Effect of ischemic postconditioning on activation of p38 mitogen activated protein kinase and cardiocyte apoptosis in rats

Acta Academiae Medicinae Sinicae

Volumn 32, Issue 5, 2010, Pages 526-532

  Zhang, Guo Ming ^a,b   Su, Shao Ping ^a   Wang, Yu ^a   Li, Tian De ^a   Li, Xiao Yan ^b   Hong, Tan ^b   Zhang, Da Wei ^a   Zhang, Hui ^a   Liu, Li Feng ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b JINAN MILITARY GENERAL HOSPITAL   (China)

Author keywords

Acute myocardial infarction; P38 mitogen activated protein kinase; Postconditioning; Reperfusion injury

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; CASPASE 8; CREATINE KINASE; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HEART INFARCTION; HEART MUSCLE CELL; HEMODYNAMIC MONITORING; ISCHEMIC POSTCONDITIONING; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; ISCHEMIC POSTCONDITIONING; MALE; MITOCHONDRIA; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 78650645584     PISSN: 1000503X     EISSN: None     Source Type: Journal    
DOI: 10.3881/j.issn.1000-503X.2010.05.012     Document Type: Article

References (18)

1. Braunwald E, Kloner RA. The stunned myocardium : prolonged, postischemic ventricular dysfunction [J]. Circulation, 1982, 66 (6): 1146-1149. (Pubitemid 13238825)
2. Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning [J]. Am J Physiol Heart Circ Physiol, 2003, 285(2): H579-H588.
3. Tsang A, Hausenloy DJ, Mocanu MM, et al. Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway [J]. Circ Res, 2004, 95 (3): 230-232.
4. Yang XM, Proctor JB, Cui L, et al. Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways [J]. J Am Coll Cardiol, 2004, 44 (5): 1103-1110. (Pubitemid 39165147)
5. Penna C, Mancardi D, Raimondo S, et al. The paradigm of postconditioning to protect the heart [J]. J Cell Mol Med, 2008, 12 (2): 435-458.
6. Kaiser RA, Bueno OF, Lips DJ, et al. Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo [J]. J Biol Chem, 2004, 279 (15): 15524-15530.
7. Zarubin T, Han J. Activation and signaling of the p38 MAP kinase pathway [J]. Cell Res, 2005, 15 (1): 11-18. (Pubitemid 41653958)
8. Liu XH, Zhang ZY, Sun S, et al. Ischemic postconditioning protects myocardium from ischemia/reperfusion injury through attenuating endoplasmic reticulum stress [J]. Shock, 2008, 30 (4): 422-427.
9. Sun HY, Wang NP, Halkos M, et al. Postconditioning attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways [J]. Apoptosis, 2006, 11 (9): 1583-1593. (Pubitemid 44253675)
10. Li Y, Ge X, Liu X. The cardioprotective effect of postconditioning is mediated by ARC through inhibiting mitochondrial apoptotic pathway [J]. Apoptosis, 2009, 14 (2): 164172.
11. Kunapuli S, Rosanio S, Schwarz ER. "How do cardiomyocytes die?" apoptosis and autophagic cell death in cardiac myocytes [J]. J Card Fail, 2006, 12 (5): 381-391. (Pubitemid 43817581)
12. Ballard-Croft C, White DJ, Maass DL, et al. Role of p38 mitogen-activated protein kinase in cardiac myocyte secretion of the inflammatory cytokine TNF-alpha [J]. Am J Physiol Heart Circ Physiol, 2001, 280 (5): H1970-H1981. (Pubitemid 32433773)
13. Wang C, Neff DA, Krolikowski JG, et al. The influence of B-cell lymphoma 2 protein, an antiapoptotic regulator of mitochondrial permeability transition, on isoflurane-induced and ischemic postconditioning in rabbits [J]. Anesth Analg, 2006, 102 (5): 1355-1360.
14. Degli Esposti M, Dive C. Mitochondrial membrane permeabilisation by Bax/Bak [J]. Biochem Biophys Res Commun, 2003, 304 (3): 455-461.
15. Kuwana T, Newmeyer DD. Bcl-2-family proteins and the role of mitochondria in apoptosis [J]. Curr Opin Cell Biol, 2003, 15 (6): 691-699. (Pubitemid 37487962)