메뉴 건너뛰기




Volumn 22, Issue 1, 2011, Pages 24-29

Improving early breast cancer detection: Focus on methylation

Author keywords

Breast neoplasms; DNA methylation; Early detection of cancer; Nipple aspirate fluid; Plasma; Serum

Indexed keywords

APC PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYTOSINE; DEATH ASSOCIATED PROTEIN KINASE; GLUTATHIONE TRANSFERASE P1; GUANOSINE; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; TRANSCRIPTION FACTOR TWIST; UVOMORULIN;

EID: 78650348240     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdq305     Document Type: Review
Times cited : (47)

References (59)
  • 1
    • 0029955159 scopus 로고    scopus 로고
    • The genetic attributable risk of breast and ovarian cancer
    • Claus EB, Schildkraut JM, Thompson WD, Risch NJ. The genetic attributable risk of breast and ovarian cancer. Cancer 1996; 77(11): 2318-2324.
    • (1996) Cancer , vol.77 , Issue.11 , pp. 2318-2324
    • Claus, E.B.1    Schildkraut, J.M.2    Thompson, W.D.3    Risch, N.J.4
  • 2
    • 0035865285 scopus 로고    scopus 로고
    • Effectiveness of breast cancer surveillance in BRCA1/2 gene mutation carriers and women with high familial risk
    • Brekelmans CTM, Seynaeve C, Bartels CCM et al. Effectiveness of breast cancer surveillance in BRCA1/2 gene mutation carriers and women with high familial risk. J Clin Oncol 2001; 19(4): 924-930.
    • (2001) J Clin Oncol , vol.19 , Issue.4 , pp. 924-930
    • Brekelmans, C.T.M.1    Seynaeve, C.2    Bartels, C.C.M.3
  • 3
    • 41549090852 scopus 로고    scopus 로고
    • The impact of a false-positive MRI on the choice for mastectomy in BRCA mutation carriers is limited
    • Hoogerbrugge N, Kamm YJ, Bult P et al. The impact of a false-positive MRI on the choice for mastectomy in BRCA mutation carriers is limited. Ann Oncol 2008; 19(4): 655-659.
    • (2008) Ann Oncol , vol.19 , Issue.4 , pp. 655-659
    • Hoogerbrugge, N.1    Kamm, Y.J.2    Bult, P.3
  • 4
    • 2342446497 scopus 로고    scopus 로고
    • The development of interval breast malignancies in patients with BRCA mutations
    • Komenaka IK, Ditkoff BA, Joseph KA et al. The development of interval breast malignancies in patients with BRCA mutations. Cancer 2004; 100(10): 2079-2083.
    • (2004) Cancer , vol.100 , Issue.10 , pp. 2079-2083
    • Komenaka, I.K.1    Ditkoff, B.A.2    Joseph, K.A.3
  • 5
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002; 16(1): 6-21.
    • (2002) Genes Dev , vol.16 , Issue.1 , pp. 6-21
    • Bird, A.1
  • 6
    • 0037133565 scopus 로고    scopus 로고
    • Comprehensive analysis of CpG islands in human chromosomes 21 and 22
    • Takai D, Jones PA. Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A 2002; 99(6): 3740-3745.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.6 , pp. 3740-3745
    • Takai, D.1    Jones, P.A.2
  • 7
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: epigenetics joins genetics
    • Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 2000; 16(4): 168-174.
    • (2000) Trends Genet , vol.16 , Issue.4 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 8
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet 1999; 21(2): 163-167.
    • (1999) Nat Genet , vol.21 , Issue.2 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 9
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: too much, but also too little
    • Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene 2002; 21: 5400-5413.
    • (2002) Oncogene , vol.21 , pp. 5400-5413
    • Ehrlich, M.1
  • 10
    • 67449113768 scopus 로고    scopus 로고
    • Cancer DNA methylation: molecular mechanisms and clinical implications
    • McCabe MT, Brandes JC, Vertino PM. Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res 2009; 15(12): 3927-3937.
    • (2009) Clin Cancer Res , vol.15 , Issue.12 , pp. 3927-3937
    • McCabe, M.T.1    Brandes, J.C.2    Vertino, P.M.3
  • 11
    • 63449113187 scopus 로고    scopus 로고
    • Epigenetic alterations in the breast: implications for breast cancer detection, prognosis and treatment
    • Dworkin AM, Huang THM, Toland AE. Epigenetic alterations in the breast: implications for breast cancer detection, prognosis and treatment. Semin Cancer Biol 2009; 19(3): 165-171.
    • (2009) Semin Cancer Biol , vol.19 , Issue.3 , pp. 165-171
    • Dworkin, A.M.1    Huang, T.H.M.2    Toland, A.E.3
  • 12
    • 48449090298 scopus 로고    scopus 로고
    • Epigenetic biomarkers for human cancer: the time is now
    • Mulero-Navarro S, Esteller M. Epigenetic biomarkers for human cancer: the time is now. Crit Rev Oncol Hematol 2008; 68(1): 1-11.
    • (2008) Crit Rev Oncol Hematol , vol.68 , Issue.1 , pp. 1-11
    • Mulero-Navarro, S.1    Esteller, M.2
  • 13
    • 59149096662 scopus 로고    scopus 로고
    • Methylated genes as new cancer biomarkers
    • Duffy MJ, Napieralski R, Martens JWM et al. Methylated genes as new cancer biomarkers. Eur J Cancer 2009; 45(3): 335-346.
    • (2009) Eur J Cancer , vol.45 , Issue.3 , pp. 335-346
    • Duffy, M.J.1    Napieralski, R.2    Martens, J.W.M.3
  • 14
    • 34848918829 scopus 로고    scopus 로고
    • Comparing the DNA hypermethylome with gene mutations in human colorectal cancer
    • Schuebel KE, Chen W, Cope L et al. Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet 2007 3(9): e157.
    • (2007) PLoS Genet , vol.3 , Issue.9
    • Schuebel, K.E.1    Chen, W.2    Cope, L.3
  • 15
    • 75649094543 scopus 로고    scopus 로고
    • Aberrant DNA methylation in contrast with mutations
    • Ushijima T, Asada K. Aberrant DNA methylation in contrast with mutations. Cancer Sci 2010; 101(2): 300-305.
    • (2010) Cancer Sci , vol.101 , Issue.2 , pp. 300-305
    • Ushijima, T.1    Asada, K.2
  • 16
    • 0343621494 scopus 로고    scopus 로고
    • Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
    • Costello JF, Fruhwald MC, Smiraglia DJ. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet 2000; 24(2): 132-138.
    • (2000) Nat Genet , vol.24 , Issue.2 , pp. 132-138
    • Costello, J.F.1    Fruhwald, M.C.2    Smiraglia, D.J.3
  • 17
    • 0242539836 scopus 로고    scopus 로고
    • Cancer epigenetics
    • Momparler RL. Cancer epigenetics. Oncogene 2003; 22(42): 6479-6483.
    • (2003) Oncogene , vol.22 , Issue.42 , pp. 6479-6483
    • Momparler, R.L.1
  • 18
    • 67449158992 scopus 로고    scopus 로고
    • Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization
    • Novak P, Jensen TJ, Garbe JC et al. Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization. Cancer Res 2009; 69(12): 5251-5258.
    • (2009) Cancer Res , vol.69 , Issue.12 , pp. 5251-5258
    • Novak, P.1    Jensen, T.J.2    Garbe, J.C.3
  • 19
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med 2008; 358(11): 1148-1159.
    • (2008) N Engl J Med , vol.358 , Issue.11 , pp. 1148-1159
    • Esteller, M.1
  • 20
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128(4): 683-692.
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 21
    • 33845333815 scopus 로고    scopus 로고
    • Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue
    • Yan PS, Venkataramu C, Ibrahim A et al. Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue. Clin Cancer Res 2006; 12(22): 6626-6636.
    • (2006) Clin Cancer Res , vol.12 , Issue.22 , pp. 6626-6636
    • Yan, P.S.1    Venkataramu, C.2    Ibrahim, A.3
  • 22
    • 0030581585 scopus 로고    scopus 로고
    • Breast-duct endoscopy to study stages of cancerous breast disease
    • Love SM, Barsky SH. Breast-duct endoscopy to study stages of cancerous breast disease. Lancet 1996; 348(9033): 997-999.
    • (1996) Lancet , vol.348 , Issue.9033 , pp. 997-999
    • Love, S.M.1    Barsky, S.H.2
  • 23
    • 70350105624 scopus 로고    scopus 로고
    • Changes in CpG islands promoter methylation patterns during ductal breast carcinoma progression
    • Hoque MO, Prencipe M, Poeta ML et al. Changes in CpG islands promoter methylation patterns during ductal breast carcinoma progression. Cancer Epidemiol Biomarkers Prev 2009; 18(10): 2694-2700.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , Issue.10 , pp. 2694-2700
    • Hoque, M.O.1    Prencipe, M.2    Poeta, M.L.3
  • 24
    • 11444266289 scopus 로고    scopus 로고
    • Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer risk
    • Lewis CM, Cler LR, Bu DW et al. Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer risk. Clin Cancer Res 2005; 11(1): 166-172.
    • (2005) Clin Cancer Res , vol.11 , Issue.1 , pp. 166-172
    • Lewis, C.M.1    Cler, L.R.2    Bu, D.W.3
  • 25
    • 34648846673 scopus 로고    scopus 로고
    • Quantification of CpG island methylation in progressive breast lesions from normal to invasive carcinoma
    • Pasquali L, Bedeir A, Ringquist S et al. Quantification of CpG island methylation in progressive breast lesions from normal to invasive carcinoma. Cancer Lett 2007; 257(1): 136-144.
    • (2007) Cancer Lett , vol.257 , Issue.1 , pp. 136-144
    • Pasquali, L.1    Bedeir, A.2    Ringquist, S.3
  • 26
    • 0030720761 scopus 로고    scopus 로고
    • Nucleic acid-based methods for the detection of cancer
    • Sidransky D. Nucleic acid-based methods for the detection of cancer. Science 1997; 278(5340): 1054-1059.
    • (1997) Science , vol.278 , Issue.5340 , pp. 1054-1059
    • Sidransky, D.1
  • 27
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003; 349(21): 2042-2054.
    • (2003) N Engl J Med , vol.349 , Issue.21 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 28
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • Laird PW. The power and the promise of DNA methylation markers. Nat Rev Cancer 2003; 3(4): 253-266.
    • (2003) Nat Rev Cancer , vol.3 , Issue.4 , pp. 253-266
    • Laird, P.W.1
  • 30
    • 3042825295 scopus 로고    scopus 로고
    • Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer
    • Fackler MJ, McVeigh M, Mehrotra J et al. Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer. Cancer Res 2004; 64(13): 4442-4452.
    • (2004) Cancer Res , vol.64 , Issue.13 , pp. 4442-4452
    • Fackler, M.J.1    McVeigh, M.2    Mehrotra, J.3
  • 31
    • 34547633677 scopus 로고    scopus 로고
    • Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing
    • Robertson G, Hirst M, Bainbridge M et al. Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nat Methods 2007; 4(8): 651-657.
    • (2007) Nat Methods , vol.4 , Issue.8 , pp. 651-657
    • Robertson, G.1    Hirst, M.2    Bainbridge, M.3
  • 33
    • 78650335775 scopus 로고    scopus 로고
    • Successful oxytocin-assisted nipple aspiration in women at increased risk for breast cancer
    • May 5 [Epub ahead of print]. doi: 10.1007/s10689-010-9344-7
    • Suijkerbuijk KP, van der Wall E, Meijrink H et al. Successful oxytocin-assisted nipple aspiration in women at increased risk for breast cancer. Fam Cancer 2010 May 5 [Epub ahead of print]. doi: 10.1007/s10689-010-9344-7.
    • (2010) Fam Cancer
    • Suijkerbuijk, K.P.1    van der Wall, E.2    Meijrink, H.3
  • 34
    • 1642576173 scopus 로고    scopus 로고
    • Detection of breast cancer in nipple aspirate fluid by CpG island hypermethylation
    • Krassenstein R, Sauter E, Dulaimi E et al. Detection of breast cancer in nipple aspirate fluid by CpG island hypermethylation. Clin Cancer Res 2004; 10(1): 28-32.
    • (2004) Clin Cancer Res , vol.10 , Issue.1 , pp. 28-32
    • Krassenstein, R.1    Sauter, E.2    Dulaimi, E.3
  • 35
    • 73549104794 scopus 로고    scopus 로고
    • Quantitative evaluation of DNA hypermethylation in malignant and benign breast tissue and fluids
    • Zhu W, Qin W, Hewett JE, Sauter ER. Quantitative evaluation of DNA hypermethylation in malignant and benign breast tissue and fluids. Int J Cancer 2010; 126(2): 474-482.
    • (2010) Int J Cancer , vol.126 , Issue.2 , pp. 474-482
    • Zhu, W.1    Qin, W.2    Hewett, J.E.3    Sauter, E.R.4
  • 36
    • 18844470774 scopus 로고    scopus 로고
    • Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR
    • Evron E, Dooley WC, Umbricht CB et al. Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR. Lancet 2001; 357(9265): 1335-1336.
    • (2001) Lancet , vol.357 , Issue.9265 , pp. 1335-1336
    • Evron, E.1    Dooley, W.C.2    Umbricht, C.B.3
  • 37
    • 33745184403 scopus 로고    scopus 로고
    • Quantitative multiplex methylation-specific PCR analysis doubles detection of tumor cells in breast ductal fluid
    • Fackler MJ, Malone K, Zhang Z et al. Quantitative multiplex methylation-specific PCR analysis doubles detection of tumor cells in breast ductal fluid. Clin Cancer Res 2006; 12(11): 3306-3310.
    • (2006) Clin Cancer Res , vol.12 , Issue.11 , pp. 3306-3310
    • Fackler, M.J.1    Malone, K.2    Zhang, Z.3
  • 38
    • 34548829889 scopus 로고    scopus 로고
    • Atypia and DNA methylation in nipple duct lavage in relation to predicted breast cancer risk
    • Euhus DM, Bu D, Ashfaq R et al. Atypia and DNA methylation in nipple duct lavage in relation to predicted breast cancer risk. Cancer Epidemiol Biomarkers Prev 2007; 16(9): 1812-1821.
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , Issue.9 , pp. 1812-1821
    • Euhus, D.M.1    Bu, D.2    Ashfaq, R.3
  • 39
    • 34248172540 scopus 로고    scopus 로고
    • Gene promoter hypermethylation in ductal lavage fluid from healthy BRCA gene mutation carriers and mutation-negative controls
    • Locke I, Kote-Jarai Z, Fackler MJ et al. Gene promoter hypermethylation in ductal lavage fluid from healthy BRCA gene mutation carriers and mutation-negative controls. Breast Cancer Res 2007; 9(1): R20.
    • (2007) Breast Cancer Res , vol.9 , Issue.1
    • Locke, I.1    Kote-Jarai, Z.2    Fackler, M.J.3
  • 40
    • 74549180973 scopus 로고    scopus 로고
    • Gene methylation in breast ductal fluid from BRCA1 and BRCA2 mutation carriers
    • Antill YC, Mitchell G, Johnson SA et al. Gene methylation in breast ductal fluid from BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev 2010; 19(1): 265-274.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , Issue.1 , pp. 265-274
    • Antill, Y.C.1    Mitchell, G.2    Johnson, S.A.3
  • 41
    • 42149087728 scopus 로고    scopus 로고
    • Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fine-needle aspirate washings of breast lesions
    • Jeronimo C, Monteiro P, Henrique R et al. Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fine-needle aspirate washings of breast lesions. Breast Cancer Res Treat 2008; 109(1): 27-34.
    • (2008) Breast Cancer Res Treat , vol.109 , Issue.1 , pp. 27-34
    • Jeronimo, C.1    Monteiro, P.2    Henrique, R.3
  • 42
    • 52649102557 scopus 로고    scopus 로고
    • DNA methylation in benign breast epithelium in relation to age and breast cancer risk
    • Euhus DM, Bu D, Milchgrub S et al. DNA methylation in benign breast epithelium in relation to age and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2008; 17(5): 1051-1059.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , Issue.5 , pp. 1051-1059
    • Euhus, D.M.1    Bu, D.2    Milchgrub, S.3
  • 43
    • 0035866393 scopus 로고    scopus 로고
    • DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells
    • Jahr S, Hentze H, Englisch S et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 2001; 61(4): 1659-1665.
    • (2001) Cancer Res , vol.61 , Issue.4 , pp. 1659-1665
    • Jahr, S.1    Hentze, H.2    Englisch, S.3
  • 44
  • 45
    • 33749024160 scopus 로고    scopus 로고
    • Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer
    • Hoque MO, Feng Q, Toure P et al. Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer. J Clin Oncol 2006; 24(26): 4262-4269.
    • (2006) J Clin Oncol , vol.24 , Issue.26 , pp. 4262-4269
    • Hoque, M.O.1    Feng, Q.2    Toure, P.3
  • 46
    • 56149088621 scopus 로고    scopus 로고
    • Quantitative detection of methylated ESR1 and 14-3-3-sigma gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy
    • Martinez-Galan J, Torres B, Del MR et al. Quantitative detection of methylated ESR1 and 14-3-3-sigma gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy. Cancer Biol Ther 2008; 7(6): 958-965.
    • (2008) Cancer Biol Ther , vol.7 , Issue.6 , pp. 958-965
    • Martinez-Galan, J.1    Torres, B.2    Del, M.R.3
  • 47
    • 2642578598 scopus 로고    scopus 로고
    • Tumor-derived aberrant methylation in plasma of invasive ductal breast cancer patients: clinical implications
    • Hu XC, Wong IH, Chow LW. Tumor-derived aberrant methylation in plasma of invasive ductal breast cancer patients: clinical implications. Oncol Rep 2003; 10(6): 1811-1815.
    • (2003) Oncol Rep , vol.10 , Issue.6 , pp. 1811-1815
    • Hu, X.C.1    Wong, I.H.2    Chow, L.W.3
  • 48
    • 4644297522 scopus 로고    scopus 로고
    • Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients
    • Dulaimi E, Hillinck J, Ibanez de Caceres I et al. Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients. Clin Cancer Res 2004; 10(18): 6189-6193.
    • (2004) Clin Cancer Res , vol.10 , Issue.18 , pp. 6189-6193
    • Dulaimi, E.1    Hillinck, J.2    Ibanez de Caceres, I.3
  • 49
    • 33749571963 scopus 로고    scopus 로고
    • Epigenetic analysis of body fluids and tumor tissues: application of a comprehensive molecular assessment for early-stage breast cancer patients
    • Taback B, Giuliano AE, Lai R et al. Epigenetic analysis of body fluids and tumor tissues: application of a comprehensive molecular assessment for early-stage breast cancer patients. Ann N Y Acad Sci 2006; 1075: 211-221.
    • (2006) Ann N Y Acad Sci , vol.1075 , pp. 211-221
    • Taback, B.1    Giuliano, A.E.2    Lai, R.3
  • 50
    • 34147158249 scopus 로고    scopus 로고
    • Detection of RASSF1A and RARbeta hypermethylation in serum DNA from breast cancer patients
    • Shukla S, Mirza S, Sharma G et al. Detection of RASSF1A and RARbeta hypermethylation in serum DNA from breast cancer patients. Epigenetics 2006; 1(2): 88-93.
    • (2006) Epigenetics , vol.1 , Issue.2 , pp. 88-93
    • Shukla, S.1    Mirza, S.2    Sharma, G.3
  • 51
    • 34447100205 scopus 로고    scopus 로고
    • Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients
    • Mirza S, Sharma G, Prasad CP et al. Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients. Life Sci 2007; 81(4): 280-287.
    • (2007) Life Sci , vol.81 , Issue.4 , pp. 280-287
    • Mirza, S.1    Sharma, G.2    Prasad, C.P.3
  • 52
    • 34147134560 scopus 로고    scopus 로고
    • Promoter hypermethylation of p16INK4A, p14ARF. CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients
    • Sharma G, Mirza S, Prasad CP et al. Promoter hypermethylation of p16INK4A, p14ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients. Life Sci 2007; 80(20): 1873-1881.
    • (2007) Life Sci , vol.80 , Issue.20 , pp. 1873-1881
    • Sharma, G.1    Mirza, S.2    Prasad, C.P.3
  • 53
    • 33846630771 scopus 로고    scopus 로고
    • Hypermethylation of tumor suppressor genes BRCA1, p16 and 14-3-3sigma in serum of sporadic breast cancer patients
    • Jing F, Zhang J, Tao J et al. Hypermethylation of tumor suppressor genes BRCA1, p16 and 14-3-3sigma in serum of sporadic breast cancer patients. Onkologie 2007; 30(1-2): 14-19.
    • (2007) Onkologie , vol.30 , Issue.1-2 , pp. 14-19
    • Jing, F.1    Zhang, J.2    Tao, J.3
  • 54
    • 38449110073 scopus 로고    scopus 로고
    • Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3
    • Tan SH, Ida H, Lau QC et al. Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3. Oncol Rep 2007; 18(5): 1225-1230.
    • (2007) Oncol Rep , vol.18 , Issue.5 , pp. 1225-1230
    • Tan, S.H.1    Ida, H.2    Lau, Q.C.3
  • 55
    • 64949112189 scopus 로고    scopus 로고
    • The presence of circulating total DNA and methylated genes is associated with circulating tumour cells in blood from breast cancer patients
    • Van der Auwera I, Elst HJ, Van Laere SJ et al. The presence of circulating total DNA and methylated genes is associated with circulating tumour cells in blood from breast cancer patients. Br J Cancer 2009; 100(8): 1277-1286.
    • (2009) Br J Cancer , vol.100 , Issue.8 , pp. 1277-1286
    • Van der Auwera, I.1    Elst, H.J.2    Van Laere, S.J.3
  • 56
    • 76749085652 scopus 로고    scopus 로고
    • Clinical significance of stratifin. ERa and PR promoter methylation in tumor and serum DNA in Indian breast cancer patients
    • Mirza S, Sharma G, Parshad R et al. Clinical significance of stratifin, ERa and PR promoter methylation in tumor and serum DNA in Indian breast cancer patients. Clin Biochem 2010; 43(4-5): 380-386.
    • (2010) Clin Biochem , vol.43 , Issue.4-5 , pp. 380-386
    • Mirza, S.1    Sharma, G.2    Parshad, R.3
  • 57
    • 0033026117 scopus 로고    scopus 로고
    • Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients
    • Silva JM, Dominguez G, Villanueva MJ et al. Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients. Br J Cancer 1999; 80(8): 1262-1264.
    • (1999) Br J Cancer , vol.80 , Issue.8 , pp. 1262-1264
    • Silva, J.M.1    Dominguez, G.2    Villanueva, M.J.3
  • 58
    • 77957365619 scopus 로고    scopus 로고
    • Gene promoter hypermethylation in tumors and plasma of breast cancer patients
    • Bae YK, Shim YR, Choi JH et al. Gene promoter hypermethylation in tumors and plasma of breast cancer patients. Cancer Res Treat 2005; 37(4): 233-240.
    • (2005) Cancer Res Treat , vol.37 , Issue.4 , pp. 233-240
    • Bae, Y.K.1    Shim, Y.R.2    Choi, J.H.3
  • 59
    • 33749567871 scopus 로고    scopus 로고
    • Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer
    • Papadopoulou E, Davilas E, Sotiriou V et al. Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer. Ann N Y Acad Sci 2006; 1075: 235-243.
    • (2006) Ann N Y Acad Sci , vol.1075 , pp. 235-243
    • Papadopoulou, E.1    Davilas, E.2    Sotiriou, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.