LYG-202, a new flavonoid with a piperazine substitution, shows antitumor effects in vivo and in vitro

Biochemical and Biophysical Research Communications

Volumn 385, Issue 4, 2009, Pages 551-556

  Zeng, Shi ^a   Liu, Wei ^a   Nie, Fei fei ^a   Zhao, Qing ^a   Rong, Jing jing ^a   Wang, Jia ^a   Tao, Lei ^a   Qi, Qi ^a   Lu, Na ^a   Li, Zhi yu ^a   Guo, Qing Long ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antitumor; Apoptosis; Caspase; Flavonoid; HepG2 cells

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CYCLOPHOSPHAMIDE; FLAVONOID; LYG 202; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRAIN HEPG2; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; ENZYME DEGRADATION; EXPERIMENTAL NEOPLASM; HUMAN; HUMAN CELL; IC 50; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMA; SARCOMA CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FLAVONES; FLAVONOIDS; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED ICR; PIPERAZINES; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS;

EID: 67249157920     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.05.099     Document Type: Article

References (31)

1. Kasibhatla S., and Tseng B. Why target apoptosis in cancer treatment?. Mol. Cancer Ther. 2 (2003) 573-580
2. Kerr J.F., Wyllie A.H., and Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26 (1972) 239-257
3. Ghobrial I.M., Witzig T.E., and Adjei A.A. Targeting apoptosis pathways in cancer therapy. CA Cancer J. Clin. 55 (2005) 178-194
4. Reed J.C. Mechanisms of apoptosis. Am. J. Pathol. 157 (2000) 1415-1430
5. Evan G.I., and Vousden K.H. Proliferation cell cycle and apoptosis in cancer. Nature 411 (2001) 342-348
6. Marx J. Cancer research. Obstacle for promising cancer therapy. Science 295 (2002) 1444
7. Finkel E. Does cancer therapy trigger cell suicide. Science 286 (1999) 2256-2258
8. Ashe P.C., and Berry M.D. Apoptotic signaling cascades. Prog. Neuropsychopharmacol. Biol. Psychiatry 27 (2003) 199-214
9. Gulbins E., Jekle A., Ferlinz K., Grassme H., and Lang F. Physiology of apoptosis. Am. J. Physiol. Renal Physiol. 279 (2000) F605-F615
10. Middleton Jr. E., Kandaswami C., and Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 52 (2000) 673-751
11. Nijveldt R.J., van Nood E., van Hoorn D.E., Boelens P.G., van Norren K., and van Leeuwen P.A. Flavonoids: a review of probable mechanisms of action and potential applications. Am. J. Clin. Nutr. 74 (2001) 418-425
12. Suh Y., Afaq F., Johnson J.J., and Mukhtar H. A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways. Carcinogenesis 30 (2009) 300-307
13. Gu H., You Q., Liu W., Yang Y., Zhao L., Qi Q., Zhao J., Wang J., Lu N., Ling H., Guo Q., and Wang X. Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice. Int. Immunopharmacol. 8 (2008) 1493-1502
14. Qiang L., Yang Y., You Q.D., Ma Y.J., Yang L., Nie F.F., Gu H.Y., Zhao L., Lu N., Qi Q., Liu W., Wang X.T., and Guo Q.L. Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study. Biochem. Pharmacol. 75 (2008) 1083-1092
15. Li H.N., Nie F.F., Liu W., Dai Q.S., Lu N., Qi Q., Li Z.Y., You Q.D., and Guo Q.L. Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. Toxicology 257 (2009) 80-85
16. Shu-yun X., Ru-lian B., and Xiu C. Methodology of Pharmacological. third ed. (2002), People's Medical Publishing House, Beijing
17. Wang W., Guo Q.L., You Q.D., Zhang K., Yang Y., Yu J., Liu W., Zhao L., Gu H.Y., Hu Y., Tan Z., and Wang X.T. The anticancer activities of Wogonin in murine sarcoma S180 both in vitro and in vivo. Biol. Pharm. Bull. 29 (2006) 1132-1137
18. Wang M., Zhang L., Han X., Yang J., Qian J., Hong S., Samaniego F., Romaguera J., and Yi Q. Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways. Blood 109 (2007) 5455-5462
19. Fazal F., Gu L., Ihnatovych I., Han Y., Hu W., Antic N., Carreira F., Blomquist J.F., Hope T.J., Ucker D.S., and de Lanerolle P. Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo. Mol. Cell. Biol. 25 (2005) 6259-6266
20. Shi Y., Sahu R.P., and Srivastava S.K. Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis. BMC Cancer 8 (2008) 294
21. Jalving M., de Jong S., Koornstra J.J., Boersma-van Ek W., Zwart N., Wesseling J., de Vries E.G., and Kleibeuker J.H. TRAIL induces apoptosis in human colorectal adenoma cell lines and human colorectal adenomas. Clin. Cancer Res. 12 (2006) 4350-4356
22. Liu T., Hannafon B., Gill L., Kelly W., and Benbrook D. Flex-Hets differentially induce apoptosis in cancer over normal cells by directly targeting mitochondria. Mol. Cancer Ther. 6 (2007) 1814-1822
23. Zisterer D.M., Campiani G., Nacci V., and Williams D.C. Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents. J. Pharmacol. Exp. Ther. 293 (2000) 48-59
24. Daniel B., and DeCoster M.A. Quantification of sPLA2-induced early and late apoptosis changes in neuronal cell cultures using combined TUNEL and DAPI staining. Brain Res. Brain Res. Protoc. 13 (2004) 144-150
25. Marcellus R.C., Lavoie J.N., Boivin D., Shore G.C., Ketner G., and Branton P.E. The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis. J. Virol. 72 (1998) 7144-7153
26. Chang H.L., Wu Y.C., Su J.H., Yeh Y.T., and Yuan S.S. Protoapigenone, a novel flavonoid, induces apoptosis in human prostate cancer cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase 1/2. J. Pharmacol. Exp. Ther. 325 (2008) 841-849
27. Sun S.Y., Hail Jr. N., and Lotan R. Apoptosis as a novel target for cancer chemoprevention. J. Natl. Cancer Inst. 96 (2004) 662-672
28. Reed J.C. Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies. Semin. Hematol. 34 (1997) 9-19
29. Gillet L., Dewals B., Farnir F., de Leval L., and Vanderplasschen A. Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo. Cancer Res. 65 (2005) 9463-9472
30. Scovassi A.I., and Poirier G.G. Poly(ADP-ribosylation) and apoptosis. Mol. Cell Biochem. 199 (1999) 125-137
31. Moubarak R.S., Yuste V.J., Artus C., Bouharrour A., Greer P.A., Menissier-de Murcia J., and Susin S.A. Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol. Cell. Biol. 27 (2007) 4844-4862