메뉴 건너뛰기




Volumn 13, Issue 3, 2010, Pages 411-427

Morin improves urate excretion and kidney function through regulation of renal organic ion transporters in hyperuricemic mice

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; GLUCOSE TRANSPORTER 9; MESSENGER RNA; MORIN; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; ORGANIC CARNITINE TRANSPORTER 1; ORGANIC CARNITINE TRANSPORTER 2; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; UNCLASSIFIED DRUG; URATE TRANSPORTER 1; URIC ACID;

EID: 78650345393     PISSN: None     EISSN: 14821826     Source Type: Journal    
DOI: 10.18433/j3q30h     Document Type: Article
Times cited : (41)

References (59)
  • 4
    • 0036783236 scopus 로고    scopus 로고
    • Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam
    • Klein B. E. K., Klein R., and Lee K. E. Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam. Diabetes Care, 25: 1790-1794, 2002.
    • (2002) Diabetes Care , vol.25 , pp. 1790-1794
    • Klein, B.E.K.1    Klein, R.2    Lee, K.E.3
  • 13
    • 31144433386 scopus 로고    scopus 로고
    • Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population
    • Graessler J., Graessler A., Unger S., Kopprasch S., Tausche A. K., Kuhlisch E., and Schroeder H. E. Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. Arthritis Rheum, 54: 292-300, 2006.
    • (2006) Arthritis Rheum , vol.54 , pp. 292-300
    • Graessler, J.1    Graessler, A.2    Unger, S.3    Kopprasch, S.4    Tausche, A.K.5    Kuhlisch, E.6    Schroeder, H.E.7
  • 15
    • 34547208011 scopus 로고    scopus 로고
    • Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues
    • Nigam S. K., Bush K. T., and Bhatnagar V. Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephr, 3: 443-448, 2007.
    • (2007) Nat Clin Pract Nephr , vol.3 , pp. 443-448
    • Nigam, S.K.1    Bush, K.T.2    Bhatnagar, V.3
  • 16
    • 0042261645 scopus 로고    scopus 로고
    • Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: Roles of organic ion transporters, rOAT1 rOAT3 and rOCT2
    • Habu Y., Yano I., Takeuchi A., Saito H., Okuda M., Fukatsu A., and Inui K. Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1 rOAT3 and rOCT2. Biochem Pharmacol, 66: 1107-1114, 2003.
    • (2003) Biochem Pharmacol , vol.66 , pp. 1107-1114
    • Habu, Y.1    Yano, I.2    Takeuchi, A.3    Saito, H.4    Okuda, M.5    Fukatsu, A.6    Inui, K.7
  • 17
    • 14644430364 scopus 로고    scopus 로고
    • Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney
    • Habu Y., Yano I., Okuda M., Fukatsu A., and Inui K. Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney. Biochem Pharmacol, 69: 993-999, 2005.
    • (2005) Biochem Pharmacol , vol.69 , pp. 993-999
    • Habu, Y.1    Yano, I.2    Okuda, M.3    Fukatsu, A.4    Inui, K.5
  • 18
    • 0035207070 scopus 로고    scopus 로고
    • Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects
    • Iseki K., Oshiro S., Tozawa M., Iseki C., Ikemiya Y., and Takishita S. Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects. Hypertens Res, 24: 691-697, 2001.
    • (2001) Hypertens Res , vol.24 , pp. 691-697
    • Iseki, K.1    Oshiro, S.2    Tozawa, M.3    Iseki, C.4    Ikemiya, Y.5    Takishita, S.6
  • 19
    • 0033921479 scopus 로고    scopus 로고
    • Structure of renal organic anion and cation transporters
    • Burckhardt G., and Wolff N. A. Structure of renal organic anion and cation transporters. Am J Physiol-Renal, 278: F853-F866, 2000.
    • (2000) Am J Physiol-Renal , vol.278
    • Burckhardt, G.1    Wolff, N.A.2
  • 20
    • 0033849976 scopus 로고    scopus 로고
    • Cellular and molecular aspects of drug transport in the kidney
    • Inui K., Masuda S., and Saito H. Cellular and molecular aspects of drug transport in the kidney. Kidney Int, 58: 944-958, 2000.
    • (2000) Kidney Int , vol.58 , pp. 944-958
    • Inui, K.1    Masuda, S.2    Saito, H.3
  • 21
    • 0035066252 scopus 로고    scopus 로고
    • Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
    • Dresser M. J., Leabman M. K., and Giacomini K. M. Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters. J Pharm Sci, 90: 397-421, 2001.
    • (2001) J Pharm Sci , vol.90 , pp. 397-421
    • Dresser, M.J.1    Leabman, M.K.2    Giacomini, K.M.3
  • 23
    • 0035991421 scopus 로고    scopus 로고
    • Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy
    • Ji L., Masuda S., Saito H., and Inui K. Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. Kidney Int, 62: 514-524, 2002.
    • (2002) Kidney Int , vol.62 , pp. 514-524
    • Ji, L.1    Masuda, S.2    Saito, H.3    Inui, K.4
  • 24
    • 1342302111 scopus 로고    scopus 로고
    • Reduced expression of organic cation transporters rOCT1 and rOCT2 in experimental diabetes
    • Grover B., Buckley D., Buckley A. R., and Cacini W. Reduced expression of organic cation transporters rOCT1 and rOCT2 in experimental diabetes. J Pharmacol Exp Ther, 308: 949-956, 2004.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 949-956
    • Grover, B.1    Buckley, D.2    Buckley, A.R.3    Cacini, W.4
  • 27
    • 33847213858 scopus 로고    scopus 로고
    • OCTN2-mediated carnitine uptake in a newly discovered human proximal tubule cell line (Caki-1)
    • Glube N., Closs E., and Langguth P. OCTN2-mediated carnitine uptake in a newly discovered human proximal tubule cell line (Caki-1). Mol Pharm, 4: 160-168, 2007.
    • (2007) Mol Pharm , vol.4 , pp. 160-168
    • Glube, N.1    Closs, E.2    Langguth, P.3
  • 28
    • 34247885858 scopus 로고    scopus 로고
    • Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats
    • Schneider R., Sauvant C., Betz B., Otremba M., Fischer D., Holzinger H., Wanner C., Galle J., and Gekle M. Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats. Am J Physiol-Renal, 292: F1599-F1605, 2007.
    • (2007) Am J Physiol-Renal , vol.292
    • Schneider, R.1    Sauvant, C.2    Betz, B.3    Otremba, M.4    Fischer, D.5    Holzinger, H.6    Wanner, C.7    Galle, J.8    Gekle, M.9
  • 31
    • 8344222080 scopus 로고    scopus 로고
    • Management of acute and chronic gouty arthritis - Present state-of-the-art
    • Schlesinger N. Management of acute and chronic gouty arthritis - Present state-of-the-art. Drugs, 64: 2399-2416, 2004.
    • (2004) Drugs , vol.64 , pp. 2399-2416
    • Schlesinger, N.1
  • 33
    • 4644275038 scopus 로고    scopus 로고
    • Serum uric acid-lowering therapies: Where are we heading in management of hyperuricemia and the potential role of uricase
    • Bomalaski J. S., and Clark M. A. Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase. Current Rheumatology Reports, Volume 6: 7, 2004.
    • (2004) Current Rheumatology Reports , vol.6 , pp. 7
    • Bomalaski, J.S.1    Clark, M.A.2
  • 34
    • 76749150408 scopus 로고    scopus 로고
    • The dual actions of Sanmiao wan as a hypouricemic agent: Down-regulation of hepatic XOD and renal mURAT1 in hyperuricemic mice
    • Wang X., Wang C. P., Hu Q. H., Lv Y. Z., Zhang X., Ouyang Z., and Kong L. D. The dual actions of Sanmiao wan as a hypouricemic agent: down-regulation of hepatic XOD and renal mURAT1 in hyperuricemic mice. J Ethnopharmacol, 128: 107-15, 2010.
    • (2010) J Ethnopharmacol , vol.128 , pp. 107-115
    • Wang, X.1    Wang, C.P.2    Hu, Q.H.3    Lv, Y.Z.4    Zhang, X.5    Ouyang, Z.6    Kong, L.D.7
  • 35
    • 77951205930 scopus 로고    scopus 로고
    • Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice
    • Hu Q. H., Jiao R. Q., Wang X., Lv Y. Z., and Kong L. D. Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice. J Ethnopharmacol, 128: 685-692, 2010.
    • (2010) J Ethnopharmacol , vol.128 , pp. 685-692
    • Hu, Q.H.1    Jiao, R.Q.2    Wang, X.3    Lv, Y.Z.4    Kong, L.D.5
  • 36
    • 34548017059 scopus 로고    scopus 로고
    • Hypouricemic action of selected flavonoids in mice: Structure-activity relationships
    • Mo S. F., Zhou F., Lv Y. Z., Hu Q. H., Zhang D. M., and Kong L. D. Hypouricemic action of selected flavonoids in mice: structure-activity relationships. Biol Pharm Bull, 30: 1551-6, 2007.
    • (2007) Biol Pharm Bull , vol.30 , pp. 1551-1556
    • Mo, S.F.1    Zhou, F.2    Lv, Y.Z.3    Hu, Q.H.4    Zhang, D.M.5    Kong, L.D.6
  • 37
    • 29344472864 scopus 로고    scopus 로고
    • The dual actions of morin (3,5,7,2 ',4 '-pentahydroxyflavone) as a hypouricemic agent: Uricosuric effect and xanthine oxidase inhibitory activity
    • Yu Z. F., Fong W. P., and Cheng C. H. K. The dual actions of morin (3,5,7,2 ',4 '-pentahydroxyflavone) as a hypouricemic agent: Uricosuric effect and xanthine oxidase inhibitory activity. J Pharmacol Exp Ther, 316: 169-175, 2006.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 169-175
    • Yu, Z.F.1    Fong, W.P.2    Cheng, C.H.K.3
  • 38
    • 34249316879 scopus 로고    scopus 로고
    • Morin (3,5,7,2 ',4 '-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells
    • Yu Z. F., Fong W. P., and Cheng C. H. K. Morin (3,5,7,2 ',4 '-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells. Drug Metab Dispos, 35: 981-986, 2007.
    • (2007) Drug Metab Dispos , vol.35 , pp. 981-986
    • Yu, Z.F.1    Fong, W.P.2    Cheng, C.H.K.3
  • 39
    • 36249009108 scopus 로고    scopus 로고
    • Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3)
    • Hong S. S., Seo K., Lim S. C., and Han H. K. Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3). Pharmacol Res, 56: 468-473, 2007.
    • (2007) Pharmacol Res , vol.56 , pp. 468-473
    • Hong, S.S.1    Seo, K.2    Lim, S.C.3    Han, H.K.4
  • 40
    • 51849093074 scopus 로고    scopus 로고
    • Protective effect of morin on the imipenem-induced nephrotoxicity in rabbits
    • Lim S. C., Im Y. B., Bae C. S., Han S. I., Kim S. E., and Han H. K. Protective effect of morin on the imipenem-induced nephrotoxicity in rabbits. Arch Pharm Res, 31: 1060-1065, 2008.
    • (2008) Arch Pharm Res , vol.31 , pp. 1060-1065
    • Lim, S.C.1    Im, Y.B.2    Bae, C.S.3    Han, S.I.4    Kim, S.E.5    Han, H.K.6
  • 42
    • 0037114923 scopus 로고    scopus 로고
    • Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output
    • Perez-Ruiz F., Calabozo M., Erauskin G. G., Ruibal A., and Herrero-Beites A. M. Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthrit Rheum-Arthr, 47: 610-613, 2002.
    • (2002) Arthrit Rheum-Arthr , vol.47 , pp. 610-613
    • Perez-Ruiz, F.1    Calabozo, M.2    Erauskin, G.G.3    Ruibal, A.4    Herrero-Beites, A.M.5
  • 43
    • 0015025817 scopus 로고
    • Simplified alkaline phosphotungstate assay for uric acid in serum
    • Carroll J. J., Coburn H., Douglass R., and Babson A. L. Simplified alkaline phosphotungstate assay for uric acid in serum. Clin Chem, 17: 158, 1971.
    • (1971) Clin Chem , vol.17 , pp. 158
    • Carroll, J.J.1    Coburn, H.2    Douglass, R.3    Babson, A.L.4
  • 44
    • 70349345913 scopus 로고    scopus 로고
    • Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy
    • Preitner F., Bonny O., Laverriere A., Rotman S., Firsov D., Da Costa A., Metref S., and Thorens B. Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. P Natl Acad Sci USA, 106: 15501-15506, 2009.
    • (2009) P Natl Acad Sci USA , vol.106 , pp. 15501-15506
    • Preitner, F.1    Bonny, O.2    Laverriere, A.3    Rotman, S.4    Firsov, D.5    da Costa, A.6    Metref, S.7    Thorens, B.8
  • 45
    • 70349647191 scopus 로고    scopus 로고
    • Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: Renal organic ion transporter involvement
    • Hu Q. H., Wang C. A., Li J. M., Zhang D. M., and Kong L. D. Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement. Am J Physiol-Renal, 297: F1080-F1091, 2009.
    • (2009) Am J Physiol-Renal , vol.297
    • Hu, Q.H.1    Wang, C.A.2    Li, J.M.3    Zhang, D.M.4    Kong, L.D.5
  • 46
    • 0034668118 scopus 로고    scopus 로고
    • Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: Comparison of endpoint and real-time methods
    • Schmittgen T. D., Zakrajsek B. A., Mills A. G., Gorn V., Singer M. J., and Reed M. W. Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: Comparison of endpoint and real-time methods. Anal Biochem, 285: 194-204, 2000.
    • (2000) Anal Biochem , vol.285 , pp. 194-204
    • Schmittgen, T.D.1    Zakrajsek, B.A.2    Mills, A.G.3    Gorn, V.4    Singer, M.J.5    Reed, M.W.6
  • 49
    • 34250005914 scopus 로고    scopus 로고
    • Uric acid changes in urine and plasma: An effective tool in screening for purine inborn errorsof metabolism and other pathological conditions
    • Simoni R. E., Gomes L. N. L. F., Scalco F. B., Oliveira C. P. H., Neto F. R. A., and de Oliveira M. L. C. Uric acid changes in urine and plasma: An effective tool in screening for purine inborn errorsof metabolism and other pathological conditions. J Inherit Metab Dis, 30: 295-309, 2007.
    • (2007) J Inherit Metab Dis , vol.30 , pp. 295-309
    • Simoni, R.E.1    Gomes, L.N.L.F.2    Scalco, F.B.3    Oliveira, C.P.H.4    Neto, F.R.A.5    de Oliveira, M.L.C.6
  • 50
    • 33846837206 scopus 로고    scopus 로고
    • New insights into renal transport of urate
    • Anzai N., Kanai Y., and Endou H. New insights into renal transport of urate. Curr Opin Rheumatol, 19: 151-157, 2007.
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 151-157
    • Anzai, N.1    Kanai, Y.2    Endou, H.3
  • 52
    • 0032919287 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney
    • Hosoyamada M., Sekine T., Kanai Y., and Endou H. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol-Renal, 276: F122-F128, 1999.
    • (1999) Am J Physiol-Renal , vol.276
    • Hosoyamada, M.1    Sekine, T.2    Kanai, Y.3    Endou, H.4
  • 54
    • 0031434178 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    • Tamai I., Yabuuchi H., Nezu J., Sai Y., Oku A., Shimane M., and Tsuji A. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. Febs Lett, 419: 107-111, 1997.
    • (1997) Febs Lett , vol.419 , pp. 107-111
    • Tamai, I.1    Yabuuchi, H.2    Nezu, J.3    Sai, Y.4    Oku, A.5    Shimane, M.6    Tsuji, A.7
  • 55
    • 0032573562 scopus 로고    scopus 로고
    • A missense mutation of mouse OCTN2, a sodium-dependent carnitine cotransporter, in the juvenile visceral steatosis mouse
    • Lu K. M., Nishimori H., Nakamura Y., Shima K., and Kuwajima M. A missense mutation of mouse OCTN2, a sodium-dependent carnitine cotransporter, in the juvenile visceral steatosis mouse. Biochem Bioph Res Co, 252: 590-594, 1998.
    • (1998) Biochem Bioph Res Co , vol.252 , pp. 590-594
    • Lu, K.M.1    Nishimori, H.2    Nakamura, Y.3    Shima, K.4    Kuwajima, M.5
  • 56
    • 0028328375 scopus 로고
    • Morina wood pigment that protects 3 types of human-cells in the cardiovascular-system against oxyradical damage
    • Wu T. W., Zeng L. H., Wu J., and Fung K. P. Morina wood pigment that protects 3 types of human-cells in the cardiovascular-system against oxyradical damage. Biochem Pharmacol, 47: 1099-1103, 1994.
    • (1994) Biochem Pharmacol , vol.47 , pp. 1099-1103
    • Wu, T.W.1    Zeng, L.H.2    Wu, J.3    Fung, K.P.4
  • 57
    • 33645923720 scopus 로고    scopus 로고
    • A 13-week subchronic toxicity study of dietary administered morin in F344 rats
    • Cho Y. M., Onodera H., Ueda M., Imai T., and Hirose M. A 13-week subchronic toxicity study of dietary administered morin in F344 rats. Food Chem Toxicol, 44: 891-897, 2006.
    • (2006) Food Chem Toxicol , vol.44 , pp. 891-897
    • Cho, Y.M.1    Onodera, H.2    Ueda, M.3    Imai, T.4    Hirose, M.5
  • 58
    • 0028318752 scopus 로고
    • The correlation between active oxygens scavenging and antioxidative effects of flavonoids
    • Hanasaki Y., Ogawa S., and Fukui S. The correlation between active oxygens scavenging and antioxidative effects of flavonoids. Free Radical Bio Med, 16: 845-850, 1994.
    • (1994) Free Radical Bio Med , vol.16 , pp. 845-850
    • Hanasaki, Y.1    Ogawa, S.2    Fukui, S.3
  • 59
    • 0344255791 scopus 로고    scopus 로고
    • Morin sulfates/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock
    • Fang S. H., Hou Y. C., Chang W. C., Hsiu S. L., Chao P. D. L., and Chiang B. L. Morin sulfates/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock. Life Sci, 74: 743-756, 2003.
    • (2003) Life Sci , vol.74 , pp. 743-756
    • Fang, S.H.1    Hou, Y.C.2    Chang, W.C.3    Hsiu, S.L.4    Chao, P.D.L.5    Chiang, B.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.