A panel of immunohistochemical stains assists in the distinction between ovarian and renal clear cell carcinoma

International Journal of Gynecological Pathology

Volumn 22, Issue 3, 2003, Pages 272-276

  Cameron, R I ^b   Ashe, P ^b   O'Rourke, D M ^b   Foster, H ^b   McCluggage, W G ^a  

^a ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

^b NONE

Author keywords

CD10; CK20; CK7; ER; Immunohistochemistry; Kidney; Ovary; RCC marker; Vimentin

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYTOKERATIN 20; CYTOKERATIN 7; ESTROGEN RECEPTOR; TUMOR MARKER; VIMENTIN;

ARTICLE; CANCER DIAGNOSIS; CLEAR CELL CARCINOMA; DIFFERENTIAL DIAGNOSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; METASTASIS; OVARY CARCINOMA; PRIORITY JOURNAL; TUMOR LOCALIZATION;

ANTIBODIES; CARCINOMA, RENAL CELL; COLORING AGENTS; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; KERATIN-20; KERATIN-7; KERATINS; KIDNEY NEOPLASMS; NEPRILYSIN; OVARIAN NEOPLASMS; RECEPTORS, ESTROGEN; TUMOR MARKERS, BIOLOGICAL; VIMENTIN;

EID: 0037531343     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.PGP.0000071044.12278.43     Document Type: Article

References (24)

1. Kennedy AW, Biscotti CV, Hart WR, et al. Ovarian clear cell carcinoma. Gynecol Oncol 1989;32:342-9.
2. Stern RC, Dash R, Bentley RC, et al. Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types. Int J Gynecol Pathol 2001;20:133-9.
3. Spencer JR, Eriksen B, Garnett JE. Metastatic renal tumor presenting as ovarian clear cell carcinoma. Urology 1993;41:582-4.
4. Young RH, Hart WR. Renal cell carcinoma metastatic to the ovary: a report of three cases emphasizing possible confusion with ovarian clear cell adenocarcinoma. Int J Gynecol Pathol 1992;11:96-104.
5. Buller RE, Braga CA, Tonagho EA, et al. Renal cell carcinoma metastatic to the ovary: a case report. J Reprod Med 1983;28: 217-20.
6. Martzloff KH, Manlove CH. Vaginal and ovarian metastases from hypernephroma: report of case and review of literature. Surg Gynecol Obstet 1949;88:145-54.
7. Vorder Bruegge CF, Hobbs JE, Wegner CR, et al. Bilateral ovarian metastases from renal adenocarcinoma: report of a case and discussion of pathogenesis. Obstet Gynecol 1957;9:198-205.
8. Nolan LP, Heatley MK. The value of immunocytochemistry in distinguishing between clear cell carcinoma of the kidney and ovary. Int J Gynecol Pathol 2001;20:155-9.
9. Arber DA, Weiss LM. CD10. A review. Appl Immunohistochem 1997;5:125-40.
10. Holm-Nielson P, Pallesen G. Expression of segment-specific antigens in the human nephron and in renal epithelial tumors. APMIS Suppl 1998;4:48-55.
11. Avery AK, Beckstead J, Renshaw AA, et al. Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms. Am J Surg Pathol 2000;24:203-10.
12. Chu P, Arber DA. Paraffin-section detection of CD10 in 505 nonhematopoeitic neoplasms. Am J Clin Pathol 2000;113:374-82.
13. McCluggage WG, Sumathi VP. CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. Histopathology 2001;39:273-8.
14. Sumathi VP, McCluggage WG. CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis. J Clin Pathol 2002;55:391-2.
15. McGregor DK, Khurann KK, Cao C, et al. Diagnosing primary and metastatic renal cell carcinoma: the use of the monoclonal antibody "renal cell carcinoma marker." Am J Surg Pathol 2001;25:1485-92.
16. Ueda G, Sawada M, Ogawa H, et al. Immunohistochemical study of cytokeratin 7 for the differential diagnosis of adenocarcinoma in the ovary. Gynecol Oncol 1993;51:219-23.
17. McCluggage WG. Recent advances in immunohistochemistry in gynaecological pathology. Histopathology 2002;4:309-26.
18. McCluggage WG. Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms. J Clin Pathol 2000;53:327-34.
19. Chu P, Wu E, Weiss LM. Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol 2000;13:962-72.
20. Mathers ME, Pollock AM, Marsh C, et al. Cytokeratin 7: a useful adjunct in the diagnosis of chromophobe renal cell carcinoma. Histopathology 2002;40:563-7.
21. Delahunt B, Eble JN. Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. Mod Pathol 1997;10:537-44.
22. Medeiros LJ, Michie SA, Johnson DE, et al. An immunoperoxidase study of renal cell carcinomas: correlation with nuclear grade, cell type, and histologic pattern. Hum Pathol 1988;19:980-7.
23. Oosterwijk E, Ruiter DJ, Wakka JC, et al. Immunohistochemical analysis of monoclonal antibodies to renal antigens. Application in the diagnosis of renal cell carcinoma. Am J Pathol 1986;123:301-9.
24. Vang R, Whitaker BP, Farhood AI, et al. Immunohistochemical analysis of clear cell carcinoma of the gynecologic tract. Int J Gynecol Pathol 2001;20:252-9.