-
1
-
-
67650874081
-
Cancer statistics
-
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009;59(4):225-49
-
(2009)
CA Cancer J Clin 2009
, vol.59
, Issue.4
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
-
2
-
-
33748643613
-
Emerging drugs to replace current leaders in first-line therapy for breast cancer
-
Cox MC, Dan TD, Swain SM, et al. Emerging drugs to replace current leaders in first-line therapy for breast cancer. Expert Opin Emerg Drugs 2006;11:489-501
-
(2006)
Expert Opin Emerg Drugs
, vol.11
, pp. 489-501
-
-
Cox, M.C.1
Dan, T.D.2
Swain, S.M.3
-
3
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon DG, Godolphin W. Studies of the her-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-12 (Pubitemid 19147683)
-
(1989)
Science
, vol.244
, Issue.4905
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
Holt, J.A.4
Wong, S.G.5
Keith, D.E.6
Levin, W.J.7
Stuart, S.G.8
Udove, J.9
Ullrich, A.10
Press, M.F.11
-
4
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplitication of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplitication of the HER-2/neu oncogene. Science 1987;235:177-82
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
5
-
-
77953248475
-
Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: A collaborative analysis of data for 10159 cases from 12 studies
-
Blows FM, Driver KE, Schmidt MK, et al. Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies. PLoS Med 2010;7(5):e1000279
-
PLoS Med 2010
, vol.7
, Issue.5
-
-
Blows, F.M.1
Driver, K.E.2
Schmidt, M.K.3
-
6
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against her2 for metastatic breast cancer that overexpresses HER2
-
DOI 10.1056/NEJM200103153441101
-
Slamon DJ, Leyland-Jones B, Shak S. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344(11):783-92 (Pubitemid 32222155)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.11
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
Fleming, T.7
Eiermann, W.8
Wolter, J.9
Pegram, M.10
Baselga, J.11
Norton, L.12
-
7
-
-
36148961294
-
Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with/without trastuzumab in patients with HER2-positive breast cancer
-
abstract 512
-
Perez E, Romond E, Suman V, et al. Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with/without trastuzumab in patients with HER2-positive breast cancer. J Clin Oncol 2007;25(185):abstract 512
-
(2007)
J Clin Oncol
, vol.25
, pp. 185
-
-
Perez, E.1
Romond, E.2
Suman, V.3
-
8
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
DOI 10.1056/NEJMoa052306
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005;353(16):1659-72 (Pubitemid 41464705)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.16
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
Goldhirsch, A.4
Untch, M.5
Smith, I.6
Gianni, L.7
Baselga, J.8
Bell, R.9
Jackisch, C.10
Cameron, D.11
Dowsett, M.12
Barrios, C.H.13
Steger, G.14
Huang, C.-S.15
Andersson, M.16
Inbar, M.17
Lichinitser, M.18
Lang, I.19
Nitz, U.20
Iwata, H.21
Thomssen, C.22
Lohrisch, C.23
Suter, T.M.24
Ruschoff, J.25
Suto, T.26
Greatorex, V.27
Ward, C.28
Straehle, C.29
McFadden, E.30
Dolci, M.S.31
Gelber, R.D.32
more..
-
9
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
DOI 10.1056/NEJMoa052122
-
Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005;353(16):1673-84 (Pubitemid 41464706)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.16
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
Suman, V.J.4
Geyer Jr., C.E.5
Davidson, N.E.6
Tan-Chiu, E.7
Martino, S.8
Paik, S.9
Kaufman, P.A.10
Swain, S.M.11
Pisansky, T.M.12
Fehrenbacher, L.13
Kutteh, L.A.14
Vogel, V.G.15
Visscher, D.W.16
Yothers, G.17
Jenkins, R.B.18
Brown, A.M.19
Dakhil, S.R.20
Mamounas, E.P.21
Lingle, W.L.22
Klein, P.M.23
Ingle, J.N.24
Wolmark, N.25
more..
-
10
-
-
34248658992
-
BCIRG 006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab with docetaxel carboplatin and trastuzumab in Her2neu positive early breast cancer patients [abstract 52]
-
Slamon D, Eiermann W, Robert N, et al. BCIRG 006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab with docetaxel, carboplatin and trastuzumab in Her2neu positive early breast cancer patients [abstract 52]. 29th Annual San Antonio Breast Cancer Symposium; 2006
-
(2006)
29th Annual San Antonio Breast Cancer Symposium
-
-
Slamon, D.1
Eiermann, W.2
Robert, N.3
-
11
-
-
77957300459
-
Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC-T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC-TH) with docetaxel carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients: BCIRG 006 study [abstract 62]
-
Slamon D, Eiermann W, Robert N, et al. Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC-T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC-TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients: BCIRG 006 study [abstract 62]. 32nd Annual SanAntonio Breast Cancer Symposium; 2009
-
(2009)
32nd Annual SanAntonio Breast Cancer Symposium
-
-
Slamon, D.1
Eiermann, W.2
Robert, N.3
-
12
-
-
33645720799
-
Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC-T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC-TH) with docetaxel carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients: BCIRG 006 study [abstract 1]
-
Slamon D, Eiermann W, Robert N, et al. Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC-T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC-TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients: BCIRG 006 study [abstract 1]. 28th Annual San Antonio Breast Cancer Symposium; 2005
-
(2005)
28th Annual San Antonio Breast Cancer Symposium
-
-
Slamon, D.1
Eiermann, W.2
Robert, N.3
-
13
-
-
33344478381
-
Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
-
DOI 10.1056/NEJMoa053028
-
Joensuu H, Kellokumpu-Lehtinen PL, Bono P, et al. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med 2006;354(8):809-20 (Pubitemid 43290919)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.8
, pp. 809-820
-
-
Joensuu, H.1
Kellokumpu-Lehtinen, P.-L.2
Bono, P.3
Alanko, T.4
Kataja, V.5
Asola, R.6
Utriainen, T.7
Kokko, R.8
Hemminki, A.9
Tarkkanen, M.10
Turpeenniemi-Hujanen, T.11
Jyrkkio, S.12
Flander, M.13
Helle, L.14
Ingalsuo, S.15
Johansson, K.16
Jaaskelainen, A.-S.17
Pajunen, M.18
Rauhala, M.19
Kaleva-Kerola, J.20
Salminen, T.21
Leinonen, M.22
Elomaa, I.23
Isola, J.24
more..
-
14
-
-
33845914783
-
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: A randomised controlled trial
-
DOI 10.1016/S0140-6736(07)60028-2, PII S0140673607600282
-
Smith I, Procter M, Gelber RD, et al. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 2007;369(9555):29-36 (Pubitemid 46039831)
-
(2007)
Lancet
, vol.369
, Issue.9555
, pp. 29-36
-
-
Smith, I.1
Procter, M.2
Gelber, R.D.3
Guillaume, S.4
Feyereislova, A.5
Dowsett, M.6
Goldhirsch, A.7
Untch, M.8
Mariani, G.9
Baselga, J.10
Kaufmann, M.11
Cameron, D.12
Bell, R.13
Bergh, J.14
Coleman, R.15
Wardley, A.16
Harbeck, N.17
Lopez, R.I.18
Mallmann, P.19
Gelmon, K.20
Wilcken, N.21
Wist, E.22
Sanchez Rovira, P.23
Piccart-Gebhart, M.J.24
more..
-
16
-
-
84901290217
-
FDA drug approval summary: Lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses HER-2
-
Ryan Q, Ibrahim A, Cohen MH, et al. FDA drug approval summary: Lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses HER-2. Oncologist 2008;13:1114-19
-
(2008)
Oncologist
, vol.13
, pp. 1114-1119
-
-
Ryan, Q.1
Ibrahim, A.2
Cohen, M.H.3
-
17
-
-
0032915392
-
Epidermal growth factor receptors: Critical mediators of multiple receptor pathways
-
DOI 10.1016/S0955-0674(99)80024-6
-
Hackel PO, Zwick E, Prenzel N, et al. Epidermal growth factor receptors: critical mediators of multiple receptor pathways. Curr Opin Cell Biol 1999;11:184-9 (Pubitemid 29164032)
-
(1999)
Current Opinion in Cell Biology
, vol.11
, Issue.2
, pp. 184-189
-
-
Hackel, P.O.1
Zwick, E.2
Prenzel, N.3
Ullrich, A.4
-
18
-
-
4544341724
-
Small molecule tyrosine kinase inhibitors
-
Lin NU, Winer EP. Small molecule tyrosine kinase inhibitors. Breast Cancer Res 2004;6:204-10
-
(2004)
Breast Cancer Res
, vol.6
, pp. 204-210
-
-
Lin, N.U.1
Winer, E.P.2
-
19
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
-
DOI 10.1093/emboj/16.7.1647
-
Graus-Porta D, Beerli RR, Daly JM, et al. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 1997;16:1647-55 (Pubitemid 27151960)
-
(1997)
EMBO Journal
, vol.16
, Issue.7
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
Hynes, N.E.4
-
20
-
-
70350204423
-
Efficacy results from the ToGA trial: A Phase III study of trastuzumab added to standard chemotherapy (CT) in first-line human epidermal growth factor receptor 2 (HER2) positive advanced gastric cacner (GC)
-
(15S):LBA astract 4509
-
Van Cutsem E, Kan Y, Chung A, et al. Efficacy results from the ToGA trial: a Phase III study of trastuzumab added to standard chemotherapy (CT) in first-line human epidermal growth factor receptor 2 (HER2) positive advanced gastric cacner (GC). J Clin Oncol 2009;27(15S):LBA astract 4509
-
(2009)
J Clin Oncol
, vol.27
-
-
Van Cutsem, E.1
Kan, Y.2
Chung, A.3
-
21
-
-
77954031486
-
Phase i study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer
-
Krop IE, Beeram M, Modi S, et al. Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. J Clin Oncol 2010;28(16):2698-704
-
J Clin Oncol 2010
, vol.28
, Issue.16
, pp. 2698-2704
-
-
Krop, I.E.1
Beeram, M.2
Modi, S.3
-
22
-
-
77949901499
-
Open-label, phase II, multicenter, randomized study of the efficacy and safety of two dose levels of pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer
-
Gianni L, Llado A, Bianchi G, et al. Open-label, phase II, multicenter, randomized study of the efficacy and safety of two dose levels of pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 2010;28(7):1131-7
-
J Clin Oncol 2010
, vol.28
, Issue.7
, pp. 1131-1137
-
-
Gianni, L.1
Llado, A.2
Bianchi, G.3
-
23
-
-
77949903478
-
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
-
Baselga J, Gelmon KA, Verma S, et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol 2010;28(7):1138-44
-
J Clin Oncol 2010
, vol.28
, Issue.7
, pp. 1138-1144
-
-
Baselga, J.1
Gelmon, K.A.2
Verma, S.3
-
24
-
-
24644458654
-
FDA drug approval summary: Erlotinib (tarceva) tablets
-
Cohen MH, Johnson JR, Chen YF, et al. FDA drug approval summary: Erlotinib (tarceva) tablets. Oncologist 2005;10:461-6
-
(2005)
Oncologist
, vol.10
, pp. 461-466
-
-
Cohen, M.H.1
Johnson, J.R.2
Chen, Y.F.3
-
25
-
-
25444522497
-
Systemic therapy for pancreatic cancer
-
Ko AH, Tempero MA. Systemic therapy for pancreatic cancer. Semin in Rad Oncol 2005;15:245-53
-
(2005)
Semin in Rad Oncol
, vol.15
, pp. 245-253
-
-
Ko, A.H.1
Tempero, M.A.2
-
26
-
-
77950497981
-
Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer
-
Burstein HJ, Sun Y, Dirix LY, et al. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer. J Clin Oncol 2010;28(8):1301-7
-
J Clin Oncol 2010
, vol.28
, Issue.8
, pp. 1301-1307
-
-
Burstein, H.J.1
Sun, Y.2
Dirix, L.Y.3
-
27
-
-
0035553174
-
The effects of the novel, reversible epidermal growth factor receptor/EbrB-2 tyrosine kinase inhibitor, GW2016, on the growth, of human normal and tumor-derived cells lines in vitro and in vivo
-
Rusnak DW, Lackey K, Affleck K, et al. The effects of the novel, reversible epidermal growth factor receptor/EbrB-2 tyrosine kinase inhibitor, GW2016, on the growth, of human normal and tumor-derived cells lines in vitro and in vivo. Mol Cancer Ther 2001;1:85-94
-
(2001)
Mol Cancer Ther
, vol.1
, pp. 85-94
-
-
Rusnak, D.W.1
Lackey, K.2
Affleck, K.3
-
28
-
-
20244388653
-
Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies
-
DOI 10.1200/JCO.2005.12.157
-
Spector NL, Xia W, Burris H, et al. Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. J Clin Oncol 2005;23(11):2502-12 (Pubitemid 47050840)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.11
, pp. 2502-2512
-
-
Spector, N.L.1
Xia, W.2
Burris III, H.3
Hurwitz, H.4
Dees, E.C.5
Dowlati, A.6
O'Neil, B.7
Overmoyer, B.8
Marcom, P.K.9
Blackwell, K.L.10
Smith, D.A.11
Koch, K.M.12
Stead, A.13
Mangum, S.14
Ellis, M.J.15
Liu, L.16
Man, A.K.17
Bremer, T.M.18
Harris, J.19
Bacus, S.20
more..
-
29
-
-
0037068741
-
Antitumor activity of GW572016: A dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
-
Xia W, Mullin RJ, Keith BR, et al. Antitumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene 2002;21:6255-63
-
(2002)
Oncogene
, vol.21
, pp. 6255-6263
-
-
Xia, W.1
Mullin, R.J.2
Keith, B.R.3
-
30
-
-
32944461545
-
Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
-
DOI 10.1158/0008-5472.CAN-05-1182
-
Konecny G, Pegram MD, Venkatesan N, et al. Activity of the dual kinase inhibitor lapatinib againse HER-2 overexpressing and trastuzumab-treated breast cancer cells. Cancer Res 2006;66:1630-9 (Pubitemid 43259947)
-
(2006)
Cancer Research
, vol.66
, Issue.3
, pp. 1630-1639
-
-
Konecny, G.E.1
Pegram, M.D.2
Venkatesan, N.3
Finn, R.4
Yang, G.5
Rahmeh, M.6
Untch, M.7
Rusnak, D.W.8
Spehar, G.9
Mullin, R.J.10
Keith, B.R.11
Gilmer, T.M.12
Berger, M.13
Podratz, K.C.14
Slamon, D.J.15
-
31
-
-
20844437246
-
Phase i pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects
-
Bence AK, Andersen EB, Halepota MA, et al. Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects. Invest New Drugs 2005;23:39-49
-
(2005)
Invest New Drugs
, vol.23
, pp. 39-49
-
-
Bence, A.K.1
Andersen, E.B.2
Halepota, M.A.3
-
32
-
-
23944476155
-
Phase i safety, pharmakokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
-
Burris HA, Hurwitz HI, Dees EC, et al. Phase I safety, pharmakokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J Clin Oncol 2005;23(23):5305-13
-
(2005)
J Clin Oncol
, vol.23
, Issue.23
, pp. 5305-5313
-
-
Burris, H.A.1
Hurwitz, H.I.2
Dees, E.C.3
-
33
-
-
0141819721
-
A phase i study of GW572016 in patients with solid tumors
-
abstract 994
-
Burris HA, Taylor C, Jones S, et al. A phase I study of GW572016 in patients with solid tumors. Proc Am Soc Clin Oncol 2003;22(258):abstract 994
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 258
-
-
Burris, H.A.1
Taylor, C.2
Jones, S.3
-
34
-
-
34548222618
-
Lapatinib-associated toxicity and practical management recommendations
-
DOI 10.1634/theoncologist.12-7-756
-
Moy B, Goss PE. Lapatinib associated toxicity and practical management recommendations. Oncologist 2007;12:756-65 (Pubitemid 47328219)
-
(2007)
Oncologist
, vol.12
, Issue.7
, pp. 756-765
-
-
Moy, B.1
Goss, P.E.2
-
35
-
-
44849108294
-
A phase II study of lapatinib monotherapy in chemotherapy-refractory HER2-positive and HER2-negative advanced or metastatic breast cancer
-
DOI 10.1093/annonc/mdm601
-
Burstein HJ, Storniolo AM, Franco S, et al. A phase II study of lapatinib monotherapy in chemotherapy-refractory HER2-positive and HER2-negative advanced or metastatic breast cancer. Ann Oncol 2008;19:1068-74 (Pubitemid 351796331)
-
(2008)
Annals of Oncology
, vol.19
, Issue.6
, pp. 1068-1074
-
-
Burstein, H.J.1
Storniolo, A.M.2
Franco, S.3
Forster, J.4
Stein, S.5
Rubin, S.6
Salazar, V.M.7
Blackwell, K.L.8
-
36
-
-
46449113024
-
Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer
-
Gomez HL, Doval DC, Chavez MA, et al. Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol 2008;26(18):2999-3005
-
(2008)
J Clin Oncol
, vol.26
, Issue.18
, pp. 2999-3005
-
-
Gomez, H.L.1
Doval, D.C.2
Chavez, M.A.3
-
37
-
-
61649118623
-
Single-agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first- or second-line trastuzumab-containing regimens
-
Blackwell KL, Pegram MD, Tan-Chiu E, et al. Single-agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first- or second-line trastuzumab-containing regimens. Ann Oncol 2009;20:1026-31
-
(2009)
Ann Oncol
, vol.20
, pp. 1026-1031
-
-
Blackwell, K.L.1
Pegram, M.D.2
Tan-Chiu, E.3
-
38
-
-
23844505880
-
Pharmakokinetics of GW572016 in an ascending dose tolerability study of phase i cancer patients
-
Koch KM, Lee D, Mangum S, et al. Pharmakokinetics of GW572016 in an ascending dose tolerability study of phase I cancer patients. Eur J Cancer 2003;1(Suppl 5):559A
-
(2003)
Eur J Cancer
, vol.1
, Issue.SUPPL. 5
-
-
Koch, K.M.1
Lee, D.2
Mangum, S.3
-
39
-
-
66149093901
-
Lapatinib monotherapy in patients with HER-2 overexpressing relapsed or refractory inflammatory breast cancer: Final results and survival of the expanded HER2+ cohort in EGF103009, a phase II study
-
Kaufman B, Trudeau M, Awada A, et al. Lapatinib monotherapy in patients with HER-2 overexpressing relapsed or refractory inflammatory breast cancer: final results and survival of the expanded HER2+ cohort in EGF103009, a phase II study. Lancet Oncol 2009;10:581-8
-
(2009)
Lancet Oncol
, vol.10
, pp. 581-588
-
-
Kaufman, B.1
Trudeau, M.2
Awada, A.3
-
40
-
-
0037301972
-
Survival of patients with metastatic breast carcinoma: Importance of prognostic markers of the primary tumor
-
DOI 10.1002/cncr.11083
-
Chang J, Clark GM, Allred DC, et al. Survival of patients with metastatic breast carcinoma: importance of prognostic markers of the primary tumor. Cancer 2003;97(545):553 (Pubitemid 36125831)
-
(2003)
Cancer
, vol.97
, Issue.3
, pp. 545-553
-
-
Chang, J.1
Clark, G.M.2
Allred, D.C.3
Mohsin, S.4
Chamness, G.5
Elledge, R.M.6
-
41
-
-
33646869874
-
Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG)
-
DOI 10.1093/annonc/mdl064
-
Pestalozzi BC, Zahrieh D, Price KN, et al. Identifying breast cancer patients at risk for central nervous system (CNS) metastases in trials of the international breast cancer study group (IBCSG). Ann Oncol 2006;17:935-44 (Pubitemid 43778983)
-
(2006)
Annals of Oncology
, vol.17
, Issue.6
, pp. 935-944
-
-
Pestalozzi, B.C.1
Zahrieh, D.2
Price, K.N.3
Holmberg, S.B.4
Lindtner, J.5
Collins, J.6
Crivellari, D.7
Fey, M.F.8
Murray, E.9
Pagani, O.10
Simoncini, E.11
Castiglione-Gertsch, M.12
Gelber, R.D.13
Coates, A.S.14
Goldhirsch, A.15
-
42
-
-
0037270804
-
Intra-arterial carboplatin and intravenous etoposide for the treatment of mtastatic brain tumors
-
DOI 10.1023/A:1021218207015
-
Newton HB, Slivka MA, Volpi C, et al. Intra-arterial carboplatin and intravenous etoposide for the treatment of metastatic brain tumors. J Neurooncol 2006;24:5658-63 (Pubitemid 36187642)
-
(2003)
Journal of Neuro-Oncology
, vol.61
, Issue.1
, pp. 35-44
-
-
Newton, H.B.1
Slivka, M.A.2
Volpi, C.3
Bourekas, E.C.4
Christoforidis, G.A.5
Baujan, M.A.6
Slone, W.7
Chakeres, D.W.8
-
43
-
-
26244462371
-
Breast cancer metastasis to the central nervous system
-
Weil RJ, Palmieri DC, Bronder JL, et al. Breast cancer metastasis to the central nervous system. Am J Pathol 2005;176:913-20 (Pubitemid 41416243)
-
(2005)
American Journal of Pathology
, vol.167
, Issue.4
, pp. 913-920
-
-
Weil, R.J.1
Palmieri, D.C.2
Bronder, J.L.3
Stark, A.M.4
Steeg, P.S.5
-
44
-
-
34250174543
-
Brain metastases: The HER2 paradigm
-
Lin NU, Winer EP. Brain metastases: the HER2 paradigm. Clin Cancer Res 2007;13:1648-55
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1648-1655
-
-
Lin, N.U.1
Winer, E.P.2
-
45
-
-
15744372470
-
Survival after brain metastases from breast cancer in the trastuzumab era [13]
-
DOI 10.1200/JCO.2005.05.249
-
Kirsch DG, Ledezma CJ, Mathews CS, et al. Survival after brain metastases from breast cancer in the trastuzumab era. J Clin Oncol 2005;23:2114-16 (Pubitemid 46211402)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.9
, pp. 2114-2116
-
-
Kirsch, D.G.1
Ledezma, C.J.2
Mathews, C.S.3
Bhan, A.K.4
Ancukiewicz, M.5
Hochberg, F.H.6
Loeffler, J.S.7
-
46
-
-
77954251392
-
Prognostic factors of survival in the trastuzumab era among women with breast cancer and brain metastases who receive whole brain radiotherapy: A single-institution review
-
Dawood S, Gonzalez-Angulo AM, Albarracin C, et al. Prognostic factors of survival in the trastuzumab era among women with breast cancer and brain metastases who receive whole brain radiotherapy: a single-institution review. Cancer 2010;116(13):3084-92
-
(2010)
Cancer
, vol.116
, Issue.13
, pp. 3084-3092
-
-
Dawood, S.1
Gonzalez-Angulo, A.M.2
Albarracin, C.3
-
47
-
-
78650443450
-
The role of systemic treatment after whole brain radiotherapy (WBRT) in breast cancer patients with brain metastases: Differences depending on biological sybtype
-
(15S):abstract #1027
-
Niwinska A, Murawska M, Lemanska I, et al. The role of systemic treatment after whole brain radiotherapy (WBRT) in breast cancer patients with brain metastases: differences depending on biological sybtype. J Clin Oncol 2009;27(15S):abstract #1027
-
(2009)
J Clin Oncol
, vol.27
-
-
Niwinska, A.1
Murawska, M.2
Lemanska, I.3
-
48
-
-
4143110253
-
Gefitinib in patients with brain metastasesfrom non-small-cell lung cancer: A prospective trial
-
DOI 10.1093/annonc/mdh276
-
Ceresoli GL, Cappuzzo F, Gregorc V, et al. Gefitinib in patients with brain metastases from non small cell lung cancer: a prospective trial. Ann Oncol 2004;15:1042-7 (Pubitemid 39089780)
-
(2004)
Annals of Oncology
, vol.15
, Issue.7
, pp. 1042-1047
-
-
Ceresoli, G.L.1
Cappuzzo, F.2
Gregorc, V.3
Bartolini, S.4
Crino, L.5
Villa, E.6
-
49
-
-
0347319031
-
Quality-of-life benefits and evidence of antitumour activity for patients with brain metastases treated with gefitinib
-
Katz A, Zalewski P. Quality of life benefits and evidence of antitumor activity for patients with brain metastases treated with gefitinib. Br J Cancer 2003;89:s15-18 (Pubitemid 38068005)
-
(2003)
British Journal of Cancer
, vol.89
, Issue.SUPPL. 2
-
-
Katz, A.1
Zalewski, P.2
-
50
-
-
42949112556
-
Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer
-
Lin NU, Carey LA, Liu MC, et al. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 2008;26(12):1993-9
-
(2008)
J Clin Oncol
, vol.26
, Issue.12
, pp. 1993-1999
-
-
Lin, N.U.1
Carey, L.A.2
Liu, M.C.3
-
51
-
-
63149110733
-
Multicenter phase II study of lapatinib in patietns with brain metastases from HER2-positive breast cancer
-
Lin NU, Dietas V, Paul D, et al. Multicenter phase II study of lapatinib in patietns with brain metastases from HER2-positive breast cancer. Clin Cancer Res 2009;15(4):1452-9
-
(2009)
Clin Cancer Res
, vol.15
, Issue.4
, pp. 1452-1459
-
-
Lin, N.U.1
Dietas, V.2
Paul, D.3
-
52
-
-
33747089049
-
Phase i clinical, biology, and pharmacokinetic study of the combination of GW572016 and capecitabine in patients with advanced solid tumors
-
Schwartz G, Chu QS, Hammond LA, et al. Phase I clinical, biology, and pharmacokinetic study of the combination of GW572016 and capecitabine in patients with advanced solid tumors. Proc Am Soc Clin Oncol 2004;23(Suppl 14):212
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, Issue.SUPPL. 14
, pp. 212
-
-
Schwartz, G.1
Chu, Q.S.2
Hammond, L.A.3
-
53
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
DOI 10.1056/NEJMoa064320
-
Geyer VE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006;355(26):2733-43 (Pubitemid 46021510)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.26
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
Chan, S.4
Romieu, C.G.5
Pienkowski, T.6
Jagiello-Gruszfeld, A.7
Crown, J.8
Chan, A.9
Kaufman, B.10
Skarlos, D.11
Campone, M.12
Davidson, N.13
Berger, M.14
Oliva, C.15
Rubin, S.D.16
Stein, S.17
Cameron, D.18
-
54
-
-
77957771125
-
Lapatinib plus capecitabine in women with HER-2-positive advanced breast cancer: Final survival analysis of a phase III randomized trial
-
Cameron D, Casey M, Oliva C, et al. Lapatinib plus capecitabine in women with HER-2-positive advanced breast cancer: final survival analysis of a phase III randomized trial. Oncologist 2010;15(9):924-34
-
(2010)
Oncologist
, vol.15
, Issue.9
, pp. 924-934
-
-
Cameron, D.1
Casey, M.2
Oliva, C.3
-
55
-
-
56549113680
-
A phase III randomized comparison of lapatinib plus capecitabine versus capcitabine alone in women with advanced breast cancer that has progressed on trastuzumab: Updated efficacy and biomarker analyses
-
Cameron D, Casey M, Press M, et al. A phase III randomized comparison of lapatinib plus capecitabine versus capcitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat 2008;112:533-43
-
(2008)
Breast Cancer Res Treat
, vol.112
, pp. 533-543
-
-
Cameron, D.1
Casey, M.2
Press, M.3
-
56
-
-
77949540771
-
An open-label expanded access study of lapatinib and capecitabine in patients with HER2-overexpressing locally advanced or metastatic breast cancer
-
Capri G, Chang J, Chen SC, et al. An open-label expanded access study of lapatinib and capecitabine in patients with HER2-overexpressing locally advanced or metastatic breast cancer. Ann Oncol 2010;21:474-80
-
Ann Oncol
, vol.2010
, Issue.21
, pp. 474-480
-
-
Capri, G.1
Chang, J.2
Chen, S.C.3
-
57
-
-
77949542447
-
Treatment of HER2-positive metastatic breat cancer with lapatinib and capecitabine in the lapatinib expanded access programme, including efficacy in brain metastases - the UK experience
-
Sutherland S, Ashley S, Miles D, et al. Treatment of HER2-positive metastatic breat cancer with lapatinib and capecitabine in the lapatinib expanded access programme, including efficacy in brain metastases - the UK experience. Br J Cancer 2010;102:995-1002
-
Br J Cancer
, vol.2010
, Issue.102
, pp. 995-1002
-
-
Sutherland, S.1
Ashley, S.2
Miles, D.3
-
58
-
-
70349912269
-
Lapatinib plus capecitabine versus capecitabine alone for HER2+ (ErbB2+) metastatic breast cancer: Quality-of-life assessment
-
Zhou X, Cella D, Cameron D, et al. Lapatinib plus capecitabine versus capecitabine alone for HER2+ (ErbB2+) metastatic breast cancer: quality-of-life assessment. Breast Cancer Res Treat 2009;117:577-89
-
(2009)
Breast Cancer Res Treat
, vol.117
, pp. 577-589
-
-
Zhou, X.1
Cella, D.2
Cameron, D.3
-
59
-
-
50249188726
-
Q-TWiST analysis of lapatinib combined with capecitabine for the treatment of metastatic breast cancer
-
Sherrill B, Amonkar MM, Stein S, et al. Q-TWiST analysis of lapatinib combined with capecitabine for the treatment of metastatic breast cancer. Br J Cancer 2008;99:711-15
-
(2008)
Br J Cancer
, vol.99
, pp. 711-715
-
-
Sherrill, B.1
Amonkar, M.M.2
Stein, S.3
-
60
-
-
57149096463
-
Phase III, double-blind, tandomized study compating lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer
-
Di Leo A, Gomez HL, Aziz Z, et al. Phase III, double-blind, tandomized study compating lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer. J Clin Oncol 2008;26(34):5544-52
-
(2008)
J Clin Oncol
, vol.26
, Issue.34
, pp. 5544-5552
-
-
Di Leo, A.1
Gomez, H.L.2
Aziz, Z.3
-
61
-
-
78650443019
-
Safety and tolerability of lapatinib in combination with taxanes (T) in patients with breast cancer
-
(38S):abstract #1027
-
Crown JP, Burris III HA, Yardley DA, et al. Safety and tolerability of lapatinib in combination with taxanes (T) in patients with breast cancer. J Clin Endocrinol Metab 2007;25(38S):abstract #1027
-
(2007)
J Clin Endocrinol Metab
, vol.25
-
-
Crown, J.P.1
Burris Iii, H.A.2
Yardley, D.A.3
-
62
-
-
69849105168
-
Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic breast cancer
-
Finn RS, Press MF, Dering J, et al. Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic breast cancer. J Clin Oncol 2009;27(24):3908-15
-
(2009)
J Clin Oncol
, vol.27
, Issue.24
, pp. 3908-3915
-
-
Finn, R.S.1
Press, M.F.2
Dering, J.3
-
63
-
-
59449088659
-
Evaluation fo lapatinib and topotecan combination therapy: Tissue culture, murine xenograft, and phase i clinical trial data
-
Molina JR, Kaufmann SH, Reid JM, et al. Evaluation fo lapatinib and topotecan combination therapy: tissue culture, murine xenograft, and phase I clinical trial data. Clin Cancer Res 2008;14(23):7900-8
-
(2008)
Clin Cancer Res
, vol.14
, Issue.23
, pp. 7900-7908
-
-
Molina, J.R.1
Kaufmann, S.H.2
Reid, J.M.3
-
64
-
-
51549101729
-
A phase i and pharmacokinetic study of lapatinib in combination with letrozole in patients with advanced cancer
-
Chu QSC, Cianfrocca ME, Goldstein LJ, et al. A phase I and pharmacokinetic study of lapatinib in combination with letrozole in patients with advanced cancer. Clin Cancer Res 2008;14(14):4484-90
-
(2008)
Clin Cancer Res
, vol.14
, Issue.14
, pp. 4484-490
-
-
Chu, Q.S.C.1
Cianfrocca, M.E.2
Goldstein, L.J.3
-
65
-
-
73149115341
-
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
-
Johnston S, Pippen J, Picot X, et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 2009;27(33):5538-46
-
(2009)
J Clin Oncol
, vol.27
, Issue.33
, pp. 5538-5546
-
-
Johnston, S.1
Pippen, J.2
Picot, X.3
-
66
-
-
77649100030
-
Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer
-
Schwartzberg LS, Franco SX, Florance A, et al. Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer. Oncologist 2010;15:122-9
-
Oncologist
, vol.2010
, Issue.15
, pp. 122-129
-
-
Schwartzberg, L.S.1
Franco, S.X.2
Florance, A.3
-
67
-
-
49149084837
-
Phase i dose escalation and pharmacokinetic study of lapatinib in combination with trastuzumab in patients with advanced ErbB2-positive breast cancer
-
Storniolo AM, Pegram MD, Overmoyer B, et al. Phase I dose escalation and pharmacokinetic study of lapatinib in combination with trastuzumab in patients with advanced ErbB2-positive breast cancer. J Clin Oncol 2008;26(20):3317-23
-
(2008)
J Clin Oncol
, vol.26
, Issue.20
, pp. 3317-3323
-
-
Storniolo, A.M.1
Pegram, M.D.2
Overmoyer, B.3
-
68
-
-
77949884661
-
Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzuman-refractory metastatic breast cancer
-
Blackwell KL, Burstein HJ, Storniolo AM, et al. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzuman-refractory metastatic breast cancer. J Clin Oncol 2010;28(7):1124-30
-
(2010)
J Clin Oncol
, vol.28
, Issue.7
, pp. 1124-1130
-
-
Blackwell, K.L.1
Burstein, H.J.2
Storniolo, A.M.3
-
69
-
-
65349110371
-
Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A German Breast Group 26/Breast International Group 03-05 Study
-
von Minckwitz G, du Bois A, Schmidt M, et al. Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a German Breast Group 26/Breast International Group 03-05 Study. J Clin Oncol 2009;27(12):1999-2006
-
(2009)
J Clin Oncol
, vol.27
, Issue.12
, pp. 1999-2006
-
-
Von Minckwitz, G.1
Du Bois, A.2
Schmidt, M.3
-
70
-
-
44049100934
-
Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
-
Li X, Lewis M, Huang J, et al. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst 2008;100(9):672-9
-
(2008)
J Natl Cancer Inst
, vol.100
, Issue.9
, pp. 672-679
-
-
Li, X.1
Lewis, M.2
Huang, J.3
|