Acute stress-induced increases in exhaled nitric oxide in asthma and their association with endogenous cortisol

American Journal of Respiratory and Critical Care Medicine

Volumn 183, Issue 1, 2011, Pages 26-30

  Ritz, Thomas ^a   Ayala, Erica S ^a   Trueba, Ana F ^a   Vance, Charles D ^b   Auchus, Richard J ^b  

^a SOUTHERN METHODIST UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Asthma; Exhaled nitric oxide; Psychosocial stress; Salivary cortisol

Indexed keywords

CORTICOSTEROID; HYDROCORTISONE; NITRIC OXIDE;

ADULT; AIRWAY; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; EXPIRED AIR; FEMALE; HUMAN; INFLAMMATION; MALE; MOOD; PATHOPHYSIOLOGY; PLETHYSMOGRAPHY; PRIORITY JOURNAL; SALIVA LEVEL; SOCIAL STRESS; STRESS; TASK PERFORMANCE;

ADOLESCENT; ADULT; ASTHMA; BREATH TESTS; EXHALATION; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; NITRIC OXIDE; RADIOIMMUNOASSAY; SALIVA; SEVERITY OF ILLNESS INDEX; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 78650761927     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201005-0691OC     Document Type: Article

References (49)

1. Marshall GD. Neuroendocrine mechanisms of immune dysregulation: applications to allergy and asthma. Ann Allergy Asthma Immunol 2004;93(2, Suppl. 1):S11-S17.
2. Miller BD, Wood BL. Emotions and family factors in childhood asthma: psychobiologic mechanisms and pathways of effect. Adv Psychosom Med 2003;24:131-160.
3. Wright RJ, Rodriguez M, Cohen S. Review of psychosocial stress and asthma: an integrated biopsychosocial approach. Thorax 1998;53:1066-1074.
4. Isenberg SA, Lehrer PM, Hochron S. The effects of suggestion and emotional arousal on pulmonary function in asthma: a review and a hypothesis regarding vagal mediation. Psychosom Med 1992;54:192-216.
5. Ritz T, Kullowatz A. Effects of stress and emotion on lung function in health and asthma. Curr Respir Med Rev 2005;1:208-219.
6. Forsythe P, Ebeling C, Gordon JR, Befus AD, Vliagoftis H. Opposing effects of short- and long- term stress on airway inflammation. Am J Respir Crit Care Med 2004;169:220-226.
7. Joachim RA, Quarcoo D, Arck P, Herz U, Renz H, Klapp B. Stress enhances airway reactivity and airway inflammation in an animal model of allergic bronchial asthma. Psychosom Med 2003;65:811-815.
8. Okuyama K, Ohwada K, Sakurada S, Sato N, Sora I, Tamura G, Takayanagi M, Ohno I. The distinctive effects of acute and chronic psychological stress on airway inflammation in a murine model of allergic asthma. Allergol Int 2007;56:29-35.
9. Chen E, Fisher EB, Bacharier LB, Strunk RC. Socioeconomic status, stress, and immune markers in adolescents with asthma. Psychosom Med 2003;65:984-992.
10. Kang DH, Coe CL, McCarthy DO, Jarjour NN, Kelly EA, Rodriguez RR, Busse WW. Cytokine profiles of stimulated blood lymphocytes in asthmatic and healthy adolescents across the school year. J Interferon Cytokine Res 1997;17:481-487.
11. Liu LY, Coe CL, Swenson CA, Kelly EA, Kita H, Busse WW. School examinations enhance airway inflammation to antigen challenge. Am J Respir Crit Care Med 2002;165:1062-1067.
12. Kullowatz A, Rosenfield D, Dahme B, Magnussen H, Kanniess F, Ritz T. Effects of stress on lung function in asthma are mediated by changes in airway inflammation. Psychosom Med 2008;70:468-475.
13. Kang DH, Weaver MT. Airway cytokine responses to acute and repeated stress in a murine model of allergic asthma. Biol Psychol 2010;84:66-73.
14. Chen E, Strunk RC, Bacharier LB, Chan M, Miller GE. Socioeconomic status associated with exhaled nitric oxide responses to acute stress in children with asthma. Brain Behav Immun 2010;24:444-450.
15. Buske-Kirschbaum A, von Auer K, Krieger S, Weis S, Rauh W, Hellhammer D. Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease? Psychosom Med 2003;65:806-810.
16. Landstra AM, Postma DS, Boezen HM, van Aalderen WM. Role of serum cortisol levels in children with asthma. Am J Respir Crit Care Med 2002;165:708-712.
17. Wamboldt MZ, Laudenslager M, Wamboldt FS, Kelsay K, Hewitt J. Adolescents with atopic disorders have an attenuated cortisol response to laboratory stress. J Allergy Clin Immunol 2003;111:509-514.
18. Sapolsky RM, Romero LM, Munck AU. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 2000;21:55-89.
19. Ritz T, Ayala ES, Trueba AF, Kullowatz A, Vance CD, Auchus RJ. Increase in airway inflammation following acute psychosocial stress and its association with cortisol levels in asthma. Psychosom Med 2010;68:A-120.
20. National Heart, Lung, and Blood Institute/National Asthma Education and Prevention Program. Expert panel report: Guidelines for the diagnosis and management of asthma. Full report 2007. NIH Publication No. 07-4051. Bethesda, MD: National Institutes of Health; 2007.
21. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview of DSM IV: patient edition (SCID-I/P), Version 2.0. New York: Biometrics Research Department; 1994.
22. Kirschbaum C, Pirke KM, Hellhammer DH. The Trier Social Stress Test: a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 1993;28:76-81.
23. American Thoracic Society, European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 2005;171:912-930.
24. Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 1988;54:1063-1070.
25. Tabachnick BG, Fidell LS. Using multivariate statistics, 5th ed. Boston: Allyn and Bacon; 2007.
26. Kharitonov SA, Gonio F, Kelly C, Meah S, Barnes PJ. Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children. Eur Respir J 2003;21:433-438.
27. Kullowatz A, Kanniess F, Ritz T. Noninvasive measurement of airway inflammation using exhaled nitric oxide: temporal stability, and relationship with climate, air pollution, and lung function. Psychosom Med 2005;67:A-48.
28. Jones SL, Herbison P, Cowan JO, Flannery EM, Hancox RJ, McLachlan CR, Taylor DR. Exhaled NO and assessment of anti-inflammatory effects of inhaled steroid: dose-response relationship. Eur Respir J 2002;20:601-608.
29. Jones SL, Kittelson J, Cowan JO, Flannery EM, Hancox RJ, McLachlan CR, Taylor DR. The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. Am J Respir Crit Care Med 2001;164:738-743.
30. Boiten FA. The effects of emotional behaviour on components of the respiratory cycle. Biol Psychol 1998;49:29-51.
31. Ritz T, Dahme B, Dubois AB, Folgering H, Fritz GK, Harver A, Kotses H, Lehrer PM, Ring C, Steptoe A, et al. Guidelines for mechanical lung function measurements in psychophysiology. Psychophysiology 2002;39:546-567.
32. Höglund CO, Axen J, Kemi C, Jernelov S, Grunewald J, Muller-Suur C, Smith Y, Gronneberg R, Eklund A, Stierna P, et al. Changes in immune regulation in response to examination stress in atopic and healthy individuals. Clin Exp Allergy 2006;36:982-992.
33. Ricciardolo FLM, Sterk PJ, Gaston B, Folkerts G. Nitric oxide in health and disease of the respiratory system. Physiol Rev 2004;84:731-765.
34. Puckett JL, George SC. Partitioned exhaled nitric oxide to noninvasively assess asthma. Respir Physiol Neurobiol 2008;163:166-177.
35. Horváth I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E, Becher G, van Beurden WJ, Corradi M, Dekhuijzen R, et al. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 2005;26:523-548.
36. Obrist PA. The cardiovascular-behavioral interaction: as it appears today. Psychophysiology 1976;13:95-107.
37. Heim C, Ehlert U, Hellhammer DH. The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 2000;25:1-35.
38. Kauffmann F, Guiochon-Mantel A, Neukirch F. Is low endogenous cortisol a risk factor for asthma? Am J Respir Crit Care Med 1999;160:1428.
39. Rodrigo GJ. Rapid effects of inhaled corticosteroids in acute asthma: an evidence-based evaluation. Chest 2006;130:1301-1311.
40. Zhou J, Liu DF, Liu C, Kang ZM, Shen XH, Chen YZ, Xu T, Jiang CL. Glucocorticoids inhibit degranulation of mast cells in allergic asthma via nongenomic mechanism. Allergy 2008;63:1177-1185.
41. Steptoe A. Psychological aspects of bronchial asthma. In: Rachman F, editor. Contributions to medical psychology. Vol. 3. Oxford: Pergamon Press; 1984. pp. 7-30.
42. Levenson RW. Effects of thematically relevant and general stressors on specificity of responding in asthmatic and nonasthmatic subjects. Psychosom Med 1979;41:28-39.
43. Ritz T, Kullowatz A, Goldman MD, Smith H-J, Kanniess F, Dahme B, Magnussen H. Airway response to emotional stimuli in asthma: the role of the cholinergic pathway. J Appl Physiol 2010;108:1542-1549.
44. von Leupoldt A, Dahme B. Emotions and airway resistance in asthma: study with whole body plethysmography. Psychophysiology 2005;42:92-97.
45. Agarwal SK, Marshall GD Jr. Glucocorticoid-induced type 1/type 2 cytokine alterations in humans: a model for stress-related immune dysfunction. J Interferon Cytokine Res 1998;18:1059-1068.
46. Sternberg EM. Neuroendocrine regulation of autoimmune/inflammatory disease. J Endocrinol 2001;169:429-435.
47. Sanders SP. Nitric oxide in asthma. Pathogenic, therapeutic, or diagnostic? Am J Respir Cell Mol Biol 1999;21:147-149.
48. Wlodarczyk JH, Gibson PG, Caeser M. Impact of inhaled corticosteroids on cortisol suppression in adults with asthma: a quantitative review. Ann Allergy Asthma Immunol 2008;100:23-30.
49. Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 1986;232:1004-1007.