Proanthocyanidins inhibit photocarcinogenesis through enhancement of DNA repair and xeroderma pigmentosum group A-dependent mechanism

Cancer Prevention Research

Volumn 3, Issue 12, 2010, Pages 1621-1629

  Vaid, Mudit ^a   Sharma, Som D ^a   Katiyar, Santosh K ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DAMAGE BINDING PROTEIN 2; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; INTERLEUKIN 12P40; MESSENGER RNA; NUCLEIC ACID BINDING PROTEIN; PROANTHOCYANIDIN; PYRIMIDINE DIMER; REPLICATION FACTOR A; REPLICATION FACTOR A1; UNCLASSIFIED DRUG; XERODERMA PIGMENTOSUM GROUP A PROTEIN; XERODERMA PIGMENTOSUM GROUP C PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PREVENTION; CANCER RISK; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DRUG MECHANISM; FEMALE; FIBROBLAST; GRAPE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PLANT SEED; PRIORITY JOURNAL; PROTEIN TRANSPORT; RADIATION CARCINOGENESIS; RADIATION INJURY; SKIN CANCER; SKIN CARCINOGENESIS; ULTRAVIOLET B RADIATION; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; DIET; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; FIBROBLASTS; GRAPE SEED EXTRACT; HUMANS; IMMUNOENZYME TECHNIQUES; INTERLEUKIN-12; MICE; MICE, INBRED C3H; MICE, KNOCKOUT; NEOPLASMS, RADIATION-INDUCED; PROANTHOCYANIDINS; PYRIMIDINE DIMERS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; ULTRAVIOLET RAYS; VITIS; XERODERMA PIGMENTOSUM GROUP A PROTEIN;

EID: 78650342669     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-10-0137     Document Type: Article

References (37)

1. Shi J, Yu J, Pohorly JE, Kakuda Y. Polyphenolics in grape seedsbiochemistry and functionality. J Med Food 2003;6:291-9.
2. Prieur C, Rigaud J, Cheynier V, Moutounet M. Oligomeric and polymeric procyanidins from grape seeds. Phytochemistry 1994;36:781-9. (Pubitemid 2098191)
3. Silva RC, Rigaud J, Cheynier V, Chemina A. Procyanidin dimers and trimers from grape seeds. Phytochemistry 1991;30:1259-64.
4. Mantena SK, Katiyar SK. Grape seed proanthocyanidins inhibit UV radiation-induced oxidative stress and activation of MAPK and NF-κB signaling in human epidermal keratinocytes. Free Rad Biol Med 2006;40:1603-14.
5. Sharma SD, Meeran SM, Katiyar SK. Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-κB signaling in vivo SKH-1 hairless mice. Mol Cancer Ther 2007;6:995-1005.
6. Nandakumar V, Singh T, Katiyar SK. Multi-targeted prevention and therapy of cancer by proanthocyanidins. Cancer Letts 2008; 269:378-87.
7. Mittal A, Elmets CA, Katiyar SK. Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation. Carcinogenesis 2003;24:1379-88. (Pubitemid 37038827)
8. Mantena SK, Baliga MS, Katiyar SK. Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells. Carcinogenesis 2006;27:1682-91.
9. Vayalil PK, Mittal A, Katiyar SK. Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NF-κB. Carcinogenesis 2004;25:987-95. (Pubitemid 38906615)
10. Meeran SM, Katiyar SK. Grape seed proanthocyanidins promote apoptosis in human epidermoid carcinoma A431 cells through alterations in Cdki-Cdk-cyclin cascade, loss of mitochondrial membrane potential, caspase-3 activation. Exp Dermatol 2007;16:405-15.
11. Bagchi D, Bagchi M, Stohs S, Ray SD, Sen CK, Preuss HG. Cellular protection with proanthocyanidins derived from grape seeds. Ann NY Acad Sci 2002;957:260-70. (Pubitemid 34721670)
12. Housman TS, Feldman SR, Williford PM, Fleischer AB Jr, Goldman ND, Acostamadiedo JM, Chen GJ. Skin cancer is among the most costly of all cancers to treat for the Medicare population. J Am Acad Dermatol 2003;48:425-9.
13. Katiyar SK, Matsui MS, Mukhtar H. Kinetics of UV light- induced cyclobutane pyrimidine dimers in human skin in vivo: an immunohistochemical analysis of both epidermis and dermis. Photochem Photobiol 2000;72:788-93.
14. Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Arch Dermatol Res 2010;302:71-83.
15. Kripke ML, Cox PA, Alas LG, Yarosh DB. Pyrimidine dimers in DNA initiated systemic immunosuppression in UV-irradiated mice. Proc Natl Acad Sci USA 1992;89:7516-20.
16. Yarosh D, Alas LG, Yee V, et al. Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice. Cancer Res 1992;52:4227-31.
17. Yarosh D, Klein J, O'Connor A, Hawk J, Rafal E, Wolf P. Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Xeroderma Pigmentosum Study Group. Lancet 2001;357:926-9.
18. de Vries A, van Oostrom CT, Hofhuis FM, et al. Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature 1995;377:169-73.
19. Cline SD, Hanawalt PC. Who's on first in the cellular response to DNA damage? Nat Rev Mol Cell Biol 2003;4:361-72.
20. Sancar A, Lindsey-Boltz LA, Unsal-Kaçmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 2004;73:39-85.
21. Bootsma D, Kraemer KH, Cleaver JE, Hoeijmakers JHJ. In: The Genetic Basis of Human Cancer. Vogelstein B, Kinzler KW, editors. New York: McGraw Hill;1998:245-74.
22. Meeran SM, Mantena SK, Meleth S, Elmets CA, Katiyar SK. Interleukin-12-deficient mice are at greater risk of ultraviolet radiation-induced skin tumors and malignant transformation of papillomas to carcinomas. Mol Cancer Ther 2006;5:825-32.
23. Meeran SM, Akhtar S, Katiyar SK. Inhibition of UVB-induced skin tumor development by drinking green tea polyphenols is mediated through DNA repair and subsequent inhibition of inflammation. J Invest Dermatol 2009;129:1258-70.
24. Katiyar SK, Vaid M, van Steeg H, Meeran SM. Green tea polyphenols prevent UV-induced immunosuppression by rapid repair of DNA damage and enhancement of nucleotide excision repair genes. Cancer Prev Res 2010;3:179-89.
25. Meeran SM, Mantena SK, Katiyar SK. Prevention of ultraviolet radiation-induced immunosuppression by (-)-epigallocatechin-3-gallate in mice is mediated through interleukin 12-dependent DNA repair. Clin Cancer Res 2006;12:2272-80.
26. Sharma SD, Katiyar SK. Dietary grape-seed proanthocyanidin inhibition of ultraviolet b-induced immune suppression is associated with induction of IL-12. Carcinogenesis 2006;27:95-102
27. Nitta M, Saijo M, Kodo N, Matsuda T, Nakatsu Y, Tamai H, Tanaka K. A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA. Nucleic Acids Res 2000;28:4212-8.
28. Wu X, Shell SM, Liu Y, Zou Y. ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Oncogene 2007;26:757-64.
29. Schwarz A, Stander S, Berneburg M, et al. Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nat Cell Biol 2002;4:26-31.
30. Colombo MP, Vagliani M, Spreafico F, et al. Amount of interleukin 12 available at the tumor site is critical for tumor regression. Cancer Res 1996;56:2531-34.
31. Brunda MJ, Luistro L, Warrier RR, et al. Antitumor and antimetastatic activity of interleukin-12 against murine tumors. J Exp Med 1993;178:1223-30.
32. Nastala CL, Edington HD, McKinney TG, et al. Recombinant IL-12 administration induces tumor-regression in association with IFN-γ production. J Immunol 1994;153:1697-706.
33. Wigginton JM, Komschlies KL, Back TC, Franco JL, Brunda MJ, Wiltrout RH. Administration of interleukin 12 with pulse interleukin 2 and the rapid and complete eradication of murine renal carcinoma. J Natl Cancer Inst 1996;88:38-43.
34. Camenisch U, Dip R, Schumacher SB, Schuler B, Naegeli H. Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair. Nat Struct Mol Biol 2006;13:278-84.
35. Dong L, Wen J, Pier E, et al. Melanocyte-stimulating hormone directly enhances UV-Induced DNA repair in keratinocytes by a xeroderma pigmentosum group A-dependent mechanism. Cancer Res 2010;70:3547-56.
36. Stoner GD, Dombkowski AA, Reen RK, et al. Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate. Cancer Res 2008;68:6460-7.
37. Lechner JF, Reen RK, Dombkowski AA, et al. Effects of a black raspberry diet on gene expression in the rat esophagus. Nutr Cancer 2008;60:61-9.