Uncoupling protein 2 and 3 gene polymorphisms and their association with type 2 diabetes in Asian Indians

Diabetes Technology and Therapeutics

Volumn 13, Issue 1, 2011, Pages 19-25

  Vimaleswaran, Karani S ^a,b   Radha, Venkatesan ^a   Ghosh, Saurabh ^c   Majumder, Partha P ^c   Sathyanarayana Rao, Manchanahalli R ^d,e   Mohan, Viswanathan ^a  

^a MADRAS DIABETES RESEARCH FOUNDATION   (India)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c INDIAN STATISTICAL INSTITUTE   (India)

^d JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

^e INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ALANINE; CYTOSINE; GLUCOSE; GUANOSINE; THYMINE; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; VALINE;

ARTICLE; ASIAN; CASE CONTROL STUDY; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HAPLOTYPE; HUMAN; INDIAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; POPULATION RESEARCH; POSTPRANDIAL STATE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; RISK REDUCTION; SEQUENCE ANALYSIS;

ADULT; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; DNA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; GLUCOSE TOLERANCE TEST; HAPLOTYPES; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INDIA; ION CHANNELS; MALE; MIDDLE AGED; MITOCHONDRIAL PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; REGRESSION ANALYSIS;

EID: 78650604639     PISSN: 15209156     EISSN: None     Source Type: Journal    
DOI: 10.1089/dia.2010.0091     Document Type: Article

References (37)

1. King H, Aubert RE, Herman WH: Global burden of diabetes, 1995-2025-prevalence, numerical estimates and projections. Diabetes Care 1998;21:1414-1431.
2. Chandalia M, Abate N, Garg A, Stray-Gundersen J, Grundy SM: Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men. J Clin Endocrinol Metab 1999;84:2329-2335.
3. Ramachandran A, Snehalatha C, Viswanathan V, Viswanathan M, Haffner SM: Risk of noninsulin dependent diabetes mellitus conferred by obesity and central adiposity in different ethnic groups: A comparative analysis between Asian Indians, Mexican Americans and Whites. Diabetes Res Clin Pract 1997;36:121-125.
4. McKeigue PM, Pierpoint T, Ferrie JE, Marmot MG: Relationship of glucose intolerance and hyperinsulinaemia to body fat pattern in south Asians and Europeans. Diabetologia 1992;35:785-791.
5. Mckeigue PM, Miller GJ, Marmot MG: Coronary artery disease in South Asian Overseas: A review. J Clin Epidemiol 1989;41:597-598.
6. Diehl AM, Hoek JB: Mitochondrial uncoupling: Role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing control.'' J Bioenerg Biomembr 1999;31:493-506.
7. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH: Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia. Nat Genet 1997;15: 269-272.
8. Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo A, Seydoux J, Muzzin P, Giacobino JP: Uncoupling protein-3: A new member of the mitochondrial carrier family with tissuespecific expression. FEBS Lett 1997;408:39-42.
9. Boss O, Hagen T, Lowell BB: Uncoupling proteins 2 and 3: Potential regulators of mitochondrial energy metabolism. Diabetes 2000;49:143-156.
10. Hanson RL, Ehm MG, Pettitt DJ, Prochazka M, Thompson DB, Timberlake D, Foroud T, Kobes S, Baier L, Burns DK, Almasy L, Blangero J, Garvey WT, Bennett PH, Knowler WC: An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. Am J Hum Genet 1998;63:1130-1138. (Pubitemid 30418584)
11. Norman RA, Thompson DB, Foroud T, Garvey WT, Bennett PH, Bogardus C, Ravussin E: Genomewide search for genes influencing percent body fat in Pima Indians: Suggestive linkage at chromosome 11q21-q22. Pima Diabetes Gene Group. Am J Hum Genet 1997;60:166-173.
12. Bouchard C, Perusse L, Chagnon YC, Warden C, Ricquier D: Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Hum Mol Genet 1997;6:1887-1889.
13. Wang H, Chu WS, Lu T, Hasstedt SJ, Kern PA, Elbein SC: Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. Am J Physiol Endocrinol Metab 2004;286:1-7.
14. Walder K, Norman RA, Hanson RL, Schrauwen P, Neverova M, Jenkinson CP, Easlick J, Warden CH, Pecqueur C, Raimbault S, Ricquier D, Silver MH, Shuldiner AR, Solanes G, Lowell BB, Chung WK, Leibel RL, Pratley R, Ravussin E: Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima Indians. Hum Mol Genet 1998;7:1431-1435.
15. Hsu YH, Niu T, Song Y, Tinker L, Kuller LH, Liu S: Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the Women's Health Initiative Observational Study. Diabetes 2008;57:1101-1107.
16. Matsunaga T, Gu N, Yamazaki H, Tsuda M, Adachi T, Yasuda K, Moritani T, Tsuda K, Nonaka M, Nishiyama T: Association of UCP2 and UCP3 polymorphisms with heart rate variability in Japanese men. J Hypertens 2009;27:305-313.
17. Deepa M, Pradeepa R, Rema M, Mohan A, Deepa R, Shanthirani S, Mohan V: The Chennai Urban Rural Epidemiology Study (CURES)-study design and methodology (urban component) (CURES-1). J Assoc Physicians India 2003; 51:863-870.
18. McLachlan GJ, Krishnan T: The EM Algorithm and Extensions: Wiley Series in Probability and Statistics. New York: John Wiley and Sons, 1997.
19. Majumdar P, Majumder PP: HAPLOPOP: A Computer Program Package to Estimate Haplotype Frequencies from Genotype Frequencies via the EM Algorithm. AHGU Technical Report. Kolkata, India: Indian Statistical Institute, 1999.
20. Schneider S, Kueffer J-M, Roessli D, Excoffier L: ARLEQUIN: A Software for Population Genetic Data Analysis. Geneva: University of Geneva, 2000.
21. Xiu LL, Weng JP, Sui Y, Wang J, Yan JH, Huang ZM: Common variants in beta 3-adrenergic-receptor and uncoupling protein-2 genes are associated with type 2 diabetes and obesity [in Chinese]. Zhonghua Yi Xue Za Zhi 2004;84: 375-379.
22. Levine AJ, Elkhouly E, Diep AT, Lee ER, Frankl H, Haile RW: The MnSOD A16V mitochondrial targeting sequence polymorphism is not associated with increased risk of distal colorectal adenomas: Data from a sigmoidoscopy-based case control study. Cancer Epidemiol Biomarkers Prev 2002;11: 1140-1141.
23. Anuradha S, Radha V, Deepa R, Hansen T, Carstensen B, Pedersen O, Mohan V: A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of type 2 diabetes in Asian Indians. Diabetes Care 2005;28:2430-2435.
24. Meirhaeghe A, Amouyel P, Helbecque N, Cottel D, Otabe S, Froguel P, Vasseur F: An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort. Diabetologia 2000;43:1424-1428.
25. Dalgaard LT, Sorensen TI, Andersen T, Hansen T, Pedersen O: An untranslated insertion variant in the uncoupling protein 2 gene is not related to body mass index and changes in body weight during a 26-year follow-up in Danish Caucasian men. Diabetologia 1999;42:1413-1416.
26. Krook A, Digby J, O'Rahilly S, Zierath JR, Wallberg- Henriksson H: Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients. Diabetes 1998;47:1528-1531. (Pubitemid 28396961)
27. Vidal H, Langin D, Andreelli F, Millet L, Larrouy D, Laville M: Lack of skeletal muscle uncoupling protein 2 and 3 mRNA induction during fasting in type-2 diabetic subjects. Am J Physiol 1999;277:830-837.
28. Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Komeda K, Satoh S, Nakano R, Ishii C, Sugiyama T, Eto K, Tsubamoto Y, Okuno A, Murakami K, Sekihara H, Hasegawa G, Naito M, Toyoshima Y, Tanaka S, Shiota K, Kitamura T, Fujita T, Ezaki O, Aizawa S, Nagai R, Tobe K, Kimura S, Kadowaki T: PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 1999;4:597-609.
29. Barroso I, Gurnell M, Crowley VE, Agostini M, Schwabe JW, Soos MA, Maslen GL, Williams TD, Lewis H, Schafer AJ, Chatterjee VK, O'Rahilly S: Dominant negative mutations in human PPAR-gamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 1999;402: 880-883.
30. Krempler F, Esterbauer H, Weitgasser R, Ebenbichler C, Patsch JR, Miller K, Xie M, Linnemayr V, Oberkofler H, Patsch W: A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans. Diabetes 2002;51:3331-3335.
31. D'Adamo M, Perego L, Cardellini M, Marini MA, Frontoni S, Andreozzi F, Sciacqua A, Lauro D, Sbraccia P, Federici M, Paganelli M, Pontiroli AE, Lauro R, Perticone F, Folli F, Sesti G: The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes. Diabetes 2004; 53:1905-1910.
32. Kovacs P, Ma L, Hanson RL, Franks P, Stumvoll M, Bogardus C, Baier LJ: Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians. Diabetologia 2005;48:2292-2295.
33. Hale PJ, Wright JV, Nattrass M: Differences in insulin sensitivity between normal men and women. Metabolism 1985;34:1133-1138.
34. Yki-Jarvinen H: Sex and insulin sensitivity. Metabolism 1984;33:1011-1015.
35. Esterbauer H, Schneitler C, Oberkofler H, Ebenbichler C, Paulweber B, Sandhofer F, Ladurner G, Hell E, Strosberg AD, Patsch JR, Krempler F, Patsch W: A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet 2001;28:178-183.
36. Basu A, Mukherjee N, Roy S, Banerjee S, Chakraborty M, Dey B, Roy M, Roy B, Bhattacharyya NP, Roychoudhury S, Majumder PP: Ethnic India: A genomic view, with special reference to peopling and structure. Genome Res 2003;13:2277-2290.
37. Devlin B, Roeder K, Wasserman L: Genomic control, a new approach to genetic-based association studies. Theor Popul Biol 2001;60:155-166.