Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes

Annals of the Rheumatic Diseases

Volumn 70, Issue 1, 2011, Pages 221-226

  Sato, Tomoo ^a   Konomi, Koji ^b   Fujii, Ryoji ^a   Aono, Hiroyuki ^b   Aratani, Satoko ^a,c   Yagishita, Naoko ^a   Araya, Natsumi ^a   Yudoh, Kazuo ^a   Beppu, Moroe ^a   Yamano, Yoshihisa ^a   Nishioka, Kusuki ^c   Nakajima, Toshihiro ^a,c  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SANTEN PHARMACEUTICAL CO LTD   (Japan)

^c TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; AGGRECANASE 2; BUTAPROST; CARRIER PROTEIN; COLLAGENASE 3; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; MESSENGER RNA; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E RECEPTOR 2; PROTEIN SLC14A1; SMALL INTERFERING RNA; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SUPERNATANT;

ALPROSTADIL; CARTILAGE, ARTICULAR; CELL SURVIVAL; CELLS, CULTURED; CHONDROCYTES; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASE 13; MEMBRANE TRANSPORT PROTEINS; OSTEOARTHRITIS, KNEE; RECEPTORS, PROSTAGLANDIN E; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 78650678829     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2009.118620     Document Type: Article

References (22)

1. Pelletier J, Martel-Pelletier J, Howell D. Etiopathogenesis of osteoarthritis. In: Koopman W, ed. Arthritis and allied conditions: a textbook of rheumatology. Philadelphia: Lippincott Williams & Wilkins 2001: 2193-215.
2. Mitchell PG, Magna HA, Reeves LM, et al. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 1996 ; 97 : 761-8.
3. Reboul P, Pelletier JP, Tardif G, et al. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. J Clin Invest 1996 ; 97 : 2011-19.
4. Neuhold LA, Killar L, Zhao W, et al. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest 2001 ; 107 : 35-44.
5. Billinghurst RC, Dahlberg L, Ionescu M, et al. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest 1997 ; 99 : 1534-45.
6. Hu Y, Xiang JS, DiGrandi MJ, et al. Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorg Med Chem 2005 ; 13 : 6629-44 .
7. Reiter LA, Robinson RP, McClure KF, et al. Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett 2004 ; 14 : 3389-95.
8. Sato T, Konomi K, Yamasaki S, et al. Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage. Arthritis Rheum 2006 ; 54 : 808-17.
9. Masuko-Hongo K, Sato T, Nishioka K. Chemokines differentially induce matrix metalloproteinase-3 and prostaglandin E2 in human articular chondrocytes. Clin Exp Rheumatol 2005 ; 23 : 57-62.
10. Olives B, Neau P, Bailly P, et al. Cloning and functional expression of a urea transporter from human bone marrow cells. J Biol Chem 1994 ; 269 : 31649-52.
11. Bos CL, Richel DJ, Ritsema T, et al. Prostanoids and prostanoid receptors in signal transduction. Int J Biochem Cell Biol 2004 ; 36 : 1187-205.
12. 2 signal through EP2 promotes the growth of articular chondrocytes. J Bone Miner Res 2005 ; 20 : 377-89.
13. Miwa M, Saura R, Hirata S, et al. Induction of apoptosis in bovine articular chondrocyte by prostaglandin E(2) through cAMP-dependent pathway. Osteoarthr Cartil 2000 ; 8 : 17-24.
14. Goldring MB, Berenbaum F. The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide. Clin Orthop Relat Res 2004;427 Suppl: S37 - 46.
15. Olivès B, Mattei MG, Huet M, et al. Kidd blood group and urea transport function of human erythrocytes are carried by the same protein. J Biol Chem 1995 ; 270 : 15607-10.
16. Li X, Ellman M, Muddasani P, et al. Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis. Arthritis Rheum 2009 ; 60 : 513-23.
17. Samuels J, Krasnokutsky S, Abramson SB. Osteoarthritis: a tale of three tissues. Bull NYU Hosp Jt Dis 2008 ; 66 : 244-50.
18. Shibakawa A, Aoki H, Masuko-Hongo K, et al. Presence of pannus-like tissue on osteoarthritic cartilage and its histological character. Osteoarthr Cartil 2003 ; 11 : 133-40 .
19. Attur M, Al-Mussawir HE, Patel J, et al. Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor. J Immunol 2008 ; 181 : 5082-8.
20. Martel-Pelletier J, Pelletier JP, Fahmi H. Cyclooxygenase-2 and prostaglandins in articular tissues. Semin Arthritis Rheum 2003 ; 33 : 155-67.
21. Hardy MM, Seibert K, Manning PT, et al. Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants. Arthritis Rheum 2002 ; 46 : 1789-803.
22. Mengshol JA, Vincenti MP, Coon CI, et al. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 2000 ; 43 : 801-11.