Structure-based in silico model profiles the binding constant of poorly soluble drugs with β-cyclodextrin

European Journal of Pharmaceutical Sciences

Volumn 42, Issue 1-2, 2011, Pages 55-64

  Li, Haiyan ^a,b   Sun, Jin ^b   Wang, Yongjun ^b   Sui, Xiaofan ^c   Sun, Le ^b   Zhang, Jiwen ^a   He, Zhonggui ^b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c Liaoning Institute for Drug Control   (China)

Author keywords

Cyclodextrin inclusion complex; Binding constant; In silico model; Poorly soluble drugs

Indexed keywords

ADENINE; ALBENDAZOLE; AMOBARBITAL; AMPHETAMINE; ATENOLOL; BERGAPTEN; BETA CYCLODEXTRIN; BROMPHENIRAMINE; CAFFEINE; CATECHIN; CIPROFLOXACIN; CLOPROSTENOL; CLOXACILLIN; CODEINE; CURCUMIN; DANAZOL; DIETHYLSTILBESTROL; DIFLUNISAL; DOXYLAMINE; ENALAPRIL; ESTRADIOL; FAMOTIDINE; FENBUFEN; FENOPROFEN; FISETIN; FLUCONAZOLE; FLUOROURACIL; FLUOXETINE; FLURBIPROFEN; GLYCOL SALICYLATE;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; DRUG BINDING; DRUG SOLUBILITY; DRUG STRUCTURE; MULTIPLE LINEAR REGRESSION ANALYSIS; PRIORITY JOURNAL; REGRESSION ANALYSIS;

BETA-CYCLODEXTRINS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; PREDICTIVE VALUE OF TESTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SOLUBILITY;

EID: 78650676766     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.10.006     Document Type: Article

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