Study of apoptotic DNA fragmentation in human spermatozoa

Human Reproduction

Volumn 15, Issue 4, 2000, Pages 830-839

  Gandini, Loredana ^a,b   Lombarde, Francesco ^a   Paoli, Donatella ^b   Caponecchia, Luisa ^b   Familiari, Giuseppe ^a   Verlengia, Cristina ^a   Dondero, Franco ^a,b   Lenzi, Andrea ^a  

^a POLICLINICO UMBERTO I   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Apoptosis; Electron microscopy; Hodgkin's disease; Human spermatozoa; Testicular cancer

Indexed keywords

DNA FRAGMENT;

ADULT; APOPTOSIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ELECTRON MICROSCOPY; HODGKIN DISEASE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; NICK END LABELING; SEMEN ANALYSIS; SPERMATOGENESIS; SPERMATOZOON; SPERMATOZOON ABNORMALITY; TESTIS CANCER;

EID: 0034108799     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/15.4.830     Document Type: Article

References (36)

1. Baccetti, B., Collodel, G. and Piomboni, P. (1996) Apoptosis in human ejaculated sperm cells. J. Submicrosc. Cytol. Pathol., 28, 587-596.
2. Baccetti, B., Strehler, E., Capitani, S. et al. (I997) The effect of follicle stimulating hormone therapy on human sperm structure. Hum. Reprod., 12, 1955-1968.
3. Billig, H., Chun, S.Y., Eisenhauer, K. and Hsueh, A.J.W. (1996) Gonadal cell apoptosis: hormone-regulated cell demise. Hum. Reprod. Update, 2, 103-117.
4. Blanco-Rodriguez, J. and Martinez-Garcia, C. (1996) Spontaneous germ cell death in the testis of the adult rat takes the form of apoptosis: re-evaluation of cell types that exhibit the ability to die during spermatogenesis. Cell Prolif., 29, 13-31.
5. Brinkworth, M.H., Weinbauer, G.F., Schlatt, S. and Nieschlag, E. (1995) The identification of male germ cells underogoing apoptosis in the rat. J. Reprod. Fertil., 195, 25-33.
6. Dondero, E, Gandini, L., Lombardo, F. et al. (1999) Pathogenetical and clinical aspects of antisperm imunity. In Gupta, S.K. (éd.), Reproductive Immunology. Narosa Publishing House, New Delhi, pp. 241-254.
7. Gorczyca, W., Traganos, E, Jesionowska, H. and Darzynkiewicz, Z. (1993) Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: analogy to apoptosis of somatic cells. Exp. Cell Res., 207, 202-205.
8. Howell, S. and Shalet, S. (1998) Gonadal damage from chemotherapy and radiotherapy. Endocrinol. Metab. Clin. North Am., 27, 927-943.
9. Hughes, CM., Lewis, S.E., McKelvey-Martin, V.J. and Thompson, W. (1996) A comparison of baseline and induced DNA damage in human spermatozoa from fertile and infertile men, using a modified comet assay. Mol. Hum. Reprod., 2, 613-619.
10. Jurisicova, A., Lopes, S., Meriano, J. et al. (1999) DNA damage in round spermatids of mice with a targeted disruption of the Pplcy gene and in testicular biopsies of patients with non-obstructive azoospermia. Mol. Hum. Reprod., 5, 323-330.
11. Kane, D.J., Sarafian, T.A., Anton, R. et al. (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science, 262, 1274-1277.
12. Karnovsky, M.J. (1965) A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy. J. Cell Biol., 27, 137A-138A.
13. Kerr, J.F.R. (1971) Shrinkage necrosis: a distinct mode of cellular death. J. Pathol., 105, 13-20.
14. Kerr, J.F.R., Wyllie, A.H. and Currie, A.R. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implication in tissue kinetics. Br. J. Cancer, 26, 239-257.
15. Kerr, J.F.R., Winterford, CM. and Harmon, B.V. (1994) Apoptosis: its significance in cancer and cancer therapy. Cancer, 73, 2013-2026.
16. Lee, J., Richburg, J.H., Shipp, E.B. et al. (1999) The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Endocrinology, 140, 852-858.
17. Lenzi, A., Picardo, M., Gandini, L. and Dondero, F. (1996) Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy. Hum. Reprod. Update, 2, 246-256.
18. Lopes, S., Jurisicova, A., Sun, J.G. and Casper, R.F. (1998) Reactive oxygen species: potential cause for DNA fragmentation in human spermatozoa. Hum. Reprod., 13, 896-900.
19. Macleod, K.F. and Jacks, T. (1999) Insights into cancer from transgenic mouse models. J. Pathol., 187, 43-60.
20. Majno, G. and Joris, I. (1995) Apoptosis, oncosis, and necrosis -an overview of the cell death. Am. J. Pathol., 146, 3-15.
21. Meirow, D. and Schenker, J.G. (1995) Cancer and male infertility. Hum. Reprod., 10, 2017-2022.
22. Nagata, S. (1997) Apoptosis by death factor. Cell, 88, 355-365.
23. Nagata, S. and Golstein, R. (1995) The Fas death factor. Science, 267, T449-1455.
24. Raff, M.C. (1992) Social controls on cell survival and cell death. Nature, 356, 397-100.
25. Sakkas, D., Mariethoz, E., Manicardi, G. et al. (1999a) Origin of DNA damage in ejaculated human spermatozoa. Rev. Reprod., 4, 31-37.
26. Sakkas, D., Mariethoz, E. and St John, J.C. (1999b) Abnormal sperm parameters in humans are indicative of an abortive apoptotic mechanism linked to the Fas-mediated pathway. Exp. Cell Res., 251, 350-355.
27. Sentman, C.L., Shutter, J.R., Hockenbery, D. et al. (1991) bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell, 67, 879-888.
28. Sinha Hikim, A.P., Wang, C, Lue, Y. et al. (1998) Spontaneous germ cell apoptosis in humans: evidence for ethnic differences in the susceptibility of germ cells in programmed cell death. J. Clin. EndocrinoL Metab., 83, 152-156.
29. Sinha Hikim, A.P. and Swerdloff, R.S. (1999) Hormonal and genetic control of germ cell apoptosis in the testis. Rev. Reprod., 4, 38-47.
30. Sun, J.G., Jurisicova, A. and Casper, R.F. (1997) Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro. Biol. Reprod., 56, 602-607.
31. Uchiyama, Y. (éd.) (1995) Apoptosis. Morphological approaches and biological significances. Arch. Histol. Cytol., 58 (Special Issue), 127-264.
32. Vaux, D.L. and Korsmeyer, S.J. (1999) Cell death in development. Cell, 96, 245-254.
33. Wyllie, A.H. (1994) Death gets a brake. Nature, 369, 272-273.
34. Wyllie, A.H., Kerr, J.F.R. and Currie, A.R. (1980) Cell death: the significance of apoptosis. Int. Rev. Cytol., 68, 251-306.
35. World Health Organization (1999) WHO Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction, 4th edn. Cambridge University Press, Cambridge.
36. Yazawa, H., Sasagawa, I., Ishigooka, M. and Nakada, T. (1999) Effect of immobilization stress on testicular germ cell apoptosis in rats. Hum. Reprod., 14, 1806-1810.