Topical application of compound ibuprofen suppresses pain by inhibiting sensory neuron hyperexcitability and neuroinflammation in a rat model of intervertebral foramen inflammation

Journal of Pain

Volumn 12, Issue 1, 2011, Pages 141-152

  Huang, Zhi Jiang ^a   Hsu, Erica ^a   Li, Hao Chuan ^a   Rosner, Anthony L ^a   Rupert, Ronald L ^a   Song, Xue Jun ^a  

^a Parker University Research Institute   (United States)

Author keywords

COX 2; Dorsal root ganglion; IL 1 ; NF B; sodium channel

Indexed keywords

CYCLOOXYGENASE 2; IBUPROFEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; SODIUM CHANNEL NAV1.7; SODIUM CHANNEL NAV1.8;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREAM; DRUG MECHANISM; ELECTROPHYSIOLOGY; ENCEPHALITIS; HYPERALGESIA; LUMBAR VERTEBRA; MALE; NERVE CELL EXCITABILITY; NONHUMAN; PAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SENSORY NERVE; SPINAL GANGLION; UPREGULATION; WESTERN BLOTTING;

ADMINISTRATION, TOPICAL; ANALGESICS, NON-NARCOTIC; ANALYSIS OF VARIANCE; ANIMALS; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; GANGLIA, SPINAL; HYPERALGESIA; IBUPROFEN; INFLAMMATION; INTERLEUKIN-1BETA; INTERVERTEBRAL DISK; MALE; MEMBRANE POTENTIALS; PAIN; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SENSORY RECEPTOR CELLS; SODIUM CHANNELS; UP-REGULATION;

EID: 78650692378     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2010.06.008     Document Type: Article

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