Perturbed amelogenin secondary structure leads to uncontrolled aggregation in amelogenesis imperfecta mutant proteins

Journal of Biological Chemistry

Volumn 285, Issue 52, 2010, Pages 40593-40603

  Lakshminarayanan, Rajamani ^a,b   Bromley, Keith M ^a   Lei, Ya Ping ^a   Snead, Malcolm L ^a   Moradian Oldak, Janet ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

AMELOGENESIS; AMELOGENIN; BIOPHYSICAL PROPERTIES; FLUORESCENCE STUDIES; FOLDED CONFORMATION; HETEROGENEOUS POPULATIONS; HUMAN DISEASE; INTRINSIC DISORDER; LARGE AGGREGATES; MOLECULAR MECHANISM; MUTANT PROTEINS; NARROW TEMPERATURE RANGES; OLIGOMERIC STATE; REFOLDING; ROOM TEMPERATURE; SECONDARY STRUCTURES; THERMAL DENATURATIONS; TRYPTOPHAN FLUORESCENCE; TWO-POINT; VARIABLE TEMPERATURE; WILD TYPES;

AMINO ACIDS; DNA SEQUENCES; DYNAMIC LIGHT SCATTERING; ENAMELS; FLUORESCENCE; HEATING; OLIGOMERS; REFRACTION;

CONFORMATIONS;

AMELOGENIN; RECOMBINANT PROTEIN; TRYPTOPHAN;

AMELOGENESIS IMPERFECTA; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA SEQUENCE; FLUORESCENCE ANALYSIS; GENE IDENTIFICATION; HUMAN; LIGHT SCATTERING; NONHUMAN; OLIGOMERIZATION; PH; POINT MUTATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; ROOM TEMPERATURE; SPECTRAL SENSITIVITY; TEMPERATURE SENSITIVITY; THERMOSTABILITY; WILD TYPE;

AMELOGENESIS IMPERFECTA; AMELOGENIN; HUMANS; POINT MUTATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY;

MURINAE;

EID: 78650412788     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.131136     Document Type: Article

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