-
1
-
-
50349094508
-
Aliskiren
-
Brown MJ. Aliskiren. Circulation 2008, 118: 773-84
-
(2008)
Circulation
, vol.118
, pp. 773-84
-
-
Brown, M.J.1
-
2
-
-
43049097195
-
Global burden of blood-pressure-related disease 2001
-
Lawes CM, Vander Hoorn S, Rodgers A. Global burden of blood-pressure-related disease, 2001. Lancet 2008;371:1513-18
-
(2008)
Lancet
, vol.371
, pp. 1513-18
-
-
Lawes, C.M.1
Vander Hoorn, S.2
Rodgers, A.3
-
4
-
-
14044271546
-
Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats
-
Wood JM, Schnell CR, Cumin F, et al. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. J Hypertens 2005;23:417-26
-
(2005)
J Hypertens
, vol.23
, pp. 417-26
-
-
Wood, J.M.1
Schnell, C.R.2
Cumin, F.3
-
5
-
-
0021855138
-
Stereochemical analysis of peptide bond hydrolysis catalyzed by the aspartic proteinase penicillopepsin
-
James MN, Sielecki AR. Stereochemical analysis of peptide bond hydrolysis catalyzed by the aspartic proteinase penicillopepsin. Biochemistry 1985;24:3701-13
-
(1985)
Biochemistry
, vol.24
, pp. 3701-13
-
-
James, M.N.1
Sielecki, A.R.2
-
6
-
-
33644789557
-
Renin inhibition with aliskiren: Where are we now, and where are we going?
-
Azizi M, Webb R, Nussberger J, et al. Renin inhibition with aliskiren: where are we now, and where are we going? J Hypertens 2006;24:243-56
-
(2006)
J Hypertens
, vol.24
, pp. 243-56
-
-
Azizi, M.1
Webb, R.2
Nussberger, J.3
-
7
-
-
56849092058
-
The renin angiotensin system in the development of cardiovascular disease: Role of aliskiren in risk reduction
-
Verdecchia P, Angeli F, Mazzotta G, et al. The renin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction. Vasc Health Risk Manag 2008;4:971-81
-
(2008)
Vasc Health Risk Manag
, vol.4
, pp. 971-81
-
-
Verdecchia, P.1
Angeli, F.2
Mazzotta, G.3
-
8
-
-
21844440280
-
Prediction of myocardial infarction by N-terminal-pro-B-type natriuretic peptide C-reactive protein, and renin in subjects with cerebrovascular disease
-
Campbell DJ, Woodward M, Chalmers JP, et al. Prediction of myocardial infarction by N-terminal-pro-B-type natriuretic peptide, C-reactive protein, and renin in subjects with cerebrovascular disease. Circulation 2005;112:110-16
-
(2005)
Circulation
, vol.112
, pp. 110-16
-
-
Campbell, D.J.1
Woodward, M.2
Chalmers, J.P.3
-
9
-
-
0025794059
-
Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension
-
Alderman MH, Madhavan S, Ooi WL, et al. Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension. N Engl J Med 1991;324:1098-104
-
(1991)
N Engl J Med
, vol.324
, pp. 1098-104
-
-
Alderman, M.H.1
Madhavan, S.2
Ooi, W.L.3
-
10
-
-
77956343748
-
Relation of elevated plasma renin activity at baseline to cardiac events in patients with angiographically proven coronary artery disease
-
Muhlestein JB, May HT, Bair TL, et al. Relation of elevated plasma renin activity at baseline to cardiac events in patients with angiographically proven coronary artery disease. Am J Cardiol 2010;106:764-9
-
(2010)
Am J Cardiol
, vol.106
, pp. 764-9
-
-
Muhlestein, J.B.1
May, H.T.2
Bair, T.L.3
-
11
-
-
28844457541
-
Determinants of increased angiotensin II levels in severe chronic heart failure patients despite ACE inhibition
-
Van de Wal RM, Plokker HW, Lok DJ, et al. Determinants of increased angiotensin II levels in severe chronic heart failure patients despite ACE inhibition. Int J Cardiol 2006;106:367-72
-
(2006)
Int J Cardiol
, vol.106
, pp. 367-72
-
-
Van De Wal, R.M.1
Plokker, H.W.2
Lok, D.J.3
-
12
-
-
0025598309
-
Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart
-
Urata H, Kinoshita A, Misono KS, et al. Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J Biol Chem 1990;265:22348-57
-
(1990)
J Biol Chem
, vol.265
, pp. 22348-57
-
-
Urata, H.1
Kinoshita, A.2
Misono, K.S.3
-
13
-
-
69249202278
-
Aliskiren monotherapy results in the greatest and the least blood pressure lowering in patients with high-and low-baseline PRA levels, respectively
-
Stanton AV, Dicker P, O'Brien ET. Aliskiren monotherapy results in the greatest and the least blood pressure lowering in patients with high-and low-baseline PRA levels, respectively. Am J Hypertens 2009;22:954-7
-
(2009)
Am J Hypertens
, vol.22
, pp. 954-7
-
-
Stanton, A.V.1
Dicker, P.2
O'Brien, E.T.3
-
14
-
-
34247644329
-
Aliskiren, the first renin inhibitor for treating hypertension: Reactive renin secretion may limit its effectiveness
-
Sealey JE, Laragh JH. Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness. Am J Hypertens 2007;20:587-97
-
(2007)
Am J Hypertens
, vol.20
, pp. 587-97
-
-
Sealey, J.E.1
Laragh, J.H.2
-
15
-
-
57749203164
-
Aliskiren fails to lower blood pressure in patients who have either low PRA levels or whose PRA falls insufficiently or reactively rises
-
Sealey JE, Laragh JH. Aliskiren fails to lower blood pressure in patients who have either low PRA levels or whose PRA falls insufficiently or reactively rises. Am J Hypertens 2009;22:112-21
-
(2009)
Am J Hypertens
, vol.22
, pp. 112-21
-
-
Sealey, J.E.1
Laragh, J.H.2
-
16
-
-
73849141617
-
Aliskiren monotherapy does not cause paradoxical blood pressure rises: Meta-analysis of data from 8 clinical trials
-
Stanton AV, Gradman AH, Schmieder RE, et al. Aliskiren monotherapy does not cause paradoxical blood pressure rises: meta-analysis of data from 8 clinical trials. Hypertension 2010;55:54-60
-
(2010)
Hypertension
, vol.55
, pp. 54-60
-
-
Stanton, A.V.1
Gradman, A.H.2
Schmieder, R.E.3
-
17
-
-
57449100853
-
Aliskiren accumulates in Renin secretory granules and binds plasma prorenin
-
Krop M, Garrelds IM, de Bruin RJ, et al. Aliskiren accumulates in Renin secretory granules and binds plasma prorenin. Hypertension 2008;52:1076-83
-
(2008)
Hypertension
, vol.52
, pp. 1076-83
-
-
Krop, M.1
Garrelds, I.M.2
De Bruin, R.J.3
-
18
-
-
78650447751
-
Food and drug administration (FDA) SG
-
Tekturna, NDA no. 021985. Available from
-
Food and Drug Administration (FDA) SG. Drug product label. Tekturna, NDA no. 021985. Available from: http://wwwaccessdatafdagov/drugsatfda-docs/label/ 2010/021985s012lblpdf. 2010
-
(2010)
Drug Product Label
-
-
-
19
-
-
0042661157
-
Structure-based design of aliskiren, a novel orally effective renin inhibitor
-
Wood JM, Maibaum J, Rahuel J, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun 2003;308:698-705
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 698-705
-
-
Wood, J.M.1
Maibaum, J.2
Rahuel, J.3
-
20
-
-
0033941893
-
Structure-based drug design: The discovery of novel nonpeptide orally active inhibitors of human renin
-
Rahuel J, Rasetti V, Maibaum J, et al. Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin. Chem Biol 2000;7:493-504
-
(2000)
Chem Biol
, vol.7
, pp. 493-504
-
-
Rahuel, J.1
Rasetti, V.2
Maibaum, J.3
-
21
-
-
77955925948
-
Grapefruit juice greatly reduces the plasma concentrations of the OATP2B1 and CYP3A4 substrate aliskiren
-
Tapaninen T, Neuvonen PJ, Niemi M. Grapefruit juice greatly reduces the plasma concentrations of the OATP2B1 and CYP3A4 substrate aliskiren. Clin Pharmacol Ther 2010;88:339-42
-
(2010)
Clin Pharmacol Ther
, vol.88
, pp. 339-42
-
-
Tapaninen, T.1
Neuvonen, P.J.2
Niemi, M.3
-
22
-
-
43449133877
-
A study of dose-proportionality in the pharmacokinetics of the oral direct renin inhibitor aliskiren in healthy subjects
-
Limoges D, Dieterich HA, Yeh CM, et al. A study of dose-proportionality in the pharmacokinetics of the oral direct renin inhibitor aliskiren in healthy subjects. Int J Clin Pharmacol Ther 2008;46:252-8
-
(2008)
Int J Clin Pharmacol Ther
, vol.46
, pp. 252-8
-
-
Limoges, D.1
Dieterich, H.A.2
Yeh, C.M.3
-
24
-
-
0032793959
-
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
-
Cvetkovic M, Leake B, Fromm MF, et al. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 1999;27:866-71
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 866-71
-
-
Cvetkovic, M.1
Leake, B.2
Fromm, M.F.3
-
25
-
-
77951591810
-
The role of CYP3A4 and p-glycoprotein in food-drug and herb-drug interactions
-
Chen J, Raymond H. The role of CYP3A4 and p-glycoprotein in food-drug and herb-drug interactions. Aust Pharmacist 2006;25:732-8
-
(2006)
Aust Pharmacist
, vol.25
, pp. 732-8
-
-
Chen, J.1
Raymond, H.2
-
26
-
-
33749267293
-
Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs
-
Cascorbi I. Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs. Pharmacol Ther 2006;112:457-73
-
(2006)
Pharmacol Ther
, vol.112
, pp. 457-73
-
-
Cascorbi, I.1
-
27
-
-
77956185912
-
Effect of ABCB1 haplotypes on the pharmacokinetics and renin-inhibiting effect of aliskiren
-
Tapaninen T, Neuvonen PJ, Niemi M. Effect of ABCB1 haplotypes on the pharmacokinetics and renin-inhibiting effect of aliskiren. Eur J Clin Pharmacol 2010;66:865-70
-
(2010)
Eur J Clin Pharmacol
, vol.66
, pp. 865-70
-
-
Tapaninen, T.1
Neuvonen, P.J.2
Niemi, M.3
-
28
-
-
34547221695
-
Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers
-
Waldmeier F, Glaenzel U, Wirz B, et al. Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers. Drug Metab Dispos 2007;35:1418-28
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1418-28
-
-
Waldmeier, F.1
Glaenzel, U.2
Wirz, B.3
-
29
-
-
54049086657
-
Pharmacokinetics of the oral direct renin inhibitor Aliskiren in combination with digoxin, atorvastatin, and detoconazole in healthy subjects: The role of P-glycoprotein in the disposition of Aliskiren
-
Vaidyanathan S, Camenisch G, Schuetz H, et al. Pharmacokinetics of the oral direct renin inhibitor Aliskiren in combination with digoxin, atorvastatin, and detoconazole in healthy subjects: the role of P-glycoprotein in the disposition of Aliskiren. J Clin Pharmacol 2008;48:1323-38
-
(2008)
J Clin Pharmacol
, vol.48
, pp. 1323-38
-
-
Vaidyanathan, S.1
Camenisch, G.2
Schuetz, H.3
-
30
-
-
4744348177
-
Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy subjects
-
Dieterle W, Corynen S, Mann J. Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy subjects. Br J Clin Pharmacol 2004;58:433-6
-
(2004)
Br J Clin Pharmacol
, vol.58
, pp. 433-6
-
-
Dieterle, W.1
Corynen, S.2
Mann, J.3
-
31
-
-
28044453329
-
Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine
-
Dieterle W, Corynen S, Vaidyanathan S, et al. Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine. Int J Clin Pharmacol Ther 2005;43:527-35
-
(2005)
Int J Clin Pharmacol Ther
, vol.43
, pp. 527-35
-
-
Dieterle, W.1
Corynen, S.2
Vaidyanathan, S.3
-
32
-
-
33749853955
-
Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers
-
Vaidyanathan S, Valencia J, Kemp C, et al. Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers. Int J Clin Pract 2006;60:1343-56
-
(2006)
Int J Clin Pract
, vol.60
, pp. 1343-56
-
-
Vaidyanathan, S.1
Valencia, J.2
Kemp, C.3
-
33
-
-
0036372173
-
Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): Comparison with enalapril
-
Nussberger J, Wuerzner G, Jensen C, et al. Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril. Hypertension 2002;39:E1-8
-
(2002)
Hypertension
, vol.39
-
-
Nussberger, J.1
Wuerzner, G.2
Jensen, C.3
-
34
-
-
79953805995
-
Itraconazole, a P-Glycoprotein and CYP3A4 Inhibitor, Markedly Raises the Plasma Concentrations and Enhances the Renin-Inhibiting Effect of Aliskiren
-
published online before print April 16, 2010 doi: 10.1177/ 0091270010365885
-
Tapaninen T, Backman JT, Kurkinen K, et al. Itraconazole, a P-Glycoprotein and CYP3A4 Inhibitor, Markedly Raises the Plasma Concentrations and Enhances the Renin-Inhibiting Effect of Aliskiren. J Clin Pharmacol 2010: published online before print April 16, 2010, doi: 10.1177/0091270010365885
-
(2010)
J Clin Pharmacol
-
-
Tapaninen, T.1
Backman, J.T.2
Kurkinen, K.3
-
35
-
-
77954512988
-
Rifampicin reduces the plasma concentrations and the renin-inhibiting effect of aliskiren
-
Tapaninen T, Neuvonen PJ, Niemi M. Rifampicin reduces the plasma concentrations and the renin-inhibiting effect of aliskiren. Eur J Clin Pharmacol 2010;66:497-502
-
(2010)
Eur J Clin Pharmacol
, vol.66
, pp. 497-502
-
-
Tapaninen, T.1
Neuvonen, P.J.2
Niemi, M.3
-
36
-
-
77956189544
-
Influence of body weight and gender on the pharmacokinetics, pharmacodynamics, and antihypertensive efficacy of Aliskiren
-
published online before print February 11,2010 doi: 10.1177/ 0091270009359525
-
Jarugula V, Yeh CM, Howard D, et al. Influence of body weight and gender on the pharmacokinetics, pharmacodynamics, and antihypertensive efficacy of Aliskiren. J Clin Pharmacol 2010: published online before print February 11, 2010, doi: 10.1177/0091270009359525
-
(2010)
J Clin Pharmacol
-
-
Jarugula, V.1
Yeh, C.M.2
Howard, D.3
-
37
-
-
77949549775
-
Pharmacokinetics, safety and tolerability of single and multiple oral doses of aliskiren in healthy Chinese subjects: A randomized, single-blind, parallel-group, placebo-controlled study
-
Hu P, Bartlett M, Karan RS, et al. Pharmacokinetics, safety and tolerability of single and multiple oral doses of aliskiren in healthy Chinese subjects: a randomized, single-blind, parallel-group, placebo-controlled study. Clin Drug Investig 2010;30:221-8
-
(2010)
Clin Drug Investig
, vol.30
, pp. 221-8
-
-
Hu, P.1
Bartlett, M.2
Karan, R.S.3
-
38
-
-
33947543780
-
Pharmacokinetics, safety, and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects
-
Vaidyanathan S, Reynolds C, Yeh CM, et al. Pharmacokinetics, safety, and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects. J Clin Pharmacol 2007;47:453-60
-
(2007)
J Clin Pharmacol
, vol.47
, pp. 453-60
-
-
Vaidyanathan, S.1
Reynolds, C.2
Yeh, C.M.3
-
39
-
-
0033574249
-
A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation
-
Modification of diet in renal disease Study Group
-
Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease Study Group. Ann Intern Med 1999;130:461-70
-
(1999)
Ann Intern Med
, vol.130
, pp. 461-70
-
-
Levey, A.S.1
Bosch, J.P.2
Lewis, J.B.3
-
40
-
-
33749861264
-
PIII-23 Aliskiren, an orally effective renin inhibitor, shows dose-linear pharmacokinetics in healthy volunteers
-
abstract P64
-
Vaidyanathan S, Limoges D, Yeh C, et al. PIII-23. Aliskiren, an orally effective renin inhibitor, shows dose-linear pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 2006;79:abstract P64
-
(2006)
Clin Pharmacol Ther
, vol.79
-
-
Vaidyanathan, S.1
Limoges, D.2
Yeh, C.3
-
41
-
-
77955921291
-
Aliskiren for geriatric lowering of systolic hypertension: A randomized controlled trial
-
Duprez DA, Munger MA, Botha J, et al. Aliskiren for geriatric lowering of systolic hypertension: a randomized controlled trial. J Hum Hypertens 2010;24:600-8
-
(2010)
J Hum Hypertens
, vol.24
, pp. 600-8
-
-
Duprez, D.A.1
Munger, M.A.2
Botha, J.3
-
43
-
-
33846456943
-
Pharmacokinetics, safety, and tolerability of the oral renin inhibitor aliskiren in patients with hepatic impairment
-
DOI 10.1177/0091270006294404
-
Vaidyanathan S, Warren V, Yeh C, et al. Pharmacokinetics, safety, and tolerability of the oral Renin inhibitor aliskiren in patients with hepatic impairment. J Clin Pharmacol 2007;47:192-200 (Pubitemid 46146485)
-
(2007)
Journal of Clinical Pharmacology
, vol.47
, Issue.2
, pp. 192-200
-
-
Vaidyanathan, S.1
Warren, V.2
Yeh, C.3
Bizot, M.-N.4
Dieterich, H.A.5
Dole, W.P.6
-
44
-
-
0026581559
-
Clinical pharmacokinetics of calcium antagonists. An update
-
Kelly JG, O'Malley K. Clinical pharmacokinetics of calcium antagonists. An update. Clin Pharmacokinet 1992;22:416-33
-
(1992)
Clin Pharmacokinet
, vol.22
, pp. 416-33
-
-
Kelly, J.G.1
O'Malley, K.2
-
45
-
-
34547628374
-
Pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with irbesartan in renal impairment
-
Vaidyanathan S, Bigler H, Yeh C, et al. Pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with irbesartan in renal impairment. Clin Pharmacokinet 2007;46:661-75
-
(2007)
Clin Pharmacokinet
, vol.46
, pp. 661-75
-
-
Vaidyanathan, S.1
Bigler, H.2
Yeh, C.3
-
46
-
-
0026753520
-
Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes
-
Ganten D, Wagner J, Zeh K, et al. Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes. Proc Natl Acad Sci USA 1992;89:7806-10
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 7806-10
-
-
Ganten, D.1
Wagner, J.2
Zeh, K.3
-
47
-
-
0027190950
-
Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes
-
Fukamizu A, Sugimura K, Takimoto E, et al. Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes. J Biol Chem 1993;268:11617-21
-
(1993)
J Biol Chem
, vol.268
, pp. 11617-21
-
-
Fukamizu, A.1
Sugimura, K.2
Takimoto, E.3
-
48
-
-
25444454353
-
Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats
-
Pilz B, Shagdarsuren E, Wellner M, et al. Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats. Hypertension 2005;46:569-76
-
(2005)
Hypertension
, vol.46
, pp. 569-76
-
-
Pilz, B.1
Shagdarsuren, E.2
Wellner, M.3
-
49
-
-
9644287897
-
Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption
-
Azizi M, Menard J, Bissery A, et al. Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol 2004;15:3126-33
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 3126-33
-
-
Azizi, M.1
Menard, J.2
Bissery, A.3
-
50
-
-
33846781398
-
Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension
-
Kushiro T, Itakura H, Abo Y, et al. Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension. Hypertens Res 2006;29:997-1005
-
(2006)
Hypertens Res
, vol.29
, pp. 997-1005
-
-
Kushiro, T.1
Itakura, H.2
Abo, Y.3
-
51
-
-
33846449197
-
Once-daily aliskiren provides effective, smooth 24-h blood pressure control in patients with hypertension
-
Mitchell J, Oh B, Herron J, et al. Once-daily aliskiren provides effective, smooth 24-h blood pressure control in patients with hypertension. J Clin Hypertens 2006;8(Suppl A):A93
-
(2006)
J Clin Hypertens
, vol.8
, Issue.SUPPL. A
-
-
Mitchell, J.1
Oh, B.2
Herron, J.3
-
52
-
-
33947182655
-
Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension
-
Oh BH, Mitchell J, Herron JR, et al. Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension. J Am Coll Cardiol 2007;49:1157-63
-
(2007)
J Am Coll Cardiol
, vol.49
, pp. 1157-63
-
-
Oh, B.H.1
Mitchell, J.2
Herron, J.R.3
-
53
-
-
34447521458
-
Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: A randomised, double-blind trial
-
Oparil S, Yarows SA, Patel S, et al. Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial. Lancet 2007;370:221-9
-
(2007)
Lancet
, vol.370
, pp. 221-9
-
-
Oparil, S.1
Yarows, S.A.2
Patel, S.3
-
54
-
-
33845785350
-
Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan
-
Pool JL, Schmieder RE, Azizi M, et al. Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan. Am J Hypertens 2007;20:11-20
-
(2007)
Am J Hypertens
, vol.20
, pp. 11-20
-
-
Pool, J.L.1
Schmieder, R.E.2
Azizi, M.3
-
55
-
-
33845366982
-
Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
-
Villamil A, Chrysant SG, Calhoun D, et al. Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. J Hypertens 2007;25:217-26
-
(2007)
J Hypertens
, vol.25
, pp. 217-26
-
-
Villamil, A.1
Chrysant, S.G.2
Calhoun, D.3
-
56
-
-
34247867955
-
Direct Renin inhibition with aliskiren in obese patients with arterial hypertension
-
Jordan J, Engeli S, Boye SW, et al. Direct Renin inhibition with aliskiren in obese patients with arterial hypertension. Hypertension 2007;49:1047-55
-
(2007)
Hypertension
, vol.49
, pp. 1047-55
-
-
Jordan, J.1
Engeli, S.2
Boye, S.W.3
-
57
-
-
36348998335
-
Aliskiren, a direct renin inhibitor, provides antihypertensive efficacy and excellent tolerability independent of age or gender in patients with hypertension
-
Dahlof B, Anderson DR, Arora V, et al. Aliskiren, a direct renin inhibitor, provides antihypertensive efficacy and excellent tolerability independent of age or gender in patients with hypertension. J Clin Hypertens 2007;9(Suppl A):A157
-
(2007)
J Clin Hypertens
, vol.9
, Issue.SUPPL. A
-
-
Dahlof, B.1
Anderson, D.R.2
Arora, V.3
-
58
-
-
0347479295
-
Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren
-
Stanton A, Jensen C, Nussberger J, et al. Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren. Hypertension 2003;42:1137-43
-
(2003)
Hypertension
, vol.42
, pp. 1137-43
-
-
Stanton, A.1
Jensen, C.2
Nussberger, J.3
-
59
-
-
14844363404
-
Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
-
Gradman AH, Schmieder RE, Lins RL, et al. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 2005;111:1012-18
-
(2005)
Circulation
, vol.111
, pp. 1012-18
-
-
Gradman, A.H.1
Schmieder, R.E.2
Lins, R.L.3
-
60
-
-
34548855067
-
A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension
-
Strasser RH, Puig JG, Farsang C, et al. A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension. J Hum Hypertens 2007;21:780-7
-
(2007)
J Hum Hypertens
, vol.21
, pp. 780-7
-
-
Strasser, R.H.1
Puig, J.G.2
Farsang, C.3
-
61
-
-
35348845563
-
Aliskiren-based therapy lowers blood pressure more effectively than ramipril-based therapy in patients with hypertension: A 6-month, randomized, double-blind trial
-
Andersen K, Weinberger MH, Egan B, et al. Aliskiren-based therapy lowers blood pressure more effectively than ramipril-based therapy in patients with hypertension: a 6-month, randomized, double-blind trial. J Am Coll Cardiol 2007;49(Suppl A):A371
-
(2007)
J Am Coll Cardiol
, vol.49
, Issue.SUPPL. A
-
-
Andersen, K.1
Weinberger, M.H.2
Egan, B.3
-
62
-
-
39849089447
-
Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: A 6-month, randomized, double-blind trial
-
Andersen K, Weinberger MH, Egan B, et al. Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial. J Hypertens 2008;26:589-99
-
(2008)
J Hypertens
, vol.26
, pp. 589-99
-
-
Andersen, K.1
Weinberger, M.H.2
Egan, B.3
-
63
-
-
67650348428
-
The AGELESS Study: The effect of aliskiren vs ramipril alone or in combination with hydrochlorothiazide and amlodipine in patients 65 years of age with systolic hypertension (abstract 4423)
-
Duprez DA, Davis P, Botha J. The AGELESS Study: The effect of aliskiren vs ramipril alone or in combination with hydrochlorothiazide and amlodipine in patients 65 years of age with systolic hypertension (abstract 4423). Circulation 2008;118:886-7
-
(2008)
Circulation
, vol.118
, pp. 886-7
-
-
Duprez, D.A.1
Davis, P.2
Botha, J.3
-
64
-
-
0035897696
-
Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
-
National Cholesterol Education Program SG
-
National Cholesterol Education Program SG. Executive summary of the third report of The National Cholesterol Education Program (NCEP) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001;285:2486-97
-
(2001)
JAMA
, vol.285
, pp. 2486-97
-
-
-
65
-
-
4544333229
-
Renin-angiotensin system and angiotensin receptor blockers in the metabolic syndrome
-
Prasad A, Quyyumi AA. Renin-angiotensin system and angiotensin receptor blockers in the metabolic syndrome. Circulation 2004;110:1507-12
-
(2004)
Circulation
, vol.110
, pp. 1507-12
-
-
Prasad, A.1
Quyyumi, A.A.2
-
66
-
-
79951682271
-
Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome
-
published online before print 8 April 2010 doi: 10.1038/jhh.2010.38
-
Krone W, Hanefeld M, Meyer HF, et al. Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome. J Hum Hypertens 2010: published online before print 8 April 2010; doi: 10.1038/jhh.2010.38
-
(2010)
J Hum Hypertens
-
-
Krone, W.1
Hanefeld, M.2
Meyer, H.F.3
-
67
-
-
38649102508
-
Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension
-
Uresin Y, Taylor AA, Kilo C, et al. Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension. J Renin Angiotensin Aldosterone Syst 2007;8:190-8
-
(2007)
J Renin Angiotensin Aldosterone Syst
, vol.8
, pp. 190-8
-
-
Uresin, Y.1
Taylor, A.A.2
Kilo, C.3
-
68
-
-
74349119971
-
Efficacy and safety of aliskiren in Japanese hypertensive patients with renal dysfunction
-
Ito S, Nakura N, Le Breton S, et al. Efficacy and safety of aliskiren in Japanese hypertensive patients with renal dysfunction. Hypertens Res 2010;33:62-6
-
(2010)
Hypertens Res
, vol.33
, pp. 62-6
-
-
Ito, S.1
Nakura, N.2
Le Breton, S.3
-
69
-
-
79958249630
-
Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure
-
McMurray JJ, Pitt B, Latini R, et al. Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circ Heart Fail 2008;1:17-24
-
(2008)
Circ Heart Fail
, vol.1
, pp. 17-24
-
-
McMurray, J.J.1
Pitt, B.2
Latini, R.3
-
70
-
-
44849114597
-
Aliskiren combined with losartan in type 2 diabetes and nephropathy
-
Parving HH, Persson F, Lewis JB, et al. Aliskiren combined with losartan in type 2 diabetes and nephropathy. N Engl J Med 2008; 358:2433-46
-
(2008)
N Engl J Med
, vol.358
, pp. 2433-46
-
-
Parving, H.H.1
Persson, F.2
Lewis, J.B.3
-
71
-
-
0032911972
-
Proteinuria, albuminuria, risk, assessment, detection, elimination (PARADE): A position paper of the National Kidney Foundation
-
Keane WF, Eknoyan G. Proteinuria, albuminuria, risk, assessment, detection, elimination (PARADE): a position paper of the National Kidney Foundation. Am J Kidney Dis 1999;33:1004-10
-
(1999)
Am J Kidney Dis
, vol.33
, pp. 1004-10
-
-
Keane, W.F.1
Eknoyan, G.2
-
72
-
-
46449118638
-
Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2) 27 rats
-
Feldman DL, Jin L, Xuan H, et al. Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2) 27 rats. Hypertension 2008;52:130-6
-
(2008)
Hypertension
, vol.52
, pp. 130-6
-
-
Feldman, D.L.1
Jin, L.2
Xuan, H.3
-
73
-
-
78649929199
-
Impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy
-
Published online before print August doi: 10.2337/dc10-0833
-
Persson F, Lewis JB, Lewis EJ, et al. Impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy. Diabetes Care 2010: Published online before print August 6, 2010, doi: 10.2337/dc10-0833
-
(2010)
Diabetes Care
, vol.6
, pp. 2010
-
-
Persson, F.1
Lewis, J.B.2
Lewis, E.J.3
-
74
-
-
77955518102
-
Optimal antiproteinuric dose of aliskiren in type 2 diabetes mellitus: A randomised crossover trial
-
Persson F, Rossing P, Reinhard H, et al. Optimal antiproteinuric dose of aliskiren in type 2 diabetes mellitus: a randomised crossover trial. Diabetologia 2010;53:1576-80
-
(2010)
Diabetologia
, vol.53
, pp. 1576-80
-
-
Persson, F.1
Rossing, P.2
Reinhard, H.3
-
75
-
-
65649099918
-
Effect of the direct renin inhibitor aliskiren either alone or in combination with losartan compared to losartan on left ventricular mass in patients with hypertension and left ventricular hypertrophy: The Aliskiren Left Ventricular Assessment of Hypertrophy (ALLAY) Trial
-
Chicago IL
-
Solomon SD. Effect of the direct renin inhibitor aliskiren, either alone or in combination with losartan, compared to losartan, on left ventricular mass in patients with hypertension and left ventricular hypertrophy: the Aliskiren Left Ventricular Assessment of Hypertrophy (ALLAY) Trial. SCAI-ACC i2 Summit/American College of Cardiology Annual Scientific Session, Chicago, IL; 2008
-
(2008)
SCAI-ACC i2 Summit/American College of Cardiology Annual Scientific Session
-
-
Solomon, S.D.1
-
76
-
-
34648831723
-
Renin inhibition: The holy grail of renin-angiotensin system blockade?
-
McInnes GT. Renin inhibition: the holy grail of renin-angiotensin system blockade? J Hum Hypertens 2007;21:766-9
-
(2007)
J Hum Hypertens
, vol.21
, pp. 766-9
-
-
McInnes, G.T.1
-
77
-
-
56749090710
-
Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren
-
Schefe JH, Neumann C, Goebel M, et al. Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren. J Hypertens 2008;26:1787-94
-
(2008)
J Hypertens
, vol.26
, pp. 1787-94
-
-
Schefe, J.H.1
Neumann, C.2
Goebel, M.3
-
78
-
-
42349086752
-
Renin inhibition by aliskiren prevents atherosclerosis progression: Comparison with irbesartan, atenolol, and amlodipine
-
Nussberger J, Aubert JF, Bouzourene K, et al. Renin inhibition by aliskiren prevents atherosclerosis progression: comparison with irbesartan, atenolol, and amlodipine. Hypertension 2008;51:1306-11
-
(2008)
Hypertension
, vol.51
, pp. 1306-11
-
-
Nussberger, J.1
Aubert, J.F.2
Bouzourene, K.3
-
79
-
-
67849128863
-
Blood pressure lowering efficacy of renin inhibitors for primary hypertension: A Cochrane systematic review
-
Musini VM, Fortin PM, Bassett K, et al. Blood pressure lowering efficacy of renin inhibitors for primary hypertension: a Cochrane systematic review. J Hum Hypertens 2009;23:495-502
-
(2009)
J Hum Hypertens
, vol.23
, pp. 495-502
-
-
Musini, V.M.1
Fortin, P.M.2
Bassett, K.3
-
80
-
-
14844363404
-
Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
-
Gradman AH, Schmieder RE, Lins RL, et al. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 2005;111:1012-18
-
(2005)
Circulation
, vol.111
, pp. 1012-18
-
-
Gradman, A.H.1
Schmieder, R.E.2
Lins, R.L.3
-
81
-
-
33749847756
-
Aliskiren, a novel renin inhibitor, has greater BP lowering than ramipril and additional BP lowering when combined with ramipril in patients with diabetes and hypertension
-
Uresin Y, Taylor A, Kilo C, et al. Aliskiren, a novel renin inhibitor, has greater BP lowering than ramipril and additional BP lowering when combined with ramipril in patients with diabetes and hypertension. J Hypertens 2006;24(Suppl 4):82
-
(2006)
J Hypertens
, vol.24
, Issue.SUPPL. 4
, pp. 82
-
-
Uresin, Y.1
Taylor, A.2
Kilo, C.3
-
82
-
-
33845329332
-
Antihypertensive efficacy and safety of the oral renin inhibitor aliskiren in patients with hypertension: A pooled analysis
-
Weir M, Bush C, Zhang J, et al. Antihypertensive efficacy and safety of the oral renin inhibitor aliskiren in patients with hypertension: a pooled analysis. Eur Heart J 2006;27(Suppl):299
-
(2006)
Eur Heart J
, vol.27
, Issue.SUPPL.
, pp. 299
-
-
Weir, M.1
Bush, C.2
Zhang, J.3
-
83
-
-
65249182083
-
Aliskiren Trial in type 2 diabetes using cardio-renal endpoints (ALTITUDE): Rationale and study design
-
Parving H-H, Brenner BM, McMurray JJV, et al. Aliskiren Trial in type 2 diabetes using cardio-renal endpoints (ALTITUDE): rationale and study design. Nephrol Dial Transplant 2009;24:1663-71
-
(2009)
Nephrol Dial Transplant
, vol.24
, pp. 1663-71
-
-
Parving, H.-H.1
Brenner, B.M.2
Jjv, M.3
-
86
-
-
67650495757
-
Managing cardiovascular and renal risk: The potential of direct renin inhibition
-
Sever PS, Gradman AH, Azizi M. Managing cardiovascular and renal risk: the potential of direct renin inhibition. J Renin Angiotensin Aldosterone Syst 2009;10:65-76
-
(2009)
J Renin Angiotensin Aldosterone Syst
, vol.10
, pp. 65-76
-
-
Sever, P.S.1
Gradman, A.H.2
Azizi, M.3
-
87
-
-
78650502099
-
Aliskiren: A novel, orally active renin inhibitor
-
Mohamed Saleem T, Jain A, Tarani P, et al. Aliskiren: a novel, orally active renin inhibitor. Syst Rev Pharm 2010;1:93-8
-
(2010)
Syst Rev Pharm
, vol.1
, pp. 93-8
-
-
Mohamed Saleem, T.1
Jain, A.2
Tarani, P.3
-
88
-
-
78650497522
-
Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with left ventricular dysfunction: ASPIRE
-
Solomon S. Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with left ventricular dysfunction: ASPIRE. American College of Cardiology, 59th Annual Scientific Sessions. 2010
-
(2010)
American College of Cardiology, 59th Annual Scientific Sessions
-
-
Solomon, S.1
-
89
-
-
78649448321
-
Efficacy of aliskiren/hydrochlorothiazide single-pill combinations in aliskiren non-responders
-
Nickenig G, Simanenkov V, Lembo G, et al. Efficacy of aliskiren/hydrochlorothiazide single-pill combinations in aliskiren non-responders. Blood Press Suppl 2008;2:31-40
-
(2008)
Blood Press Suppl
, vol.2
, pp. 31-40
-
-
Nickenig, G.1
Simanenkov, V.2
Lembo, G.3
-
90
-
-
67749116073
-
Combination therapy with various combinations of aliskiren, valsartan, and hydrochlorothiazide in hypertensive patients not adequately responsive to hydrochlorothiazide alone
-
Geiger H, Barranco E, Gorostidi M, et al. Combination therapy with various combinations of aliskiren, valsartan, and hydrochlorothiazide in hypertensive patients not adequately responsive to hydrochlorothiazide alone. J Clin Hypertens (Greenwich) 2009;11:324-32
-
(2009)
J Clin Hypertens (Greenwich)
, vol.11
, pp. 324-32
-
-
Geiger, H.1
Barranco, E.2
Gorostidi, M.3
-
91
-
-
78650447751
-
Food and drug administration (FDA) SG
-
Tekamlo, NDA no. 022545 Available from
-
Food and Drug Administration (FDA) SG. Drug product label. Tekamlo, NDA no. 022545 Available from: http://wwwaccessdatafdagov/drugsatfda-docs/label/ 2010/022545s000lblpdf. 2010
-
(2010)
Drug Product Label
-
-
-
92
-
-
77950187294
-
Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): A prespecified secondary analysis of a randomised controlled trial
-
Bakris GL, Sarafidis PA, Weir MR, et al. Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial. Lancet 2010;375:1173-81
-
(2010)
Lancet
, vol.375
, pp. 1173-81
-
-
Bakris, G.L.1
Sarafidis, P.A.2
Weir, M.R.3
|