SCOPUS 정보 검색 플랫폼

European Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2011, Pages 58-64

Self-organizing molecular field analysis on human β-secretase nonpeptide inhibitors: 5, 5-disubstituted aminohydantoins

(5) Li, Zhi a Zhou, Meng a Wu, Feng a Li, Rui a,b Ding, Zhenyu a

a SICHUAN UNIVERSITY (China)

b SHANGHAI INSTITUTE OF MATERIA MEDICA (China)

Author keywords

3D QSAR; Aminohydantoins; Autodock4; BACE 1; SOMFA

Indexed keywords

AMINOHYDANTOIN DERIVATIVE; BETA SECRETASE 1; BETA SECRETASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; IC 50; MOLECULAR DOCKING; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SELF ORGANIZING MOLECULAR FIELD ANALYSIS; SUBSTITUTION REACTION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDANTOINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650515865 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2010.10.014 Document Type: Article

Times cited : (18)

References (28)

1
- 24944550164
- L.A. Thompson, J.J. Bronson, and F.C. Zusi Curr. Pharm. Des. 11 2005 3383 3404
- (2005) Curr. Pharm. Des. , vol.11 , pp. 3383-3404
- Thompson, L.A.¹ Bronson, J.J.² Zusi, F.C.³

2
- 0021256895
- G.G. Glenner, and C.W. Wong Biochem. Biophys. Res. Commun. 120 1984 885 890
- (1984) Biochem. Biophys. Res. Commun. , vol.120 , pp. 885-890
- Glenner, G.G.¹ Wong, C.W.²

3
- 0002792366
- M. Goedert, C.M. Wischik, R.A. Crowther, J.E. Walker, and A. Klug Proc. Natl. Acd. Sci. U S A 85 1988 4051 4055
- (1988) Proc. Natl. Acd. Sci. U S A , vol.85 , pp. 4051-4055
- Goedert, M.¹ Wischik, C.M.² Crowther, R.A.³ Walker, J.E.⁴ Klug, A.⁵

4
- 20844450922
- J. Tang, X. He, X. Huang, and L. Hong Curr. Alzheimer Res. 2 2005 261 264
- (2005) Curr. Alzheimer Res. , vol.2 , pp. 261-264
- Tang, J.¹ He, X.² Huang, X.³ Hong, L.⁴

5
- 0035116273
- Y. Luo, B. Bolon, S. Kahn, B.D. Bennett, S. Babu-Khan, P. Denis, W. Fan, H. Kha, J. Zhang, Y. Gong, L. Martin, J.C. Louis, Q. Yan, W.G. Richards, M. Citron, and R. Vassar Nat. Neurosci. 4 2001 231 232
- (2001) Nat. Neurosci. , vol.4 , pp. 231-232
- Luo, Y.¹ Bolon, B.² Kahn, S.³ Bennett, B.D.⁴ Babu-Khan, S.⁵ Denis, P.⁶ Fan, W.⁷ Kha, H.⁸ Zhang, J.⁹ Gong, Y.¹⁰ Martin, L.¹¹ Louis, J.C.¹² Yan, Q.¹³ Richards, W.G.¹⁴ Citron, M.¹⁵ Vassar, R.¹⁶

6
- 0034652309
- X. Lin, G. Koelsch, S. Wu, D. Downs, A. Dashti, and J. Tang Proc. Natl. Acad. Sci. U S A 97 2000 1456 1460
- (2000) Proc. Natl. Acad. Sci. U S A , vol.97 , pp. 1456-1460
- Lin, X.¹ Koelsch, G.² Wu, S.³ Downs, D.⁴ Dashti, A.⁵ Tang, J.⁶

7
- 67651047153
- W.H. Huang, R. Sheng, and Y.Z. Hu Curr. Med. Chem. 16 2009 1806 1820
- (2009) Curr. Med. Chem. , vol.16 , pp. 1806-1820
- Huang, W.H.¹ Sheng, R.² Hu, Y.Z.³

8
- 62249167406
- R. Silvestri Med. Res. Rev. 29 2009 295 338
- (2009) Med. Res. Rev. , vol.29 , pp. 295-338
- Silvestri, R.¹

9
- 9744221865
- C.A. Coburn, S.J. Stachel, Y.M. Li, D.M. Rush, T.G. Steele, D.E. Chen, M.K. Holloway, M. Xu, Q. Huang, M.T. Lai, J. DiMuzio, M.C. Crouthamel, X.P. Shi, V. Sardana, Z. Chen, S. Munshi, L. Kuo, G.M. Makara, D.A. Annis, P.K. Tadikonda, H.M. Nash, J.P. Vacca, and T. Wang J. Med. Chem. 47 2004 6117 6119
- (2004) J. Med. Chem. , vol.47 , pp. 6117-6119
- Coburn, C.A.¹ Stachel, S.J.² Li, Y.M.³ Rush, D.M.⁴ Steele, T.G.⁵ Chen, D.E.⁶ Holloway, M.K.⁷ Xu, M.⁸ Huang, Q.⁹ Lai, M.T.¹⁰ Dimuzio, J.¹¹ Crouthamel, M.C.¹² Shi, X.P.¹³ Sardana, V.¹⁴ Chen, Z.¹⁵ Munshi, S.¹⁶ Kuo, L.¹⁷ Makara, G.M.¹⁸ Annis, D.A.¹⁹ Tadikonda, P.K.²⁰ more..

10
- 77249128954
- M.S. Malamas, J. Erdei, W.G. Wan, J. Turner, Y. Hu, E. Wagner, K. Fan, R. Chopra, A. Olland, J. Bard, S. Jacobsen, R.L. Magolda, M. Pangalos, and A.J. Robichaud J. Med. Chem. 53 2010 1146 1158
- (2010) J. Med. Chem. , vol.53 , pp. 1146-1158
- Malamas, M.S.¹ Erdei, J.² Wan, W.G.³ Turner, J.⁴ Hu, Y.⁵ Wagner, E.⁶ Fan, K.⁷ Chopra, R.⁸ Olland, A.⁹ Bard, J.¹⁰ Jacobsen, S.¹¹ Magolda, R.L.¹² Pangalos, M.¹³ Robichaud, A.J.¹⁴

11
- 76449094443
- M.S. Malamas, K. Barnes, M. Johnson, Y. Hui, P. Zhou, J. Turner, Y. Hu, E. Wagner, K. Fan, R. Chopra, A. Olland, J. Bard, and M. Pangalos Bioorg. Med. Chem. 18 2010 630 639
- (2010) Bioorg. Med. Chem. , vol.18 , pp. 630-639
- Malamas, M.S.¹ Barnes, K.² Johnson, M.³ Hui, Y.⁴ Zhou, P.⁵ Turner, J.⁶ Hu, Y.⁷ Wagner, E.⁸ Fan, K.⁹ Chopra, R.¹⁰ Olland, A.¹¹ Bard, J.¹² Pangalos, M.¹³

12
- 77949492453
- P. Zhou, Y. Li, Y. Fan, Z. Wang, R. Chopra, A. Olland, Y. Hu, R.L. Magolda, M. Pangalos, P.H. Reinhart, M.J. Turner, J. Bard, M.S. Malamas, and A.J. Robichaud Bioorg. Med. Chem. Lett. 20 2010 2326 2329
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 2326-2329
- Zhou, P.¹ Li, Y.² Fan, Y.³ Wang, Z.⁴ Chopra, R.⁵ Olland, A.⁶ Hu, Y.⁷ Magolda, R.L.⁸ Pangalos, M.⁹ Reinhart, P.H.¹⁰ Turner, M.J.¹¹ Bard, J.¹² Malamas, M.S.¹³ Robichaud, A.J.¹⁴

13
- 70350050829
- M.S. Malamas, J. Erdei, I. Gunawan, K. Barnes, M. Johnson, Y. Hui, E. Wagner, K. Fan, A. Olland, J. Bard, and A.J. Robichaud J. Med. Chem. 52 2009 6314 6323
- (2009) J. Med. Chem. , vol.52 , pp. 6314-6323
- Malamas, M.S.¹ Erdei, J.² Gunawan, I.³ Barnes, K.⁴ Johnson, M.⁵ Hui, Y.⁶ Wagner, E.⁷ Fan, K.⁸ Olland, A.⁹ Bard, J.¹⁰ Robichaud, A.J.¹¹

14
- 77955732976
- WO 2008118379 A2 20081002
- M.S. Malamas, A.J. Robichaud, A.M. Porte, K.M. Morris, W.R. Solvibile, J. Kim, WO 2008118379 A2 20081002, PCT Int. Appl. (2008).
- (2008) PCT Int. Appl.
- Malamas, M.S.¹ Robichaud, A.J.² Porte, A.M.³ Morris, K.M.⁴ Solvibile, W.R.⁵ Kim, J.⁶

15
- 78651233376
- WO 2009015369 A2 20090129
- A.K. Ghosh, C.F Liu, T. Devasamudram, H. Lei, L.M. Swanson, S.V. Ankala, J.C. Lilly, G.M. Bilcer, WO 2009015369 A2 20090129, PCT Int. Appl. (2009).
- (2009) PCT Int. Appl.
- Ghosh, A.K.¹ Liu, C.F.² Devasamudram, T.³ Lei, H.⁴ Swanson, L.M.⁵ Ankala, S.V.⁶ Lilly, J.C.⁷ Bilcer, G.M.⁸

16
- 78651233376
- WO 2005097767 A1 20051020
- A.C. Cralg, S.E. Amy, J.S. Shawn, B.O. David, J.H. Darla, M.K. Holloway, WO 2005097767 A1 20051020, PCT Int. Appl. (2005).
- (2005) PCT Int. Appl.
- Cralg, A.C.¹ Amy, S.E.² Shawn, J.S.³ David, B.O.⁴ Darla, J.H.⁵ Holloway, M.K.⁶

17
- 78650511199
- M. S. Malamas,; W. F. Fobare, W.R.S. JR, F.E. Lovering, J.S. Condon, A.J. Robichaud, US20060173049 (2006)
- M. S. Malamas,; W. F. Fobare, W.R.S. JR, F.E. Lovering, J.S. Condon, A.J. Robichaud, US20060173049 (2006).

18
- 84883048647
- WO 2006017844 A1 20060216
- B. Ellen, B. Robert, C.J. Alfonzo, R. Allen, H.R. Charies, S. Malcolm, S. Mark, D. Winter, H.L. Jos, WO 2006017844 A1 20060216, PCT Int. Appl. (2006).
- (2006) PCT Int. Appl.
- Ellen, B.¹ Robert, B.² Alfonzo, C.J.³ Allen, R.⁴ Charies, H.R.⁵ Malcolm, S.⁶ Mark, S.⁷ Winter, D.⁸ Jos, H.L.⁹

19
- 33750132225
- D.C. Cole, E.S. Manas, J.R. Stock, J.S. Condon, L.D. Jennings, A. Aulabaugh, R. Chopra, R. Cowling, J.W. Ellingboe, K.Y. Fan, B.L. Harrison, Y. Hu, S. Jacobsen, G. Jin, L. Lin, F.E. Lovering, M.S. Malamas, M.L. Stahl, J. Strand, M.N. Sukhdeo, E. Wagner, J. Wu, P. Zhou, and J. Bard J. Med. Chem. 49 2006 6158 6161
- (2006) J. Med. Chem. , vol.49 , pp. 6158-6161
- Cole, D.C.¹ Manas, E.S.² Stock, J.R.³ Condon, J.S.⁴ Jennings, L.D.⁵ Aulabaugh, A.⁶ Chopra, R.⁷ Cowling, R.⁸ Ellingboe, J.W.⁹ Fan, K.Y.¹⁰ Harrison, B.L.¹¹ Hu, Y.¹² Jacobsen, S.¹³ Jin, G.¹⁴ Lin, L.¹⁵ Lovering, F.E.¹⁶ Malamas, M.S.¹⁷ Stahl, M.L.¹⁸ Strand, J.¹⁹ Sukhdeo, M.N.²⁰ more..

20
- 84994641964
- WO 02088101 A2 20021107
- R.B. Govinda, O.S. Jeffrey, A.M. Mark, A.L. Christopher, D.B. Shawn, H.C. Joe, D.D. David, WO 02088101 A2 20021107, PCT Int. Appl. (2002).
- (2002) PCT Int. Appl.
- Govinda, R.B.¹ Jeffrey, O.S.² Mark, A.M.³ Christopher, A.L.⁴ Shawn, D.B.⁵ Joe, H.C.⁶ David, D.D.⁷

21
- 0033602217
- D.D. Robinson, P.J. Winn, P.D. Lyne, and W.G. Richards J. Med. Chem. 42 1999 573 583
- (1999) J. Med. Chem. , vol.42 , pp. 573-583
- Robinson, D.D.¹ Winn, P.J.² Lyne, P.D.³ Richards, W.G.⁴

22
- 0023751431
- R.D. Cramer, D.E. Patteerson, and J.D. Bunce J. Am. Chem. Soc. 110 1988 5959 5967
- (1988) J. Am. Chem. Soc. , vol.110 , pp. 5959-5967
- Cramer, R.D.¹ Patteerson, D.E.² Bunce, J.D.³

23
- 0043092069
- M.Y. Li, L.P. Du, B. Wu, and L. Xia Bioorg. Med. Chem. 11 2003 3945 3951
- (2003) Bioorg. Med. Chem. , vol.11 , pp. 3945-3951
- Li, M.Y.¹ Du, L.P.² Wu, B.³ Xia, L.⁴

24
- 70449688315
- S. Thareja, S. Aggarwal, T.R. Bhardwaj, and M. Kumar Europ. J. Med. Chem. 44 2009 4920 4925
- (2009) Europ. J. Med. Chem. , vol.44 , pp. 4920-4925
- Thareja, S.¹ Aggarwal, S.² Bhardwaj, T.R.³ Kumar, M.⁴

25
- 77950516649
- S. Aggarwal, S. Thareja, T.R. Bhardwaj, and M. Kumar Steroids 75 2010 411 418
- (2010) Steroids , vol.75 , pp. 411-418
- Aggarwal, S.¹ Thareja, S.² Bhardwaj, T.R.³ Kumar, M.⁴

26
- 34547804899
- N. Sachan, S.S. Kadam, and V.M. Kulkarni J. Enzym. Inhib. Med. Chem. 22 2007 267 276
- (2007) J. Enzym. Inhib. Med. Chem. , vol.22 , pp. 267-276
- Sachan, N.¹ Kadam, S.S.² Kulkarni, V.M.³

27
- 70349932423
- G.M. Morris, R. Huey, W. Lindstrom, M.F. Sanner, R.K. Belew, D.S. Goodsell, and A.J. Olson J. Comput. Chem. 30 2009 2785 2791
- (2009) J. Comput. Chem. , vol.30 , pp. 2785-2791
- Morris, G.M.¹ Huey, R.² Lindstrom, W.³ Sanner, M.F.⁴ Belew, R.K.⁵ Goodsell, D.S.⁶ Olson, A.J.⁷

28
- 0011473607
- Colorado Springs CO, USA
- J.P.S. James Stewart Computational Chemistry 2008 Colorado Springs CO, USA http://OpenMOPAC.net
- (2008) Stewart Computational Chemistry
- James, J.P.S.¹

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.