Charge differences between in vivo deposits in immunoglobulin light chain amyloidosis and non-amyloid light chain deposition disease

British Journal of Haematology

Volumn 136, Issue 5, 2007, Pages 723-728

  Kaplan, Batia ^a   Livneh, Avi ^a   Gallo, Gloria ^b  

^a HELLER INSTITUTE OF MEDICAL RESEARCH   (Israel)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Immunoglobulin light chain amyloidosis; Isoelectric focusing; Non amyloid light chain deposition disease; Plasma cell dyscrasias; Protein charge

Indexed keywords

ANION; CATION; IMMUNOGLOBULIN LIGHT CHAIN; ISOPROTEIN; POLYPEPTIDE; PROTEOGLYCAN;

AMYLOIDOSIS; ARTICLE; BASEMENT MEMBRANE; CONTROLLED STUDY; ELECTRICITY; FIBER; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN AGGREGATE; IMMUNOGLOBULIN DEPOSITION; IMMUNOGLOBULIN LIGHT CHAIN AMYLOIDOSIS; IN VITRO STUDY; IN VIVO STUDY; ISOELECTRIC POINT; NON AMYLOID LIGHT CHAIN DEPOSITION DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ISOLATION; PROTEINOSIS;

AMYLOID; AMYLOIDOSIS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ELECTROSTATICS; GLOMERULAR BASEMENT MEMBRANE; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; ISOELECTRIC FOCUSING; PARAPROTEINEMIAS; PROTEIN BINDING;

EID: 33846997579     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2006.06488.x     Document Type: Article

References (38)

1. Bellotti, V., Merlini, G., Bucciarelli, E., Perfetti, V., Quaglini, S. & Ascari, E. (1990) Relevance of class, molecular weight and isoelectric point in predicting human light chain amyloidogenicity. British Journal of Haematology, 74, 65-69.
2. Burtin, P. & Gendron, M.C. (1971) A precipitation reaction between certain human G immunoglobulins and sulfated galactans. Immunochemistry, 8, 423-429.
3. Caulfield, J.P. & Farquhar, M.G. (1976) Distribution of anionic sites in glomerular basement membranes: their possible role in filtration and attachment. Proceedings of the National Academy of Sciences of the United States of America, 73, 1646-1650.
4. Cogne, M., Preud'homme, J.L., Bauwens, M., Touchard, G. & Aucouturier, P. (1991) Structure of a monoclonal kappa chain of the V-kappa IV subgroup in the kidney and plasma cells in light chain deposition disease. Journal of Clinical Investigation, 87, 2186-2190.
5. Gallo, G.R., Caulin-Glaser T. & Lamm, M.E. (1981) Charge of circulating immune complexes as a factor in glomerular basement membrane localization in mice. Journal of Clinical Investigation, 67, 1305-1313.
6. Gallo, G., Picken, M., Frangione, B. & Buxbaum, J. (1988) Nonamyloidotic monoclonal immunoglobulin deposits lack amyloid P component. Modern Pathology, 1, 453-456.
7. Gallo, G., Picken, M., Buxbaum, J. & Frangione, B. (1989) The spectrum of monoclonal deposition disease associated with immunocytic dyscrasias. Seminars in Hematology, 26, 234-245.
8. Gallo, G., Wisniewski, T., Choi-Miura, N-H., Ghiso, J. & Frangione, B. (1994) Potential role of apolipoprotein-E in fibrillogenesis. American Journal of Pathology, 145, 526-530.
9. Gallo, G., Goni, F., Boctor, F., Vidal, R., Kumar, A., Stevens, F.J., Frangione, B. & Ghiso, J. (1996) Light chain cardiomyopathy: structural analysis of the light chain tissue deposits. American Journal of Pathology, 148, 1397-1406.
10. Gelsema, W.J., de Ligny, C.L. & der Veen, N.G. (1979) Isoelectric points of proteins, determined by isoelectric focusing in the presence of urea and ethanol. Journal of Chromatography, 171, 171-181.
11. Harris, R.J. (1995) Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture. Journal of Chromatography A, 705, 129-134.
12. Harrison, H.H. (1992) Patient-specific microheterogeneity patterns of monoclonal immunoglobulin light chains as revealed by high resolution, two-dimensional electrophoresis. Clinical Biochemistry, 25, 235-243.
13. Ivanyi, B. (1990) Frequency of light chain deposition nephropathy relative to renal amyloidosis and Bence Jones cast nephropathy in a necropsy study of patients with myeloma. Archives of Pathology and Laboratory Medicine, 114, 986-997.
14. Kanwar, Y.S. & Farquhar, M.G. (1979) Isolation of glycosaminoglycans (heparan sulfate) from glomerular basement membranes. Proceedings of the National Academy of Sciences of the United States of America, 76, 4493-4497.
15. Kanwar, Y.S., Caulin-Glaser, T., Gallo, G.R. & Lamm, M.E. (1986) Interaction of immune complexes with glomerular heparan sulfate-proteoglycans. Kidney International, 30, 842-851.
16. Kaplan, B., German, G. & Pras, M. (1993) Isolation and characterization of amyloid proteins from milligram amounts of amyloid-containing tissue. Journal of Liquid Chromatography, 16, 2249-2268.
17. Kaplan, B., Yakar, S., Kumar, A., Pras, M. & Gallo, G. (1997) zImmunochemical characterization of amyloid in diagnostic biopsy tissues. Amyloid, 4, 80-86.
18. Kaplan, B., Murphy, C.L., Ratner, V., Pras, M., Weiss, D.T. & Solomon, A. (2001) Micro-method to isolate and purify amyloid proteins for chemical characterization. Amyloid, 8, 22-29.
19. Kaplan, B., Martin, B.M., Livneh, A., Pras, M. & Gallo, G.R. (2004) Biochemical subtyping of amyloid in formalin-fixed tissue samples confirms and supplements immunohistological data. American Journal of Clinical Pathology, 121, 794-800.
20. Kaplan, B., Martin, B.M., Boykov, O., Gal, R., Pras, M., Shechtman, I., Saute, M. & Kramer, M.R. (2005a) Co-deposition of amyloidogenic immunoglobulin light and heavy chains in localized pulmonary amyloidosis. Virchows Archiv, 447, 756-761.
21. Kaplan, B., Martin, B.M., Livoff, A., Yeremenko, D., Livneh, A. & Cohen, H.I. (2005b) Gastrointestinal b2-microglobulin amyloidosis in hermodialysis patients: biochemical analysis of amyloid proteins in small formalin-fixed paraffin-embedded tissue specimens. Modern Pathology, 18, 1610-1617.
22. Khamlichi, A.A., Aucouturier, P., Silvain, C., Bauwens, M., Touchard, G., Preud'homme, J-L., Nau, F.&Cogne, M. (1992) Primary structure of a monoclonal kappa chain in myeloma with light chain deposition disease. Clinical and Experimental Immunology, 87, 122-126.
23. Levy, D.E., Horner, A.A. & Solomon, A. (1981) Immunoglobulin-sulfated polysaccharide interactions. Binding of agaropectin and heparin by human IgG proteins. Journal of Experimental Medicine, 153, 883-896.
24. Lyubarskaya, Y., Houde, D., Woodard, J., Murphy, D. & Mhatre, R. (2006) Analysis of recombinant monoclonal isoforms by electrospray ionization mass spectrometry as a strategy for streamlining characterization of recombinant monoclonal antibody charge heterogeneity. Annals of Biochemistry, 348, 24-39.
25. Makin, O.S., Atkins, E., Sikorski, P., Johansson, J. & Serpell, L.C. (2005) Molecular basis for amyloid fibril formation and stability. Proceedings of the National Academy of Sciences of the United States of America, 102, 315-320.
26. Perkins, M., Theiler, R., Lunte, S. & Jeschke, M. (2000) Determination of the origin of charge heterogeneity in a murine monoclonal antibody. Pharmaceutical Research, 17, 1110-1117.
27. Pras, M., Schubert, M., Zucker-Franklin, D., Rimon, A. & Franklin, E.C. (1968) The characterization of soluble amyloid prepared in water. Journal of Clinical Investigation, 47, 924-933.
28. Pras, M., Frangione, B., Franklin, E.C. & Gafni, J. (1982) Idiopathic AL-k IV amyloidosis presenting as a giant hepatomegaly. Israel Journal of Medical Science, 18, 866-869.
29. Randall, R.E., Williamson, Jr, W.C., Mullinax, F., Tung, M.Y. & Still, W.J.S. (1976) Manifestations of systemic light chain deposition. American Journal of Medicine, 60, 293-299.
30. Rocca, A., Khamlichi, A.A., Aucouturier, P., Noel, L.H., Denoroy, J.L., Preud'homme, J.L. & Cogne, M. (1993) Primary structure of the variable region of the V kappa 1 subgroup (ISE) in light chain deposition disease. Clinical and Experimental Immunology, 91, 506-509.
31. Schiffer, M. (1996) Molecular anatomy and the pathological expression of antibody light chains. American Journal of Pathology, 148, 1339-1344.
32. Schmelzer A.E. & Miller W.M. (2002) Hyperosmotic stress and elevated pCO2 alter monoclonal antibody charge distribution and monosaccharide content. Biotechnology Progress, 18, 346-353.
33. Skoog, B. & Wichman, A. (1986) Calculation of the isoelectric points of polypeptides from the amino-acid composition. Trends Analytical Chemistry, 5, 82-83.
34. Solomon, A., Frangione, B. & Franklin, E.C. (1982) Bence Jones proteins and light chains of immunoglobulins. Preferential association of the V λ VI subgroup of human light chains with amyloidosis AL. Journal of Clinical Investigation, 70, 452-460.
35. Tjernberg, L., Hosia, W., Bark, N., Thyberg, J. & Johansson, J. (2002) Charge attraction and β-propensity are necessary for amyloid fibril formation from tetrapeptides. Journal of Biological Chemistry, 277, 43243-43246.
36. Ui, N. (1971) Isoelectric points and conformation of proteins. I. Effect of urea on the behavior of some proteins in isoelectric focusing. Biochimica et Biophysica Acta, 229, 567-581.
37. Vidal, R., Goni, F., Stevens, F., Aucouturier, P., Kumar, A., Frangione, B., Ghiso, J. & Gallo, G. (1999) Somatic mutations of the L12a gene in V-κ1 light chain deposition disease: potential effects on aberrant protein conformation and deposition. American Journal Pathology, 155, 2009-2017.
38. Westermark, P. (1982) The heterogeneity of protein AA in secondary (reactive) systemic amyloidosis. Biochimica et Biophysica Acta, 701, 19-23.