An open randomized clinical trial in comparing two artesunate-based combination treatments on Plasmodium falciparum malaria in Nigerian children: Artesunate/sulphamethoxypyrazine/pyrimethamine (fixed dose over 24 hours) versus artesunate/amodiaquine (fixed dose over 48 hours)

Malaria Journal

Volumn 9, Issue 1, 2010, Pages

  Ayede, Idowu Adejumoke ^a   Falade, Adegoke Gbadegesin ^a   Sowunmi, Akintunde ^a   Jansen, Frans Herwig ^b  

^a UNIVERSITY OF IBADAN   (Nigeria)

^b Dafra Pharma International   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMODIAQUINE PLUS ARTESUNATE; AMONATE; ANTIMALARIAL AGENT; ARTESUNATE PLUS SULFAMETHOXYPYRAZINE PLUS PYRIMETHAMINE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CO ARINATE FDC; CREATININE; UNCLASSIFIED DRUG; AMODIAQUINE; ARTEMISININ DERIVATIVE; ARTESUNATE; PYRIMETHAMINE; SULFALENE;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ASSESSMENT; CLINICAL FEATURE; DRUG EFFICACY; DRUG SAFETY; FOLLOW UP; HEMATOCRIT; HUMAN; INFANT; LEUKOCYTE; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; NIGERIA; NONHUMAN; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; REINFECTION; SCHOOL CHILD; TREATMENT FAILURE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG COMBINATION; FEMALE; MALE; METHODOLOGY; TIME; TREATMENT OUTCOME;

ADOLESCENT; AMODIAQUINE; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; NIGERIA; PYRIMETHAMINE; SULFALENE; TIME FACTORS; TREATMENT OUTCOME;

EID: 78650667894     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-9-378     Document Type: Article

References (22)

1. Federal Ministry of Health National Malaria and Vector Control Division, Abuja, Nigeria, National antimalarial treatment policy 2005 http://nmcpnigeria. org
2. Federal Ministry of Health, National Malaria Control Programme, Abuja, Nigeria, Strategic plan 2009-2013. A road map for malaria control in Nigeria 2009 http://nmcpnigeria.org
3. A fixed-dose 24-hour regimen of artesunate plus sulfamethoxypyrazine- pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in eastern Sudan. I Adam M Magzoub ME Osman IF Khalil M Alifrangis KA Elmardi, Ann Clin Microbiol Antimicrob 2006 5 18 10.1186/1476-0711-5-18 16934158
4. Single-day, three-dose treatment with fixed dose combination artesunate/sulfamethoxypyrazine/pyrimethamine to cure Plasmodium falciparum malaria. LK Penali FH Jansen, Int J Infect Dis 2008 12 430 437 10.1016/j.ijid.2007.12.006 18343702
5. Efficacy and safety of a fixed dose artesunate-sulphamethoxypyrazine- pyrimethamine compared to artemether-lumefantrine for the treatment of uncomplicated falciparum malaria across Africa: a randomized multi-centre trial. I Sagara S Rulisa W Mbacham I Adam K Sissoko H Maiga OB Traore N Dara YT Dicko A Dicko A Djimdé FH Jansen OK Doumbo, Malar J 2009 8 63 10.1186/1475-2875-8-63 19366448
6. Comparison of different artemisinin-based combinations for the treatment of Plasmodium falciparum malaria in children in Kigali, Rwanda, an area of resistance to sulfadoxine-pyrimethamine: artesunate plus sulfadoxine/ pyrimethamine versus artesunate plus sulfamethoxypyrazine/pyrimethamine. S Rulisa JP Gatarayiha T Kabarisa G Ndayisaba, Am J Trop Med Hyg 2007 77 612 616 17978058
7. A randomized trial of artesunate-sulfamethoxypyrazine-pyrimethamine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Mali. I Sagara A Dicko A Djimde O Guindo M Kone Y Tolo MA Thera M Sogoba M Fofana A Ouattara M Sissoko HF Jansen OK Doumbo, Am J Trop Med Hyg 2006 75 630 636 17038684
8. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. H Reyburn R Mbatia C Drakeley I Carneiro E Mwakasungula O Mwerinde K Saganda J Shao A Kitua R Olomi BM Greenwood CJ Whitty, BMJ 2004 329 1212 10.1136/bmj.38251.658229.55 15542534
9. Acute bacterial meningitis in infants and children. KS Kim, Lancet Infect Dis 2010 10 32 42 10.1016/S1473-3099(09)70306-8 20129147
10. Food and Agriculture Organization of the United Nations, 2010 http://www.fao.org
11. Entomological indices of Anopheles gambiae sensu lato at a rural community in south-west Nigeria. MA Noutcha CI Anumdu, J Vector Borne Dis 2009 46 43 51 19326707
12. World Health Organization, Guidelines for the treatment of malaria Geneva: WHO Press Second 2010
13. Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria. CT Happi GO Gbotosho A Sowunmi CO Falade DO Akinboye L Gerena DE Kyle W Milhous DF Wirth AM Oduola, Am J Trop Med Hyg 2004 70 20 26 14971693
14. Genotyping of Plasmodium falciparum isolates by the polymerase chain reaction and potential uses in epidemiological studies. S Viriyakosol N Siripoon C Petcharapirat P Petcharapirat W Jarra S Thaithong KN Brown G Snounou, Bull World Health Organ 1995 73 85 95 7704931
15. World Health Organization, Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria. WHO/HTM/RBM/2003.50 2003
16. Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial. TK Mutabingwa D Anthony A Heller R Hallett J Ahmed C Drakeley BM Greenwood CJ Whitty, Lancet 2005 365 1474 1480 10.1016/S0140-6736(05)66417-3 15850631
17. Randomized, multicentre assessment of the efficacy and safety of ASAQ - a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria. JL Ndiaye M Randrianarivelojosia I Sagara P Brasseur I Ndiaye B Faye L Randrianasolo A Ratsimbasoa D Forlemu VA Moor A Traore Y Dicko N Dara V Lameyre M Diallo A Djimde A Same-Ekobo O Gaye, Malar J 2009 8 125 10.1186/1475-2875-8-125 19505304
18. Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis. J Zwang P Olliaro H Barennes M Bonnet P Brasseur H Bukirwa S Cohuet U D'Alessandro A Djimde C Karema JP Guthmann S Hamour JL Ndiaye A Mårtensson C Rwagacondo I Sagara A Same-Ekobo SB Sirima I van den Broek A Yeka WR Taylor G Dorsey M Randrianarivelojosia, Malar J 2009 8 203 10.1186/1475-2875-8-203 19698172
19. Therapeutic efficacy and effects of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine on gametocyte carriage in children with uncomplicated Plasmodium falciparum malaria in southwestern Nigeria. A Sowunmi GO Gbotosho CT Happi AA Adedeji FA Fehintola OA Folarin E Tambo BA Fateye, Am J Trop Med Hyg 2007 77 235 241 17690392
20. Open randomized study of artesunate-amodiaquine vs. chloroquine- pyrimethamine-sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in Nigerian children. A Sowunmi FA Fehintola AA Adedeji GO Gbotosho E Tambo BA Fateye TC Happi AM Oduola, Trop Med Int Health 2005 10 1161 1170 10.1111/j.1365-3156.2005.01503.x 16262741
21. Pruritus and antimalarial drugs in Africans. A Sowunmi O Walker LA Salako, Lancet 1989 2 213 10.1016/S0140-6736(89)90391-7 2568535
22. Molecular epidemiology and activity of erythrocyte G6PD variants in a homogeneous Nigerian population. OG Ademowo AG Falusi, East Afr Med J 2002 79 42 44 12380870