Intracellular traffic of oligodeoxynucleotides in and out of the nucleus: Effect of exportins and DNA structure

Oligonucleotides

Volumn 20, Issue 6, 2010, Pages 277-284

  Forsha, Stephen J ^a,b   Panyutin, Irina V ^a   Neumann, Ronald D ^a   Panyutin, Igor G ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXPORTIN 1; EXPORTIN 5; GUANINE QUADRUPLEX; LEPTOMYCIN B; MICRORNA; OLIGODEOXYNUCLEOTIDE; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL; CELL DEATH; CELL KINETICS; CELL MIGRATION; CELL NUCLEUS; CELL TRANSPORT; CYTOPLASM; DNA STRUCTURE; FIBROSARCOMA CELL; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE TRANSPORT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; QUANTITATIVE ANALYSIS;

BASE SEQUENCE; BIOLOGICAL TRANSPORT; CELL NUCLEUS; DNA; DNA PRIMERS; DOWN-REGULATION; KARYOPHERINS; NUCLEIC ACID CONFORMATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

BACTERIA (MICROORGANISMS);

EID: 78650362849     PISSN: 15454576     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.2010.0255     Document Type: Article

References (26)

1. ALAM, M.R., DIXIT, V., KANG, H., LI, Z.B., CHEN, X., TREJO, J., FISHER, M., and JULIANO, R.L. (2008). Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Nucleic Acids Res. 36, 2764-2776.
2. CASTANOTTO, D., LINGEMAN, R., RIGGS, A.D., and ROSSI, J.J. (2009). CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs. Proc. Natl. Acad. Sci. U. S. A. 106, 21655-21659.
3. CHEN, A.K., BEHLKE, M.A., and TSOURKAS, A. (2009). Sub-cellular trafficking and functionality of 2'-O-methyl and 2'-O-methyl-phosphorothioate molecular beacons. Nucleic Acids Res. 37, e149.
4. FERNANDES-ALNEMRI, T., YU, J.W., DATTA, P., WU, J., and ALNEMRI, E.S. (2009). AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458, 509-513.
5. FISHER, T.L., TERHORST, T., CAO, X., and WAGNER, R.W. (1993). Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides micro-injected into mammalian cells. Nucleic Acids Res. 21, 3857-3865.
6. GAYNUTDINOV, T.I., NEUMANN, R.D., and PANYUTIN, I.G. (2008). Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences. Nucleic Acids Res. 36, 4079-4087.
7. GIOVANNANGELI, C., and HELENE, C. (1997). Progress in developments of triplex-based strategies. Antisense Nucleic Acid Drug Dev. 7, 413-421.
8. GORLICH, D., and KUTAY, U. (1999). Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol. 15, 607-660.
9. HELENE, C., and TOULME, J.J. (1990). Specific regulation of gene expression by antisense, sense and antigene nucleic acids. Biochim. Biophys. Acta. 1049, 99-125.
10. HORNUNG, V., ABLASSER, A., CHARREL-DENNIS, M., BAUERNFEIND, F., HORVATH, G., CAFFREY, D.R., LATZ, E., and FITZGERALD, K.A. (2009). AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458, 514-518.
11. ISHIKAWA, H., MA, Z., and BARBER, G.N. (2009). STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461, 788-792.
12. JAZAYERI, A., BALESTRINI, A., GARNER, E., HABER, J.E., and COSTANZO, V. (2008). Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J 27, 1953-1962.
13. KUDO, N., MATSUMORI, N., TAOKA, H., FUJIWARA, D., SCHREINER, E.P., WOLFF, B., YOSHIDA, M., and HOR-INOUCHI, S. (1999). Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc. Natl. Acad. Sci. U. S. A. 96, 9112-9117.
14. LEONETTI, J.P., MECHTI, N., DEGOLS, G., GAGNOR, C., and LEBLEU, B. (1991). Intracellular distribution of microinjected antisense oligonucleotides. Proc. Natl. Acad. Sci. U. S. A. 88, 2702-2706.
15. LIPPS, H.J., and RHODES, D. (2009). G-quadruplex structures: in vivo evidence and function. Trends Cell. Biol. 19, 414-422.
16. LONGE, H.O., ROMESSER, P.B., RANKIN, A.M., FALLER, D.V., ELLER, M.S., GILCHREST, B.A., and DENIS, G.V. (2009). Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: mechanism and therapeutic potential. Int. J. Cancer 124, 473-482.
17. LUND, E., GUTTINGER, S., CALADO, A., DAHLBERG, J.E., and KUTAY, U. (2004). Nuclear export of microRNA precursors. Science 303, 95-98.
18. OHRT, T., MERKLE, D., BIRKENFELD, K., ECHEVERRI, C.J., and SCHWILLE, P. (2006). In situ fluorescence analysis demonstrates active siRNA exclusion from the nucleus by Exportin 5. Nucleic Acids. Res. 34, 1369-1380.
19. PENG, A., LEWELLYN, A.L., and MALLER, J.L. (2007). Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos. Mol. Cell. Biol. 27, 6852-6862.
20. QUANZ, M., CHASSOUX, D., BERTHAULT, N., AGRARIO, C., SUN, J.S., and DUTREIX, M. (2009). Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response. PLoS One 4, e6298.
21. ROBB, G.B., BROWN, K.M., KHURANA, J., and RANA, T.M. (2005). Specific and potent RNAi in the nucleus of human cells. Nat. Struct. Mol. Biol. 12, 133-137.
22. STEIN, C.A., and CHENG, Y.C. (1993). Antisense oligonucleo-tides as therapeutic agents-is the bullet really magical? Science 261, 1004-1012.
23. STEIN, C.A., and COHEN, J.S. (1988). Oligodeoxynucleotides as inhibitors of gene expression: a review. Cancer Res. 48, 2659-2668.
24. THIEL, K.W., and GIANGRANDE, P.H. (2009). Therapeutic applications of DNA and RNA aptamers. Oligonucleotides 19, 209-222.
25. WINTER, J., JUNG, S., KELLER, S., GREGORY, R.I., and DIE-DERICHS, S. (2009). Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat. Cell. Biol. 11, 228-234.
26. WOLFF, B., SANGLIER, J.J., and WANG, Y. (1997). Leptomycin B is an inhibitor of nuclear export: inhibition of nucleocytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem. Biol. 4, 139-147.