메뉴 건너뛰기




Volumn 34, Issue 3, 2010, Pages 312-321

Increased angiogenesis induced by chronic lymphocytic leukemia B cells is mediated by leukemia-derived Ang2 and VEGF

Author keywords

Angiogenesis; Angiogenesis related factors; CLL; Endothelial cells; Hypoxia; Microenvironment

Indexed keywords

ANGIOPOIETIN 2; CD34 ANTIGEN; MESSENGER RNA; VASCULOTROPIN;

EID: 77649190207     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2009.06.023     Document Type: Article
Times cited : (51)

References (46)
  • 2
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash J., Maisonpierre P.C., Compton D., Boland P., Alexander C.R., Zagzag D., et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 1999, 284:1994-1998.
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1    Maisonpierre, P.C.2    Compton, D.3    Boland, P.4    Alexander, C.R.5    Zagzag, D.6
  • 4
    • 0037204425 scopus 로고    scopus 로고
    • Biomedical significance of endothelial cell specific growth factor, angiopoietin
    • Koh G.Y., Kim I., Kwak H.J., Yun M.J., Leem J.C. Biomedical significance of endothelial cell specific growth factor, angiopoietin. Exp Mol Med 2002, 34:1-11.
    • (2002) Exp Mol Med , vol.34 , pp. 1-11
    • Koh, G.Y.1    Kim, I.2    Kwak, H.J.3    Yun, M.J.4    Leem, J.C.5
  • 5
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 6
    • 0031059348 scopus 로고    scopus 로고
    • Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia
    • Perez-Atayde A.R., Sallan S.E., Tedrow U., Connors S., Allred E., Folkman J. Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am J Pathol 1997, 150:815-821.
    • (1997) Am J Pathol , vol.150 , pp. 815-821
    • Perez-Atayde, A.R.1    Sallan, S.E.2    Tedrow, U.3    Connors, S.4    Allred, E.5    Folkman, J.6
  • 7
    • 0034655595 scopus 로고    scopus 로고
    • Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia
    • Padró T., Ruiz S., Bieker R., Bürger H., Steins M., Kienast J., et al. Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia. Blood 2000, 95:2637-2644.
    • (2000) Blood , vol.95 , pp. 2637-2644
    • Padró, T.1    Ruiz, S.2    Bieker, R.3    Bürger, H.4    Steins, M.5    Kienast, J.6
  • 8
    • 11444259307 scopus 로고    scopus 로고
    • Microenvironmental interactions and survival of CLL B-cells
    • Munk Pedersen I., Reed J. Microenvironmental interactions and survival of CLL B-cells. Leuk Lymphoma 2004, 45:2365-2372.
    • (2004) Leuk Lymphoma , vol.45 , pp. 2365-2372
    • Munk Pedersen, I.1    Reed, J.2
  • 9
    • 33645997037 scopus 로고    scopus 로고
    • The clinical and biologic importance of neovascularization and angiogenic signaling pathways in chronic lymphocytic leukemia
    • Shanafelt T.D., Kay N.E. The clinical and biologic importance of neovascularization and angiogenic signaling pathways in chronic lymphocytic leukemia. Semin Oncol 2006, 33:174-185.
    • (2006) Semin Oncol , vol.33 , pp. 174-185
    • Shanafelt, T.D.1    Kay, N.E.2
  • 11
    • 0034329298 scopus 로고    scopus 로고
    • In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells
    • Chen H., Treweeke A.T., West D.C., Till K.J., Cawley J.C., Zuzel M., et al. In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells. Blood 2000, 96:3181-3187.
    • (2000) Blood , vol.96 , pp. 3181-3187
    • Chen, H.1    Treweeke, A.T.2    West, D.C.3    Till, K.J.4    Cawley, J.C.5    Zuzel, M.6
  • 12
    • 0033885493 scopus 로고    scopus 로고
    • Increased bone marrow angiogenesis in B cell chronic lymphocytic leukemia
    • Kini A.R., Kay N.E., Peterson L.C. Increased bone marrow angiogenesis in B cell chronic lymphocytic leukemia. Leukemia 2000, 14:1414-1418.
    • (2000) Leukemia , vol.14 , pp. 1414-1418
    • Kini, A.R.1    Kay, N.E.2    Peterson, L.C.3
  • 13
    • 0036838537 scopus 로고    scopus 로고
    • Prognostic value of enhanced bone marrow angiogenesis in early B-cell chronic lymphocytic leukemia
    • Molica S., Vacca A., Ribatti D., Cuneo A., Cavazzini F., Levato D., et al. Prognostic value of enhanced bone marrow angiogenesis in early B-cell chronic lymphocytic leukemia. Blood 2002, 100:3344-3351.
    • (2002) Blood , vol.100 , pp. 3344-3351
    • Molica, S.1    Vacca, A.2    Ribatti, D.3    Cuneo, A.4    Cavazzini, F.5    Levato, D.6
  • 14
    • 0035871856 scopus 로고    scopus 로고
    • Angiogenesis is increased in B-cell chronic lymphocytic leukemia
    • Peterson L., Kini A.R. Angiogenesis is increased in B-cell chronic lymphocytic leukemia. Blood 2001, 97:2529.
    • (2001) Blood , vol.97 , pp. 2529
    • Peterson, L.1    Kini, A.R.2
  • 15
    • 33750010575 scopus 로고    scopus 로고
    • Plasma levels of basic fibroblast growth factor and vascular endothelial growth factor and their association with IgVH mutation status in patients with B-cell chronic lymphocytic leukemia
    • Smolej L., Andrys C., Peková S., Schwarz J., Belada D., Zák P. Plasma levels of basic fibroblast growth factor and vascular endothelial growth factor and their association with IgVH mutation status in patients with B-cell chronic lymphocytic leukemia. Haematologica 2006, 91:1432-1433.
    • (2006) Haematologica , vol.91 , pp. 1432-1433
    • Smolej, L.1    Andrys, C.2    Peková, S.3    Schwarz, J.4    Belada, D.5    Zák, P.6
  • 16
    • 1542503797 scopus 로고    scopus 로고
    • CD38 expression on B-cell chronic lymphocytic leukemic cells is strongly correlated with vascular endothelial growth factor expression
    • McCabe D., Bacon L., O'Regan K., Condron C., O'Donnell J.R., Murphy P.T. CD38 expression on B-cell chronic lymphocytic leukemic cells is strongly correlated with vascular endothelial growth factor expression. Leukemia 2004, 18:649-650.
    • (2004) Leukemia , vol.18 , pp. 649-650
    • McCabe, D.1    Bacon, L.2    O'Regan, K.3    Condron, C.4    O'Donnell, J.R.5    Murphy, P.T.6
  • 17
    • 33750057683 scopus 로고    scopus 로고
    • Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status
    • Huttmann A., Klein-Hitpass L., Thomale J., Deenen R., Carpinteiro A., Nückel H., et al. Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status. Leukemia 2006, 20:1774-1782.
    • (2006) Leukemia , vol.20 , pp. 1774-1782
    • Huttmann, A.1    Klein-Hitpass, L.2    Thomale, J.3    Deenen, R.4    Carpinteiro, A.5    Nückel, H.6
  • 18
    • 34249734364 scopus 로고    scopus 로고
    • Angiopoietin-2 expression in B-cell chronic lymphocytic leukemia: association with clinical outcome and immunoglobulin heavy-chain mutational status
    • Maffei R., Marasca R., Martinelli S., Castelli I., Santachiara R., Morandi E., et al. Angiopoietin-2 expression in B-cell chronic lymphocytic leukemia: association with clinical outcome and immunoglobulin heavy-chain mutational status. Leukemia 2007, 21:1312-1315.
    • (2007) Leukemia , vol.21 , pp. 1312-1315
    • Maffei, R.1    Marasca, R.2    Martinelli, S.3    Castelli, I.4    Santachiara, R.5    Morandi, E.6
  • 19
    • 0032705222 scopus 로고    scopus 로고
    • Increased serum levels of vascular endothelial growth factor predict risk of progression in early B-cell chronic lymphocytic leukaemia
    • Molica S., Vitelli G., Levato D., Gandolfo G.M., Liso V. Increased serum levels of vascular endothelial growth factor predict risk of progression in early B-cell chronic lymphocytic leukaemia. Br J Haematol 1999, 107:605-610.
    • (1999) Br J Haematol , vol.107 , pp. 605-610
    • Molica, S.1    Vitelli, G.2    Levato, D.3    Gandolfo, G.M.4    Liso, V.5
  • 20
    • 43149108875 scopus 로고    scopus 로고
    • Dysregulated angiogenesis in B-chronic lymphocytic leukemia: morphologic, immunohistochemical, and flow cytometric evidence
    • Frater J.L., Kay N.E., Goolsby C.L., Crawford S.E., Dewald G.W., Peterson L.C. Dysregulated angiogenesis in B-chronic lymphocytic leukemia: morphologic, immunohistochemical, and flow cytometric evidence. Diagn Pathol 2008, 3:16-43.
    • (2008) Diagn Pathol , vol.3 , pp. 16-43
    • Frater, J.L.1    Kay, N.E.2    Goolsby, C.L.3    Crawford, S.E.4    Dewald, G.W.5    Peterson, L.C.6
  • 21
    • 0036099930 scopus 로고    scopus 로고
    • B-CLL cells are capable of synthesis and secretion of both pro- and anti-angiogenic molecules
    • Kay N.E., Bone N.D., Tschumper R.C., Howell K.H., Geyer S.M., Dewald G.W., et al. B-CLL cells are capable of synthesis and secretion of both pro- and anti-angiogenic molecules. Leukemia 2002, 16:911-919.
    • (2002) Leukemia , vol.16 , pp. 911-919
    • Kay, N.E.1    Bone, N.D.2    Tschumper, R.C.3    Howell, K.H.4    Geyer, S.M.5    Dewald, G.W.6
  • 22
    • 1842478183 scopus 로고    scopus 로고
    • Hypoxic regulation of angiopoietin-2 expression in endothelial cells
    • Pichiule P., Chavez J.C., LaManna J.C. Hypoxic regulation of angiopoietin-2 expression in endothelial cells. J Biol Chem 2004, 279:12171-12180.
    • (2004) J Biol Chem , vol.279 , pp. 12171-12180
    • Pichiule, P.1    Chavez, J.C.2    LaManna, J.C.3
  • 23
    • 0032985888 scopus 로고    scopus 로고
    • Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells
    • Oh H., Takagi H., Suzuma K., Otani A., Matsumura M., Honda Y. Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells. J Biol Chem 1999, 274:15732-15739.
    • (1999) J Biol Chem , vol.274 , pp. 15732-15739
    • Oh, H.1    Takagi, H.2    Suzuma, K.3    Otani, A.4    Matsumura, M.5    Honda, Y.6
  • 24
    • 0032547764 scopus 로고    scopus 로고
    • Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia
    • Mandriota S.J., Pepper M.S. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Circ Res 1998, 83:852-859.
    • (1998) Circ Res , vol.83 , pp. 852-859
    • Mandriota, S.J.1    Pepper, M.S.2
  • 25
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment
    • Cheson B.D., Bennett J.M., Grever M., Kay N., Keating M.J., O'Brien S., et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996, 87:4990-4997.
    • (1996) Blood , vol.87 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, J.M.2    Grever, M.3    Kay, N.4    Keating, M.J.5    O'Brien, S.6
  • 26
    • 0019427092 scopus 로고
    • A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
    • Binet J.L., Auquier A., Dighiero G., Chastang C., Piguet H., Goasguen J., et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 1981, 48:198-206.
    • (1981) Cancer , vol.48 , pp. 198-206
    • Binet, J.L.1    Auquier, A.2    Dighiero, G.3    Chastang, C.4    Piguet, H.5    Goasguen, J.6
  • 27
    • 0035881887 scopus 로고    scopus 로고
    • Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis
    • Koga K., Todaka T., Morioka M., Hamada J., Kai Y., Yano S., et al. Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis. Cancer Res 2001, 61:6248-6254.
    • (2001) Cancer Res , vol.61 , pp. 6248-6254
    • Koga, K.1    Todaka, T.2    Morioka, M.3    Hamada, J.4    Kai, Y.5    Yano, S.6
  • 28
    • 34247117937 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducingangiopoietin-2 expression via AP-1 and Ets1
    • Ye F.C., Blackbourn D.J., Mengel M., Xie J.P., Qian L.W., Greene W., et al. Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducingangiopoietin-2 expression via AP-1 and Ets1. J Virol 2007, 81:3980-3991.
    • (2007) J Virol , vol.81 , pp. 3980-3991
    • Ye, F.C.1    Blackbourn, D.J.2    Mengel, M.3    Xie, J.P.4    Qian, L.W.5    Greene, W.6
  • 29
    • 0033902655 scopus 로고    scopus 로고
    • Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma
    • Brown L.F., Dezube B.J., Tognazzi K., Dvorak H.F., Yancopoulos G.D. Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. Am J Pathol 2000, 156:2179-2183.
    • (2000) Am J Pathol , vol.156 , pp. 2179-2183
    • Brown, L.F.1    Dezube, B.J.2    Tognazzi, K.3    Dvorak, H.F.4    Yancopoulos, G.D.5
  • 30
    • 0035180453 scopus 로고    scopus 로고
    • Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells
    • Yu Y., Varughese J., Brown L.F., Mulliken J.B., Bischoff J. Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells. Am J Pathol 2001, 159:2271-2280.
    • (2001) Am J Pathol , vol.159 , pp. 2271-2280
    • Yu, Y.1    Varughese, J.2    Brown, L.F.3    Mulliken, J.B.4    Bischoff, J.5
  • 31
    • 0032778530 scopus 로고    scopus 로고
    • Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features
    • Bunone G., Vigneri P., Mariani L., Butó S., Collini P., Pilotti S., et al. Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features. Am J Pathol 1999, 155:1967-1976.
    • (1999) Am J Pathol , vol.155 , pp. 1967-1976
    • Bunone, G.1    Vigneri, P.2    Mariani, L.3    Butó, S.4    Collini, P.5    Pilotti, S.6
  • 32
    • 0035266253 scopus 로고    scopus 로고
    • Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases
    • Etoh T., Inoue H., Tanaka S., Barnard G.F., Kitano S., Mori M. Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases. Cancer Res 2001, 61:2145-2153.
    • (2001) Cancer Res , vol.61 , pp. 2145-2153
    • Etoh, T.1    Inoue, H.2    Tanaka, S.3    Barnard, G.F.4    Kitano, S.5    Mori, M.6
  • 34
    • 20044371963 scopus 로고    scopus 로고
    • Analysis of concerted expression of angiogenic growth factors in acute myeloid leukemia: expression of angiopoietin-2 represents an independent prognostic factor for overall survival
    • Loges S., Heil G., Bruweleit M., Schoder V., Butzal M., Fischer U., et al. Analysis of concerted expression of angiogenic growth factors in acute myeloid leukemia: expression of angiopoietin-2 represents an independent prognostic factor for overall survival. J Clin Oncol 2005, 23:1109-1117.
    • (2005) J Clin Oncol , vol.23 , pp. 1109-1117
    • Loges, S.1    Heil, G.2    Bruweleit, M.3    Schoder, V.4    Butzal, M.5    Fischer, U.6
  • 35
    • 33748769772 scopus 로고    scopus 로고
    • Expression of angiopoietins and their receptor Tie2 in the bone marrow of patients with acute myeloid leukemia
    • Schliemann C., Bieker R., Padro T., Kessler T., Hintelmann H., Buchner T., et al. Expression of angiopoietins and their receptor Tie2 in the bone marrow of patients with acute myeloid leukemia. Haematologica 2006, 91:1203-1211.
    • (2006) Haematologica , vol.91 , pp. 1203-1211
    • Schliemann, C.1    Bieker, R.2    Padro, T.3    Kessler, T.4    Hintelmann, H.5    Buchner, T.6
  • 36
    • 0037311029 scopus 로고    scopus 로고
    • Expressions of vascular endothelial growth factor and angiopoietin-2 in myeloma cells
    • Uneda S., Matsuno F., Sonoki T., Tniguchi I., Kawano F., Hata H. Expressions of vascular endothelial growth factor and angiopoietin-2 in myeloma cells. Haematologica 2003, 88:113-115.
    • (2003) Haematologica , vol.88 , pp. 113-115
    • Uneda, S.1    Matsuno, F.2    Sonoki, T.3    Tniguchi, I.4    Kawano, F.5    Hata, H.6
  • 37
    • 0032843659 scopus 로고    scopus 로고
    • In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis
    • Zagzag D., Hooper A., Friedlander D.R., Chan W., Holash J., Wiegand S.J., et al. In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis. Exp Neurol 1999, 159:391-400.
    • (1999) Exp Neurol , vol.159 , pp. 391-400
    • Zagzag, D.1    Hooper, A.2    Friedlander, D.R.3    Chan, W.4    Holash, J.5    Wiegand, S.J.6
  • 38
    • 7944220649 scopus 로고    scopus 로고
    • Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2
    • Oliner J., Min H., Leal J., Yu D., Rao S., You E., et al. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 2004, 6:507-516.
    • (2004) Cancer Cell , vol.6 , pp. 507-516
    • Oliner, J.1    Min, H.2    Leal, J.3    Yu, D.4    Rao, S.5    You, E.6
  • 40
    • 33748761640 scopus 로고    scopus 로고
    • Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice
    • Perry B.N., Govindarajan B., Bhandarkar S.S., Knaus U.G., Valo M., Sturk C., et al. Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice. J Invest Dermatol 2006, 126:2316-2322.
    • (2006) J Invest Dermatol , vol.126 , pp. 2316-2322
    • Perry, B.N.1    Govindarajan, B.2    Bhandarkar, S.S.3    Knaus, U.G.4    Valo, M.5    Sturk, C.6
  • 41
    • 0034674583 scopus 로고    scopus 로고
    • Characterization and expression of a novel alternatively spliced human angiopoietin-2
    • Kim I., Kim J.H., Ryu Y.S., Jung S.H., Nah J.J., Koh G.Y. Characterization and expression of a novel alternatively spliced human angiopoietin-2. J Biol Chem 2000, 275:18550-18556.
    • (2000) J Biol Chem , vol.275 , pp. 18550-18556
    • Kim, I.1    Kim, J.H.2    Ryu, Y.S.3    Jung, S.H.4    Nah, J.J.5    Koh, G.Y.6
  • 42
    • 33746467198 scopus 로고    scopus 로고
    • Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer
    • Gu J., Yamamoto H., Ogawa M., Ngan C.Y., Danno K., Hemmi H., et al. Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer. Oncol Rep 2006, 15:779-783.
    • (2006) Oncol Rep , vol.15 , pp. 779-783
    • Gu, J.1    Yamamoto, H.2    Ogawa, M.3    Ngan, C.Y.4    Danno, K.5    Hemmi, H.6
  • 43
    • 0242408184 scopus 로고    scopus 로고
    • Angiopoietin switching regulates angiogenesis and progression of human hepatocellular carcinoma
    • Sugimachi K., Tanaka S., Taguchi K., Aishima S., Shimada M., Tsuneyoshi M. Angiopoietin switching regulates angiogenesis and progression of human hepatocellular carcinoma. J Clin Pathol 2003, 56:854-860.
    • (2003) J Clin Pathol , vol.56 , pp. 854-860
    • Sugimachi, K.1    Tanaka, S.2    Taguchi, K.3    Aishima, S.4    Shimada, M.5    Tsuneyoshi, M.6
  • 44
    • 0036899416 scopus 로고    scopus 로고
    • Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia
    • Currie M.J., Gunningham S.P., Turner K., Han C., Scott P.A., Robinson B.A., et al. Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia. J Pathol 2002, 198:502-510.
    • (2002) J Pathol , vol.198 , pp. 502-510
    • Currie, M.J.1    Gunningham, S.P.2    Turner, K.3    Han, C.4    Scott, P.A.5    Robinson, B.A.6
  • 45
    • 2542453735 scopus 로고    scopus 로고
    • The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
    • Fiedler U., Scharpfenecker M., Koidl S., Hegen A., Grunow V., Schmidt J.M., et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 2004, 103:4150-4156.
    • (2004) Blood , vol.103 , pp. 4150-4156
    • Fiedler, U.1    Scharpfenecker, M.2    Koidl, S.3    Hegen, A.4    Grunow, V.5    Schmidt, J.M.6
  • 46
    • 54049146968 scopus 로고    scopus 로고
    • The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1
    • Simon M.P., Tournaire R., Pouyssegur J. The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1. J Cell Physiol 2008, 217:809-818.
    • (2008) J Cell Physiol , vol.217 , pp. 809-818
    • Simon, M.P.1    Tournaire, R.2    Pouyssegur, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.