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Volumn 16, Issue 6, 2010, Pages 635-642

Target inhibition in antiangiogenic therapy a wide spectrum of selectivity and specificity

Author keywords

on off target; selective; specific; Vascular endothelial growth factor

Indexed keywords

3 (4 BROMO 2,6 DIFLUOROBENZYLOXY) 5 [3 [4 (1 PYRROLIDINYL)BUTYL]UREIDO] 4 ISOTHIAZOLECARBOXAMIDE; 4 [BIS(2 CHLOROETHYL)OXIDOAMINO]PHENYLALANINE; AE 941; AFLIBERCEPT; ALACIZUMAB PEGOL; ANGIOGENESIS INHIBITOR; AXITINIB; BEVACIZUMAB; BRIVANIB; CILENGITIDE; DOCETAXEL; EZN 2968; IMC 18F1; MK 0752; MOTESANIB; OMBRABULIN; OMP 21M18; PAZOPANIB; RAMUCIRUMAB; SEMAXANIB; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VADIMEZAN; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VATALANIB;

EID: 78650506417     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0b013e3181ff37cf     Document Type: Review
Times cited : (16)

References (71)
  • 1
    • 58149190795 scopus 로고    scopus 로고
    • Pathways mediating resistance to vascular endo-thelial growth factor-targeted therapy
    • Ellis LM, Hicklin DJ. Pathways mediating resistance to vascular endo-thelial growth factor-targeted therapy. Clin Cancer Res. 2008;14: 6371-6375.
    • (2008) Clin Cancer Res. , vol.14 , pp. 6371-6375
    • Ellis, L.M.1    Hicklin, D.J.2
  • 2
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol. 2002;20:4368-4380.
    • (2002) J Clin Oncol , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 3
    • 0034655246 scopus 로고    scopus 로고
    • Suppression of tumor angio-genesis and growth by gene transfer of a soluble form of vascular endo-thelial growth factor receptor into a remote organ
    • Takayama K, Ueno H, Nakanishi Y, et al. Suppression of tumor angio-genesis and growth by gene transfer of a soluble form of vascular endo-thelial growth factor receptor into a remote organ. Cancer Res. 2000;60: 2169-2177.
    • (2000) Cancer Res. , vol.60 , pp. 2169-2177
    • Takayama, K.1    Ueno, H.2    Nakanishi, Y.3
  • 4
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irino-tecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irino-tecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350:2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 6
    • 77955255788 scopus 로고    scopus 로고
    • Molecular diversity of VEGF-A as a regulator of its biological activity
    • Woolard J, Bevan HS, Harper SJ, et al. Molecular diversity of VEGF-A as a regulator of its biological activity. Microcirculation. 2009;16: 572-592.
    • (2009) Microcirculation , vol.16 , pp. 572-592
    • Woolard, J.1    Bevan, H.S.2    Harper, S.J.3
  • 7
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • DOI 10.1210/er.2003-0027
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. 2004;25:581-611. (Pubitemid 39099316)
    • (2004) Endocrine Reviews , vol.25 , Issue.4 , pp. 581-611
    • Ferrara, N.1
  • 8
    • 0032482978 scopus 로고    scopus 로고
    • Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
    • Hiratsuka S, Minowa O, Kuno J, et al. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci USA. 1998;95:9349-9354.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9349-9354
    • Hiratsuka, S.1    Minowa, O.2    Kuno, J.3
  • 9
    • 23944486372 scopus 로고    scopus 로고
    • Effect of mechanical stretch on HIF-1 and MMP-2 expression in capillaries isolated from overloaded skeletal muscles: Laser capture microdissection study
    • Milkiewicz M, Haas TL. Effect of mechanical stretch on HIF-1 and MMP-2 expression in capillaries isolated from overloaded skeletal muscles: laser capture microdissection study. Am J Physiol Heart Circ Physiol. 2005;289:H1315YH1320.
    • (2005) Am J Physiol Heart Circ Physiol. , vol.289
    • Milkiewicz, M.1    Haas, T.L.2
  • 11
    • 30744432619 scopus 로고    scopus 로고
    • Endothelial cells and VEGF in vascular development
    • Coultas L, Chawengsaksophak K, Rossant J. Endothelial cells and VEGF in vascular development. Nature. 2005;438:937-945.
    • (2005) Nature. , vol.438 , pp. 937-945
    • Coultas, L.1    Chawengsaksophak, K.2    Rossant, J.3
  • 12
    • 33144483703 scopus 로고    scopus 로고
    • Vascular endo-thelial growth factor localization in the adult
    • Maharaj AS, Saint-Geniez M, Maldonado AE, et al. Vascular endo-thelial growth factor localization in the adult. Am J Pathol. 2006;168: 639-648.
    • (2006) Am J Pathol , vol.168 , pp. 639-648
    • Maharaj, A.S.1    Saint-Geniez, M.2    Maldonado, A.E.3
  • 13
    • 0027461981 scopus 로고
    • Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues
    • Monacci WT, Merrill MJ, Oldfield EH. Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues. Am J Physiol. 1993;264:C995-C1002.
    • (1993) Am J Physiol. , vol.264
    • Monacci, W.T.1    Merrill, M.J.2    Oldfield, E.H.3
  • 14
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong GH, Rossant J, Gertsenstein M, et al. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 1995;376:66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3
  • 15
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 1983;219:983-985.
    • (1983) Science. , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3
  • 16
    • 33845242529 scopus 로고    scopus 로고
    • Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways
    • Kilic Ü, Kilic E, Jarve A, et al. Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways. J Neurosci. 2006;26:12439-12446.
    • (2006) J Neurosci , vol.26 , pp. 12439-12446
    • Kilic, Ü.1    Kilic, E.2    Jarve, A.3
  • 17
    • 0030878259 scopus 로고    scopus 로고
    • Stretch-induced VEGF expression in the heart
    • Li J, Hampton T, Morgan JP, et al. Stretch-induced VEGF expression in the heart. J Clin Invest. 1997;100:18-24.
    • (1997) J Clin Invest. , vol.100 , pp. 18-24
    • Li, J.1    Hampton, T.2    Morgan, J.P.3
  • 18
    • 33745063095 scopus 로고    scopus 로고
    • The role of neuropilins in cancer
    • Ellis LM. The role of neuropilins in cancer. Mol Cancer Ther. 2006;5: 1099-1107.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1099-1107
    • Ellis, L.M.1
  • 19
    • 33845991161 scopus 로고    scopus 로고
    • Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
    • Pan Q, Chanthery Y, Liang WC, et al. Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell. 2007;11:53-67.
    • (2007) Cancer Cell. , vol.11 , pp. 53-67
    • Pan, Q.1    Chanthery, Y.2    Liang, W.C.3
  • 20
    • 57349108643 scopus 로고    scopus 로고
    • Distribution of VEGF and Flt-1 in the normal dog tissues
    • Uchida N, Nagai K, Sakurada Y, et al. Distribution of VEGF and Flt-1 in the normal dog tissues. J Vet Med Sci. 2008;70:1273-1276.
    • (2008) J Vet Med Sci , vol.70 , pp. 1273-1276
    • Uchida, N.1    Nagai, K.2    Sakurada, Y.3
  • 21
    • 33845811455 scopus 로고    scopus 로고
    • Preparing the Bsoil the premetastatic niche
    • Kaplan RN, Rafii S, Lyden D. Preparing the Bsoil[: the premetastatic niche. Cancer Res. 2006;66:11089-11093.
    • (2006) Cancer Res. , vol.66 , pp. 11089-11093
    • Kaplan, R.N.1    Rafii, S.2    Lyden, D.3
  • 22
    • 48249137667 scopus 로고    scopus 로고
    • Therapeutic potential of novel selective-spectrum kinase inhibitors in oncology
    • Lorusso PM, Eder JP. Therapeutic potential of novel selective-spectrum kinase inhibitors in oncology. Expert Opin Investig Drugs. 2008;17: 1013-1028
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1013-1028
    • Lorusso, P.M.1    Eder, J.P.2
  • 23
    • 33846783057 scopus 로고    scopus 로고
    • Combined targeted therapies in non-small cell lung cancer: A winner strategy?
    • Cascone T, Gridelli C, Ciardiello F. Combined targeted therapies in non-small cell lung cancer: a winner strategy? Curr Opin Oncol. 2007;19: 98-102.
    • (2007) Curr Opin Oncol. , vol.19 , pp. 98-102
    • Cascone, T.1    Gridelli, C.2    Ciardiello, F.3
  • 24
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatinYpaclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatinYpaclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361:947-957.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 25
    • 0036020617 scopus 로고    scopus 로고
    • Engineering antibodies for therapy
    • Presta LG. Engineering antibodies for therapy. Curr Pharm Biotechnol. 2002;3:237-256.
    • (2002) Curr Pharm Biotechnol. , vol.3 , pp. 237-256
    • Presta, L.G.1
  • 26
    • 33846834110 scopus 로고    scopus 로고
    • Bevacizumab, a humanized anti-angiogenic monoclonal antibody for the treatment of colorectal cancer
    • Krämer I, Lipp HP. Bevacizumab, a humanized anti-angiogenic monoclonal antibody for the treatment of colorectal cancer. J Clin Pharm Ther. 2007;32:1-14.
    • (2007) J Clin Pharm Ther , vol.32 , pp. 1-14
    • Krämer, I.1    Lipp, H.P.2
  • 27
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour activity
    • Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer. 2008;8:579-591.
    • (2008) Nat Rev Cancer. , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 28
    • 36049000572 scopus 로고    scopus 로고
    • Renal side effects of anti-VEGF therapy in man: A new test system
    • Ostendorf T, De Vriese AS, Floege J. Renal side effects of anti-VEGF therapy in man: a new test system. Nephrol Dial Transplant. 2007;22: 2778-2780.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 2778-2780
    • Ostendorf, T.1    De Vriese, A.S.2    Floege, J.3
  • 29
    • 34250374471 scopus 로고    scopus 로고
    • Role of the VEGFYa signaling pathway in the glomerulus: Evidence for crosstalk between components of the glomerular filtration barrier
    • Eremina V, Baelde HJ, Quaggin SE. Role of the VEGFYa signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier. Nephron Physiol. 2007;106: p32-p37.
    • (2007) Nephron Physiol. , vol.106
    • Eremina, V.1    Baelde, H.J.2    Quaggin, S.E.3
  • 30
    • 40849130173 scopus 로고    scopus 로고
    • VEGF inhibition and renal thrombotic microangiopathy
    • Eremina V, Jefferson JA, Kowalewska J, et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med. 2008;358:1129-1136.
    • (2008) N Engl J Med , vol.358 , pp. 1129-1136
    • Eremina, V.1    Jefferson, J.A.2    Kowalewska, J.3
  • 31
    • 48249090832 scopus 로고    scopus 로고
    • A novel human-specific soluble vascular endothelial growth factor receptor 1: Cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia
    • Sela S, Itin A, Natanson-Yaron S, et al. A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia. Circ Res. 2008;102:1566-1574.
    • (2008) Circ Res. , vol.102 , pp. 1566-1574
    • Sela, S.1    Itin, A.2    Natanson-Yaron, S.3
  • 32
    • 0034979275 scopus 로고    scopus 로고
    • Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor
    • Zachary I. Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor. Am J Physiol Cell Physiol. 2001; 280:C1375-C1386. (Pubitemid 32553192)
    • (2001) American Journal of Physiology - Cell Physiology , vol.280 , Issue.6
    • Zachary, I.1
  • 33
    • 33845490014 scopus 로고    scopus 로고
    • PaclitaxelYcarboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. PaclitaxelYcarboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 2006;355: 2542-2550.
    • (2006) N Engl J Med. , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 34
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007;25: 1539-1544.
    • (2007) J Clin Oncol , vol.25 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 35
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T, Butterfield CE, Kräling BM, et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res. 2000;60:1878-1886.
    • (2000) Cancer Res. , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kräling, B.M.3
  • 36
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005;307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 37
    • 0034615992 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase
    • Rousseau S, Houle F, Kotanides H, et al. Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase. J Biol Chem. 2000;275:10661-10672.
    • (2000) J Biol Chem. , vol.275 , pp. 10661-10672
    • Rousseau, S.1    Houle, F.2    Kotanides, H.3
  • 38
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted, metronomic, and maximum-tolerated dose Bchemo-switch[ regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • Pietras K, Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose Bchemo-switch[ regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol. 2005;23:939-952.
    • (2005) J Clin Oncol , vol.23 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 39
    • 0037098860 scopus 로고    scopus 로고
    • VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma
    • Bates DO, Cui TG, Doughty JM, et al. VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma. Cancer Res. 2002;62:4123-4131.
    • (2002) Cancer Res. , vol.62 , pp. 4123-4131
    • Bates, D.O.1    Cui, T.G.2    Doughty, J.M.3
  • 40
    • 7444240909 scopus 로고    scopus 로고
    • VEGF165b, an inhibitory vascular endothelial growth factor splice variant: Mechanism of action, in vivo effect on angiogenesis and endogenous protein expression
    • Woolard J, Wang WY, Bevan HS, et al. VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res. 2004;64:7822-7835.
    • (2004) Cancer Res , vol.64 , pp. 7822-7835
    • Woolard, J.1    Wang, W.Y.2    Bevan, H.S.3
  • 41
    • 33645802473 scopus 로고    scopus 로고
    • Therapeutic potential of inhibitory VEGF splice variants
    • Bates DO, Harper SJ. Therapeutic potential of inhibitory VEGF splice variants. Future Oncol. 2005;1:467-473.
    • (2005) Future Oncol. , vol.1 , pp. 467-473
    • Bates, D.O.1    Harper, S.J.2
  • 42
    • 56349136033 scopus 로고    scopus 로고
    • Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
    • Nowak DG, Woolard J, Amin EM, et al. Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors. J Cell Sci. 2008;121:3487-3495.
    • (2008) J Cell Sci , vol.121 , pp. 3487-3495
    • Nowak, D.G.1    Woolard, J.2    Amin, E.M.3
  • 43
    • 42149152015 scopus 로고    scopus 로고
    • VEGF#inf#165#/inf#banantiangiogenic VEGF-A isoform binds and inhibits bevacizumab treatment in experimental colo-rectal carcinoma: Balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy
    • Varey AH, Rennel ES, QiuY,etal. VEGF165b,anantiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colo-rectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy. Br J Cancer. 2008;98:1366-1379.
    • (2008) Br J Cancer. , vol.98 , pp. 1366-1379
    • Varey, A.H.1    Rennel, E.S.2    Qiu, Y.3
  • 44
    • 38049018155 scopus 로고    scopus 로고
    • A quantitative analysis of kinase inhibitor selectivity
    • Karaman MW, Herrgard S, Treiber DK, et al. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol. 2008;26:127-132.
    • (2008) Nat Biotechnol , vol.26 , pp. 127-132
    • Karaman, M.W.1    Herrgard, S.2    Treiber, D.K.3
  • 45
    • 34748914140 scopus 로고    scopus 로고
    • Macrocytosis due to treatment with sunitinib
    • author reply 1352
    • Billemont B, Izzedine H, Rixe O. Macrocytosis due to treatment with sunitinib. N Engl J Med. 2007;357:1351-1352; author reply 1352.
    • (2007) N Engl J Med. , vol.357 , pp. 1351-1352
    • Billemont, B.1    Izzedine, H.2    Rixe, O.3
  • 46
    • 35448934762 scopus 로고    scopus 로고
    • Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study
    • Rixe O, Bukowski RM, Michaelson MD, et al. Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study. Lancet Oncol. 2007;8:975-984.
    • (2007) Lancet Oncol , vol.8 , pp. 975-984
    • Rixe, O.1    Bukowski, R.M.2    Michaelson, M.D.3
  • 47
    • 20044375036 scopus 로고    scopus 로고
    • The VEGF receptor tyrosine kinase inhibitor, ZD6474, inhibits angiogenesis and affects microvascular architecture within an orthotopically implanted renal cell carcinoma
    • Drevs J, Konerding MA, Wolloscheck T, et al. The VEGF receptor tyrosine kinase inhibitor, ZD6474, inhibits angiogenesis and affects microvascular architecture within an orthotopically implanted renal cell carcinoma. Angiogenesis. 2004;7:347-354.
    • (2004) Angiogenesis. , vol.7 , pp. 347-354
    • Drevs, J.1    Konerding, M.A.2    Wolloscheck, T.3
  • 48
    • 0037386774 scopus 로고    scopus 로고
    • Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
    • Ciardiello F, Caputo R, Damiano V, et al. Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. Clin Cancer Res. 2003;9: 1546-1556.
    • (2003) Clin Cancer Res , vol.9 , pp. 1546-1556
    • Ciardiello, F.1    Caputo, R.2    Damiano, V.3
  • 49
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endo-thelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge SR, Ogilvie DJ, Dukes M, et al. ZD6474 inhibits vascular endo-thelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 2002;62:4645-4655.
    • (2002) Cancer Res. , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 50
    • 69349097838 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZODIAC)
    • Herbst RS, Sun Y, Korfee S, et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (NSCLC): a randomized, double-blind phase III trial (ZODIAC). J Clin Oncol (Meeting Abstracts). 2009;27: CRA8003.
    • (2009) J Clin Oncol (Meeting Abstracts) , vol.27
    • Herbst, R.S.1    Sun, Y.2    Korfee, S.3
  • 51
    • 27144531609 scopus 로고    scopus 로고
    • JaysonG.Technology evaluation: VEGF Trap (cancer), Regeneron/Sanofi- Aventis
    • Lau SC, Rosa DD, JaysonG.Technology evaluation: VEGF Trap (cancer), Regeneron/Sanofi-Aventis. Curr Opin Mol Ther. 2005;7:493-501.
    • (2005) Curr Opin Mol Ther. , vol.7 , pp. 493-501
    • Lau, S.C.1    Rosa, D.D.2
  • 52
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA. 2002;99: 11393-11398.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 54
    • 74949119167 scopus 로고    scopus 로고
    • Phase i study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors
    • Lockhart AC, Rothenberg ML, Dupont J, et al. Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors. J Clin Oncol. 2010;28:207-214.
    • (2010) J Clin Oncol , vol.28 , pp. 207-214
    • Lockhart, A.C.1    Rothenberg, M.L.2    Dupont, J.3
  • 56
    • 33746655373 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in the kidney
    • Haase VH. Hypoxia-inducible factors in the kidney. Am J Physiol Renal Physiol. 2006;291:F271YF281.
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Haase, V.H.1
  • 57
    • 30944437448 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible transcription factors in developing human and rat kidneys
    • Bernhardt WM, Schmitt R, Rosenberger C, et al. Expression of hypoxia-inducible transcription factors in developing human and rat kidneys. Kidney Int. 2006;69:114-122.
    • (2006) Kidney Int. , vol.69 , pp. 114-122
    • Bernhardt, W.M.1    Schmitt, R.2    Rosenberger, C.3
  • 58
    • 56249131779 scopus 로고    scopus 로고
    • A RNA antagonist of hypoxia-inducible factor-1>, EZN-2968, inhibits tumor cell growth
    • Greenberger LM, Horak ID, Filpula D, et al. A RNA antagonist of hypoxia-inducible factor-1>, EZN-2968, inhibits tumor cell growth. Mol Cancer Ther. 2008;7:3598-3608.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3598-3608
    • Greenberger, L.M.1    Horak, I.D.2    Filpula, D.3
  • 59
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: A simple pathway becomes complex
    • Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol. 2006;7:678-689.
    • (2006) Nat Rev Mol Cell Biol. , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 60
    • 41049085948 scopus 로고    scopus 로고
    • Regulation of angiogenesis by homotypic and heterotypic Notch signalling in endothelial cells and pericytes: From basic research to potential therapies
    • Sainson RC, Harris AL. Regulation of angiogenesis by homotypic and heterotypic Notch signalling in endothelial cells and pericytes: from basic research to potential therapies. Angiogenesis. 2008;11:41-51.
    • (2008) Angiogenesis , vol.11 , pp. 41-51
    • Sainson, R.C.1    Harris, A.L.2
  • 61
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    • Noguera-Troise I, Daly C, Papadopoulos NJ, et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature. 2006;444:1032-1037.
    • (2006) Nature. , vol.444 , pp. 1032-1037
    • Noguera-Troise, I.1    Daly, C.2    Papadopoulos, N.J.3
  • 62
    • 34347369749 scopus 로고    scopus 로고
    • Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia
    • Chan SM, Weng AP, Tibshirani R, et al. Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia. Blood. 2007;110:278-286.
    • (2007) Blood , vol.110 , pp. 278-286
    • Chan, S.M.1    Weng, A.P.2    Tibshirani, R.3
  • 63
    • 23844446044 scopus 로고    scopus 로고
    • Suppression of p53 by Notch in lymphomagenesis: Implications for initiation and regression
    • Beverly LJ, Felsher DW, Capobianco AJ. Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression. Cancer Res. 2005;65:7159-7168.
    • (2005) Cancer Res. , vol.65 , pp. 7159-7168
    • Beverly, L.J.1    Felsher, D.W.2    Capobianco, A.J.3
  • 64
    • 33846048039 scopus 로고    scopus 로고
    • Targeting the NF-JB signaling pathway in Notch1-induced T-cell leukemia
    • Vilimas T, Mascarenhas J, Palomero T, et al. Targeting the NF-JB signaling pathway in Notch1-induced T-cell leukemia. Nat Med. 2007;13:70-77.
    • (2007) Nat Med , vol.13 , pp. 70-77
    • Vilimas, T.1    Mascarenhas, J.2    Palomero, T.3
  • 65
    • 39149128230 scopus 로고    scopus 로고
    • Focal segmental glomerulosclerosis: Recent advances
    • Pollak MR. Focal segmental glomerulosclerosis: recent advances. Curr Opin Nephrol Hypertens. 2008;17:138-142.
    • (2008) Curr Opin Nephrol Hypertens. , vol.17 , pp. 138-142
    • Pollak, M.R.1
  • 66
    • 40449123492 scopus 로고    scopus 로고
    • Notch inhibition reverses kidney failure
    • Kretzler M, Allred L. Notch inhibition reverses kidney failure. Nat Med. 2008;14:246-247.
    • (2008) Nat Med , vol.14 , pp. 246-247
    • Kretzler, M.1    Allred, L.2
  • 67
    • 40449112321 scopus 로고    scopus 로고
    • The Notch pathway in po-docytes plays a role in the development of glomerular disease
    • Niranjan T, Bielesz B, Gruenwald A, et al. The Notch pathway in po-docytes plays a role in the development of glomerular disease. Nat Med. 2008;14:290-298.
    • (2008) Nat Med. , vol.14 , pp. 290-298
    • Niranjan, T.1    Bielesz, B.2    Gruenwald, A.3
  • 68
    • 33947312487 scopus 로고    scopus 로고
    • Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron
    • Cheng HT, Kim M,Valerius MT, etal. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development. 2007;134:801-811.
    • (2007) Development , vol.134 , pp. 801-811
    • Cheng, H.T.1    Kim, M.2    Valerius, M.T.3
  • 69
    • 34548571130 scopus 로고    scopus 로고
    • Phase i pharmacokinetic (PK), and pharmacodynamic (PD) trial of the novel oral Notch inhibitor MK-0752 in patients (pts) with advanced breast cancer (BC) and other solid tumors
    • Krop IE, Kosh M, Fearen I, et al. Phase I pharmacokinetic (PK), and pharmacodynamic (PD) trial of the novel oral Notch inhibitor MK-0752 in patients (pts) with advanced breast cancer (BC) and other solid tumors. J Clin Oncol (Meeting Abstracts). 2006;24: 10574.
    • (2006) J Clin Oncol (Meeting Abstracts). , vol.24 , pp. 10574
    • Krop, I.E.1    Kosh, M.2    Fearen, I.3
  • 70
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971;285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 71
    • 3042660212 scopus 로고    scopus 로고
    • Vascular zip codes in angiogenesis and metastasis
    • Ruoslahti E. Vascular zip codes in angiogenesis and metastasis. Biochem Soc Trans. 2004;32:397-402.
    • (2004) Biochem Soc Trans. , vol.32 , pp. 397-402
    • Ruoslahti, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.