Macrophage activity in semen is significantly correlated with sperm quality in infertile men

International Journal of Andrology

Volumn 33, Issue 6, 2010, Pages 823-831

  Tremellen, K ^a,b   Tunc, O ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b Repromed   (Australia)

Author keywords

DNA; Elastase; Leucocyte; Macrophage; Neopterin; Sperm

Indexed keywords

CD45 ANTIGEN; LEUKOCYTE ELASTASE; MALONALDEHYDE; NEOPTERIN; REACTIVE OXYGEN METABOLITE;

ADULT; APOPTOSIS; ARTICLE; CELL ACTIVITY; CELL STRUCTURE; CONTROLLED STUDY; DNA FRAGMENTATION; EPIDIDYMIS; HUMAN; LIPID PEROXIDATION; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MALE GENITAL TRACT PARAMETERS; MALE INFERTILITY; OXIDATIVE STRESS; PRIORITY JOURNAL; SEMEN VOLUME; SEMINAL PLASMA; SPERM; SPERM QUALITY; SPERMATOZOON DENSITY; SPERMATOZOON MORPHOLOGY; SPERMATOZOON MOTILITY;

ADULT; APOPTOSIS; BIOLOGICAL MARKERS; DNA FRAGMENTATION; HUMANS; INFERTILITY, MALE; LEUKOCYTES; MACROPHAGES; MALE; NEOPTERIN; SEMEN; SPERMATOZOA;

EID: 78650488283     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2009.01037.x     Document Type: Article

References (55)

1. Aitken RJ & Baker HW. (1995) Seminal leukocytes: passengers, terrorists or good samaritans? Hum Reprod 10, 1736-1739.
2. Aitken RJ, Buckingham DW, Brindle J, Gomez E, Baker HW & Irvine DS. (1995) Analysis of sperm movement in relation to the oxidative stress created by leukocytes in washed sperm preparations and seminal plasma. Hum Reprod 10, 2061-2071.
3. Anderson D.J. (1990) Immunology of the Male Reproductive Tract: Implication for the Sexual Transmission of Human Immunodeficiency Virus. Oxford University Press, New York.
4. Barratt CL, Bolton AE & Cooke ID. (1990) Functional significance of white blood cells in the male and female reproductive tract. Hum Reprod 5, 639-648.
5. Benchaib M, Braun V, Lornage J, Hadj S, Salle B, Lejeune H & Guerin JF. (2003) Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique. Hum Reprod 18, 1023-1028.
6. Berdowska A & Zwirska-Korczala K. (2001) Neopterin measurement in clinical diagnosis. J Clin Pharm Ther 26, 319-329.
7. Berger RE, Karp LE, Williamson RA, Koehler J, Moore DE & Holmes KK. (1982) The relationship of pyospermia and seminal fluid bacteriology to sperm function as reflected in the sperm penetration assay. Fertil Steril 37, 557-564.
8. Bize I, Santander G, Cabello P, Driscoll D & Sharpe C. (1991) Hydrogen peroxide is involved in hamster sperm capacitation in vitro. Biol Reprod 44, 398-403.
9. Comhaire F, Zalata A, Mahmoud A, Depoorter B, Huysse L, Christophe A & Depuydt C. (1995) Diagnostic and therapeutic approach to moderate and severe male subfertility in 1995. Hum Reprod 10(Suppl. 1), 144-150.
10. Dominguez-Fandos D, Camejo MI, Ballesca JL & Oliva R. (2007) Human sperm DNA fragmentation: correlation of TUNEL results as assessed by flow cytometry and optical microscopy. Cytometry Part A 71, 1011-1018.
11. Eggert-Kruse W, Bellmann A, Rohr G, Tilgen W & Runnebaum B. (1992) Differentiation of round cells in semen by means of monoclonal antibodies and relationship with male fertility. Fertil Steril 58, 1046-1055.
12. Eggert-Kruse W, Rohr G, Demirakca T, Rusu R, Naher H, Petzoldt D & Runnebaum B. (1997) Chlamydial serology in 1303 asymptomatic subfertile couples. Hum Reprod 12, 1464-1475.
13. Eggert-Kruse W, Zimmermann K, Geissler W, Ehrmann A, Boit R & Strowitzki T. (2009) Clinical relevance of polymorphonuclear (PMN-) elastase determination in semen and serum during infertility investigation. Int J Androl 32, 317-329.
14. Esfandiari N, Sharma RK, Saleh RA, Thomas AJ Jr & Agarwal A. (2003) Utility of the nitroblue tetrazolium reduction test for assessment of reactive oxygen species production by seminal leukocytes and spermatozoa. J Androl 24, 862-870.
15. Flickinger CJ, Howards SS & Herr JC. (1995) Effects of vasectomy on the epididymis. Microsc Res Tech 30, 82-100.
16. Fraczek M, Sanocka D, Kamieniczna M & Kurpisz M. (2008) Proinflammatory cytokines as an intermediate factor enhancing lipid sperm membrane peroxidation in in vitro conditions. J Androl 29, 85-92.
17. Frungieri MB, Calandra RS, Lustig L, Meineke V, Kohn FM, Vogt HJ & Mayerhofer A. (2002) Number, distribution pattern, and identification of macrophages in the testes of infertile men. Fertil Steril 78, 298-306.
18. Gandini L, Lombardo F, Paoli D, Caponecchia L, Familiari G, Verlengia C, Dondero F & Lenzi A. (2000) Study of apoptotic DNA fragmentation in human spermatozoa. Hum Reprod 15, 830-839.
19. Haidl G, Allam JP & Schuppe HC. (2008) Chronic epididymitis: impact on semen parameters and therapeutic options. Andrologia 40, 92-96.
20. Hamerlinck FF. (1999) Neopterin: a review. Exp Dermatol 8, 167-176.
21. Henkel R, Maass G, Hajimohammad M, Menkveld R, Stalf T, Villegas J, Sanchez R, Kruger TF & Schill WB. (2003) Urogenital inflammation: changes of leucocytes and ROS. Andrologia 35, 309-313.
22. Henkel R, Kierspel E, Stalf T, Mehnert C, Menkveld R, Tinneberg HR, Schill WB & Kruger TF. (2005) Effect of reactive oxygen species produced by spermatozoa and leukocytes on sperm functions in non-leukocytospermic patients. Fertil Steril 83, 635-642.
23. Holstein AF. (1978) Spermatophagia in male seminiferous tubules. Verh Anat Ges 72, 543-544.
24. Hussein A, Ozgok Y, Ross L & Niederberger C. (2005) Clomiphene administration for cases of nonobstructive azoospermia: a multicenter study. J Androl 26, 787-791.
25. Jequier AM. (2000) Male Infertility: a guide for the clinician.
26. Jochum M, Pabst W & Schill WB. (1986) Granulocyte elastase as a sensitive diagnostic parameter of silent male genital tract inflammation. Andrologia 18, 413-419.
27. Jones R. (2004) Sperm survival versus degradation in the Mammalian epididymis: a hypothesis. Biol Reprod 71, 1405-1411.
28. Maegawa M, Kamada M, Irahara M, Yamamoto S, Yamano S, Ohmoto Y, Gima H, Thaler CJ & Aono T. (2001) Concentration of granulocyte elastase in seminal plasma is not associated with sperm motility. Arch Androl 47, 31-36.
29. Ochsendorf FR. (1999) Infections in the male genital tract and reactive oxygen species. Hum Reprod Update 5, 399-420.
30. Pelliccione F, D'Angeli A, Cordeschi G, Mihalca R, Ciociola F, Necozione S, Francavilla F & Francavilla S. (2008) Seminal macrophages in ejaculates from men with couple infertility. Int J Androl 32, 623-628.
31. Plante M, De Lamirande E & Gagnon C. (1994) Reactive oxygen species released by activated neutrophils, but not by deficient spermatozoa, are sufficient to affect normal sperm motility. Fertil Steril 62, 387-393.
32. Reinhardt A, Haidl G & Schill WB. (1997) Granulocyte elastase indicates silent male genital tract inflammation and appropriate anti-inflammatory treatment. Andrologia 29, 187-192.
33. Said TM, Agarwal A, Falcone T, Sharma RK, Bedaiwy MA & Li L. (2005) Infliximab may reverse the toxic effects induced by tumor necrosis factor alpha in human spermatozoa: an in vitro model. Fertil Steril 83, 1665-1673.
34. Schuppe HC, Meinhardt A, Allam JP, Bergmann M, Weidner W & Haidl G. (2008) Chronic orchitis: a neglected cause of male infertility? Andrologia 40, 84-91.
35. Sharma RK, Pasqualotto AE, Nelson DR, Thomas AJ Jr & Agarwal A. (2001) Relationship between seminal white blood cell counts and oxidative stress in men treated at an infertility clinic. J Androl 22, 575-583.
36. Smith DC, Barratt CL & Williams MA. (1989) The characterisation of non-sperm cells in the ejaculates of fertile men using transmission electron microscopy. Andrologia 21, 319-333.
37. Solis EA, Bouvet BR, Brufman AS, Feldman R & Gatti VN. (2003) The possible macrophage role in seminal fluid. Actas Urol Esp 27, 185-189.
38. Tomlinson MJ, Barratt CL, Bolton AE, Lenton EA, Roberts HB & Cooke ID. (1992) Round cells and sperm fertilizing capacity: the presence of immature germ cells but not seminal leukocytes are associated with reduced success of in vitro fertilization. Fertil Steril 58, 1257-1259.
39. Tomlinson MJ, Barratt CL & Cooke ID. (1993) Prospective study of leukocytes and leukocyte subpopulations in semen suggests they are not a cause of male infertility. Fertil Steril 60, 1069-1075.
40. Tunc O, Thompson J & Tremellen K. (2008) Development of the NBT assay as a marker of sperm oxidative stress. Int J Androl 33,13-21
41. Villegas J, Schulz M, Vallejos V, Henkel R, Miska W & Sanchez R. (2002) Indirect immunofluorescence using monoclonal antibodies for the detection of leukocytospermia: comparison with peroxidase staining. Andrologia 34, 69-73.
42. Wang YF & Holstein AF. (1983) Intraepithelial lymphocytes and macrophages in the human epididymis. Cell Tissue Res 233, 517-521.
43. Weiss G, Thuma PE, Biemba G, Mabeza G, Werner ER & Gordeuk VR. (1998) Cerebrospinal fluid levels of biopterin, nitric oxide metabolites, and immune activation markers and the clinical course of human cerebral malaria. J Infect Dis 177, 1064-1068.
44. WHO. (1999) WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. Cambridge University Press, Cambridge.
45. Wilton LJ, Temple-Smith PD, Baker HW & De Kretser DM. (1988) Human male infertility caused by degeneration and death of sperm in the epididymis. Fertil Steril 49, 1052-1058.
46. Wolff H. (1995) The biologic significance of white blood cells in semen. Fertil Steril 63, 1143-1157.
47. Wolff H. (1998) Methods for the detection of male genital tract inflammation. Andrologia 30(Suppl. 1), 35-39.
48. Wolff H & Anderson DJ. (1988) Male genital tract inflammation associated with increased numbers of potential human immunodeficiency virus host cells in semen. Andrologia 20, 404-410.
49. Wolff H, Politch JA, Martinez A, Haimovici F, Hill JA & Anderson DJ. (1990) Leukocytospermia is associated with poor semen quality. Fertil Steril 53, 528-536.
50. Wolff H, Bezold G, Zebhauser M & Meurer M. (1991) Impact of clinically silent inflammation on male genital tract organs as reflected by biochemical markers in semen. J Androl 12, 331-334.
51. Yeung CH & Cooper TG. (1994) Study of the role of epididymal alpha-glucosidase in the fertility of male rats by the administration of the enzyme inhibitor castanospermine. J Reprod Fertil 102, 401-410.
52. Ziyyat A, Barraud-Lange V, Sifer C, Ducot B, Wolf JP & Soufir JC. (2008) Paradoxical increase of sperm motility and seminal carnitine associated with moderate leukocytospermia in infertile patients. Fertil Steril 90, 2257-2263.
53. Zopfgen A, Priem F, Sudhoff F, Jung K, Lenk S, Loening SA & Sinha P. (2000) Relationship between semen quality and the seminal plasma components carnitine, alpha-glucosidase, fructose, citrate and granulocyte elastase in infertile men compared with a normal population. Hum Reprod 15, 840-845.
54. Zorn B, Virant-Klun I & Meden-Vrtovec H. (2000) Semen granulocyte elastase: its relevance for the diagnosis and prognosis of silent genital tract inflammation. Hum Reprod 15, 1978-1984.
55. Zorn B, Sesek-Briski A, Osredkar J & Meden-Vrtovec H. (2003) Semen polymorphonuclear neutrophil leukocyte elastase as a diagnostic and prognostic marker of genital tract inflammation - a review. Clin Chem Lab Med 41, 2-12.