The IκB kinase inhibitor nuclear factor-κB essential modulator-binding domain peptide for inhibition of injury-induced neointimal formation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 12, 2010, Pages 2458-2466

  Grassia, Gianluca ^a   Maddaluno, Marcella ^a   Musilli, Claudia ^b   De Stefano, Daniela ^a   Carnuccio, Rosa ^a   Vittoria Di Lauro, Maria ^a   Parratt, Christopher A ^c   Kennedy, Simon ^c   Di Meglio, Paola ^a,d   Ianaro, Angela ^a   Maffia, Pasquale ^a,c   Parenti, Astrid ^b   Ialenti, Armando ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

angioplasty; NEMO binding domain peptide; nuclear factor B; pharmacology; vascular biology

Indexed keywords

APOLIPOPROTEIN E; I KAPPA B KINASE; I KAPPA B KINASE GAMMA; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTICLE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; INFLAMMATION; MALE; NEOINTIMA; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANGIOPLASTY, BALLOON; ANIMALS; APOLIPOPROTEINS E; APOPTOSIS; CAROTID ARTERY INJURIES; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FEMALE; HYPERPLASIA; I-KAPPA B KINASE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, KNOCKOUT; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; PEPTIDES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR; TUNICA INTIMA;

EID: 78650416331     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.215467     Document Type: Article

References (31)

1. Collins T, Cybulsky MI. NF-KB: pivotal mediator or innocent bystander in atherogenesis? J Clin Invest. 2001;107:255-264.
2. Brand K, Page S, Rogler G, Bartsch A, Brandl R, Knuechel R, Page M, Kaltschmidt C, Baeuerle PA, Neumeier D. Activated transcription factor nuclear factor-KB is present in the atherosclerotic lesion. J Clin Invest. 1996;97:1715-1722.
3. De Winther MP, Kanters E, Kraal G, Hofker MH. Nuclear factor KB signaling in atherogenesis. Arterioscler Thromb Vasc Biol. 2005;25: 904-914.
4. Landry DB, Couper LL, Bryant SR, Lindner V. Activation of the NF-KB and IKB system in smooth muscle cells after rat arterial injury: induction of vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1. Am J Pathol. 1997;151:1085-1095.
5. Hoshi S, Goto M, Koyama N, Nomoto K, Tanaka H. Regulation of vascular smooth muscle cell proliferation by nuclear factor- KB and its inhibitor, I-KB. J Biol Chem. 2000;275:883-889.
6. Bu DX, Erl W, de Martin R, Hansson GK, Yan ZQ. IKK/3-dependent NF- KB pathway controls vascular inflammation and intimal hyperplasia. FASEB J. 2005;19:1293-1295.
7. Breuss JM, Cejna M, Bergmeister H, Kadl A, Baumgartl G, Steurer S, Xu Z, Koshelnick Y, Lipp J, De Martin R, Losert U, Lammer J, Binder BR. Activation of nuclear factor- KB significantly contributes to lumen loss in a rabbit iliac artery balloon angioplasty model. Circulation. 2002;105: 633-638.
8. Ohtani K, Egashira K, Nakano K, Zhao G, Funakoshi K, Ihara Y, Kimura S, Tominaga R, Morishita R, Sunagawa K. Stent-based local delivery of nuclear factor- KB decoy attenuates in-stent restenosis in hypercholester-olemic rabbits. Circulation. 2006;114:2773-2779.
9. Suzuki J, Tezuka D, Morishita R, Isobe M. An initial case of suppressed restenosis with nuclear factor-KB decoy transfection after percutaneous coronary intervention. J Gene Med. 2009;11:89-91.
10. Mehrhof FB, Schmidt-Ullrich R, Dietz R, Scheidereit C. Regulation of vascular smooth muscle cell proliferation: role of NF-KB revisited. Circ Res. 2005;96:958-964.
11. Chen Y, Budd RC, Kelm RJ Jr, Sobel BE, Schneider DJ. Augmentation of proliferation of vascular smooth muscle cells by plasminogen activator inhibitor type 1. Arterioscler Thromb Vasc Biol. 2006;26:1777-1783.
12. Bond M, Chase AJ, Baker AH, and Newby AC. Inhibition of transcription factor NF-KB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells. Cardiovasc Res. 2001;50:556-565.
13. Vallabhapurapu S, Karin M. Regulation and function of NF-KB transcription factors in the immune system. Annu Rev Immunol. 2009;27: 693-733.
14. May MJ, D'Acquisto F, Madge LA, Glockner J, Pober JS, Ghosh S. Selective inhibition of NF-KB activation by a peptide that blocks the interaction of NEMO with the IKB kinase complex. Science. 2000;289: 1550-1554.
15. D'Acquisto F, May MJ, Ghosh S. Inhibition of nuclear factor K B (NF-KB): an emerging theme in anti-inflammatory therapies. Mol Interv. 2002;2:22-35.
16. Di Meglio P, Ianaro A, Ghosh S. Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-KB activation. Arthritis Rheum. 2005;52:951-958.
17. Jimi E, Aoki K, Saito H, D'Acquisto F, May MJ, Nakamura I, Sudo T, Kojima T, Okamoto F, Fukushima H, Okabe K, Ohya K, Ghosh S. Selective inhibition of NF-K B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med. 2004;10:617-624.
18. Parenti A, Bellik L, Brogelli L, Filippi S, Ledda F. Endogenous VEGF-A is responsible for mitogenic effects of MCP-1 on vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2004;286:H1978-H1984.
19. Grassia G, Maddaluno M, Guglielmotti A, Mangano G, Biondi G, Maffia P, Ialenti A. The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice. Cardiovasc Res. 2009; 84:485-493.
20. Maffia P, Grassia G, Di Meglio P, Carnuccio R, Berrino L, Garside P, Ianaro A, Ialenti A. Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury. Circulation. 2006;114: 430-437.
21. Torsney E, Mayr U, Zou Y, Thompson WD, Hu Y, Xu Q. Thrombosis and neointima formation in vein grafts are inhibited by locally applied aspirin through endothelial protection. Circ Res. 2004;94:1466-1473.
22. Ianaro A, Maffia P, Cuzzocrea S, Mazzon E, Santoro MG, Di Rosa M, Ialenti A. 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-KB. FEBS Lett. 2003;553: 21-27.
23. Dzau VJ, Braun-Dullaeus RC, Sedding DG. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat Med. 2002;8:1249-1256.
24. Skaletz-Rorowski A, Eschert H, Leng J, Stallmeyer B, Sindermann JR, Pulawski E, Breithardt G. PKC S-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells. Cardiovasc Res. 2005;67:142-150.
25. Newby AC, Zaltsman AB. Molecular mechanisms in intimal hyperplasia. J Pathol. 2000;190:300-309.
26. Bendeck MP, Zempo N, Clowes AW, Galardy RE, Reidy MA. Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat. Circ Res. 1994;75:539-545.
27. Schober A, Zernecke A. Chemokines in vascular remodeling. Thromb Haemost. 2007;97:730-737.
28. Obara H, Takayanagi A, Hirahashi J, Tanaka K, Wakabayashi G, Matsumoto K, Shimazu M, Shimizu N, Kitajima M. Overexpression of truncated IKB induces TNF-a-dependent apoptosis in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2000;20: 2198-2204.
29. Baima ET, Guzova JA, Mathialagan S, Nagiec EE, Hardy MM, Song LR, Bonar SL, Weinberg RA, Selness SR, Woodard SS, Chrencik J, Hood WF, Schindler JF, Kishore N, Mbalaviele G. Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-KB essential modulator binding domain peptides. J Biol Chem. 2010;285: 13498-13506.
30. Egashira K, Suzuki J, Ito H, Aoki M, Isobe M, Morishita R. Long-term follow up of initial clinical cases with NF-KB decoy oligodeoxynucleo-tide transfection at the site of coronary stenting. J Gene Med. 2008;10: 805-809.
31. Maffia P, Zinselmeyer BH, Ialenti A, Kennedy S, Baker AH, McInnes IB, Brewer JM, Garside P. Images in cardiovascular medicine. Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E- deficient mouse carotid artery. Circulation. 2007;115: e326-e328.