Differences in specificity of heparin-dependent antibodies developed in heparin-induced thrombocytopenia and consequences on cross-reactivity with danaparoid sodium

British Journal of Haematology

Volumn 99, Issue 2, 1997, Pages 273-280

  Pouplard, Claire ^a   Amiral, Jean ^b   Borg, Jeanne Yvonne ^c   Vissac, Anne Marie ^b   Delahousse, Bénédicte ^a   Gruel, Yves ^a  

^a SERVICE DE DERMATOLOGIE   (France)

^b Laboratoire Serbia   (France)

^c HÔPITAL CHARLES NICOLLE   (France)

Author keywords

Danaparoid sodium; Heparin dependent antibodies; Heparin induced thrombocytopenia; Heparin PF4 antibodies; Orgaran

Indexed keywords

DALTEPARIN; DANAPAROID; ENOXAPARIN; HEPARIN; HEPARIN DERIVATIVE; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN; THROMBOCYTE FACTOR 4;

ADULT; AGED; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; CROSS REACTION; DEEP VEIN THROMBOSIS; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTOPENIA;

EID: 0030703541     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.4183225.x     Document Type: Article

References (27)

1. Amiral, J., Bridey, F., Dreyfus, M., Vissac, A., Fressinaud, E., Wolf, M. & Meyer, D. (1992) Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thrombosis and Haemostasis, 68, 95-96.
2. Amiral, J., Bridey, F., Wolf, M., Boyer-Neumann, C., Fressinaud, E., Vissac, A., Peynaud-Dehayle, E., Dreyfus, M. & Meyer, D. (1995) Antibodies to macromolecular platelet factor 4-heparin complexes in heparin-induced thrombocytopenia: a study of 44 cases. Thrombosis and Haemostasis. 73, 21-28.
3. Amiral, J., Marfaing-Koka, A., Wolf, M., Alessi, M.C., Tardy, B., Boyer-Neumann, C., Vissac, A.M., Fressinaud, E., Poncz, M. & Meyer, D. (1996a) Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia. Blood, 88, 410-416.
4. Amiral, J., Peynaud-Debayle, E., Wolf, M., Bridey, F., Vissac, A.M. & Meyer, D. (1996b) Generation of antibodies to heparin-PF4 complexes without thrombocytopenia in patients treated with unfractionated or low-molecular-weight heparin. American Journal of Hematology, 52, 90-95.
5. Amiral, J., Wolf. M., Fischer, A.M., Boyer-Neumann, C. Vissac, A.M. & Meyer, D. (1996c) Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin-induced thrombocytopenia. British Journal of Haematology, 92, 954-959.
6. Arnout, J. (1996) The pathogenesis of the antiphospholipid syndrome: a hypothesis based on parallelisms with heparin-induced thrombocytopenia. Thrombosis and Haemostasia, 75, 536-541.
7. Bendtzen, K., Hansen, M., Ross, C., Poulsen, L. & Svenson, M. (1995) Cytokines and autoantibodies to eytokines. Cells, 13, 206.
8. Chong, B. (1995) Heparin-induced thrombocytopenia. British Journal of Haematology, 89, 431-439.
9. Chong, B., Grace, C. & Rozenberg, M. (1981) Heparin-induced thrombocytopenia: effect of heparin platelet antibody on platelets. British Journal of Haematology, 49, 531-540.
10. Elalamy, I., Potevin, F., Lecrubier, C., Bara, L., Marie, J. & Samama, M. (1996) A fatal low-molecular-weight heparin-associated thrombocytopenia after hip surgery, possible usefulness of PF4-heparin ELISA test. Blood Coagulation and Fibrinolysis, 7, 665-671.
11. Greinacher, A., Amiral, J., Dummel, V., Vissac, A., Kiefel, V. & Mueller-Eckhardt, C. (1994a) Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet platelet factor 4/heparin enzyme-linked immunosorbent assay. Transfusion, 34, 381-385.
12. Greinacher, A., Michels, I. & Mueller-Eckhardt, C. (1992) Heparin-associated thrombocytopenia: the antibody is not heparin specific. Thrombosis and Haemostasis, 67, 545-549.
13. Greinacher, A., Potzsch, B., Amiral, J., Dummel, V, Eichner, A. & Mueller-Eckhardt, C. (1994b) Heparin-associated thrombocytopenia: isolation of the antibody and characterization of a multimolecular PF4-heparin complex as the major antigen. Thrombosis and Haemostasis, 71, 247-251.
14. Gruel, Y., Rupin, A., Watier, H., Vigier, S., Bardos, P. & Leroy, J. (1992) Anticardiolipin antibodies in heparin-associated thrombocytopenia. Thrombosis Research, 67, 601-606.
15. Horsewood, P., Warkentin, T.E., Hayward, C.P.M. & Kelton, J.G. (1996) The epitope specificity of heparin-induced thrombocytopenia. British Journal of Haematology, 95, 161-167.
16. Kelton, J., Smith, J., Warkentin, T., Hayward, C., Denomme, G. & Horsewood, P. (1994) Immunoglobulin G from patients with heparin-induced thrombocytopenia binds to a complex of heparin and platelet factor 4. Blood, 83, 3232-3239.
17. Lasne, D., Saffroy, R., Bachelot, C., Vincenot, A., Rendu, F., Papo, T., Aiach, M. & Piette, J. (1997) Tests for heparin-induced thrombocytopenia in primary antiphospholipid syndrome. Britisft Journal of Haematology, 97, 939.
18. Lecompte, T., Stieltjes, N., Shao-Kai, L., Morel, M., Kaplan, C. & Meyer-Samama, M. (1995) Heparin and streptokinase-dependent platelet activating immunoglobulin G: mechanism and diagnosis. Seminars in Thrombosis and Hemostasis, 21, 95-105.
19. Leroy, J., Leclerc, M., Delahousse, B., Guerois, C., Foloppe, P., Gruel, Y. & Toulemonde, F. (1985) Treatment of heparin-associated thrombocytopenia and thrombosis with low molecular weight heparin (CY 216). Seminars in Thrombosis and Hemostasis, 11, 326-329.
20. Magnani, H.N. (1993) Heparin-induced thrombocytopenia (HIT): an overview of 250 patients treated with Orgaran (Org-10172). Thrombosis and Haemostasis, 70, 554-561.
21. Peters, F.P.J., Doevendans, P.A.F.M., Erdkamp, F.L.G., Vanderent, E.W.C. & Deheer, F. (1996) Low molecular weight heparin-induced thrombocytopenia and thrombosis. European Journal of Haematology, 56, 329-330.
22. Roubey, R., Eisenberg, R., Harper, M. & Winfield, J. (1995) Anticardiolipin' autoantibibodies recognize b2-Glycoprotein I in the absence of phospholipid: importance of Ag density and bivalent binding. Journal of Immunology, 154, 954-960.
23. Sheridan, D., Carter, C. & Kelton, J. (1986) A diagnostic test for heparin-induced thrombocytopenia. Blood, 67, 27-30.
24. Visentin, G., Ford, S., Scott, J. & Aster, R. (1994) Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. Journal of Clinical Investigation, 93, 81-88.
25. Vun, C.M., Evans, S. & Chong, B.H. (1996) Cross-reactivity study of low molecular weight heparins and heparinoid in heparin-induced thrombocytopenia. Thrombosis Research, 81, 525-532.
26. Warkentin.,T. & Kelton, J. (1994) Interaction of heparin with platelets, including heparin-induced thrombocytopenia. Low-molecular-weight Heparins in Prophylaxis and Therapy of Thromboembolic Diseases (ed. by H. Bounameaux), pp. 75-127. Marcel Dekker, New York.
27. Warkentin, T.E. & Kelton, J.G. (1996) A 14-year study of heparin-induced thrombocytopenia. American Journal of Medicine, 101, 502-507.