Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1

European Journal of Cancer

Volumn 47, Issue 1, 2011, Pages 121-130

  Zhang, Wenjing ^a,b   Wang, Jide ^a,b   Zou, Bing ^b   Sardet, Claude ^c   Li, Jianming ^a   Lam, Colin S C ^b   Ng, Lui ^b   Pang, Roberta ^b   Hung, Ivan F N ^b   Tan, Victoria P Y ^b   Jiang, Bo ^a   Wong, Benjamin C Y ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIV MONTPELLIER   (France)

Author keywords

Colon cancer; E cadherin; Epithelial mesenchymal transition; FHL2; Snail1

Indexed keywords

FOUR AND A HALF LIM PROTEIN 2; LIM PROTEIN; PHOSPHOPROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SNAIL1; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; COLON CANCER; CONTROLLED STUDY; E BOX ELEMENT; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; WILD TYPE;

BLOTTING, WESTERN; CADHERINS; COLONIC NEOPLASMS; E-BOX ELEMENTS; EPITHELIAL-MESENCHYMAL TRANSITION; FLUORESCENT ANTIBODY TECHNIQUE; HOMEODOMAIN PROTEINS; HUMANS; LIM-HOMEODOMAIN PROTEINS; MUSCLE PROTEINS; MUTATION; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 78650417038     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2010.07.045     Document Type: Article

References (37)

1. E.A. Turley, M. Veiseh, D.C. Radisky, and M.J. Bissell Mechanisms of disease: epithelial-mesenchymal transition - does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol 5 2008 280 290
2. D. Shook, and R. Keller Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development Mech Dev 120 2003 1351 1383
3. J.P. Thiery, H. Acloque, R.Y. Huang, and M.A. Nieto Epithelial- mesenchymal transitions in development and disease Cell 139 2009 871 890
4. R.C. Bates, and A.M. Mercurio The epithelial-mesenchymal transition (EMT) and colorectal cancer progression Cancer Biol Ther 4 2005 365 370
5. J.P. Thiery Epithelial-mesenchymal transitions in tumour progression Nat Rev Cancer 2 2002 442 454
6. L.A. Giroldi, P.P. Bringuier, and M. De Weijert Role of E boxes in the repression of E-cadherin expression Biochem Biophys Res Commun 241 1997 453 458
7. X. Ji, A.S. Woodard, D.L. Rimm, and E.R. Fearon Transcriptional defects underlie loss of E-cadherin expression in breast cancer Cell Growth Differ 8 1997 773 778
8. E. Batlle, E. Sancho, and C. Franci The transcription factor Snail1 is a repressor of E-cadherin gene expression in epithelial tumour cells Nat Cell Biol 2 2000 84 89
9. Y.N. Liu, W.W. Lee, and C.Y. Wang Regulatory mechanisms controlling human E-cadherin gene expression Oncogene 24 2005 8277 8290
10. H. Peinado, D. Olmeda, and A. Cano Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7 2007 415 428
11. K. Yokoyama, N. Kamata, and R. Fujimoto Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas Int J Oncol 22 2003 891 898
12. C. Peña, J.M. García, and V. García The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL1, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas Int J Cancer 119 2006 2098 2104
13. H.K. Roy, T.C. Smyrk, J. Koetsier, T.A. Victor, and R.K. Wali The transcriptional repressor SNAIL1 is overexpressed in human colon cancer Dig Dis Sci 50 2005 42 46
14. C.W. Cheng, P.E. Wu, and J.C. Yu Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumour suppressor gene Oncogene 20 2001 3814 3823
15. W. Jiao, K. Miyazaki, and Y. Kitajima Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo Brit J Cancer 86 2002 98 101
16. B.P. Zhou, J. Deng, and W. Xia Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition Nat Cell Biol 6 2004 931 940
17. M. Johannessen, S. Møller, T. Hansen, U. Moens, and M. Van Ghelue The multifunctional roles of the four-and-a-half-LIM only protein FHL2 Cell Mol Life Sci 63 2006 268 284
18. M. Li, J. Wang, and S.S. Ng The four-and-a-half-LIM protein 2 (FHL2) is overexpressed in gliomas and associated with oncogenic activities Glia 56 2008 1328 1338
19. J. Wang, Y. Yang, and H.H. Xia Suppression of FHL2 expression induces cell differentiation and inhibits gastric and colon carcinogenesis Gastroenterology 132 2007 1066 1076
20. Y. Yang, H. Hou, E.M. Haller, S.V. Nicosia, and W. Bai Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation EMBO J 24 2005 1021 1032
21. B. Gabriel, D.C. Fischer, and M. Orlowska-Volk Expression of the transcriptional coregulator FHL2 in human breast cancer: a clinicopathologic study J Soc Gynecol Investig 13 2006 69 75
22. D. Chen, W. Xu, and E. Bales SKI activates Wnt/beta-catenin signaling in human melanoma Cancer Res 63 2003 6626 6634
23. Y. Wei, C.A. Renard, and C. Labalette Identification of the LIM protein FHL2 as a coactivator of beta-catenin J Biol Chem 278 2003 5188 5194
24. Y. Kim, M.C. Kugler, and Y. Wei Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts J Cell Biol 184 2009 309 322
25. W. Zhang, B. Jiang, and Z. Guo Four and a half LIM protein 2 (FHL2) promotes invasive potential and epithelial-mesenchymal transition in colon cancer Carcinogenesis 31 2010 1220 1229
26. J. Wang, Y. Peng, and Y.W. Sun All-trans retinoic acid induces XAF1 expression through an interferon regulatory factor-1 element in colon cancer Gastroenterology 130 2006 747 758
27. J. Wang, Q. Gu, and M. Li Identification of XAF1 as a novel cell cycle regulator through modulating G(2)/M checkpoint and interaction with checkpoint kinase 1 in gastrointestinal cancer Carcinogenesis 30 2009 1507 1516
28. J. Wang, W. Zhang, and Y. Zhang C-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer Carcinogenesis 30 2009 222 229
29. V. Stemmer, B. de Craene, G. Berx, and J. Behrens Snail promotes Wnt target gene expression and interacts with beta-catenin Oncogene 27 2008 5075 5080
30. E.M. Langer, Y. Feng, and H. Zhaoyuan Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus Dev Cel 14 2008 424 436
31. Z. Hou, H. Peng, and K. Ayyanathan The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression Mol Cell Biol 28 2008 3198 3207
32. A. Barrallo-Gimeno, and M.A. Nieto The Snail genes as inducers of cell movement and survival: implications in development and cancer Development 132 2005 3151 3161
33. V. Bolós, H. Peinado, and M.A. Pérez-Moreno The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors J Cell Sci 116 2003 499 511
34. D. Olmeda, A. Montes, and G. Moreno-Bueno Snai1 and Snai2 collaborate on tumour growth and metastasis properties of mouse skin carcinoma cell lines Oncogene 27 2008 4690 4701
35. K. Kleiber, K. Strebhardt, and B.T. Martin The biological relevance of FHL2 in tumour cells and its role as a putative cancer target Anticancer Res 27 2007 55 61
36. A. Moustakas, and C.H. Heldin Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression Cancer Sci 98 2007 1512 1520
37. N.H. Purcell, D. Darwis, and O.F. Bueno Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes Mol Cell Biol 24 2004 1081 1095