Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4+ cells after antiretroviral therapy

Journal of Infectious Diseases

Volumn 198, Issue 10, 2008, Pages 1466-1473

  Benito, José M ^a   López, Mariola ^a   Lozano, Sara ^a   González Lahoz, Juan ^a   Soriano, Vincent ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; VIRUS RNA;

ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONG TERM CARE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; VIREMIA;

ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; DOWN-REGULATION; HIV INFECTIONS; HIV-1; HUMANS; INTERLEUKIN-7; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; RNA, VIRAL; T-LYMPHOCYTE SUBSETS;

EID: 54949090812     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/592716     Document Type: Article

References (33)

1. Clerici M, Zajac R, Boswell R, Lucey D, Via C, Shearer G. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, HIV-seropositive patients: independence of CD4+ cell numbers and clinical staging. J Clin Invest 1989; 84:1892-9.
2. Hazenberg M, Miedema F. Titled balance of T cell renewal in HIV-1 infection. AIDS Rev 1999; 1:67-73.
3. Van Noesel C, Gruters R, Terpstra F, Schellekens P, Van Lier R, Miedema F. Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic HIV-infected men. J Clin Invest 1990; 86:293-9.
4. Kestens L, Vanham G, Gigase P, et al. Expression of activation antigens, HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection. AIDS 1992; 6:793-7.
5. Roederer M, Dubs J, Anderson M, Raju P, Herzenberg L. CD8 naive T cell counts decrease progressively in HIV-infected adults. J Clin Invest 1995; 95:2061-6.
6. Benito JM, Gil J, Bermejo M, Escudero A, Sanchez E, Fernandez-Cruz E. Quantitative alterations of the functionally distinct subsets of CD4 and CD8 T lymphocytes in asymptomatic HIV infection: changes in the expression of CD45RO, CD45RA, CD11b, CD38, HLA-DR, and CD25 antigens. J Acquir Immune Defic Syndr Hum Retrovirol 1997; 14:128-35.
7. Giorgi J, Liu Z, Hultin L, Cumberland W, Henessey K, Detels R. Elevated levels of CD8+CD38+ T cells in HIV infection add to the prognostic value of low CD4+ T cells levels: results of 6 years follow-up. J Acquir Immune Defic Syndr 1993; 6:904-2.
8. Mocroft A, Bofill M, Lipman M, et al. CD8+CD38+ lymphocyte percent: a useful immunological marker for monitoring HIV-1-infected patients. J Acquir Immune Defic Syndr Hum Retrovirol 1997; 14:158-62.
9. Carbone J, Gil J, Benito J, et al. Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of HIV-infected drug users. AIDS 2000; 14:2823-9.
10. Liu Z, Cumberland W, Hultin L, Prince H, Detels R, Giorgi J. Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the multicenter AIDS cohort study than CD4+ T cell count, soluble activation markers, or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr Hum Retrovirol 1997; 16:83-92.
11. Giorgi J, Hultin L, McKeating J, et al. Shorter survival in advanced HIV type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999; 179:859-70.
12. Wilson C, Ellenberg J, Douglas S, et al. CD8+CD38+ T cells but not HIV type 1 RNA viral load predict CD4+T cell loss in a predominantly minority female HIV+ adolescent population. AIDS Res Hum Retroviruses 2004; 20:263-9.
13. Lange C, Lederman M. Immune reconstitution with antiretroviral therapies in chronic HIV-1 infection. J Antimicrob Chemother 2003; 51:1-4.
14. Ghandi R, Spritzler J, Chan E, et al. Effect of baseline and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy in HIV-1 positive subjects: results from ACTG 384. J Acquir Immune Defic Syndr 2006; 42:426-34.
15. Hunt P, Martin J, Sinclair E, et al. T cell activation is associated with lower CD4+ T cell gains in HIV-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 2003; 187:1534-43.
16. Benito JM, López M, Lozano S, et al. Differential up-regulation of CD38 on different T cell subsets may influence the ability to reconstitute CD4+ T cells under successful highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2005; 38:373-81.
17. Fry T, Mackall C. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J Immunol 2005; 174:6571-6.
18. Napolitano L, Grant R, Deeks S, et al. Increased production of IL-7 accompanies HIV-1 mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 2001; 7:73-79.
19. Fry T, Connick E, Falloon J, et al. A potential role for interleukin-7 in T-cell homeostasis. Blood 2001; 97:2983-90.
20. Beq S, Rannou M, Fontanet A, Delfraissy J, Theze J, Colle J. HIV infection: pre-highly active antiretroviral therapy IL-7 plasma levels correlate with long-term CD4 cell count increase after treatment. AIDS 2004; 18:563-5.
21. Fry T, MacKall C. Interleukin-7: from bench to clinic. Blood 2002; 99:3892-904.
22. Sasson S, Zaunders J, Zanetti G, et al. Increased plasma interleukin-7 levels correlates with decreased CD127 and increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection. J Infect Dis 2006; 193:505-14.
23. Paiardini M, Cervasi B, Albrecht H, et al. Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals. J Immunol 2005; 174:2900-9.
24. Rheti B, Fluur C, Atlas A, et al. Loss of IL-7R is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients. AIDS 2005; 19:2077-86.
25. Colle J, Moreau J, Fontanet A, Lambotte O, Delfraissy J, Theze J. The correlation between levels of IL-7Ra expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients. AIDS 2007; 21:101-3.
26. Fluur C, De Milito A, Fry T, et al. Potential role for IL7 in Fas-mediated T cell apoptosis during HIV infection. J Immunol 2007; 178:5340-50.
27. Faller E, McVey M, Kakal J, MacPherson A. Interleukin-7 receptor expression is down-regulated by the HIV Tat protein. J Acquir Immune Defic Syndr 2006; 43:257-69.
28. Kaech S, Tan J, Wherry E, Konieczny B, Surch C, Ahmed R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol 2003; 4:1191-8.
29. hi memory CD8+ T cells are preserved only in HIV-infected individuals receiving early treatment. J Infect Dis 2007; 195:108-17.
30. Schuluns K, Kieper W, Jameson S, Lefracois L. Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol 2000; 1:426-32.
31. Vranjkovic A, Crawley A, Gee K, Kumar A, Angel J. IL-7 decreases IL-7 receptor α (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. International Immunology 2007; 19:1329-39.
32. Boutboul F, Puthier D, Appay V, et al. Modulation of interleukin-7 receptor expression characterizes differentiation of CD8 T cells specific for HIV, EBV and CMV. AIDS 2005; 19:1981-6.
33. Colle J, Moreau J, Fontanet A, et al. Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients. Effects of antiretroviral therapy. J Acquir Immune Defic Syndr 2006; 42:277- 85.