Modulators of endothelial cell filopodia: PECAM-1 joins the club

Cell Adhesion and Migration

Volumn 5, Issue 1, 2011, Pages 37-41

  DeLisser, Horace M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Angiogenesis; Endothelial cells; Filopodia; PECAM 1; SHP 2

Indexed keywords

ANGIOGENIC FACTOR; CD31 ANTIGEN; CHEMOTACTIC FACTOR; PHOSPHOLIPASE C GAMMA; PROTEIN TYROSINE PHOSPHATASE SHP; VASCULOTROPIN;

ANGIOGENESIS; CELL ACTIVITY; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; FILOPODIUM; NONHUMAN; NOTE; PROTEIN DOMAIN; REGULATORY MECHANISM;

EID: 78650816148     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.5.1.13575     Document Type: Note

References (55)

1. Nambiar R, McConnell RE, Tyska MJ. Myosin motor function: the ins and outs of actin-based membrane protrusions. Cell Mol Life Sci 2010; 67:1239-54.
2. Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003; 112:453-65.
3. Small JV, Auinger S, Nemethova M, Koestler S, Goldie KN, Hoenger A, et al. Unravelling the structure of the lamellipodium. J Microsc 2008; 231:479-85.
4. Faix J, Rottner K. The making of filopodia. Curr Opin Cell Biol 2006; 18:18-25.
5. Mattila PK, Lappalainen P. Filopodia: molecular architecture and cellular functions. Nat Rev Mol Cell Biol 2008; 9:446-54. (Pubitemid 351733400)
6. Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005; 438:967-74.
7. Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 2007; 8:464-78.
8. De Smet F, Segura I, De Bock K, Hohensinner PJ, Carmeliet P. Mechanisms of vessel branching: filopodia on endothelial tip cells lead the way. Arterioscler Thromb Vasc Biol 2009; 29:639-49.
9. Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 2003; 161:1163-77.
10. Gerhardt H, Ruhrberg C, Abramsson A, Fujisawa H, Shima D, Betsholtz C. Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system. Dev Dyn 2004; 231:503-9. (Pubitemid 39410884)
11. Cao G, Fehrenbach M, Williams J, Finklestein J, Zhu JX, DeLisser HM. Angiogenesis in PECAM-1-null mice. Am J Path 2009; 175:903-15.
12. Zhu JX, Cao G, Fehrenbach M, Williams J, DeLisser HM. SHP-2 phosphatase activity is required for PECAM-1-dependent cell motility. Am J Physiol Cell Physiol 2010;299:C854-65.
13. Ilan N, Madri JA. PECAM-1: old friend, new partners. Curr Opin Cell Biol 2003; 15:515-24.
14. Jackson DE. The unfolding tale of PECAM-1. FEBS Lett 2003; 540:7-14.
15. Newman PJ, Newman DK. Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology. Arterioscler Thromb Vasc Biol 2003; 23:953-64.
16. Fujiwara K. Platelet endothelial cell adhesion molecule-1 and mechanotransduction in vascular endothelial cells. J Intern Med 2006; 259:373-80.
17. Newman PJ, Berndt MC, Gorski J, White GC II, Lyman S, Paddock C, et al. PECAM-1(CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 1990; 247:1219-22. (Pubitemid 20102483)
18. Prager E, Sunder-Plassman R, Hansmann C, Koch C, Holter W, Knapp W, et al. Interaction of CD31 with a heterophilic counterreceptor involved in downregulation of human T cell responses. J Exp Med 1996; 184:41-50. (Pubitemid 26247213)
19. DeLisser HM, Yan HC, Newman PJ, Muller WA, Buck CA, Albelda SM. Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans. J Biol Chem 1993; 268:16037-46.
20. Sun J, Williams J, Yan HC, Amin KM, Albelda SM, DeLisser HM. Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression. J Biol Chem 1996 271:18561-70.
21. Coombe DR, Stevenson SM, Kinnear BF, Gandhi NS, Mancera RL, Osmond RI, et al. Platelet endothelial cell adhesion molecule 1 (PECAM-1) and its interactions with glycosaminoglycans: 2. Biochemical analyses. Biochemistry 2008; 47:4863-75.
22. Sachs UJ, Andrei-Selmer CL, Maniar A, Weiss T, Paddock C, Orlova VV, et al. The neutrophilspecific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). J Biol Chem 2007; 282:23603-12.
23. Billadeau DD, Leibson PJ. ITAMs versus ITIMs: striking a balance during cell regulation. J Clin Invest 2002; 109:161-8.
24. Jackson DE, Kupcho KR, Newman PJ. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2. J Biol Chem 1997; 272:24868-75.
25. Cao MY, Huber M, Beauchemin N, Famiglietti J, Albelda SM, Veillette A. Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases. J Biol Chem 1998; 273:15765-72. (Pubitemid 28298197)
26. Sagawa K, Kimura T, Swieter M, Siraganian RP. The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphylated adhesion molecule PECAM-1 (CD31). J Biol Chem 1997; 272:31086-91. (Pubitemid 27527557)
27. Masuda M, Osawa M, Shigematsu H, Harada N, Fujiwara K. Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cells. FEBS Lett 1997; 408:331-6. (Pubitemid 27227027)
28. Jackson DE, Ward CM, Wang R, Newman PJ. The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. J Biol Chem 1997; 272:6986-93.
29. Hua CT, Gamble JR, Vadas MA, Jackson DE. Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). J Biol Chem 1998; 273:28332-40.
30. Edmead CE, Crosby DA, Southcott M, Poole AW. Thrombin-induced association of SHP-2 with multiple tyrosine-phosphorylated proteins in human platelets. FEBS Lett 1999; 459:27-32. (Pubitemid 29447649)
31. Pumphrey NJ, Taylor V, Freeman S, Douglas MR, Bradfield PF, Young SP, et al. Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-γ1 with PECAM-1/CD31. FEBS Lett 1999; 450:77-83. (Pubitemid 29206716)
32. Pellegatta F, Chierchia SL, Zocchi MR. Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophils. J Biol Chem 1998; 273:27768-77. (Pubitemid 28496061)
33. Ilan N, Mahooti S, Rimm DL, Madri JA. PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated β-catenin. J Cell Sci 1999; 112:3005-14.
34. Ilan N, Cheung L, Pinter E, Madri JA. Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation. J Biol Chem 2000; 275:21435-43.
35. Woodfin A, Voisin MB, Nourshargh S. PECAM-1: a multi-functional molecule in inflammation and vascular biology. Arterioscler Thromb Vasc Biol 2007; 27:2514-23. (Pubitemid 350158900)
36. Carrithers M, Tandon S, Canosa S, Michaud M, Graesser D, Madri JA. Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice. Am J Pathol 2005; 166:185-96.
37. Maas M, Stapleton M, Bergom C, Mattson DL, Newman DK, Newman PJ. Endothelial cell PECAM-1 confers protection against endotoxic shock. Am J Physiol Heart Circ Physiol 2005; 288:159-64.
38. Tzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, et al. A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 2005; 437:426-31. (Pubitemid 41613506)
39. DeLisser HM, Christofidou-Solomidou M, Strieter RM, Burdick MD, Robinson CS, Wexler RS, et al. Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am J Pathol 1997; 151:671-7.
40. Cao G, O'Brien CD, Zhou Z, Sanders SM, Greenbaum JN, Makrigiannakis A, et al. The involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration. Am J Physiol Cell Physiol 2002; 282:1181-90.
41. Zhou Z, Christofidou-Solomidou M, Garlanda C, DeLisser HM. Antibody against murine PECAM-1 inhibits tumor angiogenesis in mice. Angiogenesis 1999; 3:181-8.
42. Duncan GS, Andrew DP, Takimoto H, Kaufman SA, Yoshida H, Spellberg J, et al. Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol 1999; 162:3022-30.
43. Solowiej A, Biswas P, Graesser D, Madri JA. Lack of platelet endothelial cell adhesion molecule-1 attenuates foreign body inflammation because of decreased angiogenesis. Am J Pathol 2003; 162:953-62. (Pubitemid 36237502)
44. DeLisser HM, Helmke BP, Cao G, Egan PM, Taichman D, Fehrenbach M, et al. Loss of PECAM-1 function impairs alveolarization. J Biol Chem 2006; 281:8724-31.
45. Gratzinger D, Canosa S, Engelhardt B, Madri JA. Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. FASEB J 2003; 17:1458-69. (Pubitemid 36935661)
46. Kondo S, Scheef EA, Sheibani N, Sorenson CM. PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis. Am J Physiol Cell Physiol 2007; 292:2070-83.
47. O'Brien C, Cao G, Makringiannakis A, DeLisser HM. The role of immunoreceptor tyrosine-based inhibitory motifs of platelet endothelial cell adhesion molecule (PECAM-1) in PECAM-1 dependent cell migration. Am J Physiol Cell Physiol 2004; 287:1103-13.
48. Brahmbhatt AA, Klemke RL. ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis. J Biol Chem 2003; 278:13016-25.
49. Huang C, Jacobson K, Schaller MD. MAP kinases and cell migration. J Cell Sci 2004; 117:4619-28.
50. Ren Y, Meng S, Mei L, Zhao ZJ, Jove R, Wu J. Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor. J Biol Chem 2005; 279:8497-505.
51. Dance M, Montagner A, Salles JP, Yart A, Raynal P. The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway. Cell Signal 2008; 20:453-9.
52. Raftopoulou M, Hall A. Cell migration: Rho GTPases lead the way. Dev Biol 2004; 265:23-32.
53. Cerione RA. Cdc42: new roads to travel. Trends Cell Biol 2004; 14:127-32.
54. Yang L, Wang L, Zheng Y. Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration and proliferation in primary mouse embryonic fibroblasts. Mol Biol Cell 2006; 17:4675-85. (Pubitemid 44665738)
55. DeLisser HM. Targeting PECAM-1 for anti-cancer therapy. Canc Biol Ther 2007; 6:121-2.