7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells

Food and Chemical Toxicology

Volumn 49, Issue 1, 2011, Pages 166-172

  Mun, Lidiya ^a   Jun, Min Soo ^a   Kim, Young Min ^a   Lee, Young Soo ^a   Kim, Hye Jung ^a   Seo, Han Geuk ^a   Lee, Jae Heun ^a   Son, Kun Ho ^b   Lee, Dong Hwa ^b   Kim, Yeong Shik ^c   Park, Kyungok ^d   Chang, Ki Churl ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

^b Andong National University   (South Korea)

^c Seoul National University   (South Korea)

^d SAMSUNG Electronics   (South Korea)

Author keywords

7,8 didehydrocimigenol; Adhesion molecules; Atherosclerosis; Endothelial cells; Peroxisome proliferator activated receptor; Tumor necrosis factor

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 7,8 DIDEHYDROCIMIGENOL; ANTIINFLAMMATORY AGENT; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; N (2 BENZOYLPHENYL) O [2 (METHYL 2 PYRIDINYLAMINO)ETHYL]TYROSINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; PROTEIN KINASE C; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CELL ADHESION; CIMICIFUGA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MONOCYTE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANILIDES; BASE SEQUENCE; BLOTTING, WESTERN; CELL ADHESION; CELLS, CULTURED; CIMICIFUGA; DNA PRIMERS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MONOCYTES; PPAR GAMMA; PROTEIN KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 78650259564     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.10.012     Document Type: Article

References (25)

1. Alon R., Kassner P.D., Carr M.W., Finger E.B., Hemler M.E., Springer T.A. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J. Cell Biol. 1995, 128:1243-1253.
2. Bevilacqua M.P., Nelson R.M., Mannori G., Cecconi O. Endothelial-leukocyte adhesion molecules in human disease. Ann. Rev. Med. 1994, 45:361-378.
3. Blaschke F., Carglayan E., Hsueh W.A. Peroxisome proliferator-activated receptor gamma agonists: their role as vasoprotective agents in diabetes. Endocrinol. Metabol. Clin. North Am. 2006, 35:561-674.
4. Cybulsky M.I., Gimbrone M.A. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 1991, 251:788-791.
5. DiDonato J.A., Hayakawa M., Rothwarf D.M., Zandi E., Karin M.A. Cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 1999, 388:548-554.
6. Gerritsen M.E., Carley W.W., Ranges G.E., Shen C.P., Phan S.A., Ligon G.F., Perry C.A. Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression. Am. J. Pathol. 1995, 147:278-292.
7. Hirabayashi T., Ochiai H., Sakai S., Nakajima K., Terasawa K. Inhibitory effect of ferulic acid and isoferulic acid on murine interleukin-8 production in response to influenza virus infections in vitro and in vivo. Planta Med. 1995, 61:221-226.
8. Inoue K., Kobayashi M., Yano K., Miura M., Izumi A., Mataki C., Doi T., Hamakubo T., Reid P.C., Hume D.A., Yoshida M., Aird W.C., Kodama T., Minami T. Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. Arterio. Throm. Vasc. Biol. 2006, 26:2652-2659.
9. Iiyama K., Hajra L., Iiyama M., Li H., DiChiara M., Medoff B.D., Cybulsky M.I. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Cir. Res. 1999, 85:199-207.
10. Jeon S.J., Lee D.H., Son K.H. Isolation of biologically active compounds from Cimicifuga Rhizoma and Magnolia flos 2008, Seminar on Standardization of Herbal Medicine, Ministry of Korea Food and Drug Administration, Korea, pp. 289-300.
11. Kim H.Y., Shin H.S., Park H., Kim Y.C., Yun Y.G., Park S., Shin H.J., Kim K. In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex. J. Clin. Virol. 2008, 41:122-128.
12. Li J.X., Yu Z.Y. Cimicifugae rhizoma: from origins, bioactive constituents to clinical outcomes. Curr. Med. Chem. 2006, 13:2927-2951.
13. Liu I.M., Chi T.C., Hsu F.L., Chen C.F., Cheng J.T. Isoferulic acid as active principle from the rhizoma of Cimicifuga dahurica to lower plasma glucose in diabetic rats. Planta Med. 1999, 65:712-714.
14. Marui N., Offermann M.K., Swerlick R., Kunsch C., Rosen C.A., Ahmad M., Alexander R.W., Medford R.M. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J. Clin. Invest. 1993, 92:1866-1874.
15. Nizamutdinova I.T., Jung J.J., Choi J.Y., Lee S.H., Kang S.S., Kim Y.S., Chang K.C., Kim H.J. Hesperidin, Hesperidine methyl chalone and Phellopterin from Poncirus trifoliate (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-a-stimulated human umbilical vein endothelial cells. Int. Immunopharmacol. 2008, 8:670-678.
16. Nizamutdinova I.T., Kim Y.M., Chung J.I., Shin S.C., Jeong Y.K., Seo H.G., Lee J.H., Chang K.C., Kim H.J. Anthocyanins from black soybean seed coats preferentially inhibit TNF-alpha-mediated induction of VCAM-1 over ICAM-1 through the regulation of GATAs and IRF-1. J. Agri. Food Chem. 2009, 57:7324-7330.
17. Pasceri V., Wu H.D., Willerson J.T., Yeh E.T. Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators. Circulation 2000, 101:235-238.
18. Pierce J.W., Read M.A., Ding H., Luscinskas F.W., Collins T. Salicylates inhibit IkB-a phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophile transmigration. J. Immunol. 1996, 156:3961-3969.
19. Ross R. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 1999, 340:115-126.
20. Sakai S., Kawamata H., Kogure T., Mantani N., Terasawa K., Umatake M., Ochiai H. Inhibitory effect of ferulic acid and isoferulic acid on the production of macrophage inflammatory protein-2 in response to respiratory syncytial virus infection in RAW264.7 cells. Mediators Inflamm. 1999, 8:173-175.
21. Sasaki M., Jordan P., Welbourne T., Minagar A., Joh T., Itoh M., Elrod J.W., Alexander J.S. Troglitazone, a PPAR-gamma activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-alpha. BMC Physiol. 2005, 5:3.
22. Schmid D., Woehs F., Svoboda M., Thalhammer T., Chiba P., Moeslinger T. Aqueous extracts of Cimicifuga racemosa and phenolcarboxylic constituents inhibit production of proinflammatory cytokines in LPS-stimulated human whole blood. Can. J. Physiol. Pharmacol. 2009, 87:963-972.
23. Jackson S.M., Parhami F., Xi X.P., Berliner J.A., Hsueh W.A., Law R.E., Demer L.L. Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. Arterio. Thrombo. Vasc. Biol. 1999, 19:2094-2104.
24. Tsoyi K., Kim W.S., Kim Y.M., Kim H.J., Seo H.G., Lee J.H., Yun-Choi H.S., Chang K.C. Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells. Atherosclerosis 2009, 207:412-419.
25. Umetani M., Mataki C., Minegishi N., Yamamoto M., Hamakubo T., Kodama T. Function of GATA transcription factors in induction of endothelial vascular cell adhesion molecule-1 by tumor necrosis factor-alpha. Arterio. Throm. Vasc. Biol. 2001, 21:917-922.