Cortical activation during mental rotation in male-to-female and female-to-male transsexuals under hormonal treatment

Psychoneuroendocrinology

Volumn 35, Issue 8, 2010, Pages 1213-1222

  Carrillo, Beatriz ^b   Gómez Gil, Esther ^c   Rametti, Giuseppina ^b   Junque, Carme ^b   Gomez, Ángel ^a   Karadi, Kazmer ^d   Segovia, Santiago ^a   Guillamon, Antonio ^a  

^a UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c HOSPITAL CLÍNIC   (Spain)

^d UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Cross sex hormonal treatment; FMRI; Frontal cortex; Gender identity disorders; Mental rotation; Occipital cortex; Parietal cortex; Transsexualism

Indexed keywords

ESTRADIOL; ETHINYLESTRADIOL; TESTOSTERONE;

ADULT; ARTICLE; BRAIN FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FEMALE TO MALE TRANSSEXUAL; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HORMONAL THERAPY; HUMAN; MALE; MALE TO FEMALE TRANSSEXUAL; MENTAL PERFORMANCE; MENTAL TASK; OCCIPITAL CORTEX; PARIETAL LOBE; PREFRONTAL CORTEX; PRIORITY JOURNAL;

EID: 77955576375     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2010.02.010     Document Type: Article

References (70)

1. Abdelgadir S.E., Roselli C.E., Choate J.V.A., Resko J.A. Androgen receptor messenger ribonucleic acid in brains and pituitaries of male rhesus monkeys: studies on distribution, hormonal control, and relationship to luteinizing hormone secretion. Biol. Reprod. 1999, 60:1251-1256.
2. Aleman A., Bronk E., Kessels R.P.C., Koppeschaar H.P.F., van Honk J. A single administration of testosterone improves visuospatial ability in young women. Psychoneuroendocrinology 2004, 29:612-617.
3. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2000, DSM-IV-TR, Washington, DC. 4th ed.
4. Astur R.S., Tropp J., Sava S., Constable R.T., Markus E.J. Sex differences and correlations in a virtual Morris water task, a virtual radial maze, and mental rotation. Behav. Brain Res. 2004, 151:103-115.
5. Bechara A. The role of emotion in decision-making: evidence from neurological patients with orbitofrontal damage. Brain Cognit. 2004, 55:30-40.
6. Berenbaum S.A. Cognitive function in congenital adrenal hyperplasia. Endocrinol. Metab. Clin. North Am. 2001, 30:173-192.
7. Beyenburg S., Watzka M., Clusmann H., Blümcke I., Bidlingmaier F., Elger C.E., Stoffel-Wagener B. Androgen receptor mRNA expression in the human hippocampus. Neurosci. Lett. 2000, 294:25-28.
8. Bezdickova M., Molikova R., Bebarova L., Kolar Z. Distribution of nuclear receptors for steroid hormones in the human brain: a preliminary study. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub. 2007, 151:69-71.
9. Blanchard R. The classification and labeling of nonhomosexual gender dysphorias. Arch. Sex. Behav. 1989, 18:315-334.
10. Blanchard R., Clemmensen L.H., Steiner B.W. Heterosexual and homosexual gender Dysphoria. Arch. Sex. Behav. 1987, 16:139-152.
11. Bobes J., Gutierrez M., Palao D., Ferrando L., Gibert-Rahola J., Lecrubier Y. Validez del M.I.N.I. (Mini International Neuropsychiatric Interview) en tres centros de AP en España. Psiquiatr. Biol. 1997, 4(S2):79.
12. Cherrier M.M., Rose A.L., Higano C. The effects of combined androgen blockade on cognitive function during the first cycle of intermittent androgen suppression in patients with prostate cancer. J. Urol. 2003, 170:1808-1811.
13. Cohen M.S., Kosslyn S.M., Breiter H.C., DiGirolamo G.J., Thompson W.L., Anderson A.K., Bookheimer S.Y., Rosen B.R., Belliveau J.W. Changes in cortical activity during mental rotation. A mapping study using functional MRI. Brain 1996, 119:89-100.
14. Cohen-Kettenis P.T., Gooren L.J.G. Transsexualism: a review of etiology, diagnosis and treatment. J. Psychosom. Res. 1999, 46:315-333.
15. Dietrich T., Krings T., Neulen J., Willmes K., Erberich S., Thron A., Sturm W. Effects of blood estrogen level on cortical activation patterns during cognitive activation as measured by functional MRI. Neuroimage 2001, 13:425-432.
16. Epting L.K., Overman W.H. Sex-sensitive tasks in men and women: a search for performance fluctuations across the menstrual cycle. Behav. Neurosci. 1998, 112:1304-1317.
17. Finley S.K., Kritzer M.F. Immunoreactivity for intracellular androgen receptors in identified subpopulations of neurons astrocytes and oligodendrocytes in primate prefrontal cortex. J. Neurobiol. 1999, 40:446-457.
18. Fisher C.S., Pellegrino J.W. Hemisphere differences for components of mental rotation. Brain Cognit. 1988, 7:1-15.
19. Gizewski E.R., Krause E., Wanke I., Forsting M., Senf W. Gender-specific cerebral activation during cognitive tasks using functional MRI: comparison of women in mid-luteal phase and men. Neuroradiology 2006, 48:14-20.
20. Gómez-Gil E., Trilla A., Salamero M., Godás T., Valdés M. Sociodemographic, clinical, and psychiatric characteristics of transsexuals from Spain. Arch. Sex. Behav. 2009, 38:378-392.
21. Gómez-Gil E., Cañizares S., Torres A., de la Torre F., Halperin I., Salamero M. Androgen treatment effects on memory in female-to-male transsexuals. Psychoneuroendocrinology 2009, 34:110-117.
22. Gooren L. The biology of human psychosexual differentiation. Horm. Behav. 2006, 50:589-601.
23. Green R. Sexual identity and sexual orientation. Hormones, Brain and Behavior 2002, vol. 4:463-485. Academic Press, Amsterdam.
24. Gur R.C., Alsop D., Glahn D., Petty R., Swanson C.L., Maldjian J.A., Turetsky B.I., Detre J.A., Gee J., Gur R.E. An fMRI study of sex differences in regional activation to a verbal and a spatial task. Brain Lang. 2000, 74:157-170.
25. Halari R., Sharma T., Hines M., Andrew C., Simmons A., Kumari V. Comparable fMRI activity with differential behavioral performance on mental rotation and overt verbal fluency in healthy men and women. Exp. Brain Res. 2006, 169:1-14.
26. Haraldsen I.R., Opjorsdsmoen S., Egeland T., Finset A. Sex-sensitive cognitive performance in untreated patients with early onset gender identity disorder. Psychoneuroendocrinology 2003, 28:906-915.
27. Haraldsen I.R., Egeland T., Haug E., Finset A., Opjorsdsmoen S. Cross-sex hormone treatment does not change sex-sensitive cognitive performance in gender identity disorder patients. Psychiatr. Res. 2005, 137:161-174.
28. Hausmann M., Slabbekoorn D., Van Goozen S.H.M., Cohen-Kettenis P.T., Güntürkün O. Sex hormones affect spatial abilities during the menstrual cycle. Behav. Neurosci. 2000, 114:1245-1250.
29. Hines M., Fane B.A., Pasterski V.L., Mathews G.A., Conway G.S., Brook C. Spatial abilities following prenatal androgen abnormality: targeting and mental rotations performance in individuals with congenital adrenal hyperplasia. Psychoneuroendocrinology 2003, 28:1010-1026.
30. Hines M. Prenatal testosterone and gender-related behaviour. Eur. J. Endocrinol. 2006, 155(Suppl. 1):S115-S121.
31. Hooven C.K., Chabris C.F., Ellison P.T., Kosslyn S.M. The relationship of male testosterone to components of mental rotation. Neuropsychologia 2004, 42:782-790.
32. Hugdahl K., Thomsen T., Ersland L. Sex differences in visuo-spatial processing: An fMRI study of mental rotation. Neuropsychologia 2006, 44:1575-1583.
33. Janowsky J.S. Thinking with your gonads: testosterone and cognition. Trends Cognit. Sci. 2006, 10:77-82.
34. Jordan K., Wüstenberg T., Heinze H.-J., Peters M., Jancke L. Women and men exhibit different cortical activation patterns during mental rotation tasks. Neuropsychologia 2002, 40:2397-2408.
35. Karádi K., Csathó A., Kovács B., Kosztolányi P. Subgroup analysis of sex difference on the Vandenberg-Kuse mental rotation test. Percept. Mot. Skills 2003, 96:197-200.
36. Kimura D. Sex and Cognition 1999, MIT Press, Cambridge.
37. Kosslyn S.M., Brown H.D. Hemispheric differences in visual objects processing: structural versus allocation theories. Brain Asymmetry 1995, 77-98. MIT Press, Cambridge. R.J. Davidson, K. Hugdahl (Eds.).
38. Kozaki T., Yasukouchi A. Relationships between salivary estradiol and components of mental rotation in young men. Physiol. Antropol. 2008, 27:19-24.
39. Lawrence A.A. Sexuality before and after male-to-female sex reassignment surgery. Arch. Sex. Behav. 2005, 34:147-166.
40. Linn M.C., Petersen A.C. Emergence and characterisation of gender differences in spatial abilities: a meta-analysis. Child Dev. 1985, 56:1479-1498.
41. Luders E., Sanchez F.J., Gaser C., Toga A.W., Narr K.L., Hamilton L.S., Vilain E. Regional gray matter variation in male-to-female transsexualism. Neuroimage 2009, 46:904-907.
42. Malouf M.A., Migeon C.J., Carson K.A., Petrucci L., Wisnieswski A.B. Cognitive outcome in adult women affected by congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Horm. Res. 2006, 65:142-150.
43. Miles C., Green R., Hines M. Estrogen effects on cognition, memory and mood in male-to-female transsexuals. Horm. Behav. 2006, 50:707-708.
44. Österlund M.K., Keller E., Hurd Y.L. The human forebrain has discrete estrogen receptor α messenger RNA expression: high levels in the amygdaloid complex. Neuroscience 2000, 95:333-342.
45. Österlund M.K., Gustafsson J.-A., Keller E., Hurd Y.L. Estrogen receptor β (ERβ) messenger ribonucleic acid (mRNA) expression within the human forebrain: distinct distribution pattern to ER α mRNA. J. Clin. Endocrinol. Metab. 2000, 85:3840-3846.
46. Parsons T.D., Larson P., Kratz K., Thiebaux M., Bluestein B., Buckwalter J.G., Rizo A.A. Sex differences in mental rotation and spatial rotation in virtual environment. Neuropsychologia 2004, 42:555-562.
47. Peters M. Sex differences and the factor time in solving Vanderberg and Kuse mental rotation problems. Brain Cognit. 2005, 57:176-184.
48. Peters M., Laeng B., Latham K., Jackson M., Zaiyouna R., Richardson C. A redrawn Vanderberg & Kuse mental rotation test: different versions and factors that affect performance. Brain Cognit. 1995, 28:39-58.
49. Phillips K., Silverman I. Differences in the relationship of menstrual cycle phase to spatial performance on two-and three-dimensional tasks. Horm. Behav. 1997, 32:167-175.
50. Puy L., MacLusky N.J., Becker L., Karsan N., Trachtenberg J., Brown T.J. Immunocytochemical detection of androgen receptor in human temporal cortex: characterization and application of polyclonal androgen receptor antibodies in frozen and paraffin-embedded tissues. J. Steroid Biochem. Mol. Biol. 1995, 55:197-209.
51. Resnick S.M., Berenbaum S.A., Gottesman I.I., Bouchard T.J. Early hormonal influences on cognitive functioning in congenital adrenal hyperplasia. Dev. Psychol. 1986, 22:191-198.
52. Schöning S., Engelien A., Kugel H., Schäfer S., Schiffbauer H., Zwitserlood P., Pletziger E., Beizai P., Kersting A., Ohrmann P., Greb R.R., Lehmann W., Heindel W., Arolt V., Konrad C. Functional anatomy of visuo-spatial working memory during mental rotation is influenced by sex, menstrual cycle, and sex steroids hormones. Neuropsychologia 2007, 45:3203-3214.
53. Schöning S., Engelien A., Bauer C., Kugel H., Kersting A., Roestel C., Zwitserlood P., Pyka M., Dannlowski U., Lehmann W., Heindel W., Arolt V., Konrad C. Neuroimaging differences in spatial cognition between men and male-to-female transsexuals before and during hormone therapy. J. Sex Med. Sep. 2009, 14. doi:10.1111./j.1743-6109.2009.01484.x.
54. Seurinck R., Vingerhoets G., Lange F.P., Achten E. Does egocentric mental rotation elicit sex differences?. Neuroimage 2004, 23:1440-1449.
55. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E. The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatr. 1998, 59(S20):22-33.
56. Shepard R.N., Metzler J. Mental rotation of three-dimensional objects. Science 1971, 171:701-703.
57. Slabbekoorn D., Van Goozen S.H.M., Megens J., Gooren L.J.G., Cohen-Kettenis P.T. Activating effects of cross-sex hormones on cognitive functioning: a study of short-term and long-term hormone effects in transsexuals. Psychoneuroendocrinology 1999, 24:423-447.
58. Smith L.S., van Goozen S.H.M., Kuiper A.J., Cohen-Kettenis P.T. Transsexual subtypes: clinical and theoretical significance. Psychiatr. Res. 2005, 137:151-160.
59. Sommer I.E.C., Cohen-Kettenis P.T., van Raalten T., vd Veer A.J., Ramsey L.E., Gooren L.J.G., Kahn R.S., Ramsey N.F. Effects of cross-sex hormones on cerebral activation during language and mental rotation: an fMRI study in transsexuals. Eur. Neuropsychopharm. 2008, 8:215-221.
60. Talairach J., Tournoux P. Co Planar Stereotaxic Atlas of the Human Brain 1988, Thieme Medical, New Cork.
61. Thomsen T., Hugdhal K., Ersland L., Barndon R., Ludervold A., Smievoll A.I., Roscher B.E., Sundberg H. Functional magnetic resonance imaging (fMRI) study of sex differences in a mental rotation task. Med. Sci. Monit. 2000, 6:1186-1196.
62. Ungerleider L.G., Haxby J.V. " What" and " where" in the human brain. Curr. Opin. Neurobiol. 1994, 4:157-165.
63. Vallar G. Spatial neglect, Balint-Homes' and Gerstmann's syndrome, and other spatial disorders. CNS Spectrom. 2007, 12:527-536.
64. Van Goozen S.H.M., Cohen-Kettenis P.T., Gooren L.J.G., Frijda N.H., Van de Poll N.E. Gender differences in behaviour: activating effects of cross-sex hormones. Psychoneuroendocrinology 1995, 20:343-363.
65. Vandenberg S.G., Kuse A.R. Mental rotations, a group test of three-dimensional spatial visualization. Percept. Mot. Skills 1978, 47:599-604.
66. Vingerhoets G., Lange F.P., Vandemaele P., Deblaere K., Achten E. Motor imagery in mental rotation: an fMRI study. Neuroimage 2002, 17:1623-1633.
67. Voyer D., Voyer S., Bryden M.P. Magnitude of sex differences in spatial abilities: a meta-analysis and consideration of critical variables. Psychol. Bull. 1995, 117:250-270.
68. Weiss E., Siedentopf C.M., Hofer A., Deisenhammer E.A., Hoptman M.J., Kremser C., Golaszewski S., Felber S., Fleischhacker W.W., Delazer M. Sex differences in brain activation pattern during a visuospatial cognitive task: a functional magnetic resonance imaging study in healthy volunters. Neurosci. Lett. 2003, 344:169-172.
69. World Health Organization (WHO) The ICD-10. Classification of Mental and Behavioural Disorders 1993, Diagnostic Criteria for Research, Geneva.
70. Zitzmann M. Testosterone and the brain. Aging Male 2006, 9:195-199.