Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 602-605

  Pizzi, Domenica A ^a   Leslie, Colin P ^a   Fabio, Romano Di ^a   Seri, Catia ^a   Bernasconi, Giovanni ^a   Squaglia, Michela ^a   Carnevale, Gennaro ^a   Falchi, Alessandro ^a   Greco, Elisabetta ^a   Mangiarini, Laura ^a   Negri, Michele ^a  

^a GSK   (Italy)

Author keywords

GABA transporter inhibitor; GAT 1

Indexed keywords

1 (4,4 DIPHENYL 3 BUTENYL)GUVACINE; 1 (4,4 DIPHENYL 3 BUTENYL)NIPECOTIC ACID; 4 AMINOBUTYRIC ACID CARRIER; 4 AMINOBUTYRIC ACID CARRIER 1; GUVACINE; NIPECOTIC ACID DERIVATIVE; TIAGABINE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; DRUG SYNTHESIS; HUMAN; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GABA UPTAKE INHIBITORS; NIPECOTIC ACIDS; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650513009     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.025     Document Type: Article

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