Orthogonal analytical screening for liquid chromatography-mass spectrometry method development and preparative scale-up

Journal of Chromatography A

Volumn 1218, Issue 1, 2011, Pages 74-82

  Font, Luis M ^a   Fontana, A ^a   Galceran, M T ^b   Iturrino, L ^a   Perez, V ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

HPLC method development; HPLC MS; Orthogonal screening; Preparative HPLC MS

Indexed keywords

ANALYTICAL SEPARATIONS; DATA REPORTING; HPLC METHOD; HPLC-MS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LOW-TO-HIGH; MEDICINAL CHEMISTRY; METHOD DEVELOPMENT; OPEN ACCESS; ORTHOGONAL CONDITION; ORTHOGONAL SCREENING; ORTHOGONALITY; PREPARATIVE HPLC; PREPARATIVE SEPARATION; RP-HPLC; SCALE-UP; SCREENING PROTOCOL; SOFTWARE TOOL; STATIONARY PHASIS; SYNTHESIS REACTION;

ACETONITRILE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHANOL; OPTIMIZATION; ORGANIC SOLVENTS; SYNTHESIS (CHEMICAL);

CHEMICAL ANALYSIS;

4 NITROPHENOL; ACETONITRILE; CAFFEINE; CHLORTALIDONE; COUMARIN DERIVATIVE; FLAVONE; HALOPERIDOL; HYDROXYCUMARINE; METHANOL; NABUMETONE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; AUTOMATION; CHEMICAL ANALYSIS; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; COMPUTER PROGRAM; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; PH; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; SCREENING TEST; SEPARATION TECHNIQUE; SOLVENT EFFECT; SYSTEM ANALYSIS;

ACETONITRILES; BUFFERS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; MASS SPECTROMETRY; METHANOL; MODELS, CHEMICAL; ORGANIC CHEMICALS; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SOFTWARE;

EID: 78650418519     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.10.102     Document Type: Article

References (32)

1. Weller H.N., Young M.G., Michalczyk S.J., Reitnauer G.H., Cooley R.S., Rahn P.C., Loyd D.J., Fiore D., Fischman S.J. Mol. Divers. 1997, 3:61.
2. Zeng L., Burton L., Yung K., Shushan B., Kassel D.B. J. Chromatogr. A 1998, 794:3.
3. Edwards P.J. Comb. Chem. High Throughput Screen. 2003, 6:11.
4. Johnson C.R., Zhang B., Fantauzzi P., Hocker M., Yager K.M. Tetrahedrom 1998, 54:4097.
5. Nilsson U.J. J. Chromatogr. A 2000, 885:305.
6. Espada A., Molina-Martin M., Dage J., Kuo M.-S. Drug Discov. Today 2008, 13:417.
7. Weber A., von Roedern E., Srilz H.U. J. Comb. Chem. 2005, 7:178.
8. Rishton G.M. Med. Chem. 2005, 1:519.
9. Guth O., Krewer D., Freudenberg B., Paulitz C., Hauser M., Ilg K. J. Comb. Chem. 2008, 10:875.
10. Pellet J., Lukulay P., Mao Y., Bowen W., Reed R., Ma M., Munger R.C., Dolan J.W., Wrisley L., Medwid K., Totl N.P., Chan C.C., Skibic M., Biswas K., Wells K.A., Snyder L.R. J. Chromatogr. A 2006, 1101:122.
11. Snyder L.R. J. Chromatogr. B 1997, 689:105.
12. Wilson N.S., Nelson M.D., Dolan J.W., Snyder L.R., Carr P.W. J. Chromatogr. A 2002, 961:195.
13. Molina-Martin M., Marin A., Rivera-Sagredo A., Espada A. J. Sep. Sci. 2005, 28:1742.
14. Gang X., Bendick A.D., Chen R., Sekulic S.S. J. Chromatogr. A 2004, 1050:159-171.
15. Biswas K.M., Castle B.C., Olsen B.A., Risley D.S., Skibic M.J., Wright P.B. J. Pharm. Biomed. Anal. 2009, 49:692.
16. Marín A., Burton K., Rivera-Sagredo A., Espada A., Byrne C., White C., Sharman G., Goodwin L. J. Liq. Chromatogr. Related Technol. 2008, 31:2.
17. Loeser E., Babiak S., Zhu P., Yowell G., Konigsberger M., Drumm P. Chromatographia 2006, 63:345.
18. Hewitt E.F., Lulukay P., Galushko S. J. Chromatogr. A. 2006, 1107:79.
19. Francotte E., Wetli H.A. J. Sep. Sci. 2007, 30:1255.
20. Zeng L., Xu R., Laskar D.B., Kassel D.B. J. Chromatogr. A. 2007, 1169:193.
21. Espada A., Marin A., Anta C. J. Chromatogr. A. 2004, 1030:43.
22. Blom K.F. J. Comb. Chem. 2002, 4:295.
23. Blom K.F., Glass B., Sparks R., Combs A.P. J. Comb. Chem. 2004, 6. 874
24. L.M. Font, A. Fontana, M.T. Galceran, L. Iturrino, V. Perez, Orthogonal analytical screening for HPLC method development and preparative scale-up. Poster presented at HPLC 2009 held in Dresden-Germany.
25. L.M. Font, A. Fontana, M.T. Galceran, L. Iturrino, J. Oyarzabal, HPLC-MS purification of compounds using pKa prediction for method selection. Poster presented at HPLC 2005 held in Stockholm-Sweden.
26. Espada A., Rivera-Sagredo A. J. Chromatogr. A. 2003, 987:211.
27. Espada A., Marín A., Anta C. J. Chromatogr. A. 2004, 1030:43.
28. Zhang X., Zhao X., Zhang C., Yang L., Xiong X., Zhou Y., Yang Y., Duan J. Chromatographia 2010, 71:1015.
29. Yurek D.A., Branch D.L., Kuo M.-S. J. Comb. Chem 2002, 4:138.
30. Bauser M. J. Chromatogr. Sci. 2002, 40:292.
31. Leister W., Strauss K., Wisnoski D., Zhao Z., Lindsley C. J. Comb. Chem. 2003, 5:322.
32. Wang X., Weiyong L., Rasmussen H.T. J. Chromatogr. A. 2005, 1083:58.