Effects of exercise training on vasodilatory protein expression and activity in rats

European Journal of Applied Physiology

Volumn 110, Issue 5, 2010, Pages 1019-1027

  McAllister, Richard M ^a,b   Price, Elmer M ^b,c  

^a KANSAS STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

Akt; Endothelial nitric oxide synthase; Heat shock protein 90; Phosphorylated endothelial nitric oxide synthase; Protein kinase B

Indexed keywords

CITRATE SYNTHASE; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEAT SHOCK PROTEIN 90; NITRIC OXIDE; NOS3 PROTEIN, RAT; PROTEIN KINASE B;

ANIMAL; ANIMAL EXPERIMENT; AORTA; ARTICLE; ENZYMOLOGY; MALE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RAT; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT; VASODILATATION;

ANIMALS; AORTA; CITRATE (SI)-SYNTHASE; CYCLIC GMP; HSP90 HEAT-SHOCK PROTEINS; MALE; MUSCLE, SKELETAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PHYSICAL CONDITIONING, ANIMAL; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION;

EID: 78650520560     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-010-1584-6     Document Type: Article

References (35)

1. JK Bendall NJ Alp N Warrick S Cai D Adlam K Rockett M Yokoyama S Kawashima KM Channon 2005 Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo Circ Res 97 864 871 1:CAS:528:DC%2BD2MXhtFCitr%2FF 10.1161/01.RES. 0000187447.03525.72 16179591 (Pubitemid 41552671)
2. JC Boo H Jo 2003 Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases Am J Physiol Cell Physiol 285 C499 C508 1:CAS:528:DC%2BD3sXnsVGmsL8%3D 12900384
3. PA Bush NE Gonzalez JM Griscavage LJ Ignarro 1992 Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from l-arginine Biochem Biophys Res Commun 185 960 966 1:CAS:528:DyaK38Xks1Gnsrk%3D 10.1016/0006-291X(92)91720-B 1378272
4. P Clarkson HE Montgomery MJ Mullen AE Donald AJ Powe T Bull M Jubb M World JE Deanfield 1999 Exercise training enhances endothelial function in young men JACC 33 1379 1385 1:STN:280:DyaK1M3gvVSrtw%3D%3D 10193742
5. ME Davis H Cai L McCann T Fukai DG Harrison 2003 Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training Am J Physiol Heart Circ Physiol 284 H1449 H1453 1:CAS:528: DC%2BD3sXjtlyksrY%3D 12595302
6. MD Delp MH Laughlin 1997 Time course of enhanced endothelium-mediated dilation of aorta of trained rats Med Sci Sports Exerc 29 1454 1461 1:CAS:528:DyaK2sXns1OqtL0%3D 9372482
7. MD Delp RM McAllister MH Laughlin 1993 Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta J Appl Physiol 75 1354 1363 1:CAS:528:DyaK2cXhsF2rur0%3D 8226551
8. J Fontana D Fulton Y Chen TA Fairchil TJ McCabe N Fujita T Tsuruo WC Sessa 2002 Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release Circ Res 90 866 873 1:CAS:528: DC%2BD38XjslWntbY%3D 10.1161/01.RES.0000016837.26733.BE 11988487 (Pubitemid 34633878)
9. T Fukai MR Siegfried M Ushio-Fukai Y Cheng G Kojda D Harrison 2000 Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training J Clin Invest 105 1631 1639 1:CAS:528:DC%2BD3cXjvFWmt7o%3D 10.1172/JCI9551 10841522
10. D Fulton J-P Gratton WC Sessa 2001 Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough? J Pharmacol Exp Ther 299 818 824 1:CAS:528:DC%2BD3MXovVCksbg%3D 11714864
11. G Garcia-Cardena R Fan V Shah R Sorrentino G Cirino A Papapetropoulos WC Sessa 1998 Dynamic activation of endothelial nitric oxide synthase by Hsp90 Nature 392 821 824 1:CAS:528:DyaK1cXivF2nt7k%3D 10.1038/33934 9580552 (Pubitemid 28225323)
12. DM Greif R Kou T Michel 2002 Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites Biochemistry 41 15845 15853 1:CAS:528:DC%2BD38XptFOhtL8%3D 10.1021/bi026732g 12501214 (Pubitemid 36062490)
13. R Hambrecht V Adams S Erbs A Linke N Krankel Y Shu Y Baither S Gielen H Thiele JF Gummert FW Mohr G Schuler 2003 Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase Circulation 107 3152 3158 1:CAS:528:DC%2BD3sXkslKgtrk%3D 10.1161/01.CIR.0000074229.93804.5C 12810615 (Pubitemid 36793084)
14. MB Harris BM Mitchell SG Sood RC Webb RC Venema 2008 Increased nitric oxide synthase activity and Hsp90 association in skeletal muscle following chronic exercise Eur J Appl Physiol 104 795 802 1:CAS:528:DC%2BD1cXhsVWltbbO 10.1007/s00421-008-0833-4 18784937
15. WL Haskell C Sims J Myll WM Bortz FG St. Goar EL Alderman 1993 Coronary artery size and dilating capacity in ultradistance runners Circulation 87 1076 1082 1:STN:280:DyaK3s3hsFSntA%3D%3D 8462135
16. OJ Kemi PM Haram U Wisloff O Ellingsen 2004 Aerobic fitness is associated with cardiomyocyte contractile capacity and endothelial function in exercise training and detraining Circulation 109 2897 2904 10.1161/01.CIR.0000129308. 04757.72 15173028 (Pubitemid 38780305)
17. G Kojda YC Cheng J Burchfield DG Harrison 2001 Dysfunctional regulation of endothelial nitric oxide synthase (eNOS) expression in response to exercise in mice lacking one eNOS gene Circulation 103 2839 2844 1:CAS:528: DC%2BD3MXltlyitrk%3D 11401942
18. A Koller A Huang D Sun G Kaley 1995 Exercise training augments flow-dependent dilation in rat skeletal muscle arterioles: role of endothelial nitric oxide and prostaglandins Circ Res 76 544 550 1:CAS:528:DyaK2MXksFOgsrw%3D 7534658
19. JM Lash HG Bohlen 1997 Time-and order-dependent changes in functional and NO-mediated dilation during exercise training J Appl Physiol 82 460 468 1:STN:280:DyaK2s3gt1Wqug%3D%3D 9049725
20. Laughlin MH, Korthuis RJ, Duncker DJ, Bache RJ (1996) Control of blood flow to cardiac and skeletal muscle during exercise. In: Rowell LB, Shepherd JT (eds) Handbook of physiology. Exercise: regulation and integration of multiple systems. Control of respiratory and cardiovascular systems. American Physiological Society, Bethesda, pp 705-769
21. RM McAllister MH Laughlin 1997 Short-term exercise training alters responses of porcine femoral and brachial arteries J Appl Physiol 82 1438 1444 1:CAS:528:DyaK2sXjsV2nt7w%3D 10.1063/1.365921 9134890
22. RM McAllister I Albarracin EM Price TK Smith JR Turk KD Wyatt 2005 Thyroid status and nitric oxide in rat arterial vessels Endocrinology 185 111 119 1:CAS:528:DC%2BD2MXjslGgsL8%3D 10.1677/joe.1.06022 (Pubitemid 40585072)
23. RM McAllister JL Jasperse MH Laughlin 2005 Nonuniform effects of endurance exercise training on vasodilation in rat skeletal muscle J Appl Physiol 98 753 761 1:STN:280:DC%2BD2M%2FitlKntw%3D%3D 10.1152/japplphysiol. 01263.2003 15448126 (Pubitemid 40129992)
24. RM McAllister SC Newcomer ER Pope JR Turk MH Laughlin 2008 Effects of chronic nitric oxide synthase inhibition on responses to acute exercise in swine J Appl Physiol 104 186 197 1:CAS:528:DC%2BD1cXhslOis70%3D 10.1152/japplphysiol. 00731.2007 17975123
25. GK McConnell SJ Bradley TJ Stephens BJ Canny BA Kingwell RS Lee-Young 2007 Skeletal muscle nNOSμ protein content is increased by exercise training in humans Am J Physiol Regul Integr Comp Physiol 293 R821 R828
26. TI Musch GC Haidet GA Ordway JC Longhurst JH Mitchel 1987 Training effects on the regional blood flow response to maximal exercise in foxhounds J Appl Physiol 62 1724 1732 1:STN:280:DyaL2s3ltVWhtw%3D%3D 3597244
27. WC Sessa K Pritchard N Seyedi J Wang TH Hintze 1994 Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression Circ Res 74 349 353 1:CAS:528: DyaK2cXhvVyjurw%3D 7507417
28. SA Spier MD Delp CD Meininger AJ Donato MW Ramsey JM Muller-Delp 2004 Effects of aging and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles J Physiol 556 947 958 1:CAS:528:DC%2BD2cXktFCju7k%3D 10.1113/jphysiol.2003.060301 15004211 (Pubitemid 38660325)
29. PA Srere 1969 Citrate synthase Methods Enzymol 13 3 5 1:CAS:528:DyaE3cXks1aktrk%3D 10.1016/0076-6879(69)13005-0
30. Steel RGD, Torrie JH (1980) Principles and procedures of statistics. McGraw-Hill, New York
31. D Sun A Huang A Koller G Kaley 1994 Short-term daily exercise activity enhances endothelial NO synthesis in skeletal muscle arterioles of rats J Appl Physiol 76 2241 2247 1:CAS:528:DyaK2cXmtVWltr4%3D 7520432
32. D Sun A Huang A Koller G Kaley 1998 Adaptation of flow-induced dilation of arterioles to daily exercise Microvasc Res 56 54 61 1:STN:280: DyaK1czltVWktg%3D%3D 10.1006/mvre.1998.2083 9683563 (Pubitemid 28367122)
33. D Sun A Huang A Koller G Kaley 2002 Enhanced NO-mediated dilations in skeletal muscle arterioles of chronically exercised rats Microvasc Res 64 491 496 1:CAS:528:DC%2BD38XoslSntb8%3D 10.1006/mvre.2002.2450 12453444 (Pubitemid 35370751)
34. S Takahashi ME Mendelsohn 2003 Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt J Biol Chem 278 30821 30827 1:CAS:528:DC%2BD3sXmtFeqsbg%3D 10.1074/jbc.M304471200 12799359 (Pubitemid 36994590)
35. S Takahashi ME Mendelsohn 2003 Calmodulin-dependent and-independent activation of endothelial nitric-oxide synthase by heat shock protein 90 J Biol Chem 278 9339 9344 1:CAS:528:DC%2BD3sXhvV2jtbw%3D 10.1074/jbc.M212651200 12519764 (Pubitemid 36800420)