Porcine circovirus 2 (PCV2) induces a procoagulant state in naturally infected swine and in cultured endothelial cells

Veterinary Microbiology

Volumn 141, Issue 1-2, 2010, Pages 22-30

  Marks, Fernanda S ^a   Reck Jr , José ^a   Almeida, Laura L ^a   Berger, Markus ^a   Corrêa, André M R ^a   Driemeier, David ^a   Barcellos, David E S N ^a   Guimarães, Jorge A ^a   Termignoni, Carlos ^a   Canal, Cláudio W ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Coagulation; Endothelium; Hemostasis; Porcine circovirus type 2; Swine virus; Viral pathogenesis

Indexed keywords

FIBRINOGEN; THROMBIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING TIME; CAPILLARY; CELL SURFACE; CIRCOVIRIDAE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PATHOGENESIS; PATHOPHYSIOLOGY; PHENOTYPE; PORCINE CIRCOVIRUS 2; PROTHROMBIN TIME; SWINE DISEASE; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOSIS; VASCULAR ENDOTHELIUM; VASCULITIS; VIRUS CELL INTERACTION; VIRUS INFECTION; VIRUS INFECTIVITY; VIRUS LOAD;

ANIMALS; CELL LINE; CELLS, CULTURED; CIRCOVIRIDAE INFECTIONS; CIRCOVIRUS; ENDOTHELIAL CELLS; FIBRINOGEN; HEMOSTATICS; HUMANS; IMMUNOHISTOCHEMISTRY; PLATELET AGGREGATION; POLYMERASE CHAIN REACTION; SWINE; SWINE DISEASES; THROMBIN; VIRUS REPLICATION;

ANIMALIA; PORCINE CIRCOVIRUS; PORCINE CIRCOVIRUS 2; SUIDAE;

EID: 75149149006     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetmic.2009.08.004     Document Type: Article

References (42)

1. Behling-Kelly E., and Czuprynski C.J. Endothelial cells as active participants in veterinary infections and inflammatory disorders. Anim. Health Res. Rev. 8 (2007) 47-58
2. Boom R., Sol C.J., Salimans M.M., Jansen C.L., Wertheim-van Dillen P.M., and van der Noordaa J. Rapid and simple method for purification of nucleic acids. J. Clin. Microbiol. 28 (1990) 495-503
3. Chae C. Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology. Vet. J. 168 (2004) 41-49
4. Corrêa A.M.R., Pescador C.A., Schmitz M., Zlotowski P., Rozza D.B., Oliveira E.C., Barcellos D.E.S.N., and Driemeier D. Clinical and pathological aspects of swine circovirosis in Rio Grande do Sul, southern Brazil. Braz. J. Vet. Res. 26 (2006) 9-13
5. Corrêa A.M., Zlotowski P., Barcellos D.E.S.N., Cruz C.E., and Driemeier D. Brain lesions in pigs affected with postweaning multisystemic wasting syndrome. J. Vet. Diagn. Invest. 19 (2007) 109-112
6. Darwich L., Segalés J., and Mateu E. Pathogenesis of postweaning multisystemic wasting syndrome caused by porcine circovirus 2: an immune riddle. Arch. Virol. 149 (2004) 857-874
7. Edgell C.J., McDonald C.C., and Graham J.B. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl. Acad. Sci. U.S.A. 80 (1983) 3734-3737
8. França T.N., Peixoto P.V., Brito M.F., Driemeier D., Mores N., and Zanella J. Outbreak of circovirosis (Porcine Postweaning Multisystemic Wasting Syndrome) in the state of Rio de Janeiro, Brazil. Braz. J. Vet. Res. 25 (2005) 39-53
9. Freshney R.I. Culture of Animal Cells: A Manual of Basic Techniques (2000), Wiley-Liss, New York
10. Gibbons G.H. The vascular response to injury. In: Loscalzo J., and Schafer A.I. (Eds). Thrombosis and Hemorrhage. 2nd ed. (1998), Williams & Wilkins, Baltimore 307-320
11. González X., and Notario M. Alteraciones de la hemostasia en las enfermedades virales. Rev. Cubana Hematol. Immunol. Hemoter. 15 (1999) 21-24
12. Guimarães J.A. Conceitos atuais sobre a interação dos sistemas calicreína-cinina, coagulação, renina-angiotensina, complemento e fibrinólise. Cien. Cult. 33 (1981) 1456-1459
13. Hajjar D.P., and Nicholson A.C. Viral activation of coagulation: implications for thrombosis and atherosclerosis. Ann. N. Y. Acad. Sci. 15 (1997) 155-165
14. Imai D.M., Cornish J., Nordhausen R., Ellis J., and MacLachlan N.J. Renal tubular necrosis and interstitial hemorrhage ("turkey-egg kidney") in a circovirus-infected Yorkshire cross pig. J. Vet. Diagn. Invest. 18 (2006) 496-499
15. Kroll M.H., and Sullivan R. Mechanisms of platelet activation. In: Loscalzo J., and Schafer A.I. (Eds). Thrombosis and Hemorrhage. 2nd ed. (1998), Williams & Wilkins, Baltimore 261-293
16. Lange J.V., Mitchell S.W., McCormick J.B., Walker D.H., Evatt B.L., and Ramsey R.R. Kinetic study of platelets and fibrinogen in Lassa virus-infected monkeys and early pathologic events in Mopeia virus-infected monkeys. Am. J. Trop. Med. Hyg. 34 (1985) 999-1007
17. Larochelle R., Antaya M., Morin M., and Magar R. Typing of porcine circovirus in clinical specimens by multiplex PCR. J. Virol. Methods 80 (1999) 69-75
18. Minami T., Sugiyama A., Wu S.Q., Abid R., Kodama T., and Aird W.C. Thrombin and phenotypic modulation of the endothelium. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 41-53
19. Misinzo G., Delputte P.L., Meerts P., Lefebvre D.J., and Nauwynck H.J. Porcine circovirus 2 uses heparan sulfate and chondroitin sulfate B glycosaminoglycans as receptors for its attachment to host cells. J. Virol. 80 (2006) 3487-3494
20. Ngai P.K., and Chang J.Y. A novel one-step purification of human alpha-thrombin after direct activation of crude prothrombin enriched from plasma. Biochem. J. 280 (1991) 805-808
21. Olvera A., Sibila M., Calsamiglia M., Segalés J., and Domingo M. Comparison of porcine circovirus type 2 load in serum quantified by a real time PCR in postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome naturally affected pigs. J. Virol. Methods 117 (2004) 75-80
22. Opriessnig T., Meng X.J., and Halbur P.G. Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. J. Vet. Diagn. Invest. 19 (2007) 591-615
23. Phaneuf L.R., Ceccarelli A., Laing J.R., Moloo B., and Turner P.V. Porcine dermatitis and nephropathy syndrome associated with porcine circovirus 2 infection in a Yorkshire pig. J. Am. Assoc. Lab. Anim. Sci. 46 (2007) 68-72
24. Poddar S.K. Influenza virus types and subtypes detection by single step single tube multiplex reverse transcription-polymerase chain reaction (RT-PCR) and agarose gel electrophoresis. J. Virol. Methods 99 (2002) 63-70
25. Quezada M., Ramírez E., Muñoz D., and Ruiz A. Porcine dermatitis and nephropathy syndrome: one of the principal cause of glomerulonephritis in pigs. Agro-Ciencia 20 (2004) 119-130
26. Reck J. Jr., Berger M., Marks F.S., Zingali R.B., Canal C.W., Ferreira C.A.S., Guimarães J.A., Termignoni C., in press. Pharmacological action of tick saliva upon hemostasis and the neutralization ability of sera from repeated infested hosts. Parasitology.
27. Reck Jr. J., Berger M., Terra R.M.S., Marks F.S., da Silva Vaz Jr. I., Guimarães J.A., and Termignoni C. Systemic alterations of bovine hemostasis due to Rhipicephalus (Boophilus) microplus infestation. Res. Vet. Sci. 86 (2009) 56-62
28. Seeliger F.A., Brügmann M.L., Krüger L., Greiser-Wilke I., Verspohl J., Segalés J., and Baumgärtner W. Porcine circovirus type 2-associated cerebellar vasculitis in postweaning multisystemic wasting syndrome (PMWS)-affected pigs. Vet. Pathol. 44 (2007) 621-634
29. Segalés J., Domingo M., Chianini F., Majó N., Domínguez J., Darwich L., and Mateu E. Immunosuppression in postweaning multisystemic wasting syndrome affected pigs. Vet. Microbiol. 98 (2004) 151-158
30. Segalés J., Rosell C., and Domingo M. Pathological findings associated with naturally acquired porcine circovirus type 2 associated disease. Vet. Microbiol. 98 (2004) 137-149
31. Segalés J., Allan G.M., and Domingo M. Porcine circovirus diseases. Anim. Health Res. Rev. 6 (2005) 119-142
32. Soares R.M., Durigon E.L., Bersano J.G., and Richtzenhain L.J. Detection of porcine parvovirus DNA by the polymerase chain reaction assay using primers to the highly conserved nonstructural protein gene, NS-1. J. Virol. Methods 78 (1999) 191-198
33. Sorden S.D. Update on porcine circovirus and postweaning multisystemic wasting syndrome (PMWS). Swine Health Prod. 8 (2000) 133-136
34. Sutherland M.R., Friedman H.M., and Pryzdial E.L. Thrombin enhances herpes simplex virus infection of cells involving protease-activated receptor 1. J. Thromb. Haemost. 5 (2007) 1055-1061
35. Szeredi L., and Szentirmai C. Proliferative and necrotising pneumonia and severe vascular lesions in pigs naturally infected with porcine circovirus type 2. Acta Vet. Hung. 56 (2008) 101-109
36. Tischer I., Gelderblom H., Vettermann W., and Koch M.A. A very small porcine virus with circular singlestranded DNA. Nature 295 (1982) 64-66
37. Vallée I., Tait S.W., and Powell P.P. African swine fever virus infection of porcine aortic endothelial cells leads to inhibition of inflammatory responses, activation of the thrombotic state, and apoptosis. J. Virol. 75 (2001) 10372-10382
38. van Gorp E.C., Minnema M.C., Suharti C., Mairuhu A.T., Brandjes D.P., ten Cate H., Hack C.E., and Meijers J.C. Activation of coagulation factor XI, without detectable contact activation in dengue haemorrhagic fever. Br. J. Haematol. 113 (2001) 94-99
39. van Kuppeveld F.J.M., van der Logt J.T.M., Angulo A.F., van Zoest M.J., Quint W.G.V., Niesters H.G.M., Galama J.M.D., and Melchers W.J.G. Genus- and species-specific identification of mycoplasmas by 16S rRNA amplification. Appl. Environ. Microbiol. 58 (1992) 2606-2615
40. Vilcek S., Herring A.J., Herring J.A., Nettleton P.F., Lowings J.P., and Paton D.J. Pestiviruses isolated from pigs, cattle and sheep can be allocated into at least three genogroups using polymerase chain reaction and restriction endonuclease analysis. Arch. Virol. 136 (1994) 309-323
41. Visser M.R., Tracy P.B., Vercellotti G.M., Goodman J.L., White J.G., and Jacob H.S. Enhanced thrombin generation and platelet binding on herpes simplex virus-infected endothelium. Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 8227-8230
42. Visseren F.L., Bouwman J.J., Bouter K.P., Diepersloot R.J., de Groot P.H., and Erkelens D.W. Procoagulant activity of endothelial cells after infection with respiratory viruses. Thromb. Haemost. 84 (2000) 319-324