Characterization of Necrotizing Lymphadenitis Associated with Porcine Circovirus Type 2 Infection

Journal of Comparative Pathology

Volumn 144, Issue 1, 2011, Pages 63-69

  Galindo Cardiel, I ^a,b   Grau Roma, L ^a,b   Perez Maillo M ^a   Segales J ^a,b  

^a UAB IRTA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Apoptosis; Necrotizing lymphadenitis; Porcine circovirus type 2; Post weaning multisystemic wasting syndrome; Von Willebrand factor

Indexed keywords

CASPASE 3; FIBRIN; VON WILLEBRAND FACTOR;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD VESSEL INJURY; CIRCOVIRUS; CONTROLLED STUDY; DISEASE ASSOCIATION; HIGH ENDOTHELIAL VENULE; HISTOPATHOLOGY; HYPERPLASIA; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIKUCHI DISEASE; LYMPH NODE; LYMPHOCYTE DEPLETION; NONHUMAN; PATHOGENESIS; PORCINE CIRCOVIRUS TYPE 2; PRIORITY JOURNAL; THROMBOSIS; VENULE; VIRUS GENOME; VIRUS INFECTION;

ANIMALS; CIRCOVIRIDAE INFECTIONS; CIRCOVIRUS; DNA, VIRAL; HISTIOCYTIC NECROTIZING LYMPHADENITIS; IN SITU HYBRIDIZATION; LYMPH NODES; RETROSPECTIVE STUDIES; SWINE; SWINE DISEASES;

ANIMALIA; PORCINE CIRCOVIRUS 2; SUIDAE;

EID: 78650309880     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcpa.2010.06.003     Document Type: Article

References (21)

1. Grau-Roma L., Hjulsager C.K., Sibila M., Kristensen C.S., López-Soria S., et al. Infection, excretion and seroconversion dynamics of porcine circovirus type 2 (PCV2) in pigs from post-weaning multisystemic wasting syndrome (PMWS) affected farms in Spain and Denmark. Veterinary Microbiology 2009, 135:272-282.
2. Karuppannan A.K., Jong M.H., Lee S.H., Zhu Y., Selvaraj M., et al. Attenuation of porcine circovirus 2 in SPF piglets by abrogation of ORF3 function. Virology 2009, 383:338-347.
3. Kim J., Chae C. Necrotising lymphadenitis associated with porcine circovirus type 2 in pigs. Veterinary Record 2005, 156:177-178.
4. Krakowka S., Ellis J., McNeilly F., Meehan B., Oglesbee M., et al. Features of cell degeneration and death in hepatic failure and systemic lymphoid depletion characteristic of porcine circovirus-2-associated postweaning multisystemic wasting disease. Veterinary Pathology 2004, 41:471-481.
5. Langohr I.M., Stevenson G.W., Nelson E.A., Lenz S.D., HogenEsch H., et al. Vascular lesions in pigs experimentally infected with porcine circovirus type 2 serogroup B. Veterinary Pathology 2010, 47:140-147.
6. Liu J., Chen I., Du Q., Chua H., Kwang J. The ORF3 protein of porcine circovirus type 2 is involved in viral pathogenesis in vivo. Journal of Virology 2006, 80:5065-5073.
7. Liu J., Chen I., Kwang J. Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis. Journal of Virology 2005, 79:8262-8274.
8. Mandrioli L., Sarli G., Panarese S., Baldoni S., Marcato P.S. Apoptosis and proliferative activity in lymph node reaction in postweaning multisystemic wasting syndrome (PMWS). Veterinary Immunology and Immunopathology 2004, 97:25-37.
9. Marks F.S., Reck J., Almeida L.L., Berger M., Corrêa A.M., et al. Porcine circovirus 2 (PCV2) induces a procoagulant state in naturally infected swine and in cultured endothelial cells. Veterinary Microbiology 2010, 141:22-30.
10. Nichols T.C., Bellinger D.A., Reddick R.L., Read M.S., Koch G.G., et al. Role of von Willebrand factor in arterial thrombosis. Studies in normal and von Willebrand disease pigs. Circulation 1991, 83:56-64.
11. Olvera A., Sibila M., Calsamiglia M., Segalés J., Domingo M. Comparison of porcine circovirus type 2 load in serum quantified by a real time PCR in postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome in naturally affected pigs. Journal of Virological Methods 2004, 117:75-80.
12. Opriessnig T., Janke B.H., Halbur P.G. Cardiovascular lesions in pigs naturally or experimentally infected with porcine circovirus type 2. Journal of Comparative Pathology 2006, 134:105-110.
13. Resendes A.R., Majo N., Segalés J., Mateu E., Calsamiglia M., et al. Apoptosis in lymphoid organs of pigs naturally infected by porcine circovirus type 2. Journal of General Virology 2004, 85:2837-2844.
14. Rodríguez-Arrioja G.M., Segalés J., Rosell C., Quintana J., Ayllon S., et al. Aujeszky's disease virus infection concurrent with postweaning multisystemic wasting syndrome in pigs. Veterinary Record 1999, 144:152-153.
15. Rosell C., Segalés J., Plana-Duran J., Balasch M., Rodríguez-Arrioja G.M., et al. Pathological, immunohistochemical, and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs. Journal of Comparative Pathology 1999, 120:59-78.
16. Sarli G., Mandrioli L., Laurenti M., Sidoli L., Cerati C., et al. Immunohistochemical characterisation of the lymph node reaction in pig post-weaning multisystemic wasting syndrome (PMWS). Veterinary Immunology and Immunopathology 2001, 83:53-67.
17. Seeliger F.A., Brugmann M.L., Kruger L., Greiser-Wilke I., Verspohl J., et al. Porcine circovirus type 2-associated cerebellar vasculitis in postweaning multisystemic wasting syndrome (PMWS)-affected pigs. Veterinary Pathology 2007, 44:621-634.
18. Segalés J., Allan G.M., Domingo M. Porcine circovirus diseases. Animal Health Research Reviews 2005, 6:119-142.
19. Segalés J., Domingo M. Postweaning multisystemic wasting syndrome (PMWS) in pigs. A review. Veterinary Quarterly 2002, 24:109-124.
20. Segalés J., Rosell C., Domingo M. Pathological findings associated with naturally acquired porcine circovirus type 2 associated disease. Veterinary Microbiology 2004, 98:137-149.
21. Shibahara T., Sato K., Ishikawa Y., Kadota K. Porcine circovirus induces B lymphocyte depletion in pigs with wasting disease syndrome. Journal of Veterinary Medical Science 2000, 62:1125-1131.