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Volumn 6, Issue 1, 2011, Pages 21-30

Tesamorelin for the treatment of excess abdominal fat in HIV-1-infected patients with lipodystrophy

Author keywords

excess abdominal fat; growth hormone releasing factor analogue; HIV 1 infection; lipodystrophy; tesamorelin

Indexed keywords

GLUCOSE; INSULIN; PLACEBO; RITONAVIR; SIMVASTATIN; TESAMORELIN; TRIACYLGLYCEROL;

EID: 78650430109     PISSN: 17446651     EISSN: None     Source Type: Journal    
DOI: 10.1586/eem.10.83     Document Type: Article
Times cited : (4)

References (33)
  • 1
    • 12844276053 scopus 로고    scopus 로고
    • Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: The adipocyte as a target of anti-retroviral-induced mitochondrial toxicity
    • Villarroya F, Domingo P, Giralt M. Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity. Trends Pharmacol. Sci. 26, 88-93 (2005).
    • (2005) Trends Pharmacol. Sci. , vol.26 , pp. 88-93
    • Villarroya, F.1    Domingo, P.2    Giralt, M.3
  • 2
    • 0038708272 scopus 로고    scopus 로고
    • Prospective evaluation of the effects of antiretroviral therapy on body composition in HIV-1-infected men starting therapy
    • Mallon PW, Miller J, Cooper DA et al. Prospective evaluation of the effects of antiretroviral therapy on body composition in HIV-1-infected men starting therapy. AIDS 17(7), 971-979 (2003).
    • (2003) AIDS , vol.17 , Issue.7 , pp. 971-979
    • Mallon, P.W.1    Miller, J.2    Cooper, D.A.3
  • 3
    • 26844543445 scopus 로고    scopus 로고
    • Glucose metabolism lipid and body fat changes in antiretroviral-naive subjects randomized to nelfinavir or efavirenz plus dual nucleosides
    • Dube MP, Parker RA, Tebas P et al. Glucose metabolism, lipid, and body fat changes in antiretroviral-naive subjects randomized to nelfinavir or efavirenz plus dual nucleosides. AIDS 19, 1807-1818 (2005).
    • (2005) AIDS , vol.19 , pp. 1807-1818
    • Dube, M.P.1    Parker, R.A.2    Tebas, P.3
  • 4
    • 0345064200 scopus 로고    scopus 로고
    • Combination antiretroviral therapy and the risk of myocardial infarction
    • Friis-Moller N, Sabin CA, Weber R et al. Combination antiretroviral therapy and the risk of myocardial infarction. N. Engl. J. Med. 349, 1993-2003 (2003).
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1993-2003
    • Friis-Moller, N.1    Sabin, C.A.2    Weber, R.3
  • 5
    • 11344293751 scopus 로고    scopus 로고
    • Cardiovascular risk and body-fat abnormalities in HIV-infected adults
    • Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N. Engl. J. Med. 352, 48-62 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , pp. 48-62
    • Grinspoon, S.1    Carr, A.2
  • 6
    • 24044477332 scopus 로고    scopus 로고
    • Comparative assessment of objective methods for the measurement of body fat
    • Milinkovic A, Vidal S, Bianchi L et al. Comparative assessment of objective methods for the measurement of body fat. Antivir. Ther. 8, L63 (2003).
    • (2003) Antivir. Ther. , vol.8
    • Milinkovic, A.1    Vidal, S.2    Bianchi, L.3
  • 7
    • 0035897696 scopus 로고    scopus 로고
    • Expert panel on detection evaluation and treatment of high blood cholesterol in adults
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Adult Treatment Panel III
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285, 2486-2497 (2001).
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 8
    • 73449110896 scopus 로고    scopus 로고
    • Lipodystrophy and anti-retroviral therapy as predictors of sub-clinical atherosclerosis in HIV infected subjects
    • Guaraldi G, Stentarelli C, Zona S et al. Lipodystrophy and anti-retroviral therapy as predictors of sub-clinical atherosclerosis in HIV infected subjects. Atherosclerosis 208, 222-227 (2010).
    • (2010) Atherosclerosis , vol.208 , pp. 222-227
    • Guaraldi, G.1    Stentarelli, C.2    Zona, S.3
  • 9
    • 78650473866 scopus 로고    scopus 로고
    • Visceral fat but not general adiposy is a predictor of cardiovascular disease in HIV-infected males
    • Presented at San Francisco, CA, USA February
    • Guaraldi G, Zona S, Orlando G et al. Visceral fat but not general adiposy is a predictor of cardiovascular disease in HIV-infected males. Presented at: 17th Conference on Retroviruses and Opportunistic Infection. San Francisco, CA, USA, 16-19 February 2010.
    • (2010) 17th Conference on Retroviruses and Opportunistic Infection , pp. 16-19
    • Guaraldi, G.1    Zona, S.2    Orlando, G.3
  • 10
    • 0029052046 scopus 로고
    • Adipose tissue assessed by magnetic resonance imaging in growth hormone deficient adults: The effect of growth hormone replacement and a comparison with control subject
    • Snel Y, Brummer R-JM, Doerga ME et al. Adipose tissue assessed by magnetic resonance imaging in growth hormone deficient adults: the effect of growth hormone replacement and a comparison with control subject. Am. J. Clin. Nutr. 61, 1290-1294 (1995).
    • (1995) Am. J. Clin. Nutr. , vol.61 , pp. 1290-1294
    • Snel, Y.1    Brummer, R.-J.M.2    Doerga, M.E.3
  • 11
    • 0030002534 scopus 로고    scopus 로고
    • Changes in subcutaneous and visceral fat mass during growth hormone replacement therapy in adult men
    • De Boer H, Blok GJ, Voerman B et al. Changes in subcutaneous and visceral fat mass during growth hormone replacement therapy in adult men. Int. J. Obes. Relat. Metab. Disord. 20, 580-587 (1996).
    • (1996) Int. J. Obes. Relat. Metab. Disord. , vol.20 , pp. 580-587
    • De Boer, H.1    Blok, G.J.2    Voerman, B.3
  • 12
    • 0035090230 scopus 로고    scopus 로고
    • Assessment of growth hormone dynamics in human immunodeficiency virus-related lipodystrophy
    • Rietschel P, Hadigan C, Corcoran C et al. Assessment of growth hormone dynamics in human immunodeficiency virus-related lipodystrophy. J. Clin. Endocrinol. Metab. 86, 504-510 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 504-510
    • Rietschel, P.1    Hadigan, C.2    Corcoran, C.3
  • 13
    • 0942287339 scopus 로고    scopus 로고
    • Metabolic regulation of growth hormone by free fatty acids somatostatine and ghrelin in HIV-lipodystrophy
    • Koutkia P, Meininger G, Canavan B et al. Metabolic regulation of growth hormone by free fatty acids, somatostatine, and ghrelin in HIV-lipodystrophy. Am. J. Physiol. Endocrinol. Metab. 286, E296-E303 (2004).
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.286
    • Koutkia, P.1    Meininger, G.2    Canavan, B.3
  • 14
    • 0032786310 scopus 로고    scopus 로고
    • Recombinant human growth hormone improves truncal adiposity and buffalo humps in HIV-positive patients on HAART letter
    • Torres RA, Unger KW, Cadman JA et al. Recombinant human growth hormone improves truncal adiposity and 'buffalo humps' in HIV-positive patients on HAART [letter]. AIDS 13, 2479-2481 (1999).
    • (1999) AIDS , vol.13 , pp. 2479-2481
    • Torres, R.A.1    Unger, K.W.2    Cadman, J.A.3
  • 15
    • 0032712266 scopus 로고    scopus 로고
    • Recombinant human growth hormone improves the fat redistribution syndrome lipodystrophy in patients with HIV
    • Wanke C, Gerrior J, Kantaros J et al. Recombinant human growth hormone improves the fat redistribution syndrome (lipodystrophy) in patients with HIV. AIDS 13, 2099-2103 (1999).
    • (1999) AIDS , vol.13 , pp. 2099-2103
    • Wanke, C.1    Gerrior, J.2    Kantaros, J.3
  • 16
    • 0034886796 scopus 로고    scopus 로고
    • The effects of recombinant human growth hormone on body composition and glucose metabolism in HIV-infected patients with fat accumulation
    • Lo JC, Mulligan K, Noor MA et al. The effects of recombinant human growth hormone on body composition and glucose metabolism in HIV-infected patients with fat accumulation. J. Clin. Endocrinol. Metab. 86, 3480-3487 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 3480-3487
    • Lo, J.C.1    Mulligan, K.2    Noor, M.A.3
  • 17
    • 0036682588 scopus 로고    scopus 로고
    • Effect of recombinant human growth hormone in the treatment of visceral fat accumulation in HIV infection
    • Engelson ES, Glesby MJ, Mendez D et al. Effect of recombinant human growth hormone in the treatment of visceral fat accumulation in HIV infection. J. Acquir. Immune Defic. Syndr. 30, 379-391 (2002).
    • (2002) J. Acquir. Immune Defic. Syndr. , vol.30 , pp. 379-391
    • Engelson, E.S.1    Glesby, M.J.2    Mendez, D.3
  • 18
    • 0036172410 scopus 로고    scopus 로고
    • Effects of recombinant human growth hormone on hepatic lipid and carbohydrate metabolism in HIV-infected patients with fat accumulation
    • Schwarz JM, Mulligan K, Lee J et al. Effects of recombinant human growth hormone on hepatic lipid and carbohydrate metabolism in HIV-infected patients with fat accumulation. J. Clin. Endocrinol. Metab. 87, 942 (2002).
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 942
    • Schwarz, J.M.1    Mulligan, K.2    Lee, J.3
  • 19
    • 0032559272 scopus 로고    scopus 로고
    • Plasma IGF-1 and prostate cancer risk: A prospective study
    • Chan JM, Stampfer MJ, Giovannucci E et al. Plasma IGF-1 and prostate cancer risk: a prospective study. Science 279, 563-566 (1998).
    • (1998) Science , vol.279 , pp. 563-566
    • Chan, J.M.1    Stampfer, M.J.2    Giovannucci, E.3
  • 20
    • 0032499440 scopus 로고    scopus 로고
    • Circulating concentrations of IGF-1 and the risk of breast cancer
    • Hankinson SE, Willett WC, Colditz GA et al. Circulating concentrations of IGF-1 and the risk of breast cancer. Lancet 351, 1393-1396 (1998).
    • (1998) Lancet , vol.351 , pp. 1393-1396
    • Hankinson, S.E.1    Willett, W.C.2    Colditz, G.A.3
  • 21
    • 0033531765 scopus 로고    scopus 로고
    • Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor IGF-I and IGF-binding protein-3
    • Ma J, Pollak MN, Giovannuci E et al. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J. Natl Cancer Inst. 91(7), 620-625 (1999).
    • (1999) J. Natl Cancer Inst. , vol.91 , Issue.7 , pp. 620-625
    • Ma, J.1    Pollak, M.N.2    Giovannuci, E.3
  • 22
    • 3042762914 scopus 로고    scopus 로고
    • Growth hormone-releasing hormone in HIV-infected men with lipodystrophy: A randomized controlled trial
    • Koutkia P, Canavan B, Breu J et al. Growth hormone-releasing hormone in HIV-infected men with lipodystrophy: a randomized, controlled trial. JAMA 292, 210-218 (2004).
    • (2004) JAMA , vol.292 , pp. 210-218
    • Koutkia, P.1    Canavan, B.2    Breu, J.3
  • 23
    • 0029688886 scopus 로고    scopus 로고
    • Body composition and tissue distribution in growth hormone deficient adults before and after growth hormone treatment
    • Lönn L, Johannsson G, SjÖstrÖm L et al. Body composition and tissue distribution in growth hormone deficient adults before and after growth hormone treatment. Obes. Res. 4, 45-54 (1996).
    • (1996) Obes. Res. , vol.4 , pp. 45-54
    • Lönn, L.1    Johannsson, G.2    SjÖstrÖm, L.3
  • 24
    • 24044482335 scopus 로고    scopus 로고
    • A placebo-controlled dose-ranging study of a growth hormone releasing factor in HIV-infected patients with abdominal fat accumulation
    • Falutz J, Allas S, Kotler D et al. A placebo-controlled, dose-ranging study of a growth hormone releasing factor in HIV-infected patients with abdominal fat accumulation. AIDS 19, 1279-1287 (2005).
    • (2005) AIDS , vol.19 , pp. 1279-1287
    • Falutz, J.1    Allas, S.2    Kotler, D.3
  • 25
    • 36849058739 scopus 로고    scopus 로고
    • Metabolic effects of a growth hormone releasing factor in patients with HIV
    • Falutz J, Allas S, Blot K et al. Metabolic effects of a growth hormone releasing factor in patients with HIV. N. Engl. J. Med. 357, 2359-2370 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2359-2370
    • Falutz, J.1    Allas, S.2    Blot, K.3
  • 26
    • 58149273826 scopus 로고    scopus 로고
    • Long-term safety and effects of tesamorelin a growth hormone-releasing factor analogue in HIV patients with abdominal fat accumulation
    • Falutz J, Allas S, Mamputu J-C et al. Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation. AIDS 22, 1719-1728 (2008).
    • (2008) AIDS , vol.22 , pp. 1719-1728
    • Falutz, J.1    Allas, S.2    Mamputu, J.-C.3
  • 27
    • 77649226509 scopus 로고    scopus 로고
    • Effects of tesamorelin a growth hormone releasing factor in HIV-infected patients with abdominal fat accumulation: A randomized placebo-controlled trial with a safety extension
    • Falutz J, Potvin D, Mamputu J-C et al. Effects of tesamorelin, a growth hormone releasing factor, in HIV-infected patients with abdominal fat accumulation: a randomized, placebo-controlled, trial with a safety extension. J. Acquir. Immune Defic. Syndr. 53(3), 311-322 (2010).
    • (2010) J. Acquir. Immune Defic. Syndr. , vol.53 , Issue.3 , pp. 311-322
    • Falutz, J.1    Potvin, D.2    Mamputu, J.-C.3
  • 28
    • 0023019099 scopus 로고
    • Rapid enzymatic degradation of growth hormone-releasing hormone by plasma in vitro and in vivo to a biologically inactive product cleaved at the NH2-terminus
    • Frohman LA, Downs TR, Williams TC et al. Rapid enzymatic degradation of growth hormone-releasing hormone by plasma in vitro and in vivo to a biologically inactive product cleaved at the NH2- terminus. J. Clin. Invest. 78, 906-991 (1986).
    • (1986) J. Clin. Invest , vol.78 , pp. 906-991
    • Frohman, L.A.1    Downs, T.R.2    Williams, T.C.3
  • 30
    • 78650495239 scopus 로고    scopus 로고
    • Pharmacokinetic pharmacodynamic evaluation of tesamorelin TH9507 a growth hormone-releasing factor GRF analog administered subcutaneously once daily for 14 consecutive days in healthy and HIV positive populations
    • Presented at Washington, DC, USA, June
    • Michaud S-E, Abolfathi Z. Pharmacokinetic/pharmacodynamic evaluation of tesamorelin (TH9507), a growth hormone-releasing factor (GRF) analog, administered subcutaneously once daily for 14 consecutive days in healthy and HIV positive populations. Presented at: Endocrine Society's 91st Annual Meeting. Washington, DC, USA, 10-13 June 2009.
    • (2009) Endocrine Societys 91st Annual Meeting , pp. 10-13
    • Michaud, S.-E.1    Abolfathi, Z.2
  • 31
    • 78650450338 scopus 로고    scopus 로고
    • Metabolic effects of tesamorelin TH9507 a growth hormone-releasing factor analogue in hiv-infected patients with excess abdominal fat over a period of 52 weeks a pooled analysis of 2 multicenter double- blind placebo-controlled phase 3 trials with 816 randomized patients
    • Presented at: Cologne, Germany, November
    • Falutz J, Mamputu J-C. Metabolic effects of tesamorelin (TH9507), a growth hormone-releasing factor analogue, in hiv-infected patients with excess abdominal fat over a period of 52 weeks. a pooled analysis of 2 multicenter, double- blind, placebo-controlled Phase 3 trials with 816 randomized patients. Presented at: 12th European AIDS Conference. Cologne, Germany, 11-14 November 2009.
    • (2009) 12th European AIDS Conference , pp. 11-14
    • Falutz, J.1    Mamputu, J.-C.2
  • 32
    • 33846009834 scopus 로고    scopus 로고
    • Non-clinical pharmacology and safety evaluation of TH9507 a human growth hormone-releasing factor analogue
    • Ferdinandi ES, Brazeau P, High K et al. Non-clinical pharmacology and safety evaluation of TH9507, a human growth hormone-releasing factor analogue. Basic Clin. Pharmacol. Toxicol. 100(1), 49-58 (2007).
    • (2007) Basic Clin. Pharmacol. Toxicol. , vol.100 , Issue.1 , pp. 49-58
    • Ferdinandi, E.S.1    Brazeau, P.2    High, K.3
  • 33
    • 77957569983 scopus 로고    scopus 로고
    • Impact of tesamorelin TH9507 a stabilized growth hormone-releasing factor GRF analogue on the pharmacokinetics of simvastatin and ritonavir in healthy volunteers
    • Presented at: Vancouver, BC, Canada April
    • Vincent G, Teng S. Impact of tesamorelin (TH9507), a stabilized growth hormone-releasing factor (GRF) analogue, on the pharmacokinetics of simvastatin and ritonavir in healthy volunteers. Presented at: 18th Annual Canadian Conference on HIV/AIDS Research. Vancouver, BC, Canada, 23-26 April 2009.
    • (2009) 18th Annual Canadian Conference on HIV AIDS Research , pp. 23-26
    • Vincent, G.1    Teng, S.2


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