Spinal cord involvement in multiple sclerosis: A correlative MRI and high-resolution HLA-DRB1 genotyping study

Journal of the Neurological Sciences

Volumn 300, Issue 1-2, 2011, Pages 114-119

  Qiu, Wei ^a,b,c   Raven, Sonja ^d   James, Ian ^e   Luo, Yuebei ^b,c   Wu, Jingshan ^b,c   Castley, Alison ^e   Christiansen, Frank T ^b,e   Carroll, William M ^b,c   Mastaglia, Frank L ^b,c   Kermode, Allan G ^b,c  

^a THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^d Neurointerventional and Imaging Services of Western Australia   (Australia)

^e ROYAL PERTH HOSPITAL   (Australia)

Author keywords

Diplotypes; HLA DRB1 alleles; MRI; Multiple sclerosis; Spinal cord lesions

Indexed keywords

HLA DR ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; CORRELATION COEFFICIENT; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ACTIVITY; FEMALE; GENE FREQUENCY; GENOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SCHOOL CHILD; SPINAL CORD DISEASE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; FEMALE; GENOTYPE; HLA-DR ANTIGENS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; SPINAL CORD;

EID: 78650511136     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2010.09.006     Document Type: Article

References (44)

1. D. Kidd, J.W. Thorpe, A.J. Thompson, B.E. Kendall, I.F. Moseley, and D.G. MacManus Spinal cord MRI using multi-array coils and fast spin echo. II. findings in multiple sclerosis Neurology 43 12 1993 2632 2637 (Pubitemid 24004558)
2. J.C. Bot, F. Barkhof, G. Lycklama a Nijeholt, D. van Schaardenburg, A.E. Voskuyl, and H.J. Ader Differentiation of multiple sclerosis from other inflammatory disorders and cerebrovascular disease: value of spinal MR imaging Radiology 223 1 2002 46 56 (Pubitemid 34258189)
3. L.S. Honig, and W.A. Sheremata Magnetic resonance imaging of spinal cord lesions in multiple sclerosis J Neurol Neurosurg Psychiatry 52 4 1989 459 466 (Pubitemid 19104502)
4. G.J. Lycklama a Nijeholt, F. Barkhof, P. Scheltens, J.A. Castelijns, H. Ader, and J.H. van Waesberghe MR of the spinal cord in multiple sclerosis: relation to clinical subtype and disability AJNR Am J Neuroradiol 18 6 1997 1041 1048 (Pubitemid 30416940)
5. G.J. Nijeholt, M.A. van Walderveen, J.A. Castelijns, J.H. van Waesberghe, C. Polman, and P. Scheltens Brain and spinal cord abnormalities in multiple sclerosis. Correlation between MRI parameters, clinical subtypes and symptoms Brain 121 Pt 4 1998 687 697 (Pubitemid 28162129)
6. J.C. Bot, F. Barkhof, and C.H. Polman Spinal cord abnormalities in recently diagnosed MS patients: added value of spinal MRI examination Neurology 62 2004 226 233 (Pubitemid 38167129)
7. L.M. Tartaglino, D.P. Friedman, A.E. Flanders, F.D. Lublin, R.L. Knobler, and M. Liem Multiple sclerosis in the spinal cord: MR appearance and correlation with clinical parameters Radiology 195 3 1995 725 732
8. J.W. Thorpe, D.G. MacManus, B.E. Kendall, P.S. Tofts, G.J. Barker, and W.I. McDonald Short tau inversion recovery fast spin-echo (fast STIR) imaging of the spinal cord in multiple sclerosis Magn Reson Imaging 12 7 1994 983 989
9. K. Hittmair, R. Mallek, D. Prayer, E.G. Schindler, and H. Kollegger Spinal cord lesions in patients with multiple sclerosis: comparison of MR pulse sequences AJNR Am J Neuroradiol 17 8 1996 1555 1565 (Pubitemid 26336823)
10. M.A. Rocca, G. Mastronardo, M.A. Horsfield, C. Pereira, G. Iannucci, and B. Colombo Comparison of three MR sequences for the detection of cervical cord lesions in patients with multiple sclerosis AJNR Am J Neuroradiol 20 9 1999 1710 1716 (Pubitemid 29498627)
11. S.V. Ramagopalan, and G.C. Ebers Genes for multiple sclerosis Lancet 371 9609 2008 283 285
12. J.S. Wu, I. James, W. Qiu, A. Castley, F.T. Christiansen, and W.M. Carroll HLA-DRB1 allele heterogeneity influences multiple sclerosis severity as well as risk in Western Australia J Neuroimmunol 219 1-2 2010 109 113
13. J.S. Wu, W. Qiu, J. Castley, I. James, J. Joseph, and W. Carroll Frequency of HLA-DRB1 alleles and disease-modifying effects in a large West Australian multiple sclerosis cohort J Neurol 256 2009 S158
14. M.H. Sombekke, C. Lukas, J.B. Crusius, D. Tejedor, J. Killestein, and D. Arteta HLA-DRB1*1501 and spinal cord magnetic resonance imaging lesions in multiple sclerosis Arch Neurol 66 12 2009 1531 1536
15. J.S. Wu, M.N. Zhang, W.M. Carroll, and A.G. Kermode Characterisation of the spectrum of demyelinating disease in Western Australia J Neurol Neurosurg Psychiatry 79 9 2008 1022 1026
16. C.H. Polman, S.C. Reingold, G. Edan, M. Filippi, H.P. Hartung, and L. Kappos Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria" Ann Neurol 58 6 2005 840 846 (Pubitemid 41746873)
17. W. Qiu, J.S. Wu, A. Castley, I. James, J. Joseph, and F.T. Christiansen Clinical profile and HLA-DRB1 genotype of late onset multiple sclerosis in Western Australia J Clin Neurosci 17 8 2010 1009 1013
18. D. Sayer, R. Whidborne, B. Brestovac, F. Trimboli, C. Witt, and F. Christiansen HLA-DRB1 DNA sequencing based typing: an approach suitable for high throughput typing including unrelated bone marrow registry donors Tissue Antigens 57 1 2001 46 54 (Pubitemid 32151075)
19. Q. Wei, C. Bundell, J.S. Wu, A. Castley, I. James, and P. Hollingsworth Low level of systemic autoimmunity in Western Australian multiple sclerosis patients Mult Scler 16 3 2010 351 354
20. Q. Wei, J.S. Wu, M.N. Zhang, T. Matsushita, J.I. Kira, and W.M. Carroll Longitudinally extensive myelopathy in Caucasians: a West Australian study of 26 cases from the Perth Demyelinating Diseases Database J Neurol Neurosurg Psychiatry 81 2 2010 209 212
21. T. Fog The topography of plaques in multiple sclerosis with special reference to cerebral plaques Acta Neurol Scand Suppl 15 1965 1 161
22. D.R. Oppenheimer The cervical cord in multiple sclerosis Neuropathol Appl Neurobiol 4 2 1978 151 162
23. T. Fog Topographic distribution of plaques in the spinal cord in multiple sclerosis Arch Neurol Psychiatry 63 1950 382 414
24. A.L. Horowitz, R.D. Kaplan, G. Grewe, R.T. White, and L.M. Salberg The ovoid lesion: a new MR observation in patients with multiple sclerosis AJNR Am J Neuroradiol 10 2 1989 303 305 (Pubitemid 19082619)
25. D. Kidd, F. Barkhof, R. McConnell, P.R. Algra, I.V. Allen, and T. Revesz Cortical lesions in multiple sclerosis Brain 122 Pt 1 1999 17 26 (Pubitemid 29046269)
26. Q. Wei, S. Raven, J.S. Wu, W.M. Carroll, F.L. Mastaglia, and A.G. Kermode Wedge-shaped medullary lesions in multiple sclerosis J Neurol Sci 290 1-2 2010 190 193
27. R.J. Butterfield, E.P. Blankenhorn, R.J. Roper, J.F. Zachary, R.W. Doerge, and C. Teuscher Identification of genetic loci controlling the characteristics and severity of brain and spinal cord lesions in experimental allergic encephalomyelitis Am J Pathol 157 2 2000 637 645 (Pubitemid 30626922)
28. R. Zivadinov, L. Uxa, T. Zacchi, D. Nasuelli, M. Ukmar, and C. Furlan HLA genotypes and disease severity assessed by magnetic resonance imaging findings in patients with multiple sclerosis J Neurol 250 9 2003 1099 1106 (Pubitemid 37152560)
29. R. Zivadinov, L. Uxa, A. Bratina, A. Bosco, B. Srinivasaraghavan, and A. Minagar HLA-DRB1*1501, -DQB1*0301, -DQB1*0302, -DQB1*0602, and -DQB1*0603 alleles are associated with more severe disease outcome on MRI in patients with multiple sclerosis Int Rev Neurobiol 79 2007 521 535
30. D.T. Okuda, R. Srinivasan, J.R. Oksenberg, D.S. Goodin, S.E. Baranzini, and A. Beheshtian Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures Brain 132 Pt 1 2009 250 259
31. A.E. Hensiek, S.J. Sawcer, R. Feakes, J. Deans, A. Mander, and E. Akesson HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis J Neurol Neurosurg Psychiatry 72 2 2002 184 187 (Pubitemid 34102150)
32. J.M. Stankiewicz, M. Neema, D.C. Alsop, B.C. Healy, A. Arora, and G.J. Buckle Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study J Neurol Sci 279 1-2 2009 99 105
33. G. Ganesvaran, J.M. Greer, and M.P. Pender Prominent brainstem and cerebellar involvement in multiple sclerosis with psoriasis Mult Scler 15 6 2009 763 766
34. J.S. Wu, I. James, Q. Wei, A. Castley, F.T. Christiansen, and W.M. Carroll Influence of HLA-DRB1 allele heterogeneity on disease risk and clinical course in a West Australian MS cohort: a high-resolution genotyping study Mult Scler 16 5 2010 526 532
35. C. Ballerini, F.R. Guerini, G. Rombola, E. Rosati, L. Massacesi, and P. Ferrante HLA-multiple sclerosis association in continental Italy and correlation with disease prevalence in Europe J Neuroimmunol 150 1-2 2004 178 185 (Pubitemid 38481662)
36. O. Fernandez, R-Antigüedad A, M.J. Pinto-Medel, M.M. Mendibe, N. Acosta, and B. Oliver HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain) J Neurol 256 12 2009 1977 1988
37. H.B. Rasmussen, M.A. Kelly, and J. Clausen Additive effect of the HLA-DR15 haplotype on susceptibility to multiple sclerosis Mult Scler 7 2 2001 91 93 (Pubitemid 32514522)
38. J.L. Trotter, C.L. Wegescheide, and W.F. Garvey Regional studies of myelin proteins in human brain and spinal cord Neurochem Res 9 1 1984 133 146 (Pubitemid 14172281)
39. M. Rovaris, M. Holtmannspotter, M.A. Rocca, G. Iannucci, M. Codella, and B. Viti Contribution of cervical cord MRI and brain magnetization transfer imaging to the assessment of individual patients with multiple sclerosis: a preliminary study Mult Scler 8 1 2002 52 58 (Pubitemid 34193028)
40. M. Rovaris, F. Agosta, E. Pagani, and M. Filippi Diffusion tensor MR imaging Neuroimaging Clin N Am 19 1 2009 37 43
41. B. Benedetti, M.A. Rocca, M. Rovaris, D. Caputo, M. Zaffaroni, and R. Capra A diffusion tensor MRI study of cervical cord damage in benign and secondary progressive multiple sclerosis patients J Neurol Neurosurg Psychiatry 81 1 2010 26 30
42. A. Charil, D. Caputo, R. Cavarretta, M.P. Sormani, P. Ferrante, and M. Filippi Cervical cord magnetization transfer ratio and clinical changes over 18 months in patients with relapsing-remitting multiple sclerosis: a preliminary study Mult Scler 12 5 2006 662 665 (Pubitemid 46940642)
43. P. Valsasina, F. Agosta, M. Absinta, S. Sala, D. Caputo, and M. Filippi Cervical cord functional MRI changes in relapse-onset MS patients J Neurol Neurosurg Psychiatry 81 4 2010 405 408
44. X. Lin, C.R. Tench, B. Turner, L.D. Blumhardt, and C.S. Constantinescu Spinal cord atrophy and disability in multiple sclerosis over four years: application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon beta-1a (Rebif) treatment trial J Neurol Neurosurg Psychiatry 74 8 2003 1090 1094 (Pubitemid 36936386)