Isomorph expression of BAG-1 gene, ER and PR in endometrial cancer

Anticancer Research

Volumn 30, Issue 10, 2010, Pages 4103-4108

  Porichi, Ourania ^a   Nikolaidou, Maria Evangelia ^a   Apostolaki, Aikaterini ^a   Arnogiannaki, Niki ^a   Papassideri, Issidora ^b   Chatonidis, Iordanis ^a   Tserkezoglou, Aliki ^a   Vorgias, Georgios ^c   Kassanos, Dimitrios ^b   Panotopoulou, Efstathia ^a  

^a St Savvas Regional Anticancer Oncology Hospital of Athens   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c METAXA CANCER HOSPITAL   (Greece)

Author keywords

Apoptosis; BAG 1; Endometrial carcinoma; ER; Immunohistochemistry; PR; Real time PCR

Indexed keywords

ANTINEOPLASTIC AGENT; BAG 1 PROTEIN; ESTROGEN RECEPTOR ALPHA; PARAFFIN; PROGESTERONE RECEPTOR A;

ADENOSQUAMOUS CARCINOMA; ADULT; AGED; ARTICLE; ASCITES FLUID CYTOLOGY; BRACHYTHERAPY; CANCER CHEMOTHERAPY; CANCER CLASSIFICATION; CANCER GRADING; CANCER HORMONE THERAPY; CANCER RECURRENCE; CANCER STAGING; CELL NUCLEUS; CLEAR CELL CARCINOMA; CONTROLLED STUDY; CYTOPLASM; DISEASE ASSOCIATION; DNA SYNTHESIS; ENDOMETRIOID CARCINOMA; ENDOMETRIUM CANCER; ENDOMETRIUM CARCINOMA; EVOKED RESPONSE AUDIOMETRY; EXTERNAL BEAM RADIOTHERAPY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SEROUS PAPILLARY CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, ENDOMETRIOID; DNA-BINDING PROTEINS; ENDOMETRIAL NEOPLASMS; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM STAGING; PROTEIN ISOFORMS; RECEPTORS, PROGESTERONE; TRANSCRIPTION FACTORS;

EID: 78650252760     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462, 1995.
2. Coldwell MJ, de Schoolmeester ML, Fraser GA, Pickering BM, Packham G and Willis AE: The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock. Oncogene 20(30): 4095-4100, 2001. (Pubitemid 32681614)
3. Yang X, Chernenko G, Hao Y, Ding Z, Pater MM, Pater A and Tang SC: Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells. Oncogene 17: 981-989, 1998. (Pubitemid 28425408)
4. Sharp A, Crabb SI, Townsend PA, Cutress RI, Brimmell M, Wang X and Packham G: BAG-1 in carcinogenesis. Exp R Mol Med 6(7): 1-15, 2004.
5. Townsend PA, Cutress RI, Sharp A, Brimmell M and Packham G: BAG-1: a multifunctional regulator of cell growth and survival. Biochem Biophys Acta 1603(2): 83-98, 2003a. (Pubitemid 36262942)
6. Townsend PA, Cutress RI, Sharp A, Brimmell M and Packham G: BAG-1 prevents stress-induced long-term growth inhibition in breast cancer cells via a chaperone-dependent pathway. Cancer Res 63: 4150-4157, 2003. (Pubitemid 36917940)
7. Chen J, Xiong J, Liu H, Chernenko G and Tang SC: Distinct BAG-1 isoforms have different antiapoptotic functions in BAG-1 transfected C33A human cervical carcinoma cell line. Oncogene 21: 7050-7059, 2002. (Pubitemid 35252979)
8. Cutress RI, Townsend PA, Brimmell M, Bateman AX and Packham G: BAG-1 expression and function in human cancer. Br J Cancer 87: 834-839, 2002. (Pubitemid 35252957)
9. Turner BC, Krajewski S, Krajewska M, Takayama S, Gumbs AA, Carter D, Rebbeck TR, Haffly BG and Reed JC: BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer. J Clin Oncol 19: 992-1000, 2001.
10. Sherman ME: Theories of endometrial carcinogenesis: a multidisciplinary approach. Mod Pathol 13: 295-308, 2000.
11. Witek A, Mazurek U, Paul M, Bierzynska-Macyskyn G and Wilczok T: Quantitative analysis of estrogen receptor receptor mRNA in human endometrium throughout the menstrual cycle using a real time reverse transcription polymerase chain Reaction assay. Folia Histochem Cytobiol 39(suppl 2): 116-118, 2001.
12. Utsunomiya H, Suzuki T, Harada M, Ito K, Matsuzaki S, Konno R, Sato T, Yajima A and Sasano H: Analysis of estrogen receptor alpha and beta in endometrial carcinomas: correlation with ER beta and clinicopathologic findings in 45 cases. Int J Gynecol Pathol 19(4): 335-341, 2000.
13. Matsuzaki S, Murakami T, Uehara S, Canis M, Sasano H and Okamura K: Expression of estrogen receptor alpha and beta in peritoneal and ovarian endometriosis. Fertil Steril 75(6): 1198-1205, 2001.
14. Conneely OM, Mulak-Jericevic B, DeMayo F, Lydon JP and O'Malley BW: Reproductive functions of progesterone receptors. Recent Prog Horn Res 57: 339-355, 2002.
15. Noyes RW and Herig AT: Dating the endometrial biopsy. Fertil Steril 1: 3-25, 1995.
16. Chomczynski P and Saccki N: Single-step method of RNA isolation by guanidium-thiocyanate - phenol-chloroform extraction. Anal Biochem 162: 156-159, 1985. (Pubitemid 17064313)
17. Arends MJ: Apoptosis in the endometrium. Histopathology 35: 174-178, 1999.
18. Yang X, Hao Y, Ferency A, Tang SC and Pater A: Overepxression of antiapoptotic gene BAG-1 in human cervical cancer. Exp Cell Res 247: 200-207, 1999. (Pubitemid 29393976)
19. Ribeiro-Silva A: Immunohistochemical features of a papillary squamous cell carcinoma of the endometrium with transitional cell differentiation. Diagn Pathol 2: 26, 2007.
20. Naishiro Y, Adachi M, Okuda H, Yawata A, Mitaka T, Takayama S, Reed JC, Hinoda Y and Imai K: BAG-1 accelerates cell motility of human gastric cancer cells. Oncogene 18: 3244-3251, 1999.
21. Brimmell M, Burns JS, Munson P, McDonald L, O'Hare MJ, Lakhani SR and Packham G: High level expression of differentially localize BAG-1 isoforms in some oestrogen receptor-positive human breast cancers. Br J Cancer 81: 1042-1051, 1999.
22. Song JY, Kim JM, Lee JK, Lee NW, Yeom BW, Kim SH and Lee KW: BAG-1 expression in normal endometrium, endometrial hyperplasia endometrial cancer. Acta Obstet Gynecol Scand 87(8): 862-867, 2008.
23. Hohfeld J: Regulation of the heat-shock conjugate Hsc70 in the mammalian cell: the characterization of the antiapoptotic protein BAG-1 provides novel insights. Biol Chem 379: 269-274, 1998.
24. Tang SC, Shaheta N, Chernenko G, Khalifa M and Wang X: Expression of BAG-1 in invasive breast carcinomas. J Clin Oncol 17: 1710-1719, 1999. (Pubitemid 29269239)
25. Townsend PA, Dublin E, Hart IR, Kao RH, Hanby AM, Cutress RI, Poulsam R, Ryder K, Barnes DM and Packham G: BAG-1 expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC-70 expression and clinicopathological data. J Pathol 197: 51-59, 2002.
26. Moriyama T, Littell RD, Debernardo R, Oliva E, Lynch MP, Rueda BR and Duska LR: BAG-1 expression in normal and neoplastic endometrium. Gyn Oncol 94: 289-295, 2004. (Pubitemid 39024529)
27. Tang SC: BAG-1, an anti-apoptotic tumour marker. IUBMB Lefe 53(2): 99-105, 2002.
28. Cutress RI, Townsend P, Sharp A, Maison A, Wood L, Lee R, Brimmell M, Mullee MA, Johnson PW, Royle GT, Bateman AC and Packham G: The nuclear BAG-1 isoform, BAG-1L, enhances estrogen-dependent transcription. Oncogene 22: 4973-4982, 2003.
29. Jazaeri AA, Nunes KJ, Dalton SM, Xu M, Shupnik MA and Rice LW: Well-differentiated endometrial adenocarcinomas and poorly differentiated mixed mullerian tumors have altered ER and PR isoform expression. Oncogene 20(47): 6965-6969, 2001. (Pubitemid 33052187)
30. Kumar NS, Richer J, Owen G, Litman E, Horwitz KB and Leslie KK: Selective down-regulation of progesterone receptor isoform B in poorly differentiated human endometrial cancer cells: implications of unopposed estrogen action. Cancer Res 58: 1860-1865, 1998.
31. Graham JD, Yeates C, Balleine RL, Harvey SS, Milliken JS, Bilous AM and Clarke CL: Progesterone receptor A and B protein expression in human breast cancer. J Steroid Biochem Mol Biol 56: 93-98, 1996.
32. Foley EF, Jazaeri AA, Shupnik MA, Jazaeri O and Rice LW: Selective loss of estrogen receptor beta in malignant human colon. Cancer Res 60: 245-248, 2000. (Pubitemid 30070743)
33. Sari I, Gocmen A, Bitiren M and Cakmak EA: The relationship between expression of p53/bcl-2 and clinicopathological criteria in endometrioid adenocarcinomas of the endometrium. Eur J Gynecol Oncol 25(1): 79-80, 2004. (Pubitemid 38165925)
34. Fukuda K, Mori M, Uchiyama M, Iwai K, Iwasaka T and Sugimori H: Prognostic significance of progesterone receptor. Immunohistochemistry in endometrial carcinoma. Gyn Oncol 3: 220-225, 1998.
35. Dahmoun M, Backstrom T, Boman K and Cajander S: Apoptosis, proliferation and hormone receptors in endometrial carcinoma: results depending on methods of analysis. Int J Oncol 22: 115-122, 2003.
36. Sing M, Zaino RJ, Filiaci VJ and Leslie KK: Relationship of estrogen and progesterone receptors to clinical outcome in metastatic endometrial carcinoma: a Gynecologic Oncology Group Study. Gynecol Oncol 106(2): 325-333, 2007.
37. Shabani N, Kuhn C, Kunze S, Schulze S, Mayr D, Dian D, Gingelmaier A, Schindlbeck C, Willgeroth F, Sommer H, Jeschke U. Friese K and Mylonas I: Prognostic significance of estrogen receptor alpha (ER alpha) and beta (ER beta), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas. Eur J Cancer 43(16): 2434-2444, 2007.
38. Reid - Nicholson M, Iyengar P, Hummer AJ, Linkov I, Asher M and Soslow RA: Immunophenotypic diversity of endometrial adenocarcinomas: implications for differential diagnosis. Mod Pathol 19: 1091-1100, 2006.
39. Vang R, Whitaker BP, Farhood AI, Silva EG, Ro JY and Deavers MT: Immunohistochemical analysis of clear cell carcinoma of the gynecologic tract. Int J Pathol 20: 252-259, 2001. (Pubitemid 32578111)
40. Cameron RI, Ashe P, O'Rourke DM, Foster H and McCluggage WG: A panel of immunohistochemical stains assists in the distinction between ovarian and renal clear cell carcinoma. Int J Gynecol Pathol 22: 272-276, 2003. (Pubitemid 36750410)
41. Ito K, Utsonomiya H, Yaegashi N and Sasano H: Biological roles of estrogen and progesterone in human endometrial carcinoma - new developments in potential endocrine therapy for endometrial cancer. Endocr J 54(5): 667-679, 2007. (Pubitemid 351377743)