infect Immun 63, 622-631.
29. Rodes, B., Liu, H., George, R., Johnson, S. & Steiner, B. (2000). Cloning and characterization of a gene (po/A) coding for an unusual DNA polymerase 1 from Treponema pallidum. J Med Microbiol 49, 657-667.
30. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989). Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
31. Schiffer, M., Chang, C. H. & Stevens, F. J. (1992). The functions of tryptophan residues in membrane proteins. Protein Eng 5, 213-214.
32. Shevchenko, D. V., Akins, D. R., Robinson, E., Li, M., Popova, T. G., Cox, D. L. & Radolf, J. D. (1997). Molecular characterization and cellular localization of TpLRR, a processed leucine-rich repeat protein of Treponema pallidum, the syphilis spirochete. J Bacteriol 179, 3188-3195.
33. Stamm, L. V. (1999). Biology of Treponema pallidum. In Sexually Transmitted Diseases, pp. 467-472. Edited by K. K. Holmes, P. F. Sparling, P.-A. Mardh, S. M. Lemon, W. E. Stamm, P. Piot & J. N. Wasserheit. New York: McGraw-Flill.
34. Struyve, M., Moons, M. & Tommassen, J. (1991). Carboxy-terminal phenylalanine is essential for the correct assembly of a bacterial outer membrane protein. J Mol Biol 218, 141-148.
35. Sutton, M. Y., Liu, H., Steiner, B., Pillay, A., Mickey, T., Finelli, L., Morse, S., Markowitz, L. & St Louis, M. E. (2001). Molecular subtyping of Treponema pallidum: application to a syphilis outbreak and use of blood as a new specimen. J Infect Dis 183, 1601-1606.
36. Thole, J. E. R., Stabel, L. F. E. M., Suykerbuiy, M. E. G., DeWit, M. Y. L., Klatser, P. R., Kolk, A. H. J. & Hartskeeri, R. A. (1990). A major immunogenic 36,000-molecular-weight antigen from Mycobacterium leprae contains an immunoreactive region of proline-rich repeats. Infect Immun 58, 80-87.
37. Towbin, H., Staehelin, T. & Gordon, J. (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedures and some applications. Proc Natl Acad Sci U S A 76, 4350-4354.
38. Yelton, D. B., Limberger, R. J., Curci, K., Malinosky-Rummell, F., Slivienski, L., Schouls, L. M., Van Embden, J. D. & Charon, M. W. (1991). Treponema phagedenis encodes and expresses homologs of the Treponema pallidum TmpA and TmpB proteins. Infect Immun 59, 3685-3693.