Immunocompetence may be important in the effectiveness of Mectizan® (ivermectin) in the treatment of human onchocerciasis

Acta Tropica

Volumn 84, Issue 1, 2002, Pages 49-53

  Ali, Magdi M M ^a,b   Mukhtar, Moawia M ^c   Baraka, Omer Z ^c   Homeida, Mamoun M A ^d   Kheir, Musa M ^c   Mackenzie, Charles D ^b,e  

^a TROPICAL MEDICINE RESEARCH INSTITUTE   (Sudan)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c UNIVERSITY OF KHARTOUM   (Sudan)

^d Academy of Medical Sciences and Technology Sudan   (Sudan)

^e WESTERN MICHIGAN UNIVERSITY   (United States)

Author keywords

Immune responsiveness; Ivermectin; Mectizan ; Onchocerciasis; Pruritus

Indexed keywords

IVERMECTIN;

IVERMECTIN; ONCHOCERCIASIS; PARASITE CONTROL;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DERMIS; DRUG EFFICACY; DRUG RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENCE; MICROFILARIA; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PRURITUS; RECURRENT DISEASE;

ANIMALS; ANTIGENS, HELMINTH; ANTINEMATODAL AGENTS; COHORT STUDIES; FILARICIDES; HUMANS; IMMUNOCOMPETENCE; IVERMECTIN; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MICROFILARIA; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PRURITUS; RECURRENCE; SUDAN; TREATMENT OUTCOME;

NEMATODA; ONCHOCERCA; ONCHOCERCA VOLVULUS;

EID: 0036801051     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0001-706X(02)00117-1     Document Type: Article

References (7)

1. Awadzi K., Dadzie K.Y., Klager S., Gilles H.M. The chemotherapy of onchocerciasis XIII. Studies of ivermectin in onchocerciasis patients in northern Ghana, a region with long lasting vector control. Trop. Med. Parasitol. 40:1989;361-366.
2. Brieger W.R., Awedoba A.K., Eneanya C.I., Hagan M., Ogbuagu K.F., Okello D.O., Ososanya O.O., Ovuga E.B., Noma M., Kale O.O., Burnham G.M., Remme J.H. The effects of ivermectin on onchocercal skin disease and sever itching: results of a multicenter trial. Trop. Med. Int. Health. 3:1998;951-961.
3. Brown K.R., Neu D.C. Ivermectin-clinical trials and treatment schedules in onchocerciasis. Acta Leiden. 59:1990;169-175.
4. Boussinessq M., Gardon J. La resistance de Onchocerca volulus a l'ivermectin: une eventualitte a considerer. Ann. L'Inst. Pasteur. 10:1999;81-91.
5. Ette E.L., Thomas W.O., Achumba J.I. Ivermectin: a long acting microfilaricidal agent DCIP. Ann. Pharmacother. 24:1990;426-433.
6. Grant W. What is the real target for ivermectin resistance selection in Onchocerca volvulus. Parasitol. Today. 16:2000;458-459.
7. Richards F., Hopkins D., Cupp E. Programmatic goals and approaches to onchocerciasis. Lancet. 355:2000;1663-1664.