Significance of hepatitis B virus genotypes and mutations in the development of hepatocellular carcinoma in Asia

Journal of Gastroenterology and Hepatology (Australia)

Volumn 26, Issue 1, 2011, Pages 8-12

  Chan, Henry Lik Yuen ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Core promoter; Genotype; Hepatitis B virus; Hepatocellular carcinoma; Mutation; Precore

Indexed keywords

HEPATITIS B(E) ANTIGEN; HEPATITIS B VIRUS X PROTEIN; TRANSACTIVATOR PROTEIN;

ARTICLE; ASIA; CANCER RISK; DISEASE COURSE; DOWN REGULATION; GENE MUTATION; GENOTYPE; HEPATITIS; HEPATITIS B; HEPATITIS B VIRUS; HONG KONG; HUMAN; KARYOTYPE; LIVER CELL CARCINOMA; PREVALENCE; PRIORITY JOURNAL; SEROCONVERSION; SOUTHEAST ASIA; STOP CODON; TAIWAN; ASIAN; BLOOD; ETHNOLOGY; GENETICS; IMMUNOLOGY; LIVER TUMOR; MUTATION; PATHOGENICITY; PROGNOSIS; PROMOTER REGION; RISK ASSESSMENT; RISK FACTOR; STATISTICS; VIROLOGY;

ASIA; ASIAN CONTINENTAL ANCESTRY GROUP; CARCINOMA, HEPATOCELLULAR; CODON, TERMINATOR; GENOTYPE; HEPATITIS B; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; MUTATION; PROGNOSIS; PROMOTER REGIONS, GENETIC; RISK ASSESSMENT; RISK FACTORS; TRANS-ACTIVATORS;

EID: 78650320504     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2010.06514.x     Document Type: Article

References (55)

1. Yuen MF, Hou JL, Chutaputti A. Hepatocellular carcinoma in the Asia Pacific region. J Gastroenterol. Hepatol. 2009; 24: 346-53.
2. Chan HL, Hui AY, Wong ML et al. Genotype C Hepatitis B virus infection is associated with increased risk of hepatocellular carcinoma. Gut 2004; 53: 1494-8.
3. McMahon BJ, Holck P, Bulkow L et al. Serologic and clinical outcomes of 1536 Alaska natives chronically infected with hepatitis B virus. Ann. Intern. Med. 2001; 135: 759-68.
4. Liaw YF, Tai DI, Chu CM et al. Early detection of hepatocellular carcinoma in patients with chronic type B hepatitis. A prospective study. Gastroenterology 1986; 90: 263-7.
5. Sherman M, Peltekian KM, Lee C. Screening for hepatocellular carcinoma in chronic carriers of hepatitis B virus: incidence and prevalence of hepatocellular carcinoma in a North American urban population. Hepatology 1995; 22: 432-8.
6. Chan HL, Wong GL, Wong VW. A review of the natural history of chronic hepatitis B in the era of transient elastography. Antivir. Ther. 2009; 14: 489-99.
7. Norder H, Courouce AM, Magnius LO. Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology 1994; 198: 489-503.
8. Stuyver L, De Gendt S, Van Geyt C et al. A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J. Gen. Virol. 2000; 81: 67-74.
9. Arauz Ruiz P, Norder H, Robertson BH, Magnius LO. Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J. Gen. Virol. 2002; 83: 2059-73.
10. Okamoto H, Imai M, Kametani M, Nakamura T, Mayumi M. Genomic heterogeneity of hepatitis B virus in a 54 year old woman who contracted the infection through maternal fetal transmission. Jpn. J. Exp. Med. 1987; 57: 231-6.
11. Lindh M, Andersson AS, Gusdal A. Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus-large scale analysis using a new genotyping method. J. Infect. Dis. 1997; 175: 1285-93.
12. Cho JH, Yoon KH, Lee KE et al. Distribution of hepatitis B virus genotypes in Korea. Korean. J. Hepatol. 2009; 15: 140-7.
13. Chan HL, Wong GL, Tse CH et al. HBV genotype C is associated with more severe fibrosis than genotype B. Clin. Gastroenterol. Hepatol. 2009; 7: 1361-6.
14. Kao JH, Chen PJ, Lai MY, Chen DS. Clinical and virolgoical aspects of blood donors infected with hepatitis B virus genotypes B and C. J. Clin. Microbiol. 2002; 40: 22-5.
15. Zeng G, Wang Z, Wen S et al. Geographical distribution, virologic and clinical characteristics of hepatitis B virus genotypes in China. J. Viral. Hepat. 2005; 12: 609-17.
16. Wong GL, Chan HL. Molecular virology in chronic hepatitis B: genotypes. Hosp. Med. 2005; 66: 13-6.
17. Chu CJ, Hussain M, Lok AS. Hepatitis B virus genotype is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C. Gastroenterology 2002; 122: 1756-62.
18. Chan HL, Wong ML, Hui AY, Hung LC, Chan FK, Sung JJ. Hepatitis B virus genotype C takes a more aggressive disease course than hepatitis B virus genotype B in hepatitis B e antigen positive patients. J. Clin. Microbiol. 2003; 41: 1277-9.
19. Chu CM, Liaw YF. Predictive factors for reactivation of hepatitis B following hepatitis e antigen seroconversion in chronic hepatitis B. Gastroenterology 2007; 133: 1458-65.
20. Chan HL, Tsang SW, Liew CT et al. Viral genotype and hepatitis B virus DNA levels are correlated with histological liver damage in HBeAg negative chronic hepatitis B virus infection. Am. J. Gastroenterol. 2002; 97: 406-12.
21. Kao JH. Hepatitis B viral genotypes: clinical relevance and molecular characteristics. J. Gastroenterol. Hepatol. 2002; 17: 643-50.
22. Wong GL, Chan HL. Molecular virology in chronic hepatitis B: genotypes. Hosp. Med. 2005; 66: 13-6.
23. Kao JH, Chen PJ, Lai MY, Chan DS. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000; 118: 554-9.
24. Kao JH, Chen PJ, Lai MY, Chen DS. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 2003; 124: 327-34.
25. Fujie H, Moriya K, Shintani Y, Yotsuyanagi H. Hepatitis B virus genotypes and hepatocellular carcinoma in Japan. Gastroenterology 2001; 120: 1564-5.
26. Yu MW, Yeh SH, Chen PJ et al. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. J. Natl. Cancer Inst. 2005; 97: 265-72.
27. Sumi H, Yokosuka O, Seki N et al. Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease. Hepatology 2003; 37: 19-26.
28. Yuen MF, Sablon E, Yuan HJ et al. Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis related complications, and hepatocellular carcinoma. Hepatology. 2003; 37: 562-7.
29. Yang HI, Yeh SH, Chen PJ et al. Association between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J. Natl. Cancer Inst. 2008; 100: 1134-43.
30. Sugauchi F, Orito E, Ichida T et al. Epidemiology and virological characteristics of hepatitis B virus genotype B having the recombination with genotype C. Gastroenterology 2003; 124: 925-32.
31. Kobayashi M, Suzuki F, Akuta N et al. Virological differences between patients infected with subtypes Ba and Bj of hepatitis B virus genotype B. J. Gastroenterol. Hepatol. 2005; 20: 570-6.
32. Chan HL, Tsui SK, Tse CH et al. Epidemiological and virological characteristics of two subgroups of genotype C hepatitis C virus. J. Infect. Dis. 2005; 191: 2022-32.
33. Ahn SH, Yuen L, Revill P. Clarification required for the definition of hepatitis B virus subgenotype C1 and C2. Intervirology 2009; 52: 321-2.
34. Tanaka Y, Mukaide M, Orito E et al. Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotype C1/C2 increase the risk of hepatocellular carcinoma. J. Hepatol. 2006; 45: 646-53.
35. Chan HL, Tse CH, Mo F et al. High viral load and hepatitis B subgenotype Ce are associated with increased risk of hepatocellular carcinoma. J. Clin. Oncol. 2008; 26: 177-82.
36. Scaglioni PP, Melegari M, Wands JR. Biological properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame. Virology 1997; 233: 374-81.
37. Funk ML, Rosenberg DM, Lok AS. World wide epidemiology of HbeAg negative chronic hepatitis B and associated precore and core promoter variants. J. Viral. Hepat. 2002; 9: 52-61.
38. Li JS, Tong SP, Wen YM, Vitvitski L, Zhang Q, Trepo C. Hepatitis B virus genotype A rarely circulates as an HBe minus mutant: possible contribution of a single nucleotide in the precore region. J. Virol. 1993; 67: 5402-10.
39. Rodriguez Frias F, Buti M, Jardi R et al. Hepatitis B virus infection: precore mutants and its relation to viral genotypes and core mutations. Hepatology 1995; 22: 1641-7.
40. Lok AS, Akarca U, Greene S. Mutations in the pre core region of hepatitis virus serve to enhance the stability of the secondary structure of the pre genomic encapsidation signal. Proc. Natl. Acad. Sci. USA. 1994; 91: 4077-81.
41. Chan HL, Tse CH, Ng EY et al. Phylogenetic, virological and clinical characteristics of genotype C hepatitis B virus with TCC at codon 15 of the precore region. J. Clin. Microbiol. 2006; 44: 681-7.
42. Liang TJ, Hasegawa K, Rimon N, Wands JR, Ben Porah E. A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. N. Engl. J. Med. 1991; 324: 1705-9.
43. Omata M, Ehata T, Yokosuka O, Hosoda K, Ohto M. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N. Engl. J. Med. 1991; 324: 1699-704.
44. Chan HL, Leung NW, Hussain M, Wong ML, Lok AS. Hepatitis B e antigen negative chronic hepatitis B in Hong Kong. Hepatology 2000; 31: 763-8.
45. Sung JJ, Chan HL, Wong ML et al. Relationship of clinical and virological factors with hepatitis activity in hepatitis B e antigen negative chronic hepatitis B virus infected patients. J. Viral. Hepat. 2002; 9: 229-34.
46. Chan HL, Hussain M, Lok AS. Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during Hepatitis B e antigen seroconversion. Hepatology 1999; 29: 976-84.
47. Buckwold VE, Xu Z, Chen M, Yen TS, Ou JH. Effects of a naturally occurring mutation in the hepatitis virus basal core promoter on precore gene expression and viral replication. J. Virol. 1996; 70: 5845-51.
48. Moriyama K, Okamoto H, Tsuda F, Mayumi M. Reduced precore transcription and enhanced core pregenomic transcription of hepatitis B virus DNA after replacement of the precore core promotor with sequences associated with e antigen seronegative persistent infections. Virology 1996; 226: 269-80.
49. Baptistia M, Kramvis A, Kew MC. High prevalence of 1762(T) 1764(A) mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers. Hepatology 1999; 29: 946-53.
50. Kuang SY, Jackson PE, Wang JB et al. Specific mutations of hepatitis B virus in plasma predict liver cancer development. Proc. Natl. Acad. Sci. USA. 2004; 101: 3575-80.
51. Liu S, Zhang H, Gu C et al. Association between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta analysis. J. Natl. Cancer Inst. 2009; 101: 1066-82.
52. Iavarone M, Trabut JB, Delpuech O et al. Characterisation of hepatitis B virus X protein mutants in tumor and non tumor liver cells using laser capture microdissection. J. Hepatol. 2003; 39: 253-61.
53. Sung JJ, Tsui SK, Tse CH et al. Genotype specific genomic markers associated with primary hepatoma based on complete genomic sequencing of hepatitis B virus. J. Virol. 2008; 82: 3604-11.
54. Chan HL, Sung JJ. Hepatocellular carcinoma and hepatitis B virus. Semin. Liver Dis. 2006; 26: 153-61.
55. Wong VW, Chan SL, Mo F et al. Clinical scoring system to predict hepatocellular carcinoma in chronic hepatitis carriers. J. Clin. Oncol. 2010; 28: 1660-5.