Nuclear factor κb-mediated transactivation of telomerase prevents intimal smooth muscle cell from replicative senescence during vascular repair

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 12, 2010, Pages 2604-2610

  Bu, De Xiu ^a   Johansson, Maria E ^a   Ren, Jingyi ^a,c   Xu, Da Wei ^a   Johnson, F Brad ^b   Edfeldt, Kristina ^a   Yan, Zhong Qun ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

gene expression; gene therapy; genetically altered mice; intimal hyperplasia; molecular biology; nuclear factor B; smooth muscle cell; telomerase; vascular biology

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYC PROTEIN; PROTEIN MAD1; TELOMERASE REVERSE TRANSCRIPTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; E BOX ELEMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; INTIMA; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SENESCENCE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSACTIVATION; UPREGULATION;

AMINOBENZOIC ACIDS; ANIMALS; BINDING SITES; CAROTID ARTERY INJURIES; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPERPLASIA; I-KAPPA B KINASE; MALE; MICE; MICE, KNOCKOUT; MYOCYTES, SMOOTH MUSCLE; NAPHTHALENES; NF-KAPPA B; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MYC; RATS; RATS, SPRAGUE-DAWLEY; RNA; RNA, MESSENGER; TELOMERASE; TRANSCRIPTIONAL ACTIVATION; TRANSDUCTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; TUNICA INTIMA;

EID: 78650355863     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.213074     Document Type: Article

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