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Volumn 342, Issue 7787, 2011, Pages 36-

Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: A randomised placebo controlled trial

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CYANOCOBALAMIN; DOCOSAHEXAENOIC ACID; HOMOCYSTEINE; ICOSAPENTAENOIC ACID; PLACEBO; PYRIDOXINE;

EID: 78650768130     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.c6273     Document Type: Article
Times cited : (21)

References (48)
  • 5
    • 0037831001 scopus 로고    scopus 로고
    • N-3 fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease
    • Erkkilä AT, Lehto S, Pyörälä K, Uusitupa MI. n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. Am J Clin Nutr 2003;78:65-71. (Pubitemid 39655249)
    • (2003) American Journal of Clinical Nutrition , vol.78 , Issue.1 , pp. 65-71
    • Erkkila, A.T.1    Lehto, S.2    Pyorala, K.3    Uusitupa, M.I.J.4
  • 6
    • 0346726098 scopus 로고    scopus 로고
    • Folate, vitamin B6, and B12 intakes in relation to risk of stroke among men
    • He K, Merchant A, Rimm EB, Rosner BA, Stampfer MJ, Willett WC, et al. Folate, vitamin B6, and B12 intakes in relation to risk of stroke among men. Stroke 2004;35:169-74.
    • (2004) Stroke , vol.35 , pp. 169-174
    • He, K.1    Merchant, A.2    Rimm, E.B.3    Rosner, B.A.4    Stampfer, M.J.5    Willett, W.C.6
  • 7
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis
    • Mc Cully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969;56:111-28.
    • (1969) Am J Pathol , vol.56 , pp. 111-128
    • Mc Cully, K.S.1
  • 9
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SA, OmennGS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-57.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 10
    • 0032417638 scopus 로고
    • Plasma homocysteine and coronary heart disease
    • Danesh J, Lewington S. Plasma homocysteine and coronary heart disease. J Cardiovasc Res 1988;5:229-32.
    • (1988) J Cardiovasc Res , vol.5 , pp. 229-232
    • Danesh, J.1    Lewington, S.2
  • 11
    • 0036208436 scopus 로고    scopus 로고
    • Homocyst(e)ine and cardiovascular disease: A systematic review of the evidence with special emphasis on case-control studies and nested case-control studies
    • Ford ES, Smith SJ, Stroup DF, Steinberg KK, Mueller PW, Thacker SB. Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies. Int J Epidemiol 2002;31:59-70.
    • (2002) Int J Epidemiol , vol.31 , pp. 59-70
    • Ford, E.S.1    Smith, S.J.2    Stroup, D.F.3    Steinberg, K.K.4    Mueller, P.W.5    Thacker, S.B.6
  • 12
    • 33845269095 scopus 로고    scopus 로고
    • Folic acid, homocysteine, and cardiovascular disease: Judging causality in the face of inconclusive trial evidence
    • DOI 10.1136/bmj.39000.486701.68
    • Wald DS, Wald NJ, Morris JK, Law M. Folic acid, homocysteine and cardiovascular disease: judging causality in the face of inconclusive trial evidence. BMJ 2006;333:1114-7. (Pubitemid 44863652)
    • (2006) British Medical Journal , vol.333 , Issue.7578 , pp. 1114-1117
    • Wald, D.S.1    Morris, J.K.2    Law, M.3    Wald, N.J.4
  • 13
    • 27744603884 scopus 로고    scopus 로고
    • Dose-dependent effects of folic acid on blood concentrations of homocysteine: A meta-analysis of the randomized trials
    • Homocysteine Lowering Trialists' Collaboration
    • Homocysteine Lowering Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J ClinNutr 2005;82:806-12.
    • (2005) Am J ClinNutr , vol.82 , pp. 806-812
  • 14
    • 31344459617 scopus 로고    scopus 로고
    • Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the large randomized trials
    • B-Vitamin Treatment Trialists' Collaboration
    • B-Vitamin Treatment Trialists' Collaboration. Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Am Heart J 2006;151:282-7.
    • (2006) Am Heart J , vol.151 , pp. 282-287
  • 15
    • 1242278327 scopus 로고    scopus 로고
    • Blinded comparison of folic acid and placebo in patients with ischemic heart disease: An outcome trial
    • Baker F, Picton D, Blackwood S, Hunt J, Erskine M. Blinded comparison of folic acid and placebo in patients with ischemic heart disease: an outcome trial. Circulation 2002;106 (suppl II):S741.
    • (2002) Circulation , vol.106 , Issue.SUPPL. II
    • Baker, F.1    Picton, D.2    Blackwood, S.3    Hunt, J.4    Erskine, M.5
  • 16
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial
    • Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 2004;291:565-75.
    • (2004) JAMA , vol.291 , pp. 565-575
    • Toole, J.F.1    Malinow, M.R.2    Chambless, L.E.3    Spence, J.D.4    Pettigrew, L.C.5    Howard, V.J.6
  • 18
    • 33645753544 scopus 로고    scopus 로고
    • Homocysteine lowering with folic acid and B vitamins in vascular disease
    • The Heart Outcomes Prevention Evaluation (HOPE)2 Investigators
    • The Heart Outcomes Prevention Evaluation (HOPE)2 Investigators. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006;354:1567-77.
    • (2006) N Engl J Med , vol.354 , pp. 1567-1577
  • 19
    • 43049176549 scopus 로고    scopus 로고
    • Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease
    • Albert CM, Cook NR, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, et al. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease. JAMA 2008;299:2027-36.
    • (2008) JAMA , vol.299 , pp. 2027-2036
    • Albert, C.M.1    Cook, N.R.2    Gaziano, J.M.3    Zaharris, E.4    MacFadyen, J.5    Danielson, E.6
  • 20
    • 34548566329 scopus 로고    scopus 로고
    • Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: A randomized controlled trial
    • Jamison RL,Hartigan P, Kaufman JS,Goldfarb DS, Warren SR, Guarino PD, et al. Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial. JAMA 2007;298:1163-70.
    • (2007) JAMA , vol.298 , pp. 1163-1170
    • Jamison, R.L.1    Hartigan, P.2    Kaufman, J.S.3    Goldfarb, D.S.4    Warren, S.R.5    Guarino, P.D.6
  • 21
    • 49949101867 scopus 로고    scopus 로고
    • Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography. A randomized controlled trial
    • Ebbing M, Bleie Ø, Ueland PM, Nordrehaug JE, Nilsen DW, Vollset SE, et al. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography. A randomized controlled trial. JAMA 2008;300:795-804.
    • (2008) JAMA , vol.300 , pp. 795-804
    • Ebbing, M.1    Bleie, Ø.2    Ueland, P.M.3    Nordrehaug, J.E.4    Nilsen, D.W.5    Vollset, S.E.6
  • 22
    • 77953867844 scopus 로고    scopus 로고
    • Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors
    • Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group
    • Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group. Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors. JAMA 2010;24:2485-94.
    • (2010) JAMA , vol.24 , pp. 2485-2494
  • 23
    • 77955656519 scopus 로고    scopus 로고
    • B-vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins to Prevent Stroke (VITATOPS) trial: A randomised, double-blind, parallel, placebo-controlled trial
    • The VITATOPS Trial Study Group
    • The VITATOPS Trial Study Group. B-vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial. Lancet Neurology 2010;9:855-65.
    • (2010) Lancet Neurology , vol.9 , pp. 855-865
  • 24
    • 0037137299 scopus 로고    scopus 로고
    • Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    • Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002;106:2747-57.
    • (2002) Circulation , vol.106 , pp. 2747-2757
    • Kris-Etherton, P.M.1    Harris, W.S.2    Appel, L.J.3
  • 25
    • 0036124659 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids in coronary heart disease: A meta-analysis of randomized controlled trials
    • DOI 10.1016/S0002-9343(01)01114-7, PII S0002934301011147
    • Bucher HC, Hengstler P, Schindler C, Meier G. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med 2002;112:298-304. (Pubitemid 34219443)
    • (2002) American Journal of Medicine , vol.112 , Issue.4 , pp. 298-304
    • Bucher, H.C.1    Hengstler, P.2    Schindler, C.3    Meier, G.4
  • 27
    • 2942548948 scopus 로고    scopus 로고
    • Accumulated evidence on fish consumption and coronary heart disease mortality: A meta-analysis of cohort studies
    • He K, Song Y, Daviglus ML, Liu K, Van Horn L, Dyer AR, et al. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation 2004;109:2705-11.
    • (2004) Circulation , vol.109 , pp. 2705-2711
    • He, K.1    Song, Y.2    Daviglus, M.L.3    Liu, K.4    Van Horn, L.5    Dyer, A.R.6
  • 28
    • 33747120160 scopus 로고    scopus 로고
    • N-3 fatty acids from fish or fish-oil supplements, but not alphalinoleic acid, benefit cardiovascular disease outcomes in primary-and secondary-prevention studies: A systematic review
    • Wang C, Harris WS, Chung M, Lichtenstein AH, Balk EM, Kupelnick B, et al. N-3 fatty acids from fish or fish-oil supplements, but not alphalinoleic acid, benefit cardiovascular disease outcomes in primary-and secondary-prevention studies: a systematic review. Am J Clin Nutr 2006;84:5-17.
    • (2006) Am J Clin Nutr , vol.84 , pp. 5-17
    • Wang, C.1    Harris, W.S.2    Chung, M.3    Lichtenstein, A.H.4    Balk, E.M.5    Kupelnick, B.6
  • 30
    • 0024363690 scopus 로고
    • Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and reinfarction trial (DART)
    • Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989;2:757-61.
    • (1989) Lancet , vol.2 , pp. 757-761
    • Burr, M.L.1    Fehily, A.M.2    Gilbert, J.F.3    Rogers, S.4    Holliday, R.M.5    Sweetnam, P.M.6
  • 31
    • 0345109256 scopus 로고    scopus 로고
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E aftermyocardial infarction: Results of the GISSI-Prevenzione Trial
    • Gissi-Prevenzione Investigators
    • Gissi-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E aftermyocardial infarction: results of the GISSI-Prevenzione Trial. Lancet 1999;354:447-55.
    • (1999) Lancet , vol.354 , pp. 447-455
  • 32
    • 20444461678 scopus 로고    scopus 로고
    • Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: A randomized controlled trial
    • Raitt MH, Connor WE, Morris C, Kron J, Halperin B, Chugh SS, et al. Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial. JAMA 2005;293:2884-91.
    • (2005) JAMA , vol.293 , pp. 2884-2891
    • Raitt, M.H.1    Connor, W.E.2    Morris, C.3    Kron, J.4    Halperin, B.5    Chugh, S.S.6
  • 33
    • 64849110630 scopus 로고    scopus 로고
    • Effect of fish oil on ventricular tachyarrhythmia in three studies in patients with implantable cardioverter defibrillators
    • Brouwer IA, Raitt MH, Dullemeijer C, Kraemer DF, Zock PL, Morris C, et al. Effect of fish oil on ventricular tachyarrhythmia in three studies in patients with implantable cardioverter defibrillators. Eur Heart J 2009;30:820-6.
    • (2009) Eur Heart J , vol.30 , pp. 820-826
    • Brouwer, I.A.1    Raitt, M.H.2    Dullemeijer, C.3    Kraemer, D.F.4    Zock, P.L.5    Morris, C.6
  • 35
    • 47949084265 scopus 로고    scopus 로고
    • The SU. FOL.OM3 Study: A secondary prevention trial testing the impact of supplementation with folate and B-vitamins and/or omega-3 PUFA on fatal and non fatal cardiovascular events, design, methods and participants characteristics
    • Galan P, Briancon S, Blacher J, Czernichow S, Hercberg S. The SU. FOL.OM3 Study: a secondary prevention trial testing the impact of supplementation with folate and B-vitamins and/or omega-3 PUFA on fatal and non fatal cardiovascular events, design, methods and participants characteristics. Trials 2008;9:1-9.
    • (2008) Trials , vol.9 , pp. 1-9
    • Galan, P.1    Briancon, S.2    Blacher, J.3    Czernichow, S.4    Hercberg, S.5
  • 36
    • 0034688194 scopus 로고    scopus 로고
    • Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
    • The Heart Outcomes Prevention Evaluation Study Investigators
    • Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl JMed 2000;342:145-53.
    • (2000) N Engl JMed , vol.342 , pp. 145-153
    • Yusuf, S.1    Sleight, P.2    Pogue, J.3    Bosch, J.4    Davies, R.5    Dagenais, G.6
  • 37
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
    • Homocysteine Studies Collaboration
    • Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 2002;288:2015-22.
    • (2002) JAMA , vol.288 , pp. 2015-2022
  • 38
    • 2242477014 scopus 로고    scopus 로고
    • Lowering blood homocysteine with folic acid based supplement: Meta-analysis of randomised trials
    • Homocysteine Lowering Trialists' Collaboration
    • Homocysteine Lowering Trialists' Collaboration. Lowering blood homocysteine with folic acid based supplement: meta-analysis of randomised trials. BMJ 1998;316:894-8.
    • (1998) BMJ , vol.316 , pp. 894-898
  • 40
    • 0035969545 scopus 로고    scopus 로고
    • Decreased rate of coronary restenosis after lowering of plasma homocysteine levels
    • Schnyder G, Roffi M, Pin R, Roffi M, Flammer Y, Hess OM. Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. N Engl JMed 2001;345:1593-600.
    • (2001) N Engl JMed , vol.345 , pp. 1593-1600
    • Schnyder, G.1    Roffi, M.2    Pin, R.3    Roffi, M.4    Flammer, Y.5    Hess, O.M.6
  • 42
    • 34249730020 scopus 로고    scopus 로고
    • Efficacy of folic acid supplementation in stroke prevention: A meta-analysis
    • Wang X, Qin X, Demirtas H, Li J, Mao G, Huo Y, et al. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 2007;369:1876-82.
    • (2007) Lancet , vol.369 , pp. 1876-1882
    • Wang, X.1    Qin, X.2    Demirtas, H.3    Li, J.4    Mao, G.5    Huo, Y.6
  • 43
    • 78650762844 scopus 로고    scopus 로고
    • Effects of lowering homocysteine levels with B vitamins on cardiovascukar disease, cancer and cause-specific mortality
    • forthcoming
    • Clarke R, Halsey J, Lewington A, Lonn E, Armitage J, Manson JE, et al. Effects of lowering homocysteine levels with B vitamins on cardiovascukar disease, cancer and cause-specific mortality. Arch Intern Med (forthcoming).
    • Arch Intern Med
    • Clarke, R.1    Halsey, J.2    Lewington, A.3    Lonn, E.4    Armitage, J.5    Manson, J.E.6
  • 44
    • 33947583493 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis
    • Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007;369:1090-8.
    • (2007) Lancet , vol.369 , pp. 1090-1098
    • Yokoyama, M.1    Origasa, H.2    Matsuzaki, M.3    Matsuzawa, Y.4    Saito, Y.5    Ishikawa, Y.6
  • 45
    • 53049110571 scopus 로고    scopus 로고
    • Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): A randomised, double-blind, placebo-controlled trial
    • Gissi-HF Investigators
    • Gissi-HF Investigators, Tavazzi L, Maggioni AP, Marchioli R, Barlera S, Franzosi MG, et al. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 2008;372:1223-30.
    • (2008) Lancet , vol.372 , pp. 1223-1230
    • Tavazzi, L.1    Maggioni, A.P.2    Marchioli, R.3    Barlera, S.4    Franzosi, M.G.5
  • 46
    • 78549233384 scopus 로고    scopus 로고
    • N-3 fatty acids and cardiovascular events aftermyocardial infarction
    • for the Alpha Omega Trial Group
    • Kromhout D, Giltay EJ, Geleijnse JM, for the Alpha Omega Trial Group. N-3 fatty acids and cardiovascular events aftermyocardial infarction. N Engl J Med 2010;363:2015-26.
    • (2010) N Engl J Med , vol.363 , pp. 2015-2026
    • Kromhout, D.1    Giltay, E.J.2    Geleijnse, J.M.3
  • 47
    • 0037161373 scopus 로고    scopus 로고
    • Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: Time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione
    • Marchioli R, Barzi F, Bomba E, Chieffo C, Di Gregorio D, Di Mascio R, et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 2002;105:1897-903.
    • (2002) Circulation , vol.105 , pp. 1897-1903
    • Marchioli, R.1    Barzi, F.2    Bomba, E.3    Chieffo, C.4    Di Gregorio, D.5    Di Mascio, R.6
  • 48
    • 34548412877 scopus 로고    scopus 로고
    • Omega-3 fatty acids and cardiac arrhythmias: Prior studies and recommendations for future research: A report from the National Heart, Lung, and Blood Institute and Office of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis Workshop
    • London B, Albert C, Anderson ME, Giles WR, Van Wagoner DR, Balk E, et al. Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis Workshop. Circulation 2007;116:320-35.
    • (2007) Circulation , vol.116 , pp. 320-335
    • London, B.1    Albert, C.2    Anderson, M.E.3    Giles, W.R.4    Van Wagoner, D.R.5    Balk, E.6


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