Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough

Pharmacogenetics and Genomics

Volumn 21, Issue 1, 2011, Pages 10-17

  Grilo, Antonio ^a   Sáez Rosas, María P ^a   Santos Morano, Juan ^a   Sánchez, Elena ^a   Moreno Rey, Concha ^b   Real, Luis M ^b   Ramírez Lorca, Reposo ^b   Sáez, María E ^b  

^a HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^b Neocodex   (Spain)

Author keywords

Angiotensin converting enzyme inhibitors; cough; epitasis; genetic susceptibility; polymorphisms

Indexed keywords

AMINOPEPTIDASE P; AMINOPEPTIDASE P1; BRADYKININ B2 RECEPTOR; CARBOXIPEPTIDASE N; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; KININ; MEMBRANE METALLOENDOPEPTIDASE; PEPTIDASE; PEPTIDE HYDROLASE; PROSTACYCLIN RECEPTOR; PROSTACYCLIN SYNTHASE; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E RECEPTOR 3; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; COUGHING; DISEASE PREDISPOSITION; DRUG ACTIVITY; ESSENTIAL HYPERTENSION; FEMALE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTAGLANDIN METABOLISM; RECEIVER OPERATING CHARACTERISTIC; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 78650677591     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e328341041c     Document Type: Article

References (33)

1. Khalil ME, Basher AW, Brown EJ Jr, Alhaddad IA. A remarkable medical story: benefits of angiotensin-converting enzyme inhibitors in cardiac patients. J Am Coll Cardiol 2001; 37:1757-1764
2. Punzi HA. Safety update: focus on cough. Am J Cardiol 1993; 72:45H-48H
3. Gibson GR. Enalapril-induced cough. Arch Intern Med 1989; 149:2701-2703
4. Israili ZH, Hall WD. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy: a review of the literature and pathophysiology. Ann Intern Med 1992; 117: 234-242
5. Woo J, Chan TY. A high incidence of cough associated with combination therapy of hypertension with isradipine and lisinopril in Chinese subjects. Br J Clin Pract 1991; 45:178-180
6. Trifilieff A, Da Silva A, Gies JP. Kinins and respiratory tract diseases. Eur Respir J 1993; 6:576-587
7. Furuya K, Yamaguchi E, Hirabayashi T, Itoh A, Hizawa N, Ohnuma N, Kawakami Y. Angiotensin-I-converting enzyme gene polymorphism and susceptibility to cough. Lancet 1994; 343:354
8. Mukae S, Itoh S, Aoki S, Iwata T, Nishio K, Sato R, Katagiri T. Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough. J Hum Hypertens 2002; 16:857-863
9. Zee RY, Rao VS, Paster RZ, Sweet CS, Lindpaintner K. Three candidate genes and angiotensin-converting enzyme inhibitor-related cough: a pharmacogenetic analysis. Hypertension 1998; 31:925-928
10. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81:559-575
11. Gayan J, Gonzalez-Perez A, Bermudo F, Saez ME, Royo JL, Quintas A, et al. A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis. BMC Genomics 2008; 9:360
12. Pylypchuk GB. ACE inhibitor versus angiotensin II blocker-induced cough and angioedema. Ann Pharmacother 1998; 32:1060-1066
13. Ignjatovic T, Tan F, Brovkovych V, Skidgel RA, Erdos EG. Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor. J Biol Chem 2002; 277:16847-16852
14. Fox AJ, Lalloo UG, Belvisi MG, Bernareggi M, Chung KF, Barnes PJ. Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough. Nat Med 1996; 2:814-817
15. Lee YJ, Tsai JC. Angiotensin-converting enzyme gene insertion/deletion, not bradykinin B2 receptor -58T/C gene polymorphism, associated with angiotensin-converting enzyme inhibitor-related cough in Chinese female patients with non-insulin-dependent diabetes mellitus. Metabolism 2001; 50:1346-1350
16. Lu J, Li LM, Zhan SY, Yang HY, Li XH, Cao WH, Hu YH. Study on candidate genes of benazepril related cough in Chinese hypertensives. Zhonghua Liu Xing Bing Xue Za Zhi 2003; 24:498-502
17. Woo SW, Bang S, Chung MW, Jin SK, Kim YS, Lee SH. Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans. J Clin Pharm Ther 2009; 34:561-567
18. Mukae S, Aoki S, Itoh S, Iwata T, Ueda H, Katagiri T. Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough. Hypertension 2000; 36:127-131
19. Semple PF. Putative mechanisms of cough after treatment with angiotensin converting enzyme inhibitors. J Hypertens Suppl 1995; 13:S17-S21
20. Maher SA, Birrell MA, Belvisi MG. Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy. Am J Respir Crit Care Med 2009; 180:923-928
21. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86:1343-1346
22. Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F, Soubrier F. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 1992; 51:197-205
23. McGarvey LP, Savage DA, Feeney SA, Heaney LG, Ennis M, MacMahon J, Maxwell AP. Is there an association between angiotensin-converting enzyme gene variants and chronic nonproductive cough? Chest 2000; 118:1091-1094
24. Niu T, Chen X, Xu X. Angiotensin converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: therapeutic implications. Drugs 2002; 62:977-993
25. Chung CM, Wang RY, Chen JW, Fann CS, Leu HB, Ho HY, et al. A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor. Pharmacogenomics J 2010. [Epub]
26. Takahashi T, Yamaguchi E, Furuya K, Kawakami Y. The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage. Respir Med 2001; 95:130-135
27. Yang SM, He QY, Miao YD. The relationship between polymorphism of angiotensin converting enzyme gene and cough caused by angiotensin converting enzyme inhibitors. Zhonghua Jie He He Hu Xi Za Zhi 2003; 26:203-205
28. Cao H, Hegele RA. DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency. J Hum Genet 2003; 48:20-22
29. Adam A, Cugno M, Molinaro G, Perez M, Lepage Y, Agostoni A. Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors. Lancet 2002; 359:2088-2089
30. Nikpoor B, Duan QL, Rouleau GA. Acute adverse reactions associated with angiotensin-converting enzyme inhibitors: genetic factors and therapeutic implications. Expert Opin Pharmacother 2005; 6:1851-1856
31. Duan QL, Nikpoor B, Dube MP, Molinaro G, Meijer IA, Dion P, et al. A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. Am J Hum Genet 2005; 77:617-626
32. Belvisi MG, Geppetti P. Cough. 7: Current and future drugs for the treatment of chronic cough. Thorax 2004; 59:438-440
33. Ishiura Y, Fujimura M, Nobata K, Oribe Y, Abo M, Myou S. Prostaglandin I2 enhances cough reflex sensitivity to capsaicin in the asthmatic airway. Cough 2007; 3:2