Single-day, three-dose treatment with fixed dose combination artesunate/sulfamethoxypyrazine/pyrimethamine to cure Plasmodium falciparum malaria

International Journal of Infectious Diseases

Volumn 12, Issue 4, 2008, Pages 430-437

  Penali, Louis Koné ^a   Jansen, Frans Herwig ^b  

^a INSTITUT PASTEUR DE CÔTE D'IVOIRE   (Côte d’Ivoire)

^b Dafra Pharma International   (Belgium)

Author keywords

24 hour therapy; Artesunate; Malaria; Plasmodium falciparum; Pyrimethamine; Sulfamethoxypyrazine

Indexed keywords

ARTESUNATE; PYRIMETHAMINE; SULFALENE;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; COTE D'IVOIRE; DOSAGE SCHEDULE COMPARISON; DRUG EFFICACY; DRUG MIXTURE; DRUG SAFETY; FEMALE; FEVER; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; OPEN STUDY; PARASITEMIA; PATIENT COMPLIANCE; PLASMODIUM FALCIPARUM; RANDOMIZED CONTROLLED TRIAL; REPEATED DRUG DOSE; SCHOOL CHILD; SINGLE DRUG DOSE; STATISTICAL ANALYSIS;

ANTIMALARIALS; ARTEMISININS; CHILD; COTE D'IVOIRE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALARIA, FALCIPARUM; MALE; PYRIMETHAMINE; SUCCINATES; SULFALENE;

EID: 44649130667     PISSN: 12019712     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijid.2007.12.006     Document Type: Article

References (16)

1. Woodrow C.J., Haynes R.K., and Krishna S. Artemisinins. Postgrad Med J 81 (2005) 71-78
2. Hastings I.M., and Ward S.A. Coartem (artemether-lumifantrine) in Africa: the beginning of the end. J Infect Dis 192 (2005) 1303-1304
3. Sagara I., Dicko A., Diallo A., Coulibaly M., Djimde A., Kone M., et al. Randomized clinical trial of artesunate-sulfamethoxypyrazine-pyrimethamine versus artemether-lumifantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Mali. Am J Trop Med Hyg 75 (2006) 630-636
4. Penali L.K., Jansen F.H., Offianan R., Beugre E.W., and Ahikpah N. Clinical trial comparing the efficacy and tolerability of two ACTs: sulfamethoxypyrazine/pyrimethamine/artesunate (Co-Arinate) versus artemether/lumefantrine (Co-Artem) for treating uncomplicated falciparum malaria in Ivory Coast. Acta Trop 95 (2005) 408
5. Adam I., Magzoub M., Osman M.E., Khalil I.F., Alifrangis M., and Elmardi K.A. A fixed-dose 24-hour regimen of artesunate plus sulfamethoxypyrazine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in eastern Sudan. Ann Clin Microbiol Antimicrob 5 (2006) 18
6. World Health Organization. Surveillance de la résistance aux antipaludiques. WHO/CDS/CSR/EPH/2002.17 and WHO/CDS/RBM/2002.39. Geneva: World Health Organization; 2002.
7. World Health Organization. Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria. WHO/HTM/RBM/2003.50. Geneva: World Health Organization; 2003.
8. SAS version 9.1.3 SP3, SAS Institute Inc., Cary, North Carolina, USA.
9. StatXact-3, version 3.0.1, Cytel Inc., Cambridge, MA, USA.
10. SPSS version 15.0, SPSS Claritas Inc., Chicago, USA.
11. Ashley E.A., Krudsood S., Phaiphun L., Srivilairit S., McGready R., Leowattana W., et al. Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand. J Infect Dis 190 (2004) 1773-1782
12. Silachamroon U., Krudsood S., Thanachartwet W., Tangpukdee N., Leowattana W., Chalermrut K., et al. An open, randomized trial of three-day treatment with artesunate combined with a standard dose of mefloquine divided over either two or three days, for acute, uncomplicated falciparum malaria. Southeast Asian J Trop Med Public Health 36 (2005) 591-596
13. Adjuik M., Agnamey P., Babiker A., Borrmann S., Brasseur P., Cisse M., et al. Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial. Lancet 359 (2002) 1365-1372
14. Alloueche A., Bailey W., Barton S., Bwika J., Chimpeni P., Falade C.O., et al. Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial. Lancet 363 (2004) 1843-1848
15. Medicines for Malaria Venture. New antimalarial drug enters phase II safety and efficacy trial in Asia and Africa; 2005. Available at: http://www.mmv.org/IMG/doc/Press_ReleasePANDA_Phase_II_FINALAW.doc (accessed January 2008).
16. Rulisa S., Gatarayiha J.P., Kabarisa T., and Ndayisaba G. Comparison of different artemisinin-based combinations for the treatment of P. falciparum malaria in children in high SP resistant Kigali, Rwanda: artesunate+sulfadoxine/pyrimethamine versus artesunate+sulfamethoxypyrazine/pyrimethamine. Am J Trop Med Hyg 77 (2007) 612-616