메뉴 건너뛰기




Volumn 21, Issue 6, 2010, Pages 530-538

Novel drugs in familial combined hyperlipidemia: Lessons from type 2 diabetes mellitus

Author keywords

familial combined hyperlipidemia; insulin resistance; thiazolidinediones; treatment; type 2 diabetes mellitus

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; FIBRIC ACID DERIVATIVE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; INSULIN SENSITIZING AGENT; LAROPIPRANT; METFORMIN; NICOTINIC ACID; PIOGLITAZONE; ROSIGLITAZONE; THYROMIMETIC AGENT; TRANSCRIPTION FACTOR 7 LIKE 2; UPSTREAM STIMULATORY FACTOR 1;

EID: 78650307216     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e32833ea9ec     Document Type: Review
Times cited : (19)

References (105)
  • 1
    • 0015796295 scopus 로고
    • Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia
    • Goldstein JL, Schrott HG, Hazzard WR, et al. Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J Clin Invest 1973; 52:1544-1568.
    • (1973) J Clin Invest , vol.52 , pp. 1544-1568
    • Goldstein, J.L.1    Schrott, H.G.2    Hazzard, W.R.3
  • 2
    • 2942683422 scopus 로고    scopus 로고
    • Abdominal obesity and dyslipidemia in the metabolic syndrome: Importance of type 2 diabetes and familial combined hyperlipi-demia in coronary artery disease risk
    • Carr MC, Brunzell JD. Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipi-demia in coronary artery disease risk. J Clin Endocrinol Metab 2004; 89:2601-2607.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2601-2607
    • Carr, M.C.1    Brunzell, J.D.2
  • 3
    • 0031918837 scopus 로고    scopus 로고
    • Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23
    • Pajukanta P, Nuotio I, Terwilliger JD, et al. Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23. Nat Genet 1998; 18:369-373.
    • (1998) Nat Genet , vol.18 , pp. 369-373
    • Pajukanta, P.1    Nuotio, I.2    Terwilliger, J.D.3
  • 4
    • 0033652271 scopus 로고    scopus 로고
    • Genomewide searchfor type 2diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of atype 2-diabetes locus on chromosome 1q21-q24
    • Vionnet N, Hani EH, Dupont S,et al. Genomewide searchfor type 2diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of atype 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet 2000; 67:1470-1480.
    • (2000) Am J Hum Genet , vol.67 , pp. 1470-1480
    • Vionnet, N.1    Hani, E.H.2    Dupont, S.3
  • 5
    • 12144287541 scopus 로고    scopus 로고
    • Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)
    • Pajukanta P, Lilja HE, Sinsheimer JS, et al. Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet 2004; 36:371-376.
    • (2004) Nat Genet , vol.36 , pp. 371-376
    • Pajukanta, P.1    Lilja, H.E.2    Sinsheimer, J.S.3
  • 6
    • 24144435303 scopus 로고    scopus 로고
    • Familial combined hyperlipidemia in Mexicans: Association with upstream transcription factor 1 and linkage on chromosome 16q24.1
    • Huertas-Vazquez A, Aguilar-Salinas C, Lusis AJ, et al. Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1. Arterioscler Thromb Vasc Biol 2005; 25:1985-1991.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1985-1991
    • Huertas-Vazquez, A.1    Aguilar-Salinas, C.2    Lusis, A.J.3
  • 7
    • 33846002317 scopus 로고    scopus 로고
    • The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemia
    • van der Vleuten GM, Isaacs A, Hijmans A, et al. The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemia. J Lipid Res 2007; 48:193-200.
    • (2007) J Lipid Res , vol.48 , pp. 193-200
    • Van Der Vleuten, G.M.1    Isaacs, A.2    Hijmans, A.3
  • 8
    • 33750592176 scopus 로고    scopus 로고
    • Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q
    • Zeggini E, Damcott CM, Hanson RL, et al. Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. Diabetes 2006; 55:2541-2548.
    • (2006) Diabetes , vol.55 , pp. 2541-2548
    • Zeggini, E.1    Damcott, C.M.2    Hanson, R.L.3
  • 9
    • 44949263784 scopus 로고    scopus 로고
    • Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: Association study in 2000 Dutch Caucasians
    • Meex SJ, van Vliet-Ostaptchouk JV, van der Kallen CJ, et al. Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: association study in 2000 Dutch Caucasians. Mol Genet Metab 2008; 94:352-355.
    • (2008) Mol Genet Metab , vol.94 , pp. 352-355
    • Meex, S.J.1    Van Vliet-Ostaptchouk, J.V.2    Van Der Kallen, C.J.3
  • 10
    • 26244431875 scopus 로고    scopus 로고
    • The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population
    • Ng MC, Miyake K, So WY, et al. The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population. Diabetologia 2005; 48:2018-2024.
    • (2005) Diabetologia , vol.48 , pp. 2018-2024
    • Ng, M.C.1    Miyake, K.2    So, W.Y.3
  • 11
    • 69849116067 scopus 로고    scopus 로고
    • The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels
    • Meex SJ, Weissglas-Volkov D, van der Kallen CJ, et al. The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels. Arter-ioscler Thromb Vasc Biol 2009; 29:1322-1327.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1322-1327
    • Meex, S.J.1    Weissglas-Volkov, D.2    Van Der Kallen, C.J.3
  • 12
    • 34447120709 scopus 로고    scopus 로고
    • Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians
    • Meex SJ, van Greevenbroek MM, Ayoubi TA, et al. Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians. J Clin Endocrinol Metab 2007; 92:2720-2725.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2720-2725
    • Meex, S.J.1    Van Greevenbroek, M.M.2    Ayoubi, T.A.3
  • 13
    • 33644774734 scopus 로고    scopus 로고
    • Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21- q23 with type 2 diabetes in Pima Indians
    • Thameem F, Farook VS, Bogardus C, Prochazka M. Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21- q23 with type 2 diabetes in Pima Indians. Diabetes 2006; 55:839-842.
    • (2006) Diabetes , vol.55 , pp. 839-842
    • Thameem, F.1    Farook, V.S.2    Bogardus, C.3    Prochazka, M.4
  • 14
    • 1842422877 scopus 로고    scopus 로고
    • A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population
    • Love-Gregory LD, Wasson J, Ma J, et al. A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population. Diabetes 2004; 53:1134-1140.
    • (2004) Diabetes , vol.53 , pp. 1134-1140
    • Love-Gregory, L.D.1    Wasson, J.2    Ma, J.3
  • 15
    • 9444263716 scopus 로고    scopus 로고
    • Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish
    • Damcott CM, Hoppman N, Ott SH, et al. Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish. Diabetes 2004; 53:3337-3341.
    • (2004) Diabetes , vol.53 , pp. 3337-3341
    • Damcott, C.M.1    Hoppman, N.2    Ott, S.H.3
  • 16
    • 33747039577 scopus 로고    scopus 로고
    • Common hepatic nuclear factor-4alpha variants are associated with high serum lipid levels and the metabolic syndrome
    • Weissglas-VolkovD, Huertas-VazquezA,Suviolahti E,et al. Common hepatic nuclear factor-4alpha variants are associated with high serum lipid levels and the metabolic syndrome. Diabetes. 2006; 55: 1970-1977.
    • (2006) Diabetes , vol.55 , pp. 1970-1977
    • Weissglas-Volkov, D.1    Huertas-Vazquez, A.2    Suviolahti, E.3
  • 17
    • 36649027501 scopus 로고    scopus 로고
    • TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia
    • Huertas-Vazquez A, Plaisier C, Weissglas-Volkov D, et al. TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia. Diabetologia 2008; 51:62-69.
    • (2008) Diabetologia , vol.51 , pp. 62-69
    • Huertas-Vazquez, A.1    Plaisier, C.2    Weissglas-Volkov, D.3
  • 18
    • 32544451924 scopus 로고    scopus 로고
    • Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    • Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38:320-323.
    • (2006) Nat Genet , vol.38 , pp. 320-323
    • Grant, S.F.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 19
    • 30344471828 scopus 로고    scopus 로고
    • Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus
    • Chen MP, Chung FM, Chang DM, et al. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 2006; 91:295-299.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 295-299
    • Chen, M.P.1    Chung, F.M.2    Chang, D.M.3
  • 20
    • 34548315745 scopus 로고    scopus 로고
    • The circulating PBEF/ NAMPT/visfatin level is associated with a beneficial blood lipid profile
    • Wang P, van Greevenbroek MM, Bouwman FG, et al. The circulating PBEF/ NAMPT/visfatin level is associated with a beneficial blood lipid profile. Pflugers Arch 2007; 454:971-976.
    • (2007) Pflugers Arch , vol.454 , pp. 971-976
    • Wang, P.1    Van Greevenbroek, M.M.2    Bouwman, F.G.3
  • 21
    • 27444431875 scopus 로고    scopus 로고
    • Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the athero-genic lipid profile
    • van der Vleuten GM, van Tits LJ, den Heijer M, et al. Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the athero-genic lipid profile. J Lipid Res 2005; 46:2398-2404.
    • (2005) J Lipid Res , vol.46 , pp. 2398-2404
    • Van Der Vleuten, G.M.1    Van Tits, L.J.2    Den Heijer, M.3
  • 22
    • 0034096988 scopus 로고    scopus 로고
    • Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    • Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000; 20:1595-1599.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 1595-1599
    • Hotta, K.1    Funahashi, T.2    Arita, Y.3
  • 23
    • 0036801651 scopus 로고    scopus 로고
    • Evidence of insulin resistant lipid metabolism in adipose tissue in familial combined hyperlipi-demia, but not type 2 diabetes mellitus
    • van der Kallen CJ, Voors-Pette C, Bouwman FG, et al. Evidence of insulin resistant lipid metabolism in adipose tissue in familial combined hyperlipi-demia, but not type 2 diabetes mellitus. Atherosclerosis 2002; 164:337-346.
    • (2002) Atherosclerosis , vol.164 , pp. 337-346
    • Van Der Kallen, C.J.1    Voors-Pette, C.2    Bouwman, F.G.3
  • 24
    • 0030976621 scopus 로고    scopus 로고
    • Defects of insulin action on fatty acid and carbohydrate metabolism in familial combined hyperlipidemia
    • Aitman TJ, Godsland IF, Farren B, et al. Defects of insulin action on fatty acid and carbohydrate metabolism in familial combined hyperlipidemia. Arterios-cler Thromb Vasc Biol 1997; 17:748-754.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 748-754
    • Aitman, T.J.1    Godsland, I.F.2    Farren, B.3
  • 25
    • 0033970734 scopus 로고    scopus 로고
    • Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hyper-triglyceridemic patients
    • Pihlajamaki J, Karjalainen L, Karhapaa P, et al. Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hyper-triglyceridemic patients. Arterioscler Thromb Vasc Biol 2000; 20:164-170.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 164-170
    • Pihlajamaki, J.1    Karjalainen, L.2    Karhapaa, P.3
  • 26
    • 46049089412 scopus 로고    scopus 로고
    • Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes
    • Kotronen A, Juurinen L, Tiikkainen M, et al. Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. Gastroenterology 2008; 135:122-130.
    • (2008) Gastroenterology , vol.135 , pp. 122-130
    • Kotronen, A.1    Juurinen, L.2    Tiikkainen, M.3
  • 27
    • 0027322479 scopus 로고
    • Stable isotopes show a direct relation between VLDL apoB overproduction and serum triglyceride levels and indicate a metabolically and biochemically coherent basis for familial combined hyperlipidemia
    • Venkatesan S, Cullen P, Pacy P, et al. Stable isotopes show a direct relation between VLDL apoB overproduction and serum triglyceride levels and indicate a metabolically and biochemically coherent basis for familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol 1993; 13:1110-1118.
    • (1993) Arterioscler Thromb Vasc Biol , vol.13 , pp. 1110-1118
    • Venkatesan, S.1    Cullen, P.2    Pacy, P.3
  • 28
    • 0018843763 scopus 로고
    • Very low density lipoprotein overproduction in genetic forms of hypertriglyceridaemia
    • Chait A, Albers JJ, Brunzell JD. Very low density lipoprotein overproduction in genetic forms of hypertriglyceridaemia. Eur J Clin Invest 1980; 10:17-22.
    • (1980) Eur J Clin Invest , vol.10 , pp. 17-22
    • Chait, A.1    Albers, J.J.2    Brunzell, J.D.3
  • 29
    • 38149030206 scopus 로고    scopus 로고
    • Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects
    • Kotronen A, Juurinen L, Hakkarainen A, et al. Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects. Diabetes Care 2008; 31:165-169.
    • (2008) Diabetes Care , vol.31 , pp. 165-169
    • Kotronen, A.1    Juurinen, L.2    Hakkarainen, A.3
  • 30
    • 33846318214 scopus 로고    scopus 로고
    • Fatty liver is an integral feature of familial combined hyperlipidaemia: Relationship with fat distribution and plasma lipids
    • Brouwers MC, Bilderbeek-Beckers MA, Georgieva AM, et al. Fatty liver is an integral feature of familial combined hyperlipidaemia: relationship with fat distribution and plasma lipids. Clin Sci (Lond) 2007; 112:123-130.
    • (2007) Clin Sci (Lond) , vol.112 , pp. 123-130
    • Brouwers, M.C.1    Bilderbeek-Beckers, M.A.2    Georgieva, A.M.3
  • 31
    • 0141500237 scopus 로고    scopus 로고
    • Lipoprotein distribution in the metabolic syndrome, type 2 diabetes mellitus, and familial combined hyperlipidemia
    • Ayyobi AF, Brunzell JD. Lipoprotein distribution in the metabolic syndrome, type 2 diabetes mellitus, and familial combined hyperlipidemia. Am J Cardiol 2003; 92:27-33.
    • (2003) Am J Cardiol , vol.92 , pp. 27-33
    • Ayyobi, A.F.1    Brunzell, J.D.2
  • 32
    • 33646460625 scopus 로고    scopus 로고
    • Endothelial dysfunction and low-grade inflammation explain much of the excess cardiovascular mortality in individuals with type 2 diabetes: The Hoorn Study
    • de Jager J, Dekker JM, Kooy A, et al. Endothelial dysfunction and low-grade inflammation explain much of the excess cardiovascular mortality in individuals with type 2 diabetes: the Hoorn Study. Arterioscler Thromb Vasc Biol 2006; 26:1086-1093.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1086-1093
    • De Jager, J.1    Dekker, J.M.2    Kooy, A.3
  • 33
    • 3242664628 scopus 로고    scopus 로고
    • Prothrombotic markers in familial combined hyperlipidemia: Evidence of endothelial cell activation and relation to metabolic syndrome
    • Georgieva AM, Cate HT, Keulen ET, et al. Prothrombotic markers in familial combined hyperlipidemia: evidence of endothelial cell activation and relation to metabolic syndrome. Atherosclerosis 2004; 175:345-351.
    • (2004) Atherosclerosis , vol.175 , pp. 345-351
    • Georgieva, A.M.1    Cate, H.T.2    Keulen, E.T.3
  • 34
    • 0035060964 scopus 로고    scopus 로고
    • Familial dyslipidemic hypertension syndrome: Familial combined hyperlipidemia, and the role of abdominal fat mass
    • Keulen ET, Voors-Pette C, de Bruin TW. Familial dyslipidemic hypertension syndrome: familial combined hyperlipidemia, and the role of abdominal fat mass. Am J Hypertens 2001; 14:357-363.
    • (2001) Am J Hypertens , vol.14 , pp. 357-363
    • Keulen, E.T.1    Voors-Pette, C.2    De Bruin, T.W.3
  • 35
    • 67649808126 scopus 로고    scopus 로고
    • Increased arterial stiffness in familial combined hyperlipidemia
    • Brouwers MC, Reesink KD, van Greevenbroek MM, et al. Increased arterial stiffness in familial combined hyperlipidemia. J Hypertens 2009; 27:1009-1016.
    • (2009) J Hypertens , vol.27 , pp. 1009-1016
    • Brouwers, M.C.1    Reesink, K.D.2    Van Greevenbroek, M.M.3
  • 36
    • 41149168064 scopus 로고    scopus 로고
    • Arterial stiffness in diabetes and the metabolic syndrome: A pathway to cardiovascular disease
    • Stehouwer CD, Henry RM, Ferreira I. Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease. Diabetologia 2008; 51:527-539.
    • (2008) Diabetologia , vol.51 , pp. 527-539
    • Stehouwer, C.D.1    Henry, R.M.2    Ferreira, I.3
  • 37
    • 33847166137 scopus 로고    scopus 로고
    • Pulse wave velocity in familial combined hyperlipidemia
    • ter Avest E, Holewijn S, Bredie SJ, et al. Pulse wave velocity in familial combined hyperlipidemia. Am J Hypertens. 2007; 20: 263-269.
    • (2007) Am J Hypertens , vol.20 , pp. 263-269
    • Ter Avest, E.1    Holewijn, S.2    Bredie, S.J.3
  • 38
    • 48049113447 scopus 로고    scopus 로고
    • Plasma PAI-1 levels are independently related to fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, involvement of apolipoprotein e
    • Brouwers MC, Govers-Riemslag J, Schalkwijk CG, et al. Plasma PAI-1 levels are independently related to fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, involvement of apolipoprotein E. Thromb Res 2008; 122:466-472.
    • (2008) Thromb Res , vol.122 , pp. 466-472
    • Brouwers, M.C.1    Govers-Riemslag, J.2    Schalkwijk, C.G.3
  • 39
    • 0024327968 scopus 로고
    • Increased plasminogen activator inhibitor activity in non insulin dependent diabetic patients: Relationship with plasma insulin
    • Juhan-Vague I, Roul C, Alessi MC, et al. Increased plasminogen activator inhibitor activity in non insulin dependent diabetic patients: relationship with plasma insulin. Thromb Haemost 1989; 61:370-373.
    • (1989) Thromb Haemost , vol.61 , pp. 370-373
    • Juhan-Vague, I.1    Roul, C.2    Alessi, M.C.3
  • 40
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004; 306:457-461.
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3
  • 41
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237:E214-E223.
    • (1979) Am J Physiol , vol.237
    • Defronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 42
    • 0032934826 scopus 로고    scopus 로고
    • Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectro-scopy study
    • Krssak M, Falk Petersen K, Dresner A, et al. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectro-scopy study. Diabetologia 1999; 42:113-116.
    • (1999) Diabetologia , vol.42 , pp. 113-116
    • Krssak, M.1    Falk Petersen, K.2    Dresner, A.3
  • 43
    • 0035083645 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity
    • He J, Watkins S, Kelley DE. Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity. Diabetes 2001; 50:817-823.
    • (2001) Diabetes , vol.50 , pp. 817-823
    • He, J.1    Watkins, S.2    Kelley, D.E.3
  • 44
    • 85047690933 scopus 로고    scopus 로고
    • Splanchnic lipolysis in human obesity
    • Nielsen S, Guo Z, Johnson CM, et al. Splanchnic lipolysis in human obesity. J Clin Invest 2004; 113:1582-1588.
    • (2004) J Clin Invest , vol.113 , pp. 1582-1588
    • Nielsen, S.1    Guo, Z.2    Johnson, C.M.3
  • 45
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ, et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005; 115:1343-1351.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3
  • 46
    • 33845567067 scopus 로고    scopus 로고
    • Heritability and genetic loci of fatty liver in familial combined hyperlipidemia
    • Brouwers MC, Cantor RM, Kono N, et al. Heritability and genetic loci of fatty liver in familial combined hyperlipidemia. J Lipid Res 2006; 47:2799-2807.
    • (2006) J Lipid Res , vol.47 , pp. 2799-2807
    • Brouwers, M.C.1    Cantor, R.M.2    Kono, N.3
  • 47
    • 0036198532 scopus 로고    scopus 로고
    • LDL particle size in familial combined hyperlipidemia: Effects of serum lipids, lipoprotein-modifying enzymes, and lipid transfer proteins
    • Vakkilainen J, Jauhiainen M, Ylitalo K, et al. LDL particle size in familial combined hyperlipidemia: effects of serum lipids, lipoprotein-modifying enzymes, and lipid transfer proteins. J Lipid Res 2002; 43:598-603.
    • (2002) J Lipid Res , vol.43 , pp. 598-603
    • Vakkilainen, J.1    Jauhiainen, M.2    Ylitalo, K.3
  • 48
    • 0034746490 scopus 로고    scopus 로고
    • Atherogenic role of elevated CE transfer from HDL toVLDL(1) and dense LDLin type 2 diabetes: Impact of the degree of triglyceridemia
    • Guerin M, Le Goff W, Lassel TS, et al. Atherogenic role of elevated CE transfer from HDL toVLDL(1) and dense LDLin type 2 diabetes: impact of the degree of triglyceridemia. Arterioscler Thromb Vasc Biol 2001; 21:282-288.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 282-288
    • Guerin, M.1    Le Goff, W.2    Lassel, T.S.3
  • 49
    • 0023807047 scopus 로고
    • Low-density lipoprotein subclass patterns and risk of myocardial infarction
    • Austin MA, Breslow JL, Hennekens CH, et al. Low-density lipoprotein subclass patterns and risk of myocardial infarction. JAMA 1988; 260:1917-1921.
    • (1988) JAMA , vol.260 , pp. 1917-1921
    • Austin, M.A.1    Breslow, J.L.2    Hennekens, C.H.3
  • 50
    • 60949088629 scopus 로고    scopus 로고
    • Small dense low-density lipoprotein in familial combined hyperlipidemia: Independent of metabolic syndrome and related to history of cardiovascular events
    • Pauciullo P, Gentile M, Marotta G, et al. Small dense low-density lipoprotein in familial combined hyperlipidemia: independent of metabolic syndrome and related to history of cardiovascular events. Atherosclerosis 2009; 203:320-324.
    • (2009) Atherosclerosis , vol.203 , pp. 320-324
    • Pauciullo, P.1    Gentile, M.2    Marotta, G.3
  • 51
    • 34147127812 scopus 로고    scopus 로고
    • High plasma level of remnant-like particles cholesterol in familial combined hyperlipidemia
    • de Graaf J, van der Vleuten GM, ter Avest E, et al. High plasma level of remnant-like particles cholesterol in familial combined hyperlipidemia. J Clin Endocrinol Metab 2007; 92:1269-1275.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1269-1275
    • De Graaf, J.1    Van Der Vleuten, G.M.2    Ter Avest, E.3
  • 52
    • 0029918965 scopus 로고    scopus 로고
    • Inherited susceptibility determines the distribution of dense low-density lipoprotein subfraction profiles in familial combined hyperlipidemia
    • Bredie SJ, Kiemeney LA, de Haan AF, et al. Inherited susceptibility determines the distribution of dense low-density lipoprotein subfraction profiles in familial combined hyperlipidemia. Am J Hum Genet 1996; 58:812-822.
    • (1996) Am J Hum Genet , vol.58 , pp. 812-822
    • Bredie, S.J.1    Kiemeney, L.A.2    De Haan, A.F.3
  • 53
    • 1842334456 scopus 로고    scopus 로고
    • Report of the Expert Committee on the diagnosis and classification of diabetes mellitus
    • Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997; 20:1183-1197.
    • (1997) Diabetes Care , vol.20 , pp. 1183-1197
  • 55
    • 0030745021 scopus 로고    scopus 로고
    • Nonobese patients with familial combined hyperlipidemia are insulin resistant compared with their nonaf-fected relatives
    • Bredie SJ, Tack CJ, Smits P, Stalenhoef AF. Nonobese patients with familial combined hyperlipidemia are insulin resistant compared with their nonaf-fected relatives. Arterioscler Thromb Vasc Biol 1997; 17:1465-1471.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 1465-1471
    • Bredie, S.J.1    Tack, C.J.2    Smits, P.3    Stalenhoef, A.F.4
  • 56
    • 54549121276 scopus 로고    scopus 로고
    • A diagnostic algorithm for the athero-genic apolipoprotein B dyslipoproteinemias
    • de Graaf J, Couture P, Sniderman A. A diagnostic algorithm for the athero-genic apolipoprotein B dyslipoproteinemias. Nat Clin Pract Endocrinol Metab 2008; 4:608-618.
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 608-618
    • De Graaf, J.1    Couture, P.2    Sniderman, A.3
  • 57
    • 3042558196 scopus 로고    scopus 로고
    • Nomogram to diagnose familial combined hyperlipidemia on the basis of results of a 5-year follow-up study
    • Veerkamp MJ, de Graaf J, Hendriks JC, et al. Nomogram to diagnose familial combined hyperlipidemia on the basis of results of a 5-year follow-up study. Circulation 2004; 109:2980-2985.
    • (2004) Circulation , vol.109 , pp. 2980-2985
    • Veerkamp, M.J.1    De Graaf, J.2    Hendriks, J.C.3
  • 58
    • 0037003046 scopus 로고    scopus 로고
    • A proposal to redefine familial combined hyperlipidaemia: Third workshop on FCHL held in Barcelona from 3 to 5 May 2001, during the scientific sessions of the European Society for Clinical Investigation
    • Sniderman AD, Castro Cabezas M, Ribalta J, et al. A proposal to redefine familial combined hyperlipidaemia: third workshop on FCHL held in Barcelona from 3 to 5 May 2001, during the scientific sessions of the European Society for Clinical Investigation. Eur J Clin Invest 2002; 32:71-73.
    • (2002) Eur J Clin Invest , vol.32 , pp. 71-73
    • Sniderman, A.D.1    Castro Cabezas, M.2    Ribalta, J.3
  • 59
    • 0020621407 scopus 로고
    • Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia
    • Brunzell JD, Albers JJ, Chait A, et al. Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia. J Lipid Res 1983; 24:147-155.
    • (1983) J Lipid Res , vol.24 , pp. 147-155
    • Brunzell, J.D.1    Albers, J.J.2    Chait, A.3
  • 60
    • 36349016599 scopus 로고    scopus 로고
    • Five-year follow-up of waist circumference, insulin and ALT levels in familial combined hyperlipidaemia
    • Brouwers MC, van Greevenbroek MM, Vermeulen VM, et al. Five-year follow-up of waist circumference, insulin and ALT levels in familial combined hyperlipidaemia. Clin Sci (Lond) 2007; 113:375-381.
    • (2007) Clin Sci (Lond) , vol.113 , pp. 375-381
    • Brouwers, M.C.1    Van Greevenbroek, M.M.2    Vermeulen, V.M.3
  • 61
    • 0036159488 scopus 로고    scopus 로고
    • Diagnosis of familial combined hyperlipidemia based on lipid phenotype expression in 32 families: Results of a 5-year follow-up study
    • Veerkamp MJ, de Graaf J, Bredie SJ, et al. Diagnosis of familial combined hyperlipidemia based on lipid phenotype expression in 32 families: results of a 5-year follow-up study. ArteriosclerThromb Vasc Biol 2002; 22:274-282.
    • (2002) ArteriosclerThromb Vasc Biol , vol.22 , pp. 274-282
    • Veerkamp, M.J.1    De Graaf, J.2    Bredie, S.J.3
  • 63
    • 4544366972 scopus 로고    scopus 로고
    • Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: Implications for sex differences in markers of cardiovascular risk
    • Westerbacka J, Corner A, Tiikkainen M, et al. Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk. Diabetologia 2004; 47:1360-1369.
    • (2004) Diabetologia , vol.47 , pp. 1360-1369
    • Westerbacka, J.1    Corner, A.2    Tiikkainen, M.3
  • 64
    • 34848891301 scopus 로고    scopus 로고
    • Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance
    • Adiels M, Westerbacka J, Soro-Paavonen A, et al. Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance. Diabetologia 2007; 50:2356-2365.
    • (2007) Diabetologia , vol.50 , pp. 2356-2365
    • Adiels, M.1    Westerbacka, J.2    Soro-Paavonen, A.3
  • 65
    • 18844458833 scopus 로고    scopus 로고
    • Dietary fat content modifies liver fat in overweight nondiabetic subjects
    • Westerbacka J, Lammi K, Hakkinen AM, et al. Dietary fat content modifies liver fat in overweight nondiabetic subjects. J Clin Endocrinol Metab 2005; 90:2804-2809.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2804-2809
    • Westerbacka, J.1    Lammi, K.2    Hakkinen, A.M.3
  • 66
    • 0031458498 scopus 로고    scopus 로고
    • Lipoprotein heterogeneity and apolipoprotein B metabolism
    • Packard CJ, Shepherd J. Lipoprotein heterogeneity and apolipoprotein B metabolism. Arterioscler Thromb Vasc Biol 1997; 17:3542-3556.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 3542-3556
    • Packard, C.J.1    Shepherd, J.2
  • 67
    • 39549096697 scopus 로고    scopus 로고
    • Parabolic relationship between plasma triacylglycerols and LDL-cholesterol in familial combined hyperlipidaemia: The multiple-type hyperlipidaemia explained?
    • Brouwers MC, de Graaf J, van Greevenbroek MM, et al. Parabolic relationship between plasma triacylglycerols and LDL-cholesterol in familial combined hyperlipidaemia: the multiple-type hyperlipidaemia explained? Clin Sci (Lond) 2008; 114:393-401.
    • (2008) Clin Sci (Lond) , vol.114 , pp. 393-401
    • Brouwers, M.C.1    De Graaf, J.2    Van Greevenbroek, M.M.3
  • 68
    • 50649090204 scopus 로고    scopus 로고
    • Plasma triglycerides and LDL cholesterol are related in a parabolic fashion in the general population and patients with Type 2 diabetes mellitus: Long-term follow-up results from the Hoorn study
    • Brouwers MC, Dekker JM, van Greevenbroek MM, et al. Plasma triglycerides and LDL cholesterol are related in a parabolic fashion in the general population and patients with Type 2 diabetes mellitus: long-term follow-up results from the Hoorn study. Diabet Med 2008; 25:1121-1124.
    • (2008) Diabet Med , vol.25 , pp. 1121-1124
    • Brouwers, M.C.1    Dekker, J.M.2    Van Greevenbroek, M.M.3
  • 69
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002; 8:1288-1295.
    • (2002) Nat Med , vol.8 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3
  • 70
    • 54249088172 scopus 로고    scopus 로고
    • Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations
    • Orho-Melander M, Melander O, Guiducci C, et al. Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes 2008; 57:3112-3121.
    • (2008) Diabetes , vol.57 , pp. 3112-3121
    • Orho-Melander, M.1    Melander, O.2    Guiducci, C.3
  • 71
    • 77952533413 scopus 로고    scopus 로고
    • Investigation of variants identified in Caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples
    • Weissglas-Volkov D, Aguilar-Salinas CA, Sinsheimer JS, et al. Investigation of variants identified in Caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. Circ Cardiovasc Genet 2010; 3:31-38.
    • (2010) Circ Cardiovasc Genet , vol.3 , pp. 31-38
    • Weissglas-Volkov, D.1    Aguilar-Salinas, C.A.2    Sinsheimer, J.S.3
  • 72
    • 33845467054 scopus 로고    scopus 로고
    • Hepatic glucose production is more sensitive to insulin-mediated inhibition than hepatic VLDL-triglyceride production
    • den Boer MA, Voshol PJ, Kuipers F, et al. Hepatic glucose production is more sensitive to insulin-mediated inhibition than hepatic VLDL-triglyceride production. Am J Physiol Endocrinol Metab 2006; 291:E1360-E1364.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Den Boer, M.A.1    Voshol, P.J.2    Kuipers, F.3
  • 73
    • 77951950385 scopus 로고    scopus 로고
    • Five-year incidence of type 2 diabetes mellitus in patients with familial combined hyperlipidaemia
    • Brouwers MC, van der Kallen CJ, Schaper NC, et al. Five-year incidence of type 2 diabetes mellitus in patients with familial combined hyperlipidaemia. Neth J Med 2010; 68:163-167.
    • (2010) Neth J Med , vol.68 , pp. 163-167
    • Brouwers, M.C.1    Van Der Kallen, C.J.2    Schaper, N.C.3
  • 74
    • 33846283872 scopus 로고    scopus 로고
    • Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia
    • Ter Avest E, Sniderman AD, Bredie SJ, et al. Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia. Clin Sci (Lond) 2007; 112:131-139.
    • (2007) Clin Sci (Lond) , vol.112 , pp. 131-139
    • Ter Avest, E.1    Sniderman, A.D.2    Bredie, S.J.3
  • 75
    • 73849137508 scopus 로고    scopus 로고
    • Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway
    • Van Himbergen TM, Otokozawa S, Matthan NR, et al. Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. Arterioscler Thromb Vasc Biol 2010; 30:113-120.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 113-120
    • Van Himbergen, T.M.1    Otokozawa, S.2    Matthan, N.R.3
  • 76
    • 0025970749 scopus 로고
    • Familial combined hyperlipidaemia linked to the apolipoprotein AI-CII-AIV gene cluster on chromosome 11q23-q24
    • Wojciechowski AP, Farrall M, Cullen P, et al. Familial combined hyperlipidaemia linked to the apolipoprotein AI-CII-AIV gene cluster on chromosome 11q23-q24. Nature 1991; 349:161-164.
    • (1991) Nature , vol.349 , pp. 161-164
    • Wojciechowski, A.P.1    Farrall, M.2    Cullen, P.3
  • 77
    • 0033782243 scopus 로고    scopus 로고
    • Replication of linkage of familial combined hyperlipidemia to chromosome 1q with additional heterogeneous effect of apolipoprotein A-I/C-III/A-IV locus
    • The NHLBI Family Heart Study
    • Coon H, Myers RH, Borecki IB, et al. Replication of linkage of familial combined hyperlipidemia to chromosome 1q with additional heterogeneous effect of apolipoprotein A-I/C-III/A-IV locus. The NHLBI Family Heart Study. Arterioscler Thromb Vasc Biol 2000; 20:2275-2280.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 2275-2280
    • Coon, H.1    Myers, R.H.2    Borecki, I.B.3
  • 78
    • 0033913206 scopus 로고    scopus 로고
    • G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia
    • Pihlajamaki J, Karjalainen L, Karhapaa P, et al. G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol 2000; 20:1789-1795.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 1789-1795
    • Pihlajamaki, J.1    Karjalainen, L.2    Karhapaa, P.3
  • 79
    • 17444444680 scopus 로고    scopus 로고
    • Gender-related association between the -93T->G/D9N haplotype of the lipoprotein lipase gene and elevated lipid levels in familial combined hyperlipidemia
    • Hoffer MJ, Bredie SJ, Snieder H, et al. Gender-related association between the -93T->G/D9N haplotype of the lipoprotein lipase gene and elevated lipid levels in familial combined hyperlipidemia. Atherosclerosis 1998; 138:91-99.
    • (1998) Atherosclerosis , vol.138 , pp. 91-99
    • Hoffer, M.J.1    Bredie, S.J.2    Snieder, H.3
  • 80
    • 0033853598 scopus 로고    scopus 로고
    • The V73M mutation in the hepatic lipase gene is associated with elevated cholesterol levels in four Dutch pedigrees with familial combined hyperlipidemia
    • Hoffer MJ, Snieder H, Bredie SJ, et al. The V73M mutation in the hepatic lipase gene is associated with elevated cholesterol levels in four Dutch pedigrees with familial combined hyperlipidemia. Atherosclerosis 2000; 151:443-450.
    • (2000) Atherosclerosis , vol.151 , pp. 443-450
    • Hoffer, M.J.1    Snieder, H.2    Bredie, S.J.3
  • 81
    • 16944363110 scopus 로고    scopus 로고
    • No evidence of linkage between familial combined hyperlipidemia and genes encoding lipolytic enzymes in Finnish families
    • Pajukanta P, Porkka KV, Antikainen M, et al. No evidence of linkage between familial combined hyperlipidemia and genes encoding lipolytic enzymes in Finnish families. ArteriosclerThromb Vasc Biol 1 997; 17:841-850.
    • (1997) ArteriosclerThromb Vasc Biol , vol.17 , pp. 841-850
    • Pajukanta, P.1    Porkka, K.V.2    Antikainen, M.3
  • 82
    • 54349112435 scopus 로고    scopus 로고
    • Frequency of low-density lipoprotein receptor gene mutations in patients with a clinical diagnosis of familial combined hyperlipidemia in a clinical setting
    • Civeira F, Jarauta E, Cenarro A, et al. Frequency of low-density lipoprotein receptor gene mutations in patients with a clinical diagnosis of familial combined hyperlipidemia in a clinical setting. J Am Coll Cardiol 2008; 52:1546-1553.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1546-1553
    • Civeira, F.1    Jarauta, E.2    Cenarro, A.3
  • 83
    • 57349089246 scopus 로고    scopus 로고
    • A PCSK9 variant and familial combined hyperlipidaemia
    • Abifadel M, Bernier L, DubucG, et al.A PCSK9 variant and familial combined hyperlipidaemia. J Med Genet 2008; 45:780-786.
    • (2008) J Med Genet , vol.45 , pp. 780-786
    • Abifadel, M.1    Bernier, L.2    Dubuc, G.3
  • 84
    • 77951875017 scopus 로고    scopus 로고
    • Triglyceride-mediated pathways and coronary disease: Collaborative analysis of 101 studies
    • Sarwar N, Sandhu MS, Ricketts SL, et al. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet 2010; 375:1634-1639.
    • (2010) Lancet , vol.375 , pp. 1634-1639
    • Sarwar, N.1    Sandhu, M.S.2    Ricketts, S.L.3
  • 85
    • 77952708442 scopus 로고    scopus 로고
    • Effects of fibrates on cardiovascular outcomes: A systematic review and meta-analysis
    • Jun M, Foote C, Lv J, et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet 2010; 375:1875-1884.
    • (2010) Lancet , vol.375 , pp. 1875-1884
    • Jun, M.1    Foote, C.2    Lv, J.3
  • 86
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • Ginsberg HN, Elam MB, LovatoLC, et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 2010; 362:1563-1574.
    • (2010) N Engl J Med , vol.362 , pp. 1563-1574
    • Ginsberg, H.N.1    Elam, M.B.2    Lovato, L.C.3
  • 87
    • 77954519409 scopus 로고    scopus 로고
    • Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease
    • Fabbrini E, Mohammed BS, Korenblat KM, et al. Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease. J Clin Endocrinol Metab 2010; 95:2727-2735.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2727-2735
    • Fabbrini, E.1    Mohammed, B.S.2    Korenblat, K.M.3
  • 88
    • 72049129430 scopus 로고    scopus 로고
    • Extended-release niacin or ezetimibe and carotid intima-media thickness
    • Taylor AJ, Villines TC, Stanek EJ, et al. Extended-release niacin or ezetimibe and carotid intima-media thickness. N Engl J Med 2009; 361:2113-2122.
    • (2009) N Engl J Med , vol.361 , pp. 2113-2122
    • Taylor, A.J.1    Villines, T.C.2    Stanek, E.J.3
  • 89
    • 41949100903 scopus 로고    scopus 로고
    • Effects of laropiprant on nicotinic acid-induced flushing in patients with dyslipidemia
    • Paolini JF, Mitchel YB, Reyes R, et al. Effects of laropiprant on nicotinic acid-induced flushing in patients with dyslipidemia. Am J Cardiol 2008; 101:625-630.
    • (2008) Am J Cardiol , vol.101 , pp. 625-630
    • Paolini, J.F.1    Mitchel, Y.B.2    Reyes, R.3
  • 90
    • 48349085741 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein inhibition: Friend or foe?
    • Joy TR, Hegele RA. Microsomal triglyceride transfer protein inhibition: friend or foe? Nat Clin Pract Cardiovasc Med 2008; 5:506-508.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 506-508
    • Joy, T.R.1    Hegele, R.A.2
  • 91
    • 48349088178 scopus 로고    scopus 로고
    • Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia
    • Samaha FF, McKenney J, Bloedon LT, et al. Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia. Nat Clin Pract Cardiovasc Med 2008; 5:497-505.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 497-505
    • Samaha, F.F.1    McKenney, J.2    Bloedon, L.T.3
  • 92
    • 77949349469 scopus 로고    scopus 로고
    • Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia
    • Ladenson PW, Kristensen JD, Ridgway EC, et al. Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia. N Engl J Med 2010; 362:906-916.
    • (2010) N Engl J Med , vol.362 , pp. 906-916
    • Ladenson, P.W.1    Kristensen, J.D.2    Ridgway, E.C.3
  • 93
    • 77749270649 scopus 로고    scopus 로고
    • Effects of the thyromimetic agent diiodothyropropionic acid on body weight, body mass index, and serum lipoproteins: A pilot prospective, randomized, controlled study
    • Ladenson PW, McCarren M, Morkin E, et al. Effects of the thyromimetic agent diiodothyropropionic acid on body weight, body mass index, and serum lipoproteins: a pilot prospective, randomized, controlled study. J Clin Endocrinol Metab 2010; 95:1349-1354.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1349-1354
    • Ladenson, P.W.1    McCarren, M.2    Morkin, E.3
  • 94
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346:393-403.
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3
  • 95
    • 53749096863 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes
    • Holman RR, Paul SK, Bethel MA, et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008; 359:1577-1589.
    • (2008) N Engl J Med , vol.359 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3
  • 96
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial in macroVascular Events): A randomised controlled trial
    • Dormandy JA, Charbonnel B, Eckland DJ, et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005; 366:1279-1289.
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.3
  • 97
    • 33748748206 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomised controlled trial
    • Gerstein HC, Yusuf S, Bosch J, et al. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet 2006; 368:1096-1105.
    • (2006) Lancet , vol.368 , pp. 1096-1105
    • Gerstein, H.C.1    Yusuf, S.2    Bosch, J.3
  • 98
    • 0025605498 scopus 로고
    • Cholesterol lowering effect of metformin in combined hyperlipidemia: Placebo controlled double blind trial
    • Pentikainen PJ, Voutilainen E, Aro A, et al. Cholesterol lowering effect of metformin in combined hyperlipidemia: placebo controlled double blind trial. Ann Med 1990; 22:307-312.
    • (1990) Ann Med , vol.22 , pp. 307-312
    • Pentikainen, P.J.1    Voutilainen, E.2    Aro, A.3
  • 99
    • 0036551421 scopus 로고    scopus 로고
    • A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone
    • Khan MA, St Peter JV, Xue JL. A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone. Diabetes Care 2002; 25:708-711.
    • (2002) Diabetes Care , vol.25 , pp. 708-711
    • Khan, M.A.1    St Peter, J.V.2    Xue, J.L.3
  • 100
    • 73849109435 scopus 로고    scopus 로고
    • Thiazolidinediones and the liver in humans
    • Yki-Jarvinen H. Thiazolidinediones and the liver in humans. Curr Opin Lipidol 2009; 20:477-483.
    • (2009) Curr Opin Lipidol , vol.20 , pp. 477-483
    • Yki-Jarvinen, H.1
  • 101
    • 51249092912 scopus 로고    scopus 로고
    • Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content
    • Ravikumar B, Gerrard J, Dalla Man C, et al. Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content. Diabetes 2008; 57:2288-2295.
    • (2008) Diabetes , vol.57 , pp. 2288-2295
    • Ravikumar, B.1    Gerrard, J.2    Dalla Man, C.3
  • 102
    • 20944439286 scopus 로고    scopus 로고
    • Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus
    • Nagashima K, Lopez C, Donovan D, et al. Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus. J Clin Invest 2005; 115:1323-1332.
    • (2005) J Clin Invest , vol.115 , pp. 1323-1332
    • Nagashima, K.1    Lopez, C.2    Donovan, D.3
  • 103
    • 33644823712 scopus 로고    scopus 로고
    • Effects of pioglitazone in familial combined hyperlipidaemia
    • Abbink EJ, De Graaf J, De Haan JH, et al. Effects of pioglitazone in familial combined hyperlipidaemia. J Intern Med 2006; 259:107-116.
    • (2006) J Intern Med , vol.259 , pp. 107-116
    • Abbink, E.J.1    De Graaf, J.2    De Haan, J.H.3
  • 104
    • 35248839502 scopus 로고    scopus 로고
    • Pioglitazone added to conventional lipid-lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: Relation to liver, muscle and regional body fat content
    • Thomas EL, Potter E, Tosi I, et al. Pioglitazone added to conventional lipid-lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content. Atherosclerosis 2007; 195:e181-e190.
    • (2007) Atherosclerosis , vol.195
    • Thomas, E.L.1    Potter, E.2    Tosi, I.3
  • 105
    • 68949207969 scopus 로고    scopus 로고
    • Actos Now for the prevention of diabetes (ACT NOW) study
    • Defronzo RA, Banerji M, Bray GA, et al. Actos Now for the prevention of diabetes (ACT NOW) study. BMC Endocr Disord 2009; 9:17.
    • (2009) BMC Endocr Disord , vol.9 , pp. 17
    • Defronzo, R.A.1    Banerji, M.2    Bray, G.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.